Abstract:
:The p190 protein (also called MSA1 or MSP1) of the asexual blood stage forms of Plasmodium falciparum, a human malaria vaccine candidate, shows polymorphism between different isolates. Mice were immunized with p190-3, a recombinant protein which contains mostly conserved sequences derived from the p190 protein of the K1 parasite isolate. Proliferative T-cell responses of lymph node cells from immunized mice were assessed by stimulation in vitro with p190-3 or preparations of parasitized red blood cells (PRBC) containing the native protein. The p190-3-specific T cells from C57BL/6 mice consistently responded to some P. falciparum isolates, representing either the K1 or MAD20 serotype of p190, but not to other P. falciparum strains or to rodent malaria parasite-infected red blood cells. p190-3-specific T-cell responses from other mouse strains (BALB/c, C3H/He) did not distinguish between P. falciparum isolates. The polymorphic epitopes which were preferentially recognized by T cells from C57BL/6 mice were identified.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Süss G,Matile H,Meloen RH,Takacs B,Pink JRdoi
10.1111/j.1365-3024.1993.tb00592.xsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
127-34issue
3eissn
0141-9838issn
1365-3024journal_volume
15pub_type
杂志文章abstract::Fasciola hepatica infection has been shown to suppress sheep lymphocyte proliferation in vitro and this is at least partially attributable to excretory/secretory products (ES) released by F. hepatica parasites. We identified a suppressive component in ES by analysing the effect of ES fractions, separated by gel filtra...
journal_title:Parasite immunology
pub_type: 杂志文章
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abstract:AIMS:Merozoite surface protein 8 (MSP-8) of Plasmodium parasites plays an important role in erythrocyte invasion and is a potential malaria vaccine candidate. METHODS AND RESULTS:In this study, virus-like particles (VLPs) expressing MSP-8 of Plasmodium berghei on the surface of influenza virus matrix protein 1 (M1) co...
journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12157
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1986.tb01037.x
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1992.tb00012.x
更新日期:1992-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1984.tb00814.x
更新日期:1984-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1995.tb00893.x
更新日期:1995-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2008.01036.x
更新日期:2008-08-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2006.00903.x
更新日期:2006-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2006.00910.x
更新日期:2007-01-01 00:00:00
abstract::Cyclophosphamide (Cy) is known to produce a marked eosinophilia in mice after antigen challenge. In this study, we studied the effect of Cy on eosinophilia in helminthic infection. Peripheral blood eosinophils were counted in SJL mice following a large dose of Cy injection, infection with Toxocara canis, and both Cy i...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1985.tb00074.x
更新日期:1985-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12215
更新日期:2015-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1986.tb00874.x
更新日期:1986-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12401
更新日期:2017-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1985.tb00096.x
更新日期:1985-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.0141-9838.2004.00705.x
更新日期:2004-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-3024.2005.00760.x
更新日期:2005-05-01 00:00:00
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journal_title:Parasite immunology
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更新日期:2017-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12281
更新日期:2015-12-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1982.tb00437.x
更新日期:1982-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12097
更新日期:2014-04-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2007.00949.x
更新日期:2007-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1994-04-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12517
更新日期:2018-04-01 00:00:00
abstract::Opisthorchis viverrini infection causes opisthorchiasis and is a risk factor for cholangiocarcinoma via chronic inflammation. To investigate the mechanism of O. viverrini -induced liver disease, we applied a proteomic approach to examine alterations in hepatic protein levels in O. viverrini -infected hamsters. Two-dim...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2009.01189.x
更新日期:2010-05-01 00:00:00
abstract::A 17 kD protein of Necator americanus was isolated by SDS-PAGE and used to raise monospecific antisera in rabbits. ELISA and Western blotting against a range of parasite extracts demonstrated the species specificity of this protein. It is expressed at all stages of the life-cycle, appears to be accumulated through the...
journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00