Abstract：
:microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This study focuses on the regulation and function of the central nervous system (CNS)-specific miRNA-124a in the spinal cord of mice in a formalin model of inflammatory nociception. miRNA-124a is constitutively expressed in the spinal cord of mice, particularly in neurons of the dorsal horn. Peripheral noxious stimulation with formalin led to significant down-regulation of its expression. Knock-down of miRNA-124a by intravenous administration of a specific miRNA-124a inhibitor further increased the nociceptive behavior associated with an upregulation of the pain-relevant miRNA-124a target MeCP2 and proinflammatory marker genes. In contrast, administration of a miRNA-124a mimic counteracted these effects and decreased nociception by down-regulation of the target gene. In conclusion, our results indicate that miRNA-124a is involved in inflammatory nociception by regulation of relevant target proteins and might therefore constitute a novel target for anti-inflammatory therapy.
journal_name
Painjournal_title
Painauthors
Kynast KL,Russe OQ,Möser CV,Geisslinger G,Niederberger Edoi
10.1016/j.pain.2012.11.010subject
Has Abstractpub_date
2013-03-01 00:00:00pages
368-376issue
3eissn
0304-3959issn
1872-6623pii
00006396-201303000-00010journal_volume
154pub_type
杂志文章相关文献
PAIN文献大全abstract：:An 82-year-old woman experienced generalized pruritus not due to skin or systemic disease. Scratching the skin with a needle induced a crisis of intense pruritus, insensitive to any drug. The pruritus had the characteristics of a central sensation. ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90055-3
更新日期：1991-06-01 00:00:00
abstract：:We developed a mouse model of cancer pain to investigate its underlying mechanisms. SCC-7, squamous cell carcinoma (SCC) derived from C3H mice, was inoculated subcutaneously into either the plantar region or thigh in male C3H/Hej mice. Heat and mechanical sensitivity as well as spontaneous behavior were measured at th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.05.010
更新日期：2005-09-01 00:00:00
abstract：:Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sodium channel subtype...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.06.015
更新日期：2014-10-01 00:00:00
abstract：:The behavioural response of infant rats to intraplantar injection of formalin consists of specific directed behaviours (limb flexion, shaking and licking the injected paw) and non-specific behaviours that are also induced by non-nociceptive stimulation (squirming, hind limb kicks and whole body jerks), with specific i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)00277-L
更新日期：1995-09-01 00:00:00
abstract：:The spinal ascending pathways responsible for neuronal ventrobasal (VB) thalamic responses elicited by joint stimulation of the posterior paw were determined in arthritic rats used as a model of experimental pain. Responses of a same neurone to mechanical (movement--pressure--brushing) or thermal stimulation (50 degre...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(86)90059-X
更新日期：1986-09-01 00:00:00
abstract：:Increased blood pressure and sweet taste are often associated with decreased pain sensitivity. Animal research suggests that endogenous opioids are involved in both these relationships. Fifty-eight healthy young adults (36 male, 22 female) participated in two sessions receiving a placebo tablet or 50mg of naltrexone o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.05.003
更新日期：2008-03-01 00:00:00
abstract：:Measuring health complaints by administrating a single report is common. Our aim was to assess variation in pain and other subjective complaints over an extended period, whether a single-sample produces representative data, and determine associations between complaints. Health-complaint reports were collected from pos...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.03.016
更新日期：2004-07-01 00:00:00
abstract：:Thirty-eight patients maintained on opioid analgesics for non-malignant pain were retrospectively evaluated to determine the indications, course, safety and efficacy of this therapy. Oxycodone was used by 12 patients, methadone by 7, and levorphanol by 5; others were treated with propoxyphene, meperidine, codeine, pen...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(86)90091-6
更新日期：1986-05-01 00:00:00
abstract：:Quantitative sensory testing of heat pain sensation has become an important tool to evaluate small caliber afferent nerve function in peripheral neuropathy. In earlier studies, we found that topical application of capsaicin in humans results in the loss of epidermal nerve fibers (ENFs) with a corresponding decrease in...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(00)00444-9
更新日期：2001-04-01 00:00:00
abstract：:Constipation is the most common adverse event (AE) of opioid therapy. This multicenter, phase 2 study evaluated the efficacy and safety of linaclotide in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain syndromes (NCT02270983). Adults with OIC (<3 spontaneous bowel movements [SBMs]/we...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001754
更新日期：2020-05-01 00:00:00
abstract：:Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.05.002
更新日期：2009-08-01 00:00:00
abstract：:The N-methyl-D-aspartic acid (NMDA) receptor antagonist D, L-2-amino-5-phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide dynamic range (WDR) neurons after carrageenan inflammation compared with control neurons without inflammation in the receptive field. This indicates that even a sh...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(99)00155-4
