Genetic manipulation of African trypanosomes as a tool to dissect the immunobiology of infection.

abstract：:Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserve...

journal_title：Parasite immunology

authors： Osier FH,Polley SD,Mwangi T,Lowe B,Conway DJ,Marsh K

更新日期：2007-08-01 00:00:00

abstract：:HIV and T. gondii infection markers were measured among 383 Intravenous Drug Users (IDU). And cytokine concentrations (IL-4, IL-6, IL-10, IL-12, IFN-gamma and TNF-alpha) were determined. The results showed IDU with HIV infection or HIV/T. gondii co-infection could disturb Th regulatory mechanism. ...

journal_title：Parasite immunology

authors： Li JR,Gong RY,Li YP,Bai Y,You F,Deng S

更新日期：2010-02-01 00:00:00

abstract：:Very little has been reported comparing resistance to coccidiosis in fast or slow growing broilers, the latter of which are becoming more prevalent in the broiler industry. We examined mRNA expression in the intestines of fast and slow growing broilers following Eimeria infection. We show that by day 13 post-infection...

journal_title：Parasite immunology

authors： Giles T,Sakkas P,Belkhiri A,Barrow P,Kyriazakis I,Foster N

更新日期：2019-09-01 00:00:00

abstract：:Neospora caninum is a cyst-forming coccidian parasite which in cattle can cause abortion and birth of feeble calves. For the serological diagnosis of neosporosis, antibodies directed to the parasite can be demonstrated by ELISA, utilizing N. caninum proteins incorporated into iscoms (immunostimulating complexes) as an...

journal_title：Parasite immunology

authors： Björkman C,Hemphill A

更新日期：1998-02-01 00:00:00

abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...

journal_title：Parasite immunology

authors： Irigoín F,Würzner R,Sim RB,Ferreira AM

更新日期：1996-07-01 00:00:00

abstract：:Nematode parasites cause significant infections in both humans and animals. They are complex, multicellular organisms that present unique challenges for the host, in particular with respect to the recognition of their unusual surface structures by the innate defence system. The innate immune system is now recognized t...

journal_title：Parasite immunology

authors： de Veer MJ,Kemp JM,Meeusen EN

更新日期：2007-01-01 00:00:00

abstract：:Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil ...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1982-09-01 00:00:00

abstract：:The zymosan-triggered chemiluminescence response of peritoneal exudate cells from mice infected with relatively virulent or avirulent Toxoplasma gondii strains was examined at various intervals after infection. Toxoplasma infections increased the background chemiluminescence compared with controls, but higher values w...

journal_title：Parasite immunology

authors： Masihi KN,Werner H,Gillert KE,Lange W

更新日期：1984-05-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia c...

journal_title：Parasite immunology

authors： Schetters TP,Scholtes NC,Kleuskens JA,Bos HJ

更新日期：1996-01-01 00:00:00

abstract：:The current study aimed to detect the complement-binding proteins in the excretory-secretory (ES) products of adult filarial parasite Setaria equina (SeqES). Tests for complement activation pathways (CH50 and APH50 ) in normal human serum (NHS) after incubation with SeqES were performed. Quantitative detection of comp...

journal_title：Parasite immunology

authors： Abdel-Latif M

更新日期：2020-02-01 00:00:00

abstract：:Helper T cell cytokine and antibody responses were investigated in mice after infection with Babesia microti (King strain). Infection of CBA mice with 106 parasitized erythrocytes resulted in the development of a transitory high parasitaemia which peaked 14 days post infection (DPI), and was resolved at 24 DPI. Th1 re...

journal_title：Parasite immunology

authors： Chen D,Copeman DB,Burnell J,Hutchinson GW

更新日期：2000-02-01 00:00:00

abstract：:To study the role of autoreactive T cells in the pathogenesis of cardiomyopathy in Chagas' disease, we generated a cell line by repeated in vitro antigenic stimulation of purified splenic CD4+ T lymphocytes from a chronically Trypanosoma cruzi-infected mouse. Cells from this line were confirmed to be CD4+ CD8- and pro...

journal_title：Parasite immunology

authors： Ribeiro-Dos-Santos R,Mengel JO,Postol E,Soares RA,Ferreira-Fernandez E,Soares MB,Pontes-De-Carvalho LC

更新日期：2001-02-01 00:00:00

abstract：:Antigenic proteins of Echinostoma caproni (Trematoda) against mouse IgM, IgA, IgG, IgG1 and IgG2a were investigated by immunoproteomics. Excretory/secretory products (ESP) of E. caproni separated by two-dimensional (2D) gel electrophoresis were transferred to nitrocellulose membranes and probed with the different mous...

journal_title：Parasite immunology

authors： Sotillo J,Valero L,Sánchez Del Pino MM,Fried B,Esteban JG,Marcilla A,Toledo R

更新日期：2008-05-01 00:00:00

abstract：:The C57BL/6 mouse strain is resistant to Leishmania (L.) major infection and, unlike susceptible BALB/c, develops small self-healing cutaneous lesions. The specific antibody responses of C57BL/6 and BALB/c mice were previously characterized by the predominance of IgG2a ('resistant' isotype associated with Th1) and IgG...

journal_title：Parasite immunology

authors： Sassi A,Kaak O,Ben Ammar Elgaied A

更新日期：2015-10-01 00:00:00

abstract：:Culex pipiens and Aedes aegypti mosquitoes were fed on C3H/HeJ mice and systemic cytokine production was quantified from stimulated lymphocytes harvested four to ten days after feeding. Mosquito feeding on C3H/HeJ mice significantly down regulated IFN gamma production seven to ten days post feeding by Cx. pipiens and ...

