Genetic factors influence the development of mechanical hypersensitivity, motor deficits and morphological damage after transient spinal cord ischemia in the rat.

abstract：:Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at ...

journal_title：Pain

authors： Giamberardino MA,Berkley KJ,Iezzi S,de Bigontina P,Vecchiet L

更新日期：1997-06-01 00:00:00

abstract：:This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...

journal_title：Pain

authors： Nicholas MK,Wilson PH,Goyen J

更新日期：1992-03-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene-related peptide was found to play important roles in cardiovascular, digestive, and sensory functi...

journal_title：Pain

authors： Iyengar S,Ossipov MH,Johnson KW

更新日期：2017-04-01 00:00:00

abstract：:Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery...

journal_title：Pain

authors： Davis KD,Dostrovsky JO

更新日期：1986-06-01 00:00:00

abstract：ABSTRACT:The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized trial...

journal_title：Pain

authors： Olsson E,Ahl H,Bengtsson K,Vejayaram DN,Norman E,Bruschettini M,Eriksson M

更新日期：2021-02-01 00:00:00

abstract：:A short form of the McGill Pain Questionnaire (SF-MPQ) has been developed. The main component of the SF-MPQ consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate or 3 = severe. Three pain scores are derived from the sum of the intensity rank valu...

journal_title：Pain

authors： Melzack R

更新日期：1987-08-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) has a pivotal role in human pain processing by integrating sensory, executive, attentional, emotional, and motivational components of pain. Cognitive modulation of pain-related ACC activation has been shown by hypnosis, illusion and anticipation. The expectation of a potentially nox...

journal_title：Pain

authors： Mohr C,Binkofski F,Erdmann C,Büchel C,Helmchen C

更新日期：2005-04-01 00:00:00

abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...

journal_title：Pain

authors： Smith SM,Amtmann D,Askew RL,Gewandter JS,Hunsinger M,Jensen MP,McDermott MP,Patel KV,Williams M,Bacci ED,Burke LB,Chambers CT,Cooper SA,Cowan P,Desjardins P,Etropolski M,Farrar JT,Gilron I,Huang IZ,Katz M,Kerns RD

更新日期：2016-05-01 00:00:00

abstract：:The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...

journal_title：Pain

authors： Defrin R,Tsedek I,Lugasi I,Moriles I,Urca G

更新日期：2010-11-01 00:00:00

abstract：:In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic...

journal_title：Pain

authors： Azkue JJ,Liu XG,Zimmermann M,Sandkühler J

更新日期：2003-12-01 00:00:00

abstract：:Procedural pain is associated with poorer neurodevelopment in infants born very preterm (≤ 32 weeks gestational age), however, the etiology is unclear. Animal studies have demonstrated that early environmental stress leads to slower postnatal growth; however, it is unknown whether neonatal pain-related stress affects ...

journal_title：Pain

authors： Vinall J,Miller SP,Chau V,Brummelte S,Synnes AR,Grunau RE

更新日期：2012-07-01 00:00:00

abstract：:Idiopathic chronic pain conditions with a mismatch between anatomical abnormalities and symptoms can be categorized as somatoform pain disorder according to the DSM-IV criteria. A dysfunction of pain processing circuits has been suggested as one underlying pathophysiological factor. There is accumulating evidence for ...

journal_title：Pain

authors： Gündel H,Valet M,Sorg C,Huber D,Zimmer C,Sprenger T,Tölle TR

更新日期：2008-07-15 00:00:00

abstract：:Chronic pain is currently considered a public health problem with high costs to the individual and society. To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain. The aims of this study were to estimate the prevalence of chronic pain in the adult Danish pop...

journal_title：Pain

authors： Kurita GP,Sjøgren P,Juel K,Højsted J,Ekholm O

更新日期：2012-12-01 00:00:00

abstract：:microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...

journal_title：Pain

authors： Kynast KL,Russe OQ,Möser CV,Geisslinger G,Niederberger E

更新日期：2013-03-01 00:00:00

abstract：:We investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, do...

journal_title：Pain

authors： de Andrade DC,Mhalla A,Adam F,Texeira MJ,Bouhassira D

更新日期：2011-02-01 00:00:00

abstract：:This report describes a placebo-controlled study of transcutaneous electrical nerve stimulation (TENS) applied to the contralateral lower leg and outer ears of an amputee with non-painful phantom sensations. The subject received TENS or placebo stimulation on separate sessions in which baseline periods of no stimulati...

journal_title：Pain

authors： Katz J,France C,Melzack R

更新日期：1989-03-01 00:00:00

abstract：:Many treatments used for women with vulvodynia are based solely upon expert opinion. This randomized trial aimed to test the relative efficacy of cognitive-behavioral therapy (CBT) and supportive psychotherapy (SPT) in women with vulvodynia. Of the 50 participants, 42 (84%) completed 10-week treatments and 47 (94%) co...

journal_title：Pain

authors： Masheb RM,Kerns RD,Lozano C,Minkin MJ,Richman S

更新日期：2009-01-01 00:00:00

abstract：:Evidence of the relationship between childhood abuse and pain problems in adulthood has been based on cross-sectional studies using retrospective self-reports of childhood victimization. The objective of the current study was to determine whether childhood victimization increases risk for adult pain complaints, using ...

journal_title：Pain

authors： Raphael KG,Widom CS,Lange G

更新日期：2001-05-01 00:00:00

abstract：:Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...

journal_title：Pain

authors： Freidin MB,Tsepilov YA,Stanaway IB,Meng W,Hayward C,Smith BH,Khoury S,Parisien M,Bortsov A,Diatchenko L,Børte S,Winsvold BS,Brumpton BM,Zwart JA,Aulchenko YS,Suri P,Williams FMK,HUNT All-In Pain.

