Recent advancements and new perspectives in animal models for Neurocysticercosis immunopathogenesis.


:Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human) and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tapeworm). Hence, developing an animal model for T. solium that mimics its natural course of infection is quite challenging. We have reviewed here the animal models frequently used to study immunopathogenesis of cysticercosis and also discussed their usefulness for NCC studies. We found that researchers have used mice, rats, guinea pigs, dogs, cats and pigs as models for this disease with varying degrees of success. Mice and rats models have been utilized extensively for immunopathogenesis studies due to their relative ease of handling and abundance of commercially available reagents to study these small animal models. These models have provided some very exciting results for in-depth understanding of the disease. Of late, the experimentally/naturally infected swine model is turning out to be the best animal model as the disease progression closely resembles human infection in pigs. However, handling large experimental animals has its own challenges and limitations.


Parasite Immunol


Parasite immunology


Arora N,Tripathi S,Kumar P,Mondal P,Mishra A,Prasad A




Has Abstract


2017-07-01 00:00:00










  • Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica.

    abstract::Host cell death induced by Entamoeba histolytica is an important mechanism for both host defence and microbial immune evasion during human amoebiasis. However, the signalling pathways underlying cell death induced by E. histolytica are not fully understood. This study investigated the involvement of the protein tyrosi...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Kim KA,Lee YA,Shin MH

    更新日期:2010-03-01 00:00:00

  • Follow-up of Gambian children recruited to a pilot safety and immunogenicity study of the malaria vaccine SPf66.

    abstract::A pilot safety and immunogenicity trial of the malaria vaccine SPf66 was undertaken in The Gambia in 1993. One hundred and fifty infants aged 6-11 months were immunized with either 0.5 mg or 1.0 mg of SPf66 produced either in Colombia or in the USA or with a control vaccine. Children who received SPf66 experienced mor...

    journal_title:Parasite immunology

    pub_type: 临床试验,杂志文章


    authors: Bojang KA,Obaro SK,Leach A,D'Alessandro U,Bennett S,Metzger W,Ballou WR,Targett GA,Greenwood BM

    更新日期:1997-12-01 00:00:00

  • A cell surface antigen associated with Theileria parva lawrencei-infected bovine lymphoid cells.

    abstract::Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Newson J,Naessens J,Stagg DA,Black SJ

    更新日期:1986-03-01 00:00:00

  • Antibody responses to the host-protective Taenia solium oncosphere protein TSOL18 in pigs are directed against conformational epitopes.

    abstract::TSOL18 is a recombinant protein that has been shown in repeated experimental trials to be capable of protecting pigs against challenge infection with the cestode parasite Taenia solium. Antibodies raised by the vaccine are capable of killing the parasite in an in vitro culture and it is believed that antibody and comp...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Assana E,Gauci CG,Kyngdon CT,Zoli AP,Dorny P,Geerts S,Lightowlers MW

    更新日期:2010-06-01 00:00:00

  • Variants with reduced virulence derived from Leishmania major after mutagen treatment.

    abstract::After several in vitro treatments of a virulent population of Leishmania major with the mutagen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), five clones (vir-) were obtained that did not produce cutaneous lesions after subcutaneous injection of 10(6) promastigotes. All the control clones (vir+) obtained from the non-...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Marchand M,Daoud S,Titus RG,Louis J,Boon T

    更新日期:1987-01-01 00:00:00

  • Standardization of a technique for analysing the frequency of parasite-specific cytotoxic T lymphocyte precursors in cattle immunized with Theileria parva.

    abstract::A limiting dilution microculture system was optimized to quantify the frequency of Theileria parva-specific cytotoxic T lymphocyte precursors (CTLp) in peripheral blood mononuclear cells (PBMC) from immune cattle. Optimal results were obtained with responder cell input levels ranging from 2 x 10(4)/well to 6.25 x 10(2...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Taracha EL,Goddeeris BM,Scott JR,Morrison WI

    更新日期:1992-03-01 00:00:00

  • Influence of the HLA class II polymorphism in chronic Chagas' disease.

    abstract::Chagas' disease or American trypanosomiasis due to Trypanosoma cruzi has existed at least since the time of the Inca empire and contributes significantly to cardiovascular morbidity and mortality in several countries of this continent. Due to the fundamental role of human class II molecules polymorphic residues in the...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Fernandez-Mestre MT,Layrisse Z,Montagnani S,Acquatella H,Catalioti F,Matos M,Balbas O,Makhatadze N,Dominguez E,Herrera F,Madrigal A

    更新日期:1998-04-01 00:00:00

  • Myocardial fibrosis in chagas disease and molecules related to fibrosis.

    abstract::Chronic Chagas cardiomyopathy (CCC) is responsible for the disease's greater morbidity and poor prognosis. Although understanding the pathophysiology of CCC and the fundamentals of its clinical management derives from research related to other cardiomyopathies, there are peculiarities that distinguish CCC from the oth...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Chaves AT,Menezes CAS,Costa HS,Nunes MCP,Rocha MOC

