Virus-like particles expressing Plasmodium berghei MSP-8 induce protection against P. berghei infection.

abstract：:The role of MHC class II in the presentation of Heligmosomoides polygyrus antigens has been investigated, using a number of T cell hybridomas produced in A and E positive and negative mice. By using fixed and irradiated antigen presenting cells (APC), further evidence has emerged, to support earlier data, that there c...

journal_title：Parasite immunology

authors： Mason SD,Gustad TR,David CS,Robinson M

更新日期：1996-09-01 00:00:00

abstract：:In vitro released products of the adult stage of the bovine lungworm. Dictyocaulus viviparus, were characterized according to their SDS-PAGE profile, glycosylation pattern, in vitro synthesis and antigenicity in the context of infection and vaccination with irradiated larvae. Biosynthetic labelling experiments with 35...

journal_title：Parasite immunology

authors： Britton C,Canto GJ,Urquhart GM,Kennedy MW

更新日期：1993-03-01 00:00:00

abstract：:Mice infected with lethal P. berghei or P. yoelii malaria develop anti-lymphocyte autoantibodies less than a week after infection. The autoantibodies are IgM, T-dependent and cytotoxic to a subpopulation of non-T lymphocytes at 37 degrees C in the presence of mouse or guinea-pig complement. Non-lethal P. yoelii and P....

journal_title：Parasite immunology

authors： de Souza JB,Playfair JH

更新日期：1983-05-01 00:00:00

abstract：:Research undertaken over the past 40 years has established many of the general principals concerning immunity to taeniid cestodes. Although much is well understood about the host-protective mechanisms against taeniids and this knowledge has been exploited in studies on vaccine development, many aspects require further...

journal_title：Parasite immunology

authors： Lightowlers MW

更新日期：2010-11-01 00:00:00

abstract：:A recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission....

journal_title：Parasite immunology

authors： O'Meara WP,Lang T

更新日期：2009-09-01 00:00:00

abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...

journal_title：Parasite immunology

authors： Van Milligen FJ,Cornelissen JB,Hendriks IM,Gaasenbeek CP,Bokhout BA

更新日期：1998-06-01 00:00:00

abstract：:Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserve...

journal_title：Parasite immunology

authors： Osier FH,Polley SD,Mwangi T,Lowe B,Conway DJ,Marsh K

更新日期：2007-08-01 00:00:00

abstract：:Previous work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adult Haemonchus contortus using thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further ...

journal_title：Parasite immunology

authors： Knox DP,Smith SK,Redmond DL,Smith WD

更新日期：2005-04-01 00:00:00

abstract：:Successful endoparasites of mammals must outwit the sophisticated immune systems of their hosts that have evolved to detect and destroy/eradicate them. Many species of helminth parasite can directly or indirectly manipulate host immunity: helminth-derived molecules can suppress or skew activity of many immune cell phe...

journal_title：Parasite immunology

authors： McKay DM

更新日期：2015-06-01 00:00:00

abstract：:To study the role of autoreactive T cells in the pathogenesis of cardiomyopathy in Chagas' disease, we generated a cell line by repeated in vitro antigenic stimulation of purified splenic CD4+ T lymphocytes from a chronically Trypanosoma cruzi-infected mouse. Cells from this line were confirmed to be CD4+ CD8- and pro...

journal_title：Parasite immunology

authors： Ribeiro-Dos-Santos R,Mengel JO,Postol E,Soares RA,Ferreira-Fernandez E,Soares MB,Pontes-De-Carvalho LC

更新日期：2001-02-01 00:00:00

abstract：:The capacity of peritoneal exudate cells (PEC) obtained from mice infected or immunized with Plasmodium berghei to produce reactive oxygen species (ROS) and the biological basis of this response was investigated, using luminol-dependent zymosan-triggered chemiluminescence (CL). CL response of PEC from infected mice in...

