Screening for immunomodulatory proteins of the intestinal parasitic nematode Heligmosomoides polygyrus.

abstract：:We assayed the vaccine potentialities of a recombinant S. bovis-derived glutathione S-transferase (rSb28GST), member of a molecular family already shown to have protective capacities in the S. mansoni and S. japonicum models. Injection of the rSb28GST in Freund's Complete Adjuvant resulted in good specific IgG respons...

journal_title：Parasite immunology

authors： Boulanger D,Trottein F,Mauny F,Bremond P,Couret D,Pierce RJ,Kadri S,Godin C,Sellin E,Lecocq JP

更新日期：1994-08-01 00:00:00

abstract：:In vitro released products of the adult stage of the bovine lungworm. Dictyocaulus viviparus, were characterized according to their SDS-PAGE profile, glycosylation pattern, in vitro synthesis and antigenicity in the context of infection and vaccination with irradiated larvae. Biosynthetic labelling experiments with 35...

journal_title：Parasite immunology

authors： Britton C,Canto GJ,Urquhart GM,Kennedy MW

更新日期：1993-03-01 00:00:00

abstract：:Onchocerca volvulus and the human immunodeficiency virus (HIV) are two immunocompromising infectious agents of major public health concern in Uganda. To examine the effect of coinfection with O. volvulus and HIV on cellular immune responses, lymphocyte proliferative responses and cytokine production of peripheral bloo...

journal_title：Parasite immunology

authors： Sentongo E,Rubaale T,Büttner DW,Brattig NW

更新日期：1998-09-01 00:00:00

abstract：:Data from experimental and human cryptosporidiosis have established a major role of specific immunity in the control of Cryptosporidium parvum infection. In this work, alterations in spleen and Peyer's patch (Pp) lymphocytes were investigated in the course of a spontaneously resolutive gut cryptosporidiosis in four-da...

journal_title：Parasite immunology

authors： Mariotte D,Comby E,Brasseur P,Ballet JJ

更新日期：2004-01-01 00:00:00

abstract：:Plasma from chronic or advanced hepatosplenic schistosomiasis (mansoni) patients (PCS) suppressed mitogen-induced responses of normal human peripheral blood mononuclear cells. 1 x 10(5) Ficoll-Hypaque isolated lymphocytes were cultured in 100 microliter RPMI 1640 media with 100 microliter plasma preparation and stimul...

journal_title：Parasite immunology

authors： Kamal KA,Higashi GI

更新日期：1982-07-01 00:00:00

abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...

journal_title：Parasite immunology

authors： Irigoín F,Würzner R,Sim RB,Ferreira AM

更新日期：1996-07-01 00:00:00

abstract：:Fasciola hepatica secretes a cathepsin L proteinase that is suggested to play an in vivo role in immunoprotection since the enzyme can cleave host immunoglobulin. In the present report, rabbit anti-cathepsin L IgG was shown to bind to the cathepsin L enzyme and inhibit its ability to cleave IgG molecules. Cathepsin L ...

journal_title：Parasite immunology

authors： Smith AM,Carmona C,Dowd AJ,McGonigle S,Acosta D,Dalton JP

更新日期：1994-06-01 00:00:00

abstract：:Human recombinant tumour necrosis factor (rTNF) enhanced monoclonal IgE-dependent eosinophil-mediated cytotoxicity to schistosomula of Schistosoma japonicum in a dose-dependent manner. The enhancing effect of rTNF was also observed for the antibody-dependent cytotoxicity of a human eosinophilic leukemia cell line, EoL...

journal_title：Parasite immunology

authors： Janecharut T,Hata H,Takahashi H,Yoshida S,Saito H,Kojima S

更新日期：1992-11-01 00:00:00

abstract：:Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late-stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflecte...

journal_title：Parasite immunology

authors： Wang X,Fu Q,Song R,Duan B,Bergquist R,Xu J,Li S,Zhou D,Qin Z

更新日期：2018-10-01 00:00:00

abstract：:The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have ...

