Abstract:
:Human recombinant tumour necrosis factor (rTNF) enhanced monoclonal IgE-dependent eosinophil-mediated cytotoxicity to schistosomula of Schistosoma japonicum in a dose-dependent manner. The enhancing effect of rTNF was also observed for the antibody-dependent cytotoxicity of a human eosinophilic leukemia cell line, EoL-3, but not of another cell line, EoL-1. Observation by a slow-motion movie camera demonstrated that activated EoL-3 cells adhered to the surface of schistosomula by 6 h after incubation, which triggered intracellular movement of eosinophil granules. The granules were concentrated toward the surface of the larvae and then degranulation started. The cell membrane was left as a balloon-like remnant. Cell sorting analysis by FACStar indicated that the expression of receptors for C3bi (CR3) and low affinity FcR for IgE (Fc epsilon RII) increased on the surface of EoL-3 cells after stimulation with rTNF, while this was not observed for EoL-1 cells.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Janecharut T,Hata H,Takahashi H,Yoshida S,Saito H,Kojima Sdoi
10.1111/j.1365-3024.1992.tb00033.xkeywords:
subject
Has Abstractpub_date
1992-11-01 00:00:00pages
605-16issue
6eissn
0141-9838issn
1365-3024journal_volume
14pub_type
杂志文章abstract::A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...
journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1986-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1985-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1983.tb00732.x
更新日期:1983-03-01 00:00:00
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journal_title:Parasite immunology
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更新日期:1999-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1984.tb00790.x
更新日期:1984-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12458
更新日期:2017-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12323
更新日期:2016-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1982.tb00442.x
更新日期:1982-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2009.01160.x
更新日期:2010-01-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1990.tb00936.x
更新日期:1990-01-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12083
更新日期:2014-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-3024.2003.00607.x
更新日期:2003-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1994.tb00320.x
更新日期:1994-12-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12039
更新日期:2013-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.2002.00448.x
更新日期:2002-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12779
更新日期:2020-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1999.00223.x
更新日期:1999-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1996.d01-39.x
更新日期:1996-12-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1981.tb00405.x
更新日期:1981-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1997.d01-190.x
更新日期:1997-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1990.tb00996.x
更新日期:1990-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2011.01297.x
更新日期:2011-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1991.tb00553.x
更新日期:1991-11-01 00:00:00