Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T-cell responses in vivo and in vitro.

abstract：:In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after i...

journal_title：Parasite immunology

authors： Chiuso-Minicucci F,Marra NM,Zorzella-Pezavento SF,França TG,Ishikawa LL,Amarante MR,Amarante AF,Sartori A

更新日期：2010-01-01 00:00:00

abstract：:The carrier effect, using TNP-labelled schistosomula was used to measure the helper T-cell activity against the schistosomula surface in CBA mice exposed to 30 cercariae of Schistosoma mansoni. After infection the helper T-cell activity reached a peak in 8--10 days, but by 6 weeks it had declined to background levels....

journal_title：Parasite immunology

authors： Ramalho-Pinto FJ,Smithers SR

更新日期：1981-10-01 00:00:00

abstract：:As an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent st...

journal_title：Parasite immunology

authors： Cohen SB,Denkers EY

更新日期：2015-03-01 00:00:00

abstract：:In a double-blind study 393 seronegative dogs, residing in a holoendemic area for Leishmania donovani infantum infection, were randomly assigned to an immunization with a partly purified L.d. infantum-derived preparation, or received adjuvant only. During the first year of the study period the rate of infection was si...

journal_title：Parasite immunology

authors： Dunan S,Frommel D,Monjour L,Ogunkolade BW,Cruz A,Quilici M

更新日期：1989-07-01 00:00:00

abstract：:Modulation of macrophage/dendritic cell (DC) cytokine production by the filarial nematode phosphorylcholine (PC)-containing product, ES-62, is mediated by Toll-like receptor (TLR) 4 and signal transduction depends on the TLR adaptor MyD88. Intriguingly, comparison of TLR4 knock-out (ko) mice with TLR4 mutant C3H/HeJ m...

journal_title：Parasite immunology

authors： Goodridge HS,McGuiness S,Houston KM,Egan CA,Al-Riyami L,Alcocer MJ,Harnett MM,Harnett W

更新日期：2007-03-01 00:00:00

abstract：:African trypanosomes are well known for their ability to avoid immune elimination by switching the immunodominant variant surface glycoprotein (VSG) coat during infection. However, antigenic variation is only one of several means by which trypanosomes manipulate the immune system of their hosts. In this article, the r...

journal_title：Parasite immunology

authors： Mansfield JM,Paulnock DM

更新日期：2005-10-01 00:00:00

abstract：:Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected by GI nematodes, making this group of parasitic nematodes a major burden to gl...

journal_title：Parasite immunology

authors： Sharpe C,Thornton DJ,Grencis RK

更新日期：2018-04-01 00:00:00

abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...

journal_title：Parasite immunology

authors： Van Milligen FJ,Cornelissen JB,Hendriks IM,Gaasenbeek CP,Bokhout BA

更新日期：1998-06-01 00:00:00

abstract：:Malaria parasites have a complex, multistage life cycle and there is a widely held view that each stage displays a distinct set of antigens presented to the immune system. Yet, molecular analysis of malaria parasites suggests that many putative antigenic targets are shared amongst the different stages. The specificiti...

journal_title：Parasite immunology

authors： Müller K,Gibbins MP,Matuschewski K,Hafalla JCR

更新日期：2017-07-01 00:00:00

abstract：:Cryptocaryon irritans is one of the most important ectoparasites of marine fish. To identify the potential role of immune-related genes in antiparasitic immune responses in fish, we monitored the expression change of IL-8, COX-2, C-type lectin and transferrin in local and systemic immune organs of orange-spotted group...

journal_title：Parasite immunology

authors： Li YW,Dan XM,Zhang TW,Luo XC,Li AX

更新日期：2011-12-01 00:00:00

abstract：:A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H-2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H-2 molecules. Three types of antigen presentation were obs...

journal_title：Parasite immunology

authors： Robinson M,Gustad TR,Garner SD,David CS

更新日期：1995-05-01 00:00:00

abstract：:Infective forms of Trypanosoma cruzi, the parasite that causes Chagas' disease, express on their surface an enzyme denominated trans-sialidase (TS). The present study was designed to evaluate the naturally acquired immune responses to a bacterial recombinant protein representing the catalytic domain of TS in chronical...

journal_title：Parasite immunology

authors： Ribeirão M,Pereira-Chioccola VL,Rénia L,Augusto Fragata Filho A,Schenkman S,Rodrigues MM

更新日期：2000-01-01 00:00:00

abstract：:Inhibitory monoclonal antibody (MoAb) 8E7/55 recognizes a parasitophorous vacuole membrane (PVM) antigen in Plasmodium falciparum. Previous studies have identified the epitope, DNNLVSGP, recognized by the MoAb. A synthetic peptide containing this sequence was synthesized and coupled to diphtheria toxoid (DT) and was f...

journal_title：Parasite immunology

authors： Lord R,Jones GL,Spencer L,Saul A

更新日期：1993-11-01 00:00:00

abstract：:Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells wit...

journal_title：Parasite immunology

authors： Stephens R,Ndungu FM,Langhorne J

更新日期：2009-01-01 00:00:00

abstract：:Onchocerciasis is caused by the filarial nematode Onchocerca volvulus and is a major public health problem in West and Central Africa. With only partial and long-term treatment currently available, there is a need to develop a suitable vaccine. We analysed the antibody response to infective L3 larvae because this stag...