    更新日期:2019-10-01 00:00:00

  • Gene expression profiling of ovine keratinocytes stimulated with Psoroptes ovis mite antigen--a preliminary study.

    abstract::Sheep scab is caused by the noninvasive mite, Psoroptes ovis, which initiates a profound pro-inflammatory skin response leading to lesion development. To investigate these early events between the skin and the parasite, primary ovine epidermal keratinocyte cultures were generated and challenged with mite derived antig...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Watkins CA,Mackellar A,Frew D,Mackie C,George A,Hopkins J,Burgess ST,McNeilly TN,Huntley JF

    更新日期:2009-06-01 00:00:00

  • Theileria parva and the bovine CTL response: down but not out?

    abstract::Theileria parva is a tick-borne intracellular protozoan of cattle, with obligate sequential differentiation stages in lymphocytes and erythrocytes. Immunity is mediated by cytotoxic T lymphocytes (CTL) that target and clear parasitized lymphocytes but allow persistence of infected erythrocytes, which are required for ...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: McKeever DJ

    更新日期:2006-07-01 00:00:00

  • Regional specialization of the surface of a parasitic nematode.

    abstract::A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Ortega-Pierres G,Clark NW,Parkhouse RM

    更新日期:1986-11-01 00:00:00

  • MicroRNA-mediated regulation of immune responses to intestinal helminth infections.

    abstract::Intestinal helminth infections are highly prevalent in the developing world, often resulting in chronic infection and inflicting high host morbidity. With the emergence of drug-resistant parasites, a limited number of chemotherapeutic drugs available and stalling vaccine efforts, an increased understanding of antihelm...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Entwistle LJ,Wilson MS

    更新日期:2017-02-01 00:00:00

  • Antibody-independent binding and activation of complement by Schistosoma mansoni adult worms.

    abstract::The in vitro binding serum complement (C) components to Schistosoma mansoni worms was studied. By exposing frozen sections of adult male and female parasites to normal human serum, binding of both classical and alternative pathway C components was observed. By immunofluorescence (IFL) microscopy selective binding of C...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Linder E,Huldt G

    更新日期:1983-03-01 00:00:00

  • Protein-energy malnutrition as a risk factor for visceral leishmaniasis: a review.

    abstract::The protein-energy malnutrition (PEM) and visceral leishmaniasis (VL) are important problems of public health, which affect millions of people worldwide. Currently, it has been accepted that the immunity or susceptibility to infect-parasitic diseases are directly related to the nutritional status of the host. However,...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Malafaia G

    更新日期:2009-10-01 00:00:00

  • Schistosoma mansoni: characterization of two protective monoclonal antibodies.

    abstract::Two monoclonal antibodies against the surface of S. mansoni schistosomula were found to confer significant passive protection to mice (M7B3A, range 28-70%; M22H12C, range 14-58%). No additive effect was observed when both were transferred together. Neither McAb bound to the cercarial surface but both bound to the surf...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Bickle QD,Andrews BJ,Taylor MG

    更新日期:1986-01-01 00:00:00

  • Brugia pahangi infections in cats: antibody responses which correlate with the change from the microfilaraemic to the amicrofilaraemic state.

    abstract::The humoral responses of eight cats infected with Brugia pahangi to somatic antigens from all life-cycle stages were examined quantitatively by ELISA and qualitatively by immunoblotting for almost a year post infection. Six cats spontaneously became amicrofilaraemic: their production of IgG antibodies against somatic ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Fletcher C,Birch DW,Samad R,Denham DA

    更新日期:1986-07-01 00:00:00

  • Susceptible mice present higher macrophage activation than resistant mice during infections with myotropic strains of Trypanosoma cruzi.

    abstract::The kinetics of macrophage activation were compared among inbred strains of mice (C3H, BALB, B6 and B10.A) that are known to differ in their relative resistance to infections with the myotropic strains (Colombian and CL) of Trypanosoma cruzi. The parameters utilized to measure macrophage activation were rapid spreadin...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Russo M,Starobinas N,Ribeiro-Dos-Santos R,Minoprio P,Eisen H,Hontebeyrie-Joskowicz M

    更新日期:1989-07-01 00:00:00

  • Not peripheral parasitaemia but the level of soluble parasite antigen in plasma correlates with vaccine efficacy against Babesia canis.

    abstract::Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia c...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Schetters TP,Scholtes NC,Kleuskens JA,Bos HJ

    更新日期:1996-01-01 00:00:00

  • Regulatory effects of IL-12 and IL-18 on Onchocerca volvulus- and Entamoeba histolytica-specific cellular reactivity and cytokine profiles.

    abstract::In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. We found that IL-18 was highly capable of reducing ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Pfaff AW,Kirch AK,Hoffmann WH,Banla M,Schulz-Key H,Geiger SM,Soboslay PT

