Abstract：
:Dipetalonema viteae (Filarioidea) infections were established in inbred strains of mice by the s.c. implantation of adult female worms and the resulting microfilaraemia and adult worm survival monitored. BALB/c mice were the most susceptible strain examined, showing a high level microfilaraemia of approximately 6 month's duration. C57Bl/10, CBA/Ca and C3H/He mice were all equally resistant to infection, showing a low level of microfilaraemia of approximately 1 month's duration. The response of NIH mice was intermediate. Relatively little strain difference was seen in adult worm survival although worms lived slightly longer in C57Bl/10 mice than in BALB/c mice. The adult females became depleted of microfilariae over a period of approximately 1 month before becoming encapsulated in host tissue. Challenge infections given to mice previously implanted with worms resulted in lower level, shorter lasting microfilaraemias than those seen in the initial primary infections. All strains showed immunity when challenged. High responsiveness (resistance) was inherited as a dominant trait in F1 hybrids produced by crossing high and low responder strains. Genes linked with the major histocompatibility complex (H-2) were found to have no effect on the response phenotype as demonstrated by the similar responses of H-2 congenic mice on the BALB/c or C57bl/10 backgrounds. The response phenotype of radiation chimaeras was determined by the phenotype of the donor from which bone marrow (BM) cells were taken for reconstitution. Susceptible BALB/c mice reconstituted with resistant B10D2/n BM behaved identically to the donor strain, indicating that the genetic variation which exists between mouse strains in their responses to D. viteae is expressed through a population of BM derived cells and is not simply a consequence of host structure or physiology.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Storey N,Wakelin D,Behnke JMdoi
10.1111/j.1365-3024.1985.tb00081.xsubject
Has Abstractpub_date
1985-07-01 00:00:00pages
349-58issue
4eissn
0141-9838issn
1365-3024journal_volume
7pub_type
杂志文章abstract：:A protein-lipopolysaccharide complex has previously been postulated as necessary to protect susceptible mice against Salmonella typhimurium infection. Lipopolysaccharide attached to non-specific proteins, bovine serum albumin or methylated BSA, gave a specific delayed-type hypersensitivity (DTH) reaction when injected...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1982.tb00437.x
更新日期：1982-07-01 00:00:00
abstract：:Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12281
更新日期：2015-12-01 00:00:00
abstract：:The antigenicity of the biosynthetically labelled somatic and excretory/secretory proteins of adult Fasciola hepatica was investigated over 20 weeks of an infection with F. hepatica in sheep. The antibody response was initially detected by ELISA 2 weeks after infection, and was sustained at this level for the remainde...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00267.x
更新日期：1991-01-01 00:00:00
abstract：:Entamoeba histolytica is known to induce host cell death via activation of calpain and caspases. In this study, we investigated the specific proteases involved in the degradation of cytoskeletal proteins during Jurkat T-cell death induced by E. histolytica. Amoebic trophozoites induced marked degradation of paxillin, ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2011.01290.x
更新日期：2011-06-01 00:00:00
abstract：:The p190 protein (also called MSA1 or MSP1) of the asexual blood stage forms of Plasmodium falciparum, a human malaria vaccine candidate, shows polymorphism between different isolates. Mice were immunized with p190-3, a recombinant protein which contains mostly conserved sequences derived from the p190 protein of the ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1993.tb00592.x
更新日期：1993-03-01 00:00:00
abstract：:CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) ad...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01093.x
更新日期：2009-04-01 00:00:00
abstract：AIMS:Merozoite surface protein 8 (MSP-8) of Plasmodium parasites plays an important role in erythrocyte invasion and is a potential malaria vaccine candidate. METHODS AND RESULTS:In this study, virus-like particles (VLPs) expressing MSP-8 of Plasmodium berghei on the surface of influenza virus matrix protein 1 (M1) co...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12781
更新日期：2020-11-01 00:00:00
