Elimination of P. berghei liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity.

abstract：:Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserve...

journal_title：Parasite immunology

authors： Osier FH,Polley SD,Mwangi T,Lowe B,Conway DJ,Marsh K

更新日期：2007-08-01 00:00:00

abstract：:On a B10 (Lshs) genetic background, the development of acquired T cell mediated immunity to Leishmania donovani infection in mice is under H-2 linked genetic control. Following intravenous inoculation of 10(7) amastigotes three phenotypic patterns of recovery have been described: 'early cure' (H-2r,s), 'cure' (H-2b) a...

journal_title：Parasite immunology

authors： Ulczak OM,Blackwell JM

更新日期：1983-09-01 00:00:00

abstract：:This study examines several aspects of a polymorphic, immunodominant molecule (PIM) found in the protozoan parasite, Theileria parva. The antigen is present in all T.p. parva stocks examined, and in the related subspecies, T.p.bovis and T.p.lawrencei. It is the predominant antigen recognized by antisera from immune ca...

journal_title：Parasite immunology

authors： Toye PG,Goddeeris BM,Iams K,Musoke AJ,Morrison WI

更新日期：1991-01-01 00:00:00

abstract：:The carrier effect, using TNP-labelled schistosomula was used to measure the helper T-cell activity against the schistosomula surface in CBA mice exposed to 30 cercariae of Schistosoma mansoni. After infection the helper T-cell activity reached a peak in 8--10 days, but by 6 weeks it had declined to background levels....

journal_title：Parasite immunology

authors： Ramalho-Pinto FJ,Smithers SR

更新日期：1981-10-01 00:00:00

abstract：:We describe an ELISA for trophozoite-specific IgA in the intestinal secretions of mice infected with Giardia muris. Using this method, trophozoite-specific IgA was demonstrated in intestinal secretions of Giardia-infected immunocompetent BALB/c mice. Such antibody was undetectable in the intestinal secretions of Giard...

journal_title：Parasite immunology

authors： Heyworth MF,Kung JE,Caplin AB

更新日期：1988-11-01 00:00:00

abstract：:The role of MHC class II in the presentation of Heligmosomoides polygyrus antigens has been investigated, using a number of T cell hybridomas produced in A and E positive and negative mice. By using fixed and irradiated antigen presenting cells (APC), further evidence has emerged, to support earlier data, that there c...

journal_title：Parasite immunology

authors： Mason SD,Gustad TR,David CS,Robinson M

更新日期：1996-09-01 00:00:00

abstract：:Research on infectious agents as a possible cause of schizophrenia has become prominent in the past decade. Toxoplasma gondii has emerged as a prime candidate for a variety of reasons; (i) many studies have reported that individuals with schizophrenia, compared to controls, have a higher prevalence of antibodies to T....

journal_title：Parasite immunology

authors： Yolken RH,Dickerson FB,Fuller Torrey E

更新日期：2009-11-01 00:00:00

abstract：:Previous studies have shown that Leishmania elongation initiation factor (LeIF) antigen causes a partial immunity against leishmaniasis. The antigen develops type I immunity by overexpression of inflammatory cytokines such as interleukin-12 (IL-12), IFN-γ and TNF-α. Therefore, We evaluated immune responses induced by ...

journal_title：Parasite immunology

authors： Maspi N,Ghaffarifar F,Sharifi Z,Dalimi A

更新日期：2016-04-01 00:00:00

abstract：:Entamoeba histolytica is known to induce host cell death via activation of calpain and caspases. In this study, we investigated the specific proteases involved in the degradation of cytoskeletal proteins during Jurkat T-cell death induced by E. histolytica. Amoebic trophozoites induced marked degradation of paxillin, ...

journal_title：Parasite immunology

authors： Lee YA,Kim KA,Shin MH

更新日期：2011-06-01 00:00:00

abstract：:Cysteine proteinase enriched fractions obtained by thiol-sepharose chromatography of Ostertagia ostertagi membrane-bound protein extract (S3-thiol) or total adult excretory-secretory (ES-thiol) products were tested in a vaccination experiment to evaluate their protective efficacy against O. ostertagi in cattle. Calves...

journal_title：Parasite immunology

authors： Geldhof P,Claerebout E,Knox D,Vercauteren I,Looszova A,Vercruysse J

更新日期：2002-05-01 00:00:00

abstract：:The role of CD4+ and CD8+ T cells in protective immunity to Trichuris muris was studied in CD4+ or CD8+ or both CD4+ and CD8+ T cell-depleted BALB/c mice. To assess in vivo depletion of T-cell subsets, CD4+ and CD8+ T cells in the Peyer's patches, the mesenteric lymph nodes (MLN), and the spleens of mice treated with ...

journal_title：Parasite immunology

authors： Koyama K,Tamauchi H,Ito Y

更新日期：1995-03-01 00:00:00

abstract：:Urine and stool specimens from 425 school children in Swaziland were examined for evidence of Schistosoma mansoni or Schistosoma haematobium infection. Concurrently, saliva collections were analysed for ABH secretory ability and blood samples were typed for ABO, Rh and Lewis groups. Among individuals infected with S. ...

journal_title：Parasite immunology

authors： Trangle KL,Goluska MJ,O'Leary MJ,Douglas SD

更新日期：1979-07-01 00:00:00

abstract：:In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. We found that IL-18 was highly capable of reducing ...

journal_title：Parasite immunology

authors： Pfaff AW,Kirch AK,Hoffmann WH,Banla M,Schulz-Key H,Geiger SM,Soboslay PT

