Abstract:
:Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. The results of these studies may be challenged due to methodological problems. We therefore conducted a double-blind, controlled, cross-over study on the effect of acute hyperglycemia on nociceptive and non-nociceptive thresholds in 10 type 1 (insulin-dependent) diabetic patients (diabetes < 5 years) without symptoms or clinical signs of peripheral neuropathy. During an overnight fast, blood glucose concentration was normalized by refract insulin injections. Then, blood glucose was kept at 6 mmol/l for 3 h by an intravenous infusion of glucose and insulin. On one study day, blood glucose was kept at 6 mmol/l for a further 3 h and on another day, blood glucose was elevated to 12 mmol/l during 0.5 h by additional glucose infusion and kept at that level for 2.5 h. Sensory testing was carried out twice during the initial 3 h with euglycemia and 3 times during the following period with either hyper- or euglycemia. The test procedure included determination of pain detection and pain tolerance thresholds to heat (wrists) and pressure (fingers) as well as detection thresholds to warmth/cooling (wrist), vibration (finger), and mechanical (wrist) stimulation. The changes in neither nociceptive nor non-nociceptive thresholds showed any statistically significant differences between the 2 study days. The pressure pain detection and tolerance thresholds showed, however, minor decreases at each of the test days, probably due to cutaneous sensitization caused by the repeated measurements. Compared to baseline, the pressure pain thresholds decreased significantly on the day with hyperglycemia. None of the other thresholds showed such changes.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Painjournal_title
Painauthors
Thye-Rønn P,Sindrup SH,Arendt-Nielsen L,Brennum J,Hother-Nielsen O,Beck-Nielsen Hdoi
10.1016/0304-3959(94)90148-1subject
Has Abstractpub_date
1994-01-01 00:00:00pages
43-49issue
1eissn
0304-3959issn
1872-6623pii
00006396-199401000-00006journal_volume
56pub_type
临床试验,杂志文章,随机对照试验相关文献
PAIN文献大全abstract::Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(99)00259-6
更新日期:2000-03-01 00:00:00
abstract::Coeliac plexus block (CPB) is one of the few neurolytic procedures that is still considered very useful in managing chronic cancer pain. We describe what we believe to be the fifth case in the literature of paraplegia following coeliac plexus block with ethyl alcohol. Clinical and neurophysiological examination confir...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90015-H
更新日期:1993-12-01 00:00:00
abstract::After a pilot study had indicated that the topical application of guanethidine might be of value in the treatment of tooth dentine hypersensitivity, a double-blind study was undertaken to investigate whether guanethidine was more effective than a distilled water control in alleviating dentinal pain. In 39 adult subjec...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(93)90205-4
更新日期:1993-08-01 00:00:00
abstract::Iatrogenic Cushing's syndrome has been reported after the use of nasal, aerosol, oral, and intramuscular steroid preparations. Presented is a case of Cushing's syndrome due to an epidural injection of methylprednisolone. A 24-year-old man had left arm pain after an occupational injury. Electromyography revealed C7 rad...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91054-M
更新日期:1990-01-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.025
更新日期:2010-12-01 00:00:00
abstract::This study aimed to investigate the efficacy of an attention training technique (ATT) on pain ratings, threshold and tolerance during the cold pressor task. One hundred and three undergraduate students were randomly assigned to receive either threat-alleviating or threat-inducing information about the task. Participan...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.05.027
更新日期:2010-09-01 00:00:00
abstract::The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00115-5
更新日期:2003-08-01 00:00:00
abstract::Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may highlight potential intervention strategies. This study uses a novel...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001193
更新日期:2018-06-01 00:00:00
abstract::This study aimed to identify areas of disagreement in the management of neurogenic pain. A short questionnaire was mailed to 179 consultants with an interest in chronic pain (response rate 89%). The questionnaire listed 11 specific conditions involving nerve pain (e.g., post-herpetic neuralgia, causalgia) together wit...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90035-N
更新日期:1993-09-01 00:00:00
abstract::VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly incr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.03.012
更新日期:2014-07-01 00:00:00
abstract::Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important ad...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001375
更新日期:2018-12-01 00:00:00
abstract::Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial d...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2005.03.041
更新日期:2005-08-01 00:00:00
abstract::Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.01.011
更新日期:2009-04-01 00:00:00
abstract::Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.07.019
更新日期:2014-10-01 00:00:00
abstract::Pain scales using faces are commonly used tools for assessing pain in children capable of communicating. However, some children require other types of pain scales because they have difficulties in understanding faces pain scales. The goal of this study was to develop and validate the "Pain Block" concrete ordinal scal...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1097/j.pain.0000000000001131
更新日期:2018-04-01 00:00:00
abstract::The effects of pretreatment with desipramine, a selective noradrenaline (NA) uptake blocker, on spinal antinociception by 5-hydroxytryptamine (5-HT), morphine and an adenosine analog (NECA) in the rat hot-plate test were examined to determine if endogenous NA is involved in the spinal action of these agents. Desiprami...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90118-U
更新日期:1992-07-01 00:00:00
abstract::Although EMLA is known to be an effective topical anesthetic, its rate of success is unknown. Indeed, researchers have suggested that EMLA may fail with young and apprehensive children. Therefore, the objectives of this study were to assess EMLA's rate of success as well as factors which predict success. A double-blin...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(95)00100-X
更新日期:1996-01-01 00:00:00
abstract::Genetic influence on the sensory, motor and histopathological outcome of transient spinal cord ischemia was studied in Sprague-Dawley (SD), spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Ischemia caused minor motor deficits and no identifiable morphological damage in the spinal cord of the majority of SD...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90152-F
更新日期:1993-11-01 00:00:00
abstract::Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.03.026
更新日期:2011-09-01 00:00:00
abstract::Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.02.006
更新日期:2007-11-01 00:00:00
abstract::Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling pathway has been shown to regulate synaptic differentiation and transmission. Therefore, this study was to investigate the function of the Notch signaling pathway in the ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002014
更新日期:2021-01-01 00:00:00
abstract::Concerns over prescription opioids contributing to high levels of opioid use disorder and overdose have led policymakers and clinicians to seek means to reduce inappropriate and high-dose initial prescriptions. To inform such efforts, we sought to describe the clinical indications associated with opioid initiation and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001242
更新日期:2018-08-01 00:00:00
abstract::Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2013.03.006
更新日期:2013-07-01 00:00:00
abstract::Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Di...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001413
更新日期:2019-01-01 00:00:00
abstract::Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002126
更新日期:2020-10-26 00:00:00
abstract::Evidence of the relationship between childhood abuse and pain problems in adulthood has been based on cross-sectional studies using retrospective self-reports of childhood victimization. The objective of the current study was to determine whether childhood victimization increases risk for adult pain complaints, using ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00270-6
更新日期:2001-05-01 00:00:00
abstract::Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460336.31600.01
更新日期:2015-03-01 00:00:00
abstract::Behavioral studies have suggested that placebo analgesia is partly mediated by the endogenous opioid system. Expanding on these results we have shown that the opioid-receptor-rich rostral anterior cingulate cortex (rACC) is activated in both placebo and opioid analgesia. However, there are also differences between the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.03.011
更新日期:2010-07-01 00:00:00
abstract::The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.j.pain.0000460309.94442.44
更新日期:2015-02-01 00:00:00
abstract::In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.08.007
更新日期:2003-12-01 00:00:00