journal_title：Parasite immunology

authors： Li M,Li YJ

更新日期：1987-05-01 00:00:00

abstract：:Cysteine proteinase enriched fractions obtained by thiol-sepharose chromatography of Ostertagia ostertagi membrane-bound protein extract (S3-thiol) or total adult excretory-secretory (ES-thiol) products were tested in a vaccination experiment to evaluate their protective efficacy against O. ostertagi in cattle. Calves...

journal_title：Parasite immunology

authors： Geldhof P,Claerebout E,Knox D,Vercauteren I,Looszova A,Vercruysse J

更新日期：2002-05-01 00:00:00

abstract：:To determine the role of T cells and mast cells in intestinal pathology and immune expulsion of intestinal nematodes, worm burdens, goblet cell responses and villus structures were analysed in T- and B-cell-deficient severe combined immunodeficiency (SCID) mice, athymic nu/nu mice and mast cell deficient W/W(v) mice a...

journal_title：Parasite immunology

authors： Hashimoto K,Uchikawa R,Tegoshi T,Takeda K,Yamada M,Arizono N

更新日期：2009-08-01 00:00:00

abstract：:Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected by GI nematodes, making this group of parasitic nematodes a major burden to gl...

journal_title：Parasite immunology

authors： Sharpe C,Thornton DJ,Grencis RK

更新日期：2018-04-01 00:00:00

abstract：:The Bacillus thuringiensis Cry1Ac protoxin (pCry1Ac) is a promising mucosal immunogen and adjuvant that induces protective immunity against Naegleria fowleri and malaria infection models. We determined whether pCry1Ac acted as a protective adjuvant against infection with Taenia crassiceps. BALB/C mice were thrice i.p....

journal_title：Parasite immunology

authors： Ibarra-Moreno S,García-Hernández AL,Moreno-Fierros L

更新日期：2014-06-01 00:00:00

abstract：:Infective forms of Trypanosoma cruzi, the parasite that causes Chagas' disease, express on their surface an enzyme denominated trans-sialidase (TS). The present study was designed to evaluate the naturally acquired immune responses to a bacterial recombinant protein representing the catalytic domain of TS in chronical...

journal_title：Parasite immunology

authors： Ribeirão M,Pereira-Chioccola VL,Rénia L,Augusto Fragata Filho A,Schenkman S,Rodrigues MM

更新日期：2000-01-01 00:00:00

abstract：:Leishmania major causes mild-to-severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug-resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we compared the genes expressed by virulent and avirulent...

journal_title：Parasite immunology

authors： Zutshi S,Kumar S,Sarode A,Roy S,Sarkar A,Saha B

更新日期：2020-02-01 00:00:00

abstract：:Infection with Trypanosoma cruzi was established in the reduviid vector, Dipetalogaster maximus, by repeated feedings on mice with high parasitaemias, and metacyclic trypomastigotes (IMT) were collected in insect urine after blood meals. The infectivity of IMT in mice was assessed by placing varying numbers of organis...

journal_title：Parasite immunology

authors： Kirchhoff LV,Hoft DF

更新日期：1990-01-01 00:00:00

abstract：:We compared the antigenicity of p126 Plasmodium falciparum peptides with predicted antigenic regions identified using the methods described by Garnier et al. (1978) and Chou & Fasman (1974). For this purpose nine different P. falciparum peptides were synthesized in accordance with the deduced amino acid sequence of th...

journal_title：Parasite immunology

authors： Ferreira-da-Cruz Mde F,Giovanni-de-Simone S,Banic DM,Canto-Cavalheiro M,Camus D,Daniel-Ribeiro CT

更新日期：1996-03-01 00:00:00

abstract：:Cryptosporidiosis is a zoonotic protozoan disease that affects the gastrointestinal tract of animals and humans. Diarrhoea as the most important indication of the infection leads to high economic losses in livestock industries and is a life threatening infection in immunocompromised individuals. In the absence of the ...

journal_title：Parasite immunology

authors： Askari N,Shayan P,Mokhber-Dezfouli MR,Ebrahimzadeh E,Lotfollahzadeh S,Rostami A,Amininia N,Ragh MJ

更新日期：2016-05-01 00:00:00

abstract：:We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria-naive HIV-uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodi...