journal_title：Parasite immunology

authors： Zeidner NS,Higgs S,Happ CM,Beaty BJ,Miller BR

更新日期：1999-01-01 00:00:00

abstract：:A whole-killed malaria blood-stage vaccine (WKV) is promising in reducing the morbidity and mortality of malaria patients, but its efficacy needs to be improved. We found that the antimalarial drug chloroquine could augment the protective efficacy of the WKV of Plasmodium yoelii. The direct antimalarial effect of chlo...

journal_title：Parasite immunology

authors： Fu Y,Lu X,Zhu F,Zhao Y,Ding Y,Ye L,Guo B,Liu T,Xu W

更新日期：2020-01-01 00:00:00

abstract：:Research undertaken over the past 40 years has established many of the general principals concerning immunity to taeniid cestodes. Although much is well understood about the host-protective mechanisms against taeniids and this knowledge has been exploited in studies on vaccine development, many aspects require further...

journal_title：Parasite immunology

authors： Lightowlers MW

更新日期：2010-11-01 00:00:00

abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...

journal_title：Parasite immunology

authors： Van Milligen FJ,Cornelissen JB,Hendriks IM,Gaasenbeek CP,Bokhout BA

更新日期：1998-06-01 00:00:00

abstract：:Helminth parasites induce a strong Th2 response, characterized by high levels of IgE and elevated signature cytokines such as IL-5. As many global deworming programmes are underway, there is concern that this might lead to emergence of Th1-mediated pathologies when the counterbalancing helminth-induced Th2 response is...

journal_title：Parasite immunology

authors： de Ruiter K,Tahapary DL,Wammes LJ,Wiria AE,Hamid F,van Lieshout L,Smit JWA,Houwing-Duistermaat JJ,Sartono E,Supali T,Yazdanbakhsh M

更新日期：2017-06-01 00:00:00

abstract：:Leishmania mexicana is the causal agent of cutaneous leishmaniasis in Mexico. Dendritic cells (DC) are one of the host cells of Leishmania parasites. Intracellular microorganisms inhibit host cell apoptosis as a strategy to ensure their survival in infected cells. We have previously shown that Leishmania mexicana prom...

journal_title：Parasite immunology

authors： Vázquez-López R,Argueta-Donohué J,Wilkins-Rodríguez A,Escalona-Montaño A,Aguirre-García M,Gutiérrez-Kobeh L

更新日期：2015-11-01 00:00:00

abstract：:A protein-lipopolysaccharide complex has previously been postulated as necessary to protect susceptible mice against Salmonella typhimurium infection. Lipopolysaccharide attached to non-specific proteins, bovine serum albumin or methylated BSA, gave a specific delayed-type hypersensitivity (DTH) reaction when injected...

journal_title：Parasite immunology

authors： Plant JE,Wilson BM,Glynn AA

更新日期：1982-07-01 00:00:00

abstract：:The purpose of this study was to monitor local cytokine responses to Dictyocaulus viviparus in calves during primary infection and re-infection. Bronchoalveolar lavage fluid (BALF) was collected weekly from experimentally infected calves and interleukin-2 (IL-2), IL-4, IL-5, IL-10 and IFN-γ mRNA expression was quantif...

journal_title：Parasite immunology

authors： Holmgren S,Hagberg Gustavsson M,Lundén A,Wattrang E

更新日期：2014-02-01 00:00:00

abstract：:Entamoeba histolytica is known to induce host cell death via activation of calpain and caspases. In this study, we investigated the specific proteases involved in the degradation of cytoskeletal proteins during Jurkat T-cell death induced by E. histolytica. Amoebic trophozoites induced marked degradation of paxillin, ...

journal_title：Parasite immunology

authors： Lee YA,Kim KA,Shin MH

更新日期：2011-06-01 00:00:00

abstract：:A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H-2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H-2 molecules. Three types of antigen presentation were obs...

journal_title：Parasite immunology

authors： Robinson M,Gustad TR,Garner SD,David CS

更新日期：1995-05-01 00:00:00

abstract：:The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of bo...

journal_title：Parasite immunology

authors： Kváč M,Kodádková A,Sak B,Květoňová D,Jalovecká M,Rost M,Salát J

更新日期：2011-04-01 00:00:00

abstract：:A recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission....

journal_title：Parasite immunology

authors： O'Meara WP,Lang T

更新日期：2009-09-01 00:00:00

abstract：:The soluble portion of a large particle fraction which was derived from the muscle larva of T. spiralis was subjected to molecular sizing column chromatography using Sephacryl S-200. Five major peaks of 280 nm absorbing material were obtained. Analysis by immunoelectrophoresis revealed that each peak contained antigen...

journal_title：Parasite immunology

authors： Despommier DD

更新日期：1981-10-01 00:00:00

abstract：:Sheep were sensitized by weekly infections with Teladorsagia circumcincta over a 9-week period. After a 12-week rest, sheep were divided into four groups and killed without challenge or 3, 5 and 10 days post challenge (DPC) with 50000 L3. Recovery of challenge larvae from abomasal scrapings was highest at 3 DPC while ...

journal_title：Parasite immunology

authors： Balic A,Bowles VM,Liu YS,Meeusen EN

更新日期：2003-07-01 00:00:00

abstract：AIMS:Industrial growth has increased the exposure to endocrine disruptor compounds (EDCs) in all organisms. Bisphenol A (BPA), an EDC, has been demonstrated to be involved in the susceptibility to parasite infections. However, few studies have analysed this connection in more depth. The aim of this study was to determi...

journal_title：Parasite immunology

authors： Nava-Castro KE,Togno-Peirce C,Palacios-Arreola MI,Del Rio-Araiza VH,Hernandez-Bello R,Morales Montor J

更新日期：2020-09-01 00:00:00