Abstract:
:The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have focused on the elucidation of these modifications. Furthermore, investigations of the human population have correlated Toxoplasma seropositivity with changes in neurological functions; however, the complex underlying mechanisms of the subtle behavioural alteration are still not fully understood. The parasites are able to induce direct modifications in the infected cells, for example by altering dopamine metabolism, by functionally silencing neurons as well as by hindering apoptosis. Moreover, indirect effects of the peripheral immune system and alterations of the immune status of the CNS, observed during chronic infection, might also contribute to changes in neuronal connectivity and synaptic plasticity. In this review, we will provide an overview and highlight recent advances, which describe changes in the neuronal function and morphology upon T. gondii infection.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Parlog A,Schlüter D,Dunay IRdoi
10.1111/pim.12157subject
Has Abstractpub_date
2015-03-01 00:00:00pages
159-70issue
3eissn
0141-9838issn
1365-3024journal_volume
37pub_type
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journal_title:Parasite immunology
pub_type: 杂志文章
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abstract::Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...
journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1996.d01-17.x
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.2000.00307.x
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journal_title:Parasite immunology
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doi:10.1111/pim.12686
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2009.01174.x
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.2002.00448.x
更新日期:2002-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 临床试验,杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1999.00201.x
更新日期:1999-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1986-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1996.d01-50.x
更新日期:1996-02-01 00:00:00
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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更新日期:1993-03-01 00:00:00
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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更新日期:2014-06-01 00:00:00
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1985-09-01 00:00:00
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journal_title:Parasite immunology
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更新日期:2009-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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