journal_title：Parasite immunology

authors： Froebel K,Howard W,Schafer JR,Howie F,Whitworth J,Kaleebu P,Brown AL,Riley E

更新日期：2004-05-01 00:00:00

abstract：:Over the past several decades, outbreaks of emerging infectious diseases (EIDs) in wild birds have attracted worldwide media attention, either because of their extreme virulence or because of alarming spillovers into agricultural animals or humans. The pathogens involved have been found to infect a variety of bird hos...

journal_title：Parasite immunology

authors： Staley M,Bonneaud C

更新日期：2015-05-01 00:00:00

abstract：:Leishmania mexicana is the causal agent of cutaneous leishmaniasis in Mexico. Dendritic cells (DC) are one of the host cells of Leishmania parasites. Intracellular microorganisms inhibit host cell apoptosis as a strategy to ensure their survival in infected cells. We have previously shown that Leishmania mexicana prom...

journal_title：Parasite immunology

authors： Vázquez-López R,Argueta-Donohué J,Wilkins-Rodríguez A,Escalona-Montaño A,Aguirre-García M,Gutiérrez-Kobeh L

更新日期：2015-11-01 00:00:00

abstract：:The role of the spleen in amoebic infection was examined in mice, using strains selected as being either genetically-susceptible (C57BL/6) or genetically-resistant (A/J) to amoebiasis. Splenectomized and sham-operated animals were inoculated intracaecally with 2.5 X 10(5) polyxenic trophozoites of E. histolytica at 6,...

journal_title：Parasite immunology

authors： Ghadirian E,Kongshavn PA

更新日期：1985-09-01 00:00:00

abstract：:Immunization with naked DNA represents an attractive strategy for development of vaccines against a variety of infections including those caused by protozoan parasites. Recently, we have described that immunization with a plasmid containing the trans-sialidase (TS) gene induced protective immunity against Trypanosoma ...

journal_title：Parasite immunology

authors： Pereira-Chioccola VL,Costa F,Ribeirão M,Soares IS,Arena F,Schenkman S,Rodrigues MM

更新日期：1999-02-01 00:00:00

abstract：:Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- an...

journal_title：Parasite immunology

authors： Quinnell RJ,Bethony J,Pritchard DI

更新日期：2004-11-01 00:00:00

abstract：:Visceral leishmaniasis (VL) or Kala azar (KA) is a systemic disease caused by the parasites of the Leishmania donovani complex. Control measures rely on treatment with antileishmanial agents, however, fraught with problems such as toxicity or drug resistance. The incidence rate is on the rise for children, for reasons...

journal_title：Parasite immunology

authors： Ansari NA,Kumar R,Raj A,Salotra P

更新日期：2008-08-01 00:00:00

abstract：:The incidence of both type 1 (T1D) and type 2 diabetes (T2D) is drastically increasing, and it is predicted that the global prevalence of diabetes will reach almost 600 million cases by 2035. Even though the pathogenesis of both types of diabetes is distinct, the immune system is actively involved in both forms of the...

journal_title：Parasite immunology

authors： Surendar J,Indulekha K,Hoerauf A,Hübner MP

更新日期：2017-05-01 00:00:00

abstract：:Toxoplasma gondii-specific murine CD4+ T cell clone 3Tx9 belongs to the Th1 subtype by virtue of secreting high levels of interleukin(IL)-2, interferon-gamma and tumor necrosis factor without producing IL4 and IL10. To characterize the clonal antigen, Toxoplasma lysate-was separated by SDS-PAGE and probed in T cell bl...

journal_title：Parasite immunology

authors： Reichmann G,Dlugonska H,Fischer HG

更新日期：1997-05-01 00:00:00

abstract：:Malaria, particularly Plasmodium falciparum, continues to disproportionately affect pregnant women. In addition to the profoundly deleterious impact of maternal malaria on the health of the mother and foetus, malaria infection in pregnancy has been shown to affect the development of the foetal and infant immune system...

journal_title：Parasite immunology

authors： Harrington WE,Kakuru A,Jagannathan P

更新日期：2019-03-01 00:00:00