abstract：:The ability of Toxoplasma gondii to cause clinical disease in immune-competent and immune-deficient hosts coupled with its ease of use in vitro and availability of murine models has led to its use as a model organism to study how the immune system controls an intracellular infection. This article reviews the studies t...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12712
更新日期：2020-07-01 00:00:00
abstract：:The natural site of infection for T. gondii is the mucosal surface of the intestine, so the protective immunity obtained after natural infection with T. gondii points to the importance of developing a vaccine that stimulates mucosal defences. In this study, an aroA- and aroD- attenuated strain of Salmonella typhimuriu...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2005.00738.x
更新日期：2005-01-01 00:00:00
abstract：:The pathogenesis of Acanthamoeba keratitis (AK) is complicated. In our previous studies, TLR4 was found involved in the process of infection by Acanthamoeba in human corneal cells. The purpose of this study was to investigate the role of Toll-like receptor 4 (TLR4) signalling pathway in Wistar rats challenged with Aca...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2010.01247.x
更新日期：2011-01-01 00:00:00
abstract：:Leishmania enter macrophages through receptor-mediated phagocytosis and survive the harsh environment of a phagolysosome. Here, we investigated the interaction between mannose receptor (MR), Toll-like receptor 2 (TLR2), and Leishmania, and the subsequent impact on phagosome maturation. Leishmania parasites are able to...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12521
更新日期：2018-04-01 00:00:00
abstract：:The objective of this study was to evaluate abomasal cytokine responses in helminth-naive calves and calves vaccinated with protective antigen fractions from Ostertagia ostertagi after an experimental challenge infection with infective third stage (L3) larvae. Abomasal lymph nodes and/or abomasal mucosa were collected...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2005.00780.x
更新日期：2005-09-01 00:00:00
abstract：:CD4(+) T cells play a critical role in determining the disease outcome in murine cutaneous leishmaniasis, and selective usage of T-cell receptor (TCR) is implied in promoting Leishmania major infection. However, little information is available on TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells. In thi...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2010.01268.x
更新日期：2011-03-01 00:00:00
abstract：:The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme of Immunization (EPI). We have completed a trial of the peptide vaccine SPf66 in Tanzanian infants, given alongsi...
journal_title：Parasite immunology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-3024.2000.00322.x
更新日期：2000-09-01 00:00:00
abstract：:The capacity of peritoneal exudate cells (PEC) obtained from mice infected or immunized with Plasmodium berghei to produce reactive oxygen species (ROS) and the biological basis of this response was investigated, using luminol-dependent zymosan-triggered chemiluminescence (CL). CL response of PEC from infected mice in...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1987.tb00509.x
更新日期：1987-05-01 00:00:00
abstract：:In schistosomiasis endemic areas, intensities of reinfection after treatment are greater amongst young children than amongst adults, and high levels of parasite-specific IgE are associated with resistance to reinfection in an age-dependent manner. Previously we have reported that, in Western blots, a 22 kDa band was r...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1997.d01-186.x
更新日期：1997-02-01 00:00:00
abstract：:Fasciola hepatica infection has been shown to suppress sheep lymphocyte proliferation in vitro and this is at least partially attributable to excretory/secretory products (ES) released by F. hepatica parasites. We identified a suppressive component in ES by analysing the effect of ES fractions, separated by gel filtra...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.0141-9838.2001.00438.x
更新日期：2002-02-01 00:00:00
abstract：:SUMMARY Previous experiments have shown that genetic resistance to infection by Teladorsagia circumcincta in sheep can be measured by the level of IgA in gastric mucus, jointly with other parameters. The aim of this study has been to observe the influence of IgA on adult worms. The experiment was carried out with Chur...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2005.00769.x
更新日期：2005-06-01 00:00:00
abstract：:Neospora caninum is a coccidian parasite of veterinary importance by causing abortion or stillbirth in cattle among other problems in diverse animal species. We assessed an experimental murine model for its suitability to study the immune response to N. caninum infection. Thus, wild-type (wt) C57BL/6 mice and B-cell (...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1999.00223.x