journal_title：Parasite immunology

authors： Parlog A,Schlüter D,Dunay IR

更新日期：2015-03-01 00:00:00

abstract：:Cysticercosis is acquired when swine ingest human faeces contaminated with Taenia solium eggs. Humans become tapeworm carriers when they ingest infected pork meat. They can also develop cysticercosis after inadvertently swallowing T. solium eggs. Human neurocysticercosis (NCC) is considered as a public health problem ...

journal_title：Parasite immunology

authors： Flisser A,Gyorkos TW

更新日期：2007-12-01 00:00:00

abstract：:Chagas' disease or American trypanosomiasis due to Trypanosoma cruzi has existed at least since the time of the Inca empire and contributes significantly to cardiovascular morbidity and mortality in several countries of this continent. Due to the fundamental role of human class II molecules polymorphic residues in the...

journal_title：Parasite immunology

authors： Fernandez-Mestre MT,Layrisse Z,Montagnani S,Acquatella H,Catalioti F,Matos M,Balbas O,Makhatadze N,Dominguez E,Herrera F,Madrigal A

更新日期：1998-04-01 00:00:00

abstract：:UV-irradiated and gamma-irradiated schistosomula of Schistosoma mansoni induce high levels of resistance to challenge infection in experimental hosts. It was observed that both types of irradiation severely inhibited protein synthesis by the parasite larvae. Schistosomula were treated with the metabolic inhibitor acti...

journal_title：Parasite immunology

authors： Wales A,Kusel JR,Jones JT

更新日期：1992-09-01 00:00:00

abstract：:Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes. In children under 7 years of age in The Gambia, serum IgG responses were measured to P. falciparum merozoite antig...

journal_title：Parasite immunology

authors： Akpogheneta OJ,Dunyo S,Pinder M,Conway DJ

更新日期：2010-04-01 00:00:00

abstract：:Type I hypersensitivity reactions in the intestinal tract of sensitized animals may contribute to resistance to reinfection with Fasciola hepatica. Colonic mucosae isolated from previously infected rats were voltage clamped in Ussing chambers. Antigen was prepared as a crude homogenate from adult liver fluke. Assay of...

journal_title：Parasite immunology

authors： O'Malley KE,Sloan T,Joyce P,Baird AW

更新日期：1993-08-01 00:00:00

abstract：:Opisthorchis viverrini infection causes opisthorchiasis and is a risk factor for cholangiocarcinoma via chronic inflammation. To investigate the mechanism of O. viverrini -induced liver disease, we applied a proteomic approach to examine alterations in hepatic protein levels in O. viverrini -infected hamsters. Two-dim...

journal_title：Parasite immunology

authors： Khoontawad J,Wongkham C,Hiraku Y,Yongvanit P,Prakobwong S,Boonmars T,Pinlaor P,Pinlaor S

更新日期：2010-05-01 00:00:00

abstract：:Naturally acquired humoral immune responses to Pfs16, an integral membrane protein expressed in Plasmodium falciparum gametocytes and sporozoites, were investigated in The Gambia. A high prevalence of antibodies to this molecule was detected by peptide ELISA. Ninety-three per cent of the people taking part in a survey...

journal_title：Parasite immunology

authors： Baker DA,Drakeley CJ,Ong CS,Lulat AG,Greenwood BM,Targett GA

更新日期：1996-10-01 00:00:00

abstract：:Studies to clarify the mechanisms of apoptosis in host cells, A31 (BALB/3T3 clone A31 fibroblasts), caused by two intracellular protozoan parasites, Toxoplasma gondii and Neospora caninum, were carried out in an in vitro system. The viability of N. caninum-infected cells was significantly reduced following treatment w...

journal_title：Parasite immunology

authors： Nishikawa Y,Makala L,Otsuka H,Mikami T,Nagasawa H

更新日期：2002-07-01 00:00:00

abstract：:Theileria parva is a tick-borne intracellular protozoan of cattle, with obligate sequential differentiation stages in lymphocytes and erythrocytes. Immunity is mediated by cytotoxic T lymphocytes (CTL) that target and clear parasitized lymphocytes but allow persistence of infected erythrocytes, which are required for ...