更新日期：2003-06-01 00:00:00

abstract：:An indirect enzyme linked immunsorbent assay (ELISA) for detection of antibodies to Neospora caninum in serum from dogs is described. Extracted tachyzoite proteins incorporated into immunostimulating complexes (iscoms) were used as coating antigen. A mixture of a monoclonal antibody to dog immunoglobulin G and a horse...

journal_title：Parasite immunology

authors： Björkman C,Lundén A,Holmdahl J,Barber J,Trees AJ,Uggla A

更新日期：1994-12-01 00:00:00

abstract：:In the last years, microRNAs (miRNAs) have been established as important post-transcriptional regulators of critical physiological processes in animals and plants. Here, we summarize what is known about miRNA biosynthesis, expression and function in the malaria vector mosquito Anopheles gambiae with a particular empha...

journal_title：Parasite immunology

authors： Lampe L,Levashina EA

更新日期：2017-02-01 00:00:00

abstract：:Na-ASP-2 is a major protein secreted by infective third-stage larvae (L3) of the human hookworm Necator americanus upon host entry. It was chosen as a lead vaccine candidate for its ability to elicit protective immune responses. However, clinical development of this antigen as a recombinant vaccine was halted because ...

journal_title：Parasite immunology

authors： Zhan B,Santiago H,Keegan B,Gillespie P,Xue J,Bethony J,de Oliveira LM,Jiang D,Diemert D,Xiao SH,Jones K,Feng X,Hotez PJ,Bottazzi ME

更新日期：2012-08-01 00:00:00

abstract：:Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil ...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1982-09-01 00:00:00

abstract：:CD4(+) T cells play a critical role in determining the disease outcome in murine cutaneous leishmaniasis, and selective usage of T-cell receptor (TCR) is implied in promoting Leishmania major infection. However, little information is available on TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells. In thi...

journal_title：Parasite immunology

authors： Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L

更新日期：2011-03-01 00:00:00

abstract：:Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites. Nucleated cells in the spleen increased in number in Py-infected mice and were maximal at the time of recove...

journal_title：Parasite immunology

authors： Lelchuk R,Taverne J,Agomo PU,Playfair JH

更新日期：1979-04-01 00:00:00

abstract：:In vitro released products of the adult stage of the bovine lungworm. Dictyocaulus viviparus, were characterized according to their SDS-PAGE profile, glycosylation pattern, in vitro synthesis and antigenicity in the context of infection and vaccination with irradiated larvae. Biosynthetic labelling experiments with 35...

journal_title：Parasite immunology

authors： Britton C,Canto GJ,Urquhart GM,Kennedy MW

更新日期：1993-03-01 00:00:00

abstract：:The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness w...

journal_title：Parasite immunology

authors： Schweitzer AN,Taylor DW

更新日期：1991-05-01 00:00:00

abstract：:Haemonchus contortus is an economically important parasite that survives the host defense system by modulating the immune response. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is secreted by the parasite and the host responds by producing anti-enzyme antibodies. The enzyme inhibits complement cascade, an arm of t...

journal_title：Parasite immunology

authors： Rajan P,Mishra PKK,Joshi P

更新日期：2019-02-01 00:00:00

abstract：:Eleven strains of Trypanosoma cruzi, originating from a variety of vertebrate and invertebrate hosts in distinct geographical regions, were examined for the reactivity of metacyclic stages with the monoclonal antibody 1G7. Trypomastigotes of five strains were susceptible to complement-dependent 1G7-mediated lysis. Hig...

journal_title：Parasite immunology

authors： Mortara RA,Araguth MF,Yoshida N

更新日期：1988-07-01 00:00:00

abstract：:Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia c...

journal_title：Parasite immunology

authors： Schetters TP,Scholtes NC,Kleuskens JA,Bos HJ

更新日期：1996-01-01 00:00:00

abstract：:HIV and T. gondii infection markers were measured among 383 Intravenous Drug Users (IDU). And cytokine concentrations (IL-4, IL-6, IL-10, IL-12, IFN-gamma and TNF-alpha) were determined. The results showed IDU with HIV infection or HIV/T. gondii co-infection could disturb Th regulatory mechanism. ...

journal_title：Parasite immunology

authors： Li JR,Gong RY,Li YP,Bai Y,You F,Deng S

更新日期：2010-02-01 00:00:00

abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...

journal_title：Parasite immunology

authors： Irigoín F,Würzner R,Sim RB,Ferreira AM

更新日期：1996-07-01 00:00:00

abstract：:Previous work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adult Haemonchus contortus using thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further ...

journal_title：Parasite immunology

authors： Knox DP,Smith SK,Redmond DL,Smith WD

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:More than 11 million people were estimated to have been infected by Schistosoma japonicum in China before the 1950s. However, few studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI). OBJECTIVE:We aimed to evaluate the association of PSI with fatty liver a...

journal_title：Parasite immunology

authors： Zou ZQ,Liu M,Zhong HQ,Guan GY

更新日期：2021-01-17 00:00:00

abstract：:A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...

journal_title：Parasite immunology

authors： Ortega-Pierres G,Clark NW,Parkhouse RM

更新日期：1986-11-01 00:00:00

abstract：:Serum from cats (Felis catus) that were repeatedly infected with Brugia pahangi and had become amicrofilaraemic (mf-ve) was injected intravenously into microfilaraemic (mf+ve) cats. If more than 1 microliter of immune serum per 1000 mf was injected, microfilarial counts fell dramatically within minutes and, in some ca...

journal_title：Parasite immunology

authors： Medeiros F,Baldwin CI,Denham DA

更新日期：1996-02-01 00:00:00