更新日期：2020-09-30 00:00:00

abstract：:The primary purpose of this study was to examine the extent to which specific patient attitudes and beliefs about medical care and self-care for back pain predict future healthcare use. An automated database allowed examination of the predictive relationships in two primary care patient samples. In general, beliefs th...

journal_title：Pain

authors： Saunders KW,Von Korff M,Pruitt SD,Moore JE

更新日期：1999-11-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled study of low-level laser therapy (LLLT) in 90 subjects with chronic neck pain was conducted with the aim of determining the efficacy of 300 mW, 830 nm laser in the management of chronic neck pain. Subjects were randomized to receive a course of 14 treatments over 7 weeks ...

journal_title：Pain

authors： Chow RT,Heller GZ,Barnsley L

更新日期：2006-09-01 00:00:00

abstract：:We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...

journal_title：Pain

authors： Roca G,Aguilar JL,Gomar C,Mazo V,Costa J,Vidal F

更新日期：1996-12-01 00:00:00

abstract：:Previous evidence suggests that, in adult animals, nerve growth factor (NGF) can induce hyperalgesia, and may be an endogenous mediator in some persistent pain states. Here we have studied the effects of single intradermal injections of 50-500 ng of human recombinant NGF into the plantar skin of adult rat hindpaws. We...

journal_title：Pain

authors： Andreev NY,Dimitrieva N,Koltzenburg M,McMahon SB

更新日期：1995-10-01 00:00:00

abstract：:Current knowledge on pain-related cerebral networks has relied so far on stimulus-induced brain responses, but not on the analysis of brain activity during spontaneous pain attacks. In this case report, correlation between intracerebral field potentials and online sensations during spontaneously painful epileptic seiz...

journal_title：Pain

authors： Isnard J,Magnin M,Jung J,Mauguière F,Garcia-Larrea L

更新日期：2011-04-01 00:00:00

abstract：:Intrathecal administration of serotonin type 2 (5-HT(2)) receptor agonists, alpha-methyl-5-hydroxytryptamine maleate (alpha-m-5-HT) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI), produces antiallodynic effects in a rat model of neuropathic pain. In the present study, we examined the antial...

journal_title：Pain

authors： Obata H,Saito S,Sakurazawa S,Sasaki M,Usui T,Goto F

更新日期：2004-03-01 00:00:00

abstract：:The role of 5-hydroxytryptamine (5-HT)(4), 5-HT(6), and 5-HT(7) receptors in formalin-induced secondary allodynia and hyperalgesia in rats was assessed. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term secondary mechanical allodynia and hyperalgesia. Pretreatment (-10...

journal_title：Pain

authors： Godínez-Chaparro B,Barragán-Iglesias P,Castañeda-Corral G,Rocha-González HI,Granados-Soto V

更新日期：2011-03-01 00:00:00

abstract：:Nerve growth factor (NGF) is known to produce hyperalgesia as well as to stimulate synthesis of neuropeptides in dorsal root ganglia (DRG). In the present study, we wanted to determine the effects of local NGF administration and assess to which extent mast cell-dependent factors are mediating NGF responses. Rats recei...

journal_title：Pain

authors： Amann R,Schuligoi R,Herzeg G,Donnerer J

更新日期：1996-02-01 00:00:00

abstract：:The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...

journal_title：Pain

authors： Zhang YQ,Gao X,Ji GC,Huang YL,Wu GC,Zhao ZQ

更新日期：2002-08-01 00:00:00

abstract：:Non-invasive, movement-based models were used to investigate muscle pain. In rats, the masseter muscle was rapidly stretched or electrically stimulated during forced lengthening to produce eccentric muscle contractions (EC). Both EC and stretching disrupted scattered myofibers and produced intramuscular plasma extrava...

journal_title：Pain

authors： Dessem D,Ambalavanar R,Evancho M,Moutanni A,Yallampalli C,Bai G

更新日期：2010-05-01 00:00:00

abstract：:The purpose of this study was to assess the hypothesis that pain and depression negatively impact the cognitive functioning of individuals with rheumatoid arthritis (RA). One hundred twenty-one community-dwelling RA patients (ages 34-84) completed a battery of cognitive tasks and multiple measures of pain and depressi...

journal_title：Pain

authors： Brown SC,Glass JM,Park DC

更新日期：2002-04-01 00:00:00