    更新日期:2003-06-01 00:00:00

  • Development and suppression of a population of late-adhering macrophages in mouse malaria.

    abstract::Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites. Nucleated cells in the spleen increased in number in Py-infected mice and were maximal at the time of recove...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Lelchuk R,Taverne J,Agomo PU,Playfair JH

    更新日期:1979-04-01 00:00:00

  • The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages.

    abstract::CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) ad...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Gomes IN,Palma LC,Campos GO,Lima JG,DE Almeida TF,DE Menezes JP,Ferreira CA,Santos RR,Buck GA,Manque PA,Ozaki LS,Probst CM,DE Freitas LA,Krieger MA,Veras PS

    更新日期:2009-04-01 00:00:00

  • Elimination of P. berghei liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity.

    abstract::Immunization of mammals with irradiated malaria sporozoites protects from a subsequent contact with the parasite. Protective immunity is directed against the pre-erythrocytic stages of the parasite, sporozoites and liver stages. Specific antibodies neutralize part of the infectious sporozoites infected by the mosquito...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Renggli J,Hahne M,Matile H,Betschart B,Tschopp J,Corradin G

    更新日期:1997-03-01 00:00:00

  • Partial purification and characterization of protection-inducing antigens from the muscle larva of Trichinella spiralis by molecular sizing chromatography and preparative flatbed isoelectric focusing.

    abstract::The soluble portion of a large particle fraction which was derived from the muscle larva of T. spiralis was subjected to molecular sizing column chromatography using Sephacryl S-200. Five major peaks of 280 nm absorbing material were obtained. Analysis by immunoelectrophoresis revealed that each peak contained antigen...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Despommier DD

    更新日期:1981-10-01 00:00:00

  • Eosinophilia, granuloma formation and migratory behaviour of larvae in the congenitally athymic mouse infected with Toxocara canis.

    abstract::Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Sugane K,Oshima T

    更新日期:1982-09-01 00:00:00

  • The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice.

    abstract::CD4(+) T cells play a critical role in determining the disease outcome in murine cutaneous leishmaniasis, and selective usage of T-cell receptor (TCR) is implied in promoting Leishmania major infection. However, little information is available on TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells. In thi...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L

    更新日期:2011-03-01 00:00:00

  • Genetic manipulation of African trypanosomes as a tool to dissect the immunobiology of infection.

    abstract::The variant surface glycoprotein (VSG) coat of African trypanosomes exhibits immunobiological functions distinct from its prominent role as a variant surface antigen. In order to address questions regarding immune stealth effects of VSG switch-variant coats, and the innate immune system activating effects of shed VSG ...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Mansfield JM,Paulnock DM

    更新日期:2008-04-01 00:00:00

  • Susceptibility of B-cell deficient C57BL/6 (microMT) mice to Neospora caninum infection.

    abstract::Neospora caninum is a coccidian parasite of veterinary importance by causing abortion or stillbirth in cattle among other problems in diverse animal species. We assessed an experimental murine model for its suitability to study the immune response to N. caninum infection. Thus, wild-type (wt) C57BL/6 mice and B-cell (...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Eperon S,Brönnimann K,Hemphill A,Gottstein B

    更新日期:1999-05-01 00:00:00

  • Different serum cytokine levels in chronic vs. acute Anisakis simplex sensitization-associated urticaria.

    abstract::The knowledge on immune mechanisms of chronic urticaria (CU) at the cytokine level is widely scarce. We compared pro- and anti-inflammatory as well as Th1- and Th2-associated serum cytokine levels in two phenotypes of CU: associated with (CU+) and without (CU⁻) sensitization against Anisakis simplex, a ubiquitous fish...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Daschner A,Rodero M,DE Frutos C,Valls A,Vega F,Blanco C,Cuéllar C

    更新日期:2011-06-01 00:00:00

  • Induction of a marked eosinophilia by cyclophosphamide in Toxocara canis infected SJL mice.

    abstract::Cyclophosphamide (Cy) is known to produce a marked eosinophilia in mice after antigen challenge. In this study, we studied the effect of Cy on eosinophilia in helminthic infection. Peripheral blood eosinophils were counted in SJL mice following a large dose of Cy injection, infection with Toxocara canis, and both Cy i...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Sugane K,Oshima T

    更新日期:1985-05-01 00:00:00

  • Parasite-specific IgM plays a significant role in the protective immune response to asexual erythrocytic stage Plasmodium chabaudi AS infection.

    abstract::A comparison of Plasmodium chabaudi AS infection in BALB/c and BALB/c IgM-deficient mice demonstrated a protective role for IgM during infection. IgM-/- mice, unlike microMT mice, display competent B cell humoral immune responses. Increased susceptibility of IgM-/- mice was demonstrated by increased mortality, an adva...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Couper KN,Phillips RS,Brombacher F,Alexander J

    更新日期:2005-05-01 00:00:00