Low Back Pain Rating scale: validation of a tool for assessment of low back pain.

abstract：:We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...

journal_title：Pain

authors： Mackie AM,Coda BC,Hill HF

更新日期：1991-09-01 00:00:00

abstract：:The local anesthetic lidocaine was injected into the dentate gyrus (DG) of alert, unrestrained rats 10 min prior to investigation within the formalin test. Regional anesthesia of the DG resulted in a reduction of pain scores when administered contralateral to the site of subcutaneous formalin injection. The analgesic ...

journal_title：Pain

authors： McKenna JE,Melzack R

更新日期：1992-04-01 00:00:00

abstract：:Effective assessment and management of pain in patients with cancer is strengthened by the patient's report of how much pain interferes with daily functioning. This requires a clear delineation of different levels of pain interference. We derived optimal cutpoints for differentiating between mild, moderate, and severe...

journal_title：Pain

authors： Shi Q,Mendoza TR,Dueck AC,Ma H,Zhang J,Qian Y,Bhowmik D,Cleeland CS

更新日期：2017-06-01 00:00:00

abstract：:The opiate antagonist naloxone has been reported to cause pain relief. Therefore, the effect was determined of naloxone, injected intravenously, on the activity in single neurones of the dorsomedial part of the ventral nucleus (VDM) in the thalamus of rats under urethane anaesthesia elicited by electrical stimulation ...

journal_title：Pain

authors： Jurna I

更新日期：1988-12-01 00:00:00

abstract：:The physiological properties of joint capsule mechanoreceptors in the ankle joint of the chicken were studied in the 3-h period immediately after intra-articular injection of microcrystal sodium urate. The electrical activity was recorded from single C- and A-delta sensory fibres dissected from the parafibular nerve. ...

journal_title：Pain

authors： Gentle MJ

更新日期：1997-04-01 00:00:00

abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...

journal_title：Pain

authors： Inbal R,Rousso M,Ashur H,Wall PD,Devor M

更新日期：1987-02-01 00:00:00

abstract：:For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met wi...

journal_title：Pain

authors： van Hecke O,Kamerman PR,Attal N,Baron R,Bjornsdottir G,Bennett DLH,Bennett MI,Bouhassira D,Diatchenko L,Freeman R,Freynhagen R,Haanpää M,Jensen TS,Raja SN,Rice ASC,Seltzer Z,Thorgeirsson TE,Yarnitsky D,Smith BH

更新日期：2015-11-01 00:00:00

abstract：:Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. The results of these studies may be challenged due to methodological problems. We therefore conducted a double-blind, controlled, cross-over study on the effect of acute hyperglycemia on nociceptive and n...

journal_title：Pain

authors： Thye-Rønn P,Sindrup SH,Arendt-Nielsen L,Brennum J,Hother-Nielsen O,Beck-Nielsen H

更新日期：1994-01-01 00:00:00

abstract：:Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...

journal_title：Pain

authors： Noppers IM,Niesters M,Aarts LPHJ,Bauer MCR,Drewes AM,Dahan A,Sarton EY

更新日期：2011-09-01 00:00:00

abstract：:Migraine encompasses a broader spectrum of sensory symptoms than just headache. These "other" symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinal...

journal_title：Pain

authors： Peng KP,May A

更新日期：2019-07-01 00:00:00

abstract：:Systemic opioid dosing until adequate analgesia in neuropathic pain may involve intolerable and untreatable side effects. Peripheral opioid receptor mechanisms may participate in the antinociceptive effect of systemic morphine. We evaluated the effect of peripherally injected morphine alone, and the ability of the fun...

journal_title：Pain

authors： Martinez V,Christensen D,Kayser V

更新日期：2002-10-01 00:00:00

abstract：:We have previously reported that the level of 5-HT in the masseter muscle is increased in patients with fibromyalgia as compared with healthy subjects and that high intramuscular level of 5-HT is associated with muscle pain. We have also reported that injection of the 5-HT(3) receptor antagonist granisetron (GRA) into...

journal_title：Pain

authors： Ernberg M,Lundeberg T,Kopp S

更新日期：2003-02-01 00:00:00

abstract：:Women with chronic pelvic pain experience serious distress and lifestyle disruption. Confronted with a difficult condition to diagnose and treat effectively, doctors express a negative perception of this group of 'heartsink' patients. This study aimed to characterise medical attitudes towards the treatment of women wi...

journal_title：Pain

authors： Selfe SA,Van Vugt M,Stones WR

更新日期：1998-08-01 00:00:00

abstract：:An evaluation of the analgesic, mood and side effects of the combination of intramuscular morphine and oral cocaine was conducted in 17 patients with postoperative pain and 19 others with chronic malignant pain for the purpose of assessing the therapeutic merits of so-called 'euphoriant' elixirs in the management of p...

journal_title：Pain

authors： Kaiko RF,Kanner R,Foley KM,Wallenstein SL,Canel AM,Rogers AG,Houde RW

更新日期：1987-10-01 00:00:00

abstract：:Chronic neuropathic pain is associated with long-term changes at multiple levels of the neuroaxis, including in the brain, where electrical stimulation has been used to manage severe pain conditions. However, the clinical outcome of deep brain stimulation is often mixed, and the mechanisms are poorly understood. By me...

journal_title：Pain

authors： Iwata M,LeBlanc BW,Kadasi LM,Zerah ML,Cosgrove RG,Saab CY

更新日期：2011-11-01 00:00:00

abstract：:In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic...