journal_title：Parasite immunology

authors： Faulkner H,Gardon J,Kamgno J,Enyong P,Boussinesq M,Bradley JE

更新日期：2001-09-01 00:00:00

abstract：:Host cell death induced by Entamoeba histolytica is an important mechanism for both host defence and microbial immune evasion during human amoebiasis. However, the signalling pathways underlying cell death induced by E. histolytica are not fully understood. This study investigated the involvement of the protein tyrosi...

journal_title：Parasite immunology

authors： Kim KA,Lee YA,Shin MH

更新日期：2010-03-01 00:00:00

abstract：:DNA immunization represents a promising vaccine strategy that has been reasonably successful, and will likely play an even greater role in vaccine development as these vaccines continue to be improved. We have developed a partially protective DNA vaccine against schistosome infection based on a 23-kDa integral membran...

journal_title：Parasite immunology

authors： Da'Dara AA,Skelly PJ,Walker CM,Harn DA

更新日期：2003-08-01 00:00:00

abstract：:Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that d...

journal_title：Parasite immunology

authors： Pleasance J,Wiedosari E,Raadsma HW,Meeusen E,Piedrafita D

更新日期：2011-09-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:Hyporesponsiveness induced by Heligmosomoides polygyrus was quantified and the relationship between TGF-beta and inflammation was identified in BALB/c mice. The immune response and pathological changes modified by neutralization of TGF-beta were characterized in vivo. Nine and twelve days following infection, BALB/c m...

journal_title：Parasite immunology

authors： Doligalska M,Rzepecka J,Drela N,Donskow K,Gerwel-Wronka M

更新日期：2006-08-01 00:00:00

abstract：:Successful endoparasites of mammals must outwit the sophisticated immune systems of their hosts that have evolved to detect and destroy/eradicate them. Many species of helminth parasite can directly or indirectly manipulate host immunity: helminth-derived molecules can suppress or skew activity of many immune cell phe...

journal_title：Parasite immunology

authors： McKay DM

更新日期：2015-06-01 00:00:00

abstract：:Haemonchus contortus is an economically important parasite that survives the host defense system by modulating the immune response. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is secreted by the parasite and the host responds by producing anti-enzyme antibodies. The enzyme inhibits complement cascade, an arm of t...

journal_title：Parasite immunology

authors： Rajan P,Mishra PKK,Joshi P

更新日期：2019-02-01 00:00:00

abstract：:Resistance to S. mansoni cercarial challenge, induced by prior infection of rats with cercariae, is analysed by substitution of alternatives to the primary cercarial exposure. Intravenous injections of either live or killed 4-week stage worms have been examined, utilizing two different routes of injection, one or two ...

journal_title：Parasite immunology

authors： Knopf PM,Spitalny KC,Dang A

更新日期：1984-03-01 00:00:00

abstract：:Immunoprecipitations of in vitro translation products of mRNA from adult Schistosoma mansoni worms with sera from chronically infected mice of 12 inbred strains reveal a strain-dependent heterogeneity in the antibody responses to schistosome antigens. Of the strains tested the response to the 86K antigen was restricte...

journal_title：Parasite immunology

authors： Kee KC,Taylor DW,Cordingley JS,Butterworth AE,Munro AJ

更新日期：1986-11-01 00:00:00

abstract：:The antigenicity of the biosynthetically labelled somatic and excretory/secretory proteins of adult Fasciola hepatica was investigated over 20 weeks of an infection with F. hepatica in sheep. The antibody response was initially detected by ELISA 2 weeks after infection, and was sustained at this level for the remainde...

journal_title：Parasite immunology

authors： Sexton JL,Milner AR,Campbell NJ

更新日期：1991-01-01 00:00:00

abstract：:Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and...

journal_title：Parasite immunology

authors： Caraballo L,Acevedo N,Zakzuk J

更新日期：2019-06-01 00:00:00

abstract：:The anti-leishmanial effect of the 'carbohydrate-fraction', isolated from an edible mushroom Astraeus hygrometricus, was evaluated against Leishmania donovani infection both in vitro and in vivo. Ahf-Car induced the expression of inducible nitric oxide synthase 2 (iNOS2) and pro-inflammatory cytokines like TNF-α and I...

journal_title：Parasite immunology

authors： Hussain A,Ghosh S,Roy K,Nath S,Sarkar B,Dutta A,Maji P,Basu S,Paul S,Dey S,Chakraborty K,Raychaudhury B,Acharya K,Ganguly J,Pal C

更新日期：2020-10-31 00:00:00

abstract：:Parasitic nematodes of the small-ruminant gastrointestinal tract pose a problem worldwide. The impact of these pathogens is worsened by the emergence of anthelmintic resistance to all three available classes of drugs. In addition to causing considerable economic loss, these parasites are detrimental to the health and ...

journal_title：Parasite immunology

authors： McNeilly TN,Devaney E,Matthews JB

更新日期：2009-07-01 00:00:00

abstract：:ES-62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)-induced airway hyper-responsiveness in mice by virtue of covalently attached anti-inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs...

journal_title：Parasite immunology

authors： Janicova L,Rzepecka J,Rodgers DT,Doonan J,Bell KS,Lumb FE,Suckling CJ,Harnett MM,Harnett W

更新日期：2016-06-01 00:00:00

abstract：:Over the past several decades, outbreaks of emerging infectious diseases (EIDs) in wild birds have attracted worldwide media attention, either because of their extreme virulence or because of alarming spillovers into agricultural animals or humans. The pathogens involved have been found to infect a variety of bird hos...

journal_title：Parasite immunology

authors： Staley M,Bonneaud C

更新日期：2015-05-01 00:00:00