Abstract:
:Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that different anatomical tissues display distinct cytokine profiles consistent with liver fluke migration. The study also reveals a significant difference in the cytokine and antibody profiles of ITT sheep infected with F. gigantica compared with F. hepatica, with a higher ratio of IL-4/IFN-γ mRNA expression and specific IgG1/IgG2 antibodies strongly correlating with pathology. Interestingly, the significant type-1 cytokine profile occurred in the lymph node closest to the site of infection at a time when the effective immune response against F. gigantica liver flukes is thought to occur. When the same F. gigantica infection in the resistant ITT sheep was compared with the susceptible Merino breed, the resistant type-1 phenotype against liver fluke infection was only observed in the ITT sheep. These studies provide the first evidence to suggest that the induction of an early type-1 immune response in this natural sheep host may be responsible for the ability to resist liver fluke infection.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Pleasance J,Wiedosari E,Raadsma HW,Meeusen E,Piedrafita Ddoi
10.1111/j.1365-3024.2011.01305.xsubject
Has Abstractpub_date
2011-09-01 00:00:00pages
495-505issue
9eissn
0141-9838issn
1365-3024journal_volume
33pub_type
杂志文章abstract::Resistance to S. mansoni cercarial challenge, induced by prior infection of rats with cercariae, is analysed by substitution of alternatives to the primary cercarial exposure. Intravenous injections of either live or killed 4-week stage worms have been examined, utilizing two different routes of injection, one or two ...
journal_title:Parasite immunology
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00