journal_title：Pain

authors： Azkue JJ,Liu XG,Zimmermann M,Sandkühler J

更新日期：2003-12-01 00:00:00

abstract：:The clinical effectiveness of locally administered opioids is still under discussion; in particular, the potency of morphine in settings other than intra-articular arthroscopy has been questioned. We developed another pain model, postpartum resection of the fallopian tubes for sterilisation, in which each patient serv...

journal_title：Pain

authors： Rorarius M,Suominen P,Baer G,Pajunen P,Tuimala R,Laippala P

更新日期：1999-01-01 00:00:00

abstract：:Anecdotal reports suggest that the general anaesthetic drug ketamine, taken orally in low doses, can give rise to some extra analgesia in patients with refractory neuropathic pain. This study was designed to determine the proportion of patients with chronic neuropathic pain responding to oral ketamine, and then to sep...

journal_title：Pain

authors： Haines DR,Gaines SP

更新日期：1999-11-01 00:00:00

abstract：:P2X3 purinoceptor cellular distribution was studied in rat sensory neurons in naive animals and following peripheral nerve injury using immunohistochemical methods. Specific antiserum was raised in rabbits and characterized by Western blot, absorption assays and labeling of recombinant receptors. In naive animals, P2X...

journal_title：Pain

authors： Novakovic SD,Kassotakis LC,Oglesby IB,Smith JA,Eglen RM,Ford AP,Hunter JC

更新日期：1999-03-01 00:00:00

abstract：:Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...

journal_title：Pain

authors： Vachon-Presseau E,Roy M,Woo CW,Kunz M,Martel MO,Sullivan MJ,Jackson PL,Wager TD,Rainville P

更新日期：2016-08-01 00:00:00

abstract：:Electrophysiological evidence has been obtained suggesting the presence of reciprocal excitation between descending pathways from the nucleus raphe magnus (NRM) and adjacent reticular formation (Ret.F) and spinal cord neurones projecting to these brain stem areas. In decerebrate and decerebellate cats, 40 spinal cord ...

journal_title：Pain

authors： Cervero F,Wolstencroft JH

更新日期：1984-10-01 00:00:00

abstract：:A controlled trial of diamorphine (diacetylmorphine, heroin) and morphine is reported in which the two drugs were administered regularly by mouth in individually determined effective analgesic doses. Elixirs contained cocaine hydrochloride 10 mg/dose; other drugs were prescribed when indicated clinically. 699 patients...

journal_title：Pain

authors： Twycross RG

更新日期：1977-04-01 00:00:00

abstract：:Our aim was to assess the discriminative capacity of the McGill Pain Questionnaire (MPQ) in patients with temporomandibular joint (TMJ) disorders or with myogenous facial pain (MP). The MPQ was administered to 57 TMJ and 28 MP patients who were also asked to assess the level of pain using the Visual Analog Scale (VAS)...

journal_title：Pain

authors： Mongini F,Italiano M

更新日期：2001-04-01 00:00:00

abstract：:Chronic pain often interferes with daily functioning, and may become a threat to an individual's sense of self. Despite the development of a recent theoretical account focussing upon the relationship between the presence of chronic pain and a person's self, research investigating this idea is limited. In the present s...

journal_title：Pain

authors： Van Ryckeghem DML,De Houwer J,Van Bockstaele B,Van Damme S,De Schryver M,Crombez G

更新日期：2013-12-01 00:00:00

abstract：:Fibromyalgia (FM) is a prevalent and disabling chronic disease. Recent studies have found elevated levels of glutamate in several brain regions, leading to hypotheses about the usefulness of glutamate-blocking drugs such as memantine in the treatment of FM. The aim of this study was to evaluate the efficacy of memanti...

journal_title：Pain

authors： Olivan-Blázquez B,Herrera-Mercadal P,Puebla-Guedea M,Pérez-Yus MC,Andrés E,Fayed N,López-Del-Hoyo Y,Magallon R,Roca M,Garcia-Campayo J

更新日期：2014-12-01 00:00:00

abstract：:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...

journal_title：Pain

authors： Walker LS,Sherman AL,Bruehl S,Garber J,Smith CA

更新日期：2012-09-01 00:00:00

abstract：:In a double-blind, cross-over study, ibuprofen (600 mg), a peripherally-acting selective kappa-opioid receptor agonist (7.5 mg), or placebo were given orally in experiments on healthy volunteers 1 h before assessment of pain thresholds to radiant heat and of pain ratings to controlled mechanical impact stimuli. Mechan...

journal_title：Pain

authors： Bickel A,Dorfs S,Schmelz M,Forster C,Uhl W,Handwerker OH

更新日期：1998-06-01 00:00:00

abstract：:Combined oral administration of morphine sulfate (MS) and the over-the-counter antitussive drug and N-methyl-D-aspartate receptor antagonist dextromethorphan (DM) prevented the development of tolerance to the antinociceptive effects of MS (15, 24, or 32 mg/kg) in rats. This combined oral treatment regimen also attenua...

journal_title：Pain

authors： Mao J,Price DD,Caruso FS,Mayer DJ

更新日期：1996-10-01 00:00:00

abstract：:We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain. The hypothalamic-pituitary-adrenal (HPA) axis is known to respond to stressful stimuli, including pain. To examine whether the blockade of tolerance by pain is related to HPA activity, ...

journal_title：Pain

authors： Vaccarino AL,Couret LC Jr

更新日期：1995-12-01 00:00:00

abstract：:An experimental mononeuropathy was produced in rats by unilateral loose ligation of the sciatic nerve, with a contralateral sham surgery. Repeated bilateral sensory testing was performed over time to investigate any threshold differences between the loose ligature side and the contralateral control side. A prolonged r...

journal_title：Pain

authors： Kingery WS,Castellote JM,Wang EE

更新日期：1993-12-01 00:00:00