更新日期：1999-12-01 00:00:00
abstract：:Contrary to a clinical aphorism that early head and neck cancer is painless, we show that patients who develop head and neck cancer experience significant pain at the time of initial diagnosis. We compared orofacial pain sensitivity in groups of patients with normal oral mucosa, oral precancer, and newly diagnosed ora...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.02.009
更新日期：2011-05-01 00:00:00
abstract：:Medullary on- and off-cell responses to tail heating were studied in lightly anesthetized rats. In 10 animals the electromyographic (EMG) activation of tail muscles was recorded simultaneously with on- or off-cells. The on-cell burst or the off-cell pause always preceded segmental EMG activation by about 0.5 sec. In t...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90009-2
更新日期：1989-11-01 00:00:00
abstract：:This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00448-7
更新日期：2003-05-01 00:00:00
abstract：:Bone is one of the leading sites of metastasis for frequently diagnosed malignancies, including those arising in the breast, prostate and lung. Although these cancers develop unnoticed and are painless in their primary sites, bone metastases result in debilitating pain. Deeper investigation of this pain may reveal eti...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000681
更新日期：2016-11-01 00:00:00
abstract：:We investigated whether intraoperative 'subanesthetic doses' of ketamine have a postoperative anti-hyperalgesic and an analgesic effect and which is the preferential route of administration, either systemic (intravenous, i.v.) or epidural. One hundred patients scheduled for rectal adenocarcinoma surgery under combined...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0304-3959(01)00278-0
更新日期：2001-06-01 00:00:00
abstract：:Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(83)90102-1
更新日期：1983-11-01 00:00:00
abstract：:The present study evaluated the efficacy of a clinician-guided Internet-delivered cognitive behaviour therapy (iCBT) program, the Pain Course, to reduce disability, anxiety, and depression associated with chronic pain. Sixty-three adults with chronic pain were randomised to either a Treatment Group or waitlist Control...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2013.03.005
更新日期：2013-06-01 00:00:00
abstract：:P2X3 purinoceptor cellular distribution was studied in rat sensory neurons in naive animals and following peripheral nerve injury using immunohistochemical methods. Specific antiserum was raised in rabbits and characterized by Western blot, absorption assays and labeling of recombinant receptors. In naive animals, P2X...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(98)00225-5
更新日期：1999-03-01 00:00:00
abstract：:The experience of anger (i.e. trait anger) and anger management style (i.e. anger-in, anger-out) are related to sensitivity to acute and chronic pain stimuli, although underlying mechanisms are unknown. This study tested whether anger variables are associated with impaired endogenous opioid antinociceptive activity, a...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0304-3959(02)00104-5
更新日期：2002-09-01 00:00:00
abstract：:Children of parents with chronic pain have higher rates of pain and internalizing (eg, anxiety and depressive) symptoms than children of parents without chronic pain. Parental modeling of pain behaviour and reinforcement of child pain have been hypothesized to underlie these relationships. These mechanisms were tested...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001658
更新日期：2019-11-01 00:00:00
abstract：:The present study was undertaken to investigate the possible involvement of peripheral nociceptors in 3 diagnostic categories of elderly patients with chronic pain. The 3 diagnostic groups consisted of: chronic lower lumbar pain of degenerative musculoskeletal etiology (LLP), post-herpetic neuralgia (PHN) and pain of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91104-Q
更新日期：1990-04-01 00:00:00
abstract：:The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...
journal_title：Pain
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.pain.2005.07.002
更新日期：2005-10-01 00:00:00
abstract：:Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/S0304-3959(98)00118-3
更新日期：1999-01-01 00:00:00
abstract：:In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.07.035
更新日期：2013-11-01 00:00:00
abstract：:Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve inju...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.10.024
更新日期：2013-02-01 00:00:00
abstract：:Eight patients with established lower limb postamputation stump pain were given lumbar intrathecal fentanyl 25 micrograms and lidocaine 70 mg 2 weeks apart in an attempt to better understand the role of peripheral and central mechanisms in this condition. Baseline pain was recorded and then analgetic and side effects ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)90064-K
更新日期：1990-02-01 00:00:00
abstract：:Capsaicin has been used extensively as an experimental tool and in traditional and proprietary topical medications for acute soft tissue injuries. More recently it has been prescribed for several chronic pain conditions where it is usually administered topically for periods of several weeks. Here we have studied the c...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90101-3
更新日期：1991-03-01 00:00:00
abstract：:Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.12.022
更新日期：2005-03-01 00:00:00