更新日期：1999-05-01 00:00:00
abstract：:Urine and stool specimens from 425 school children in Swaziland were examined for evidence of Schistosoma mansoni or Schistosoma haematobium infection. Concurrently, saliva collections were analysed for ABH secretory ability and blood samples were typed for ABO, Rh and Lewis groups. Among individuals infected with S. ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1979.tb00701.x
更新日期：1979-07-01 00:00:00
abstract：:Schistosomiasis japonicum is one of the most serious zoonotic diseases in the world. There is increasing evidence to show that host miRNAs are modulated following Schistosoma japonicum infection, and some of these miRNAs may play important regulatory roles in response to schistosome infection. Several host miRNAs have...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12416
更新日期：2017-02-01 00:00:00
abstract：:The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria duri...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2007.01017.x
更新日期：2008-03-01 00:00:00
abstract：:To investigate whether soluble Plasmodium falciparum antigens possess endotoxin-like properties, the interaction of Limulus amoebocyte lysate (LAL) with defined soluble antigens from Plasmodium falciparum was studied by various crossed immunoelectrophoretic methods and immunoblotting. The soluble P. falciparum antigen...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1988.tb00247.x
更新日期：1988-11-01 00:00:00
abstract：:Intestinal helminth infections are highly prevalent in the developing world, often resulting in chronic infection and inflicting high host morbidity. With the emergence of drug-resistant parasites, a limited number of chemotherapeutic drugs available and stalling vaccine efforts, an increased understanding of antihelm...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12406
更新日期：2017-02-01 00:00:00
abstract：:We compared the antigenicity of p126 Plasmodium falciparum peptides with predicted antigenic regions identified using the methods described by Garnier et al. (1978) and Chou & Fasman (1974). For this purpose nine different P. falciparum peptides were synthesized in accordance with the deduced amino acid sequence of th...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1996.d01-62.x
更新日期：1996-03-01 00:00:00
abstract：:Leishmania mexicana is the causal agent of cutaneous leishmaniasis in Mexico. Dendritic cells (DC) are one of the host cells of Leishmania parasites. Intracellular microorganisms inhibit host cell apoptosis as a strategy to ensure their survival in infected cells. We have previously shown that Leishmania mexicana prom...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12275
更新日期：2015-11-01 00:00:00
abstract：:Toxoplasma gondii-specific murine CD4+ T cell clone 3Tx9 belongs to the Th1 subtype by virtue of secreting high levels of interleukin(IL)-2, interferon-gamma and tumor necrosis factor without producing IL4 and IL10. To characterize the clonal antigen, Toxoplasma lysate-was separated by SDS-PAGE and probed in T cell bl...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1997.d01-201.x
更新日期：1997-05-01 00:00:00
abstract：:In the last years, microRNAs (miRNAs) have been established as important post-transcriptional regulators of critical physiological processes in animals and plants. Here, we summarize what is known about miRNA biosynthesis, expression and function in the malaria vector mosquito Anopheles gambiae with a particular empha...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12405
更新日期：2017-02-01 00:00:00
abstract：:Theileria parva is a tick-borne intracellular protozoan of cattle, with obligate sequential differentiation stages in lymphocytes and erythrocytes. Immunity is mediated by cytotoxic T lymphocytes (CTL) that target and clear parasitized lymphocytes but allow persistence of infected erythrocytes, which are required for ...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2006.00824.x
更新日期：2006-07-01 00:00:00
abstract：:Data from experimental and human cryptosporidiosis have established a major role of specific immunity in the control of Cryptosporidium parvum infection. In this work, alterations in spleen and Peyer's patch (Pp) lymphocytes were investigated in the course of a spontaneously resolutive gut cryptosporidiosis in four-da...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.0141-9838.2004.00676.x
更新日期：2004-01-01 00:00:00