journal_title：Parasite immunology

authors： McKeever DJ

更新日期：2006-07-01 00:00:00

abstract：:The effect of the humoral immune response on the weight and fecundity of the hookworm Necator americanus was examined in an endemically-infected human population. There was a highly significant negative correlation between total IgE levels and parasite weight and fecundity, after controlling for any effects of host ag...

journal_title：Parasite immunology

authors： Pritchard DI,Quinnell RJ,Walsh EA

更新日期：1995-02-01 00:00:00

abstract：:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...

journal_title：Parasite immunology

authors： Namangala B,Brys L,Magez S,De Baetselier P,Beschin A

更新日期：2000-07-01 00:00:00

abstract：:Naegleria fowleri, a free-living amoeba, is the causative pathogen of primary amoebic meningoencephalitis in humans and experimental mice. N. fowleri is capable of destroying tissues and host cells through lytic necrosis. However, the mechanism by which N. fowleri induces host cell death is unknown. Electron microscop...

journal_title：Parasite immunology

authors： Song KJ,Jang YS,Lee YA,Kim KA,Lee SK,Shin MH

更新日期：2011-07-01 00:00:00

abstract：:Cells collected from C57B1/6 mice infected with monomorphic and pleomorphic clones of Trypanosoma brucei parasites (ILTat 1.4 and GUTat 3.1) were analysed for the incorporation of 125I-Iododeoxyuridine into DNA of total splenic lymphocytes and of B and T lymphocytes isolated on a fluorescence activated cell sorter. Th...

journal_title：Parasite immunology

authors： Sendashonga CN,Black SJ

更新日期：1986-09-01 00:00:00

abstract：:Although the precise host-defence mechanisms are not completely understood, T-cell-mediated immune responses are believed to play a pivotal role in controlling parasite infection. In this study, the potential HLA*A2 restricted peptides were predicted and the ability of peptides to bind HLA-A*02 was confirmed by a MHC ...

journal_title：Parasite immunology

authors： Dikhit MR,Amit A,Singh AK,Kumar A,Mansuri R,Sinha S,Topno RK,Mishra R,Das VNR,Pandey K,Sahoo GC,Ali V,Bimal S,Das P

更新日期：2017-09-01 00:00:00

abstract：:A whole-killed malaria blood-stage vaccine (WKV) is promising in reducing the morbidity and mortality of malaria patients, but its efficacy needs to be improved. We found that the antimalarial drug chloroquine could augment the protective efficacy of the WKV of Plasmodium yoelii. The direct antimalarial effect of chlo...

journal_title：Parasite immunology

authors： Fu Y,Lu X,Zhu F,Zhao Y,Ding Y,Ye L,Guo B,Liu T,Xu W

更新日期：2020-01-01 00:00:00

abstract：:In modern societies, diseases that are driven by dysregulated immune responses are increasing at an alarming pace, such as inflammatory bowel diseases and diabetes. There is an urgent need to understand these epidemiological trends, which are likely to be driven by the changing environment of the last few decades. The...

journal_title：Parasite immunology

authors： Loke P,Lim YA

更新日期：2015-06-01 00:00:00

abstract：:Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that d...

journal_title：Parasite immunology

authors： Pleasance J,Wiedosari E,Raadsma HW,Meeusen E,Piedrafita D

更新日期：2011-09-01 00:00:00

abstract：:CD4(+) T cells play a critical role in determining the disease outcome in murine cutaneous leishmaniasis, and selective usage of T-cell receptor (TCR) is implied in promoting Leishmania major infection. However, little information is available on TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells. In thi...

journal_title：Parasite immunology

authors： Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L

更新日期：2011-03-01 00:00:00

abstract：:Trichuris muris is an intestinal nematode that invades the colonic epithelium triggering a mucosal inflammation. Vitamin A and its active metabolite retinoic acid are strongly linked with the modulation of gut immune responses. Here, we describe the temporal changes in the expression of aldehyde dehydrogenase (ALDH) e...

journal_title：Parasite immunology

authors： Hurst RJ,Else KJ

更新日期：2013-07-01 00:00:00

abstract：:Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for ...

journal_title：Parasite immunology

authors： Venturin GL,Bragato JP,Silva KL,de Lima VM

更新日期：2015-12-01 00:00:00