Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones.


:Previous evidence suggests that, in adult animals, nerve growth factor (NGF) can induce hyperalgesia, and may be an endogenous mediator in some persistent pain states. Here we have studied the effects of single intradermal injections of 50-500 ng of human recombinant NGF into the plantar skin of adult rat hindpaws. We found that doses of 250 ng and more produced a prolonged and stable thermal hyperalgesia to radiant heat. NGF did not produce overt pain behaviour as judged by the absence of paw licking or guarding of the injected paw. In animals subjected to surgical or chemical sympathectomy, by repeated systemic guanethidine treatments, the hyperalgesic effects of NGF were markedly reduced. We also found that NGF produced plasma extravasation in rat skin, using the Evan's blue method, with a dose dependency similar to that determined for hyperalgesia. Together, these findings suggest that NGF can lead to a rapid activation and sensitization of cutaneous nociceptors. However, these actions appear at least partly indirect, requiring the presence of normal sympathetic post-ganglionic terminals.






Andreev NY,Dimitrieva N,Koltzenburg M,McMahon SB




Has Abstract


1995-10-01 00:00:00
















  • Epidural administration of opiates by a new device.

    abstract::Epidural administration of opiates as a long-term treatment of cancer pain, even for out-patients, is now well established. Most reports describe intermittent injections given several times a day, which may have technical and personal disadvantages. Continuous epidural infusion may be preferable. This report describes...


    pub_type: 杂志文章


    authors: Ingemar F,Ahlgren H,Ahlgren MBE

    更新日期:1987-12-01 00:00:00

  • Intrathecal tri-cyclic antidepressants produce spinal anesthesia.

    abstract::Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...


    pub_type: 杂志文章


    authors: Chen YW,Huang KL,Liu SY,Tzeng JI,Chu KS,Lin MT,Wang JJ

    更新日期:2004-11-01 00:00:00

  • Anti-nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain.

    abstract::Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...


    pub_type: 杂志文章


    authors: Majuta LA,Mitchell SAT,Kuskowski MA,Mantyh PW

    更新日期:2018-11-01 00:00:00

  • Noxious cold evokes multiple sensations with distinct time courses.

    abstract::A noxious cold stimulus can evoke multiple sensations each occurring with a different time course. We have performed psychophysical studies to identify the time course of five sensations evoked by a noxious cold stimulus applied to the hand. Subjects continuously rated either pain, ache, cold, heat or prickle sensatio...


    pub_type: 杂志文章


    authors: Davis KD,Pope GE

    更新日期:2002-07-01 00:00:00

  • Unexplained peculiarities of the dorsal root ganglion.

    abstract::The cell soma of primary afferent neurons in the dorsal root ganglion (DRG) is assigned by classical neurophysiology the role of a metabolic depot, charged with supporting the peripheral sensory ending, the conducting axon, and the central synaptic terminals. However, certain peculiarities of DRG morphology and physio...


    pub_type: 杂志文章,评审


    authors: Devor M

    更新日期:1999-08-01 00:00:00

  • Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.

    abstract::Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...


    pub_type: 杂志文章


    authors: Liaw WJ,Stephens RL Jr,Binns BC,Chu Y,Sepkuty JP,Johns RA,Rothstein JD,Tao YX

    更新日期:2005-05-01 00:00:00

  • Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres.

    abstract::The M-current has been proposed as a potential target for analgesia under neuropathic pain conditions. M-currents and/or their molecular correlates, KCNQ proteins, have been demonstrated in key elements of the nociceptive system including spinal and dorsal root ganglion neurons. Here we demonstrate that retigabine, a ...


    pub_type: 杂志文章


    authors: Roza C,Lopez-Garcia JA

    更新日期:2008-09-15 00:00:00

  • The dexamethasone suppression test as a biologic marker of depression in chronic pain.

    abstract::The relationship between chronic pain and depression has become enmeshed in the literature. In an attempt to unravel the relationship between chronic pain and depression, the authors studied a uniform group of 80 chronic back pain patients with and without depression using the dexamethasone suppression test (DST). The...


    pub_type: 杂志文章


    authors: France RD,Krishnan RRK

    更新日期:1985-01-01 00:00:00

  • Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: implications for circuitry.

    abstract::Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...


    pub_type: 杂志文章


    authors: Heinricher MM,McGaraughty S

    更新日期:1998-04-01 00:00:00

  • Problems of long-term spinal opioid treatment in advanced cancer patients.

    abstract::Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...


    pub_type: 杂志文章,评审


    authors: Mercadante S

    更新日期:1999-01-01 00:00:00

  • Migraine understood as a sensory threshold disease.

    abstract::Migraine encompasses a broader spectrum of sensory symptoms than just headache. These "other" symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinal...


    pub_type: 杂志文章,评审


    authors: Peng KP,May A

    更新日期:2019-07-01 00:00:00

  • Medical students' attitudes toward pain before and after a brief course on pain.

    abstract::The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...


    pub_type: 杂志文章


    authors: Wilson JF,Brockopp GW,Kryst S,Steger H,Witt WO

    更新日期:1992-09-01 00:00:00

  • Significance of pain in psychiatric hospital patients.

    abstract::In a consecutive series of 227 psychiatric hospital admissions, data were recorded in respect of the complaint of pain. Eighty-six (38%) had pain. Fourty-four (19%) mentioned it spontaneously and 49 (22%) had no relevant physical cause. Women were affected more often than men (P less than 0.01) and tended to complain ...


    pub_type: 杂志文章


    authors: Delaplaine R,Ifabumuyi OI,Merskey H,Zarfas J

    更新日期:1978-04-01 00:00:00

  • A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy--a 12-month follow-up.

    abstract::The discTRODE probe applies radiofrequency (RF) current, heating the annulus to treat chronic discogenic low back pain. Randomized controlled studies have not been published. We assessed the long-term effect and safety aspects of percutaneous intradiscal radiofrequency thermocoagulation (PIRFT) with the discTRODE prob...


    pub_type: 杂志文章,随机对照试验


    authors: Kvarstein G,Måwe L,Indahl A,Hol PK,Tennøe B,Digernes R,Stubhaug A,Tønnessen TI,Beivik H

    更新日期:2009-10-01 00:00:00

  • A comprehensive categorical and bibliometric analysis of published research articles on pediatric pain from 1975 to 2010.

    abstract::The field of pediatric pain research began in the mid-1970s and has undergone significant growth and development in recent years as evidenced by the variety of books, conferences, and journals on the topic and also the number of disciplines engaged in work in this area. Using categorical and bibliometric meta-trend an...


    pub_type: 历史文章,杂志文章,评审


    authors: Caes L,Boerner KE,Chambers CT,Campbell-Yeo M,Stinson J,Birnie KA,Parker JA,Huguet A,Jordan A,MacLaren Chorney J,Schinkel M,Dol J

    更新日期:2016-02-01 00:00:00

  • Relieving effect of TENS on painful muscle contraction produced by an impairment of reciprocal innervation: an electrophysiological analysis.

    abstract::A young female outpatient experienced painful tonic contractions in the right triceps surae muscles as a result of a partial damage of the right peroneal nerve. Electrophysiological recordings of the soleus muscle showed a tonic EMG activity and an hyperexcitability of the monosynaptic H reflex (Hmax/Mmax ratio: 90%)....


    pub_type: 杂志文章


    authors: Wilier JC

    更新日期:1988-03-01 00:00:00

  • Role of unilateral percutaneous cervical cordotomy in the treatment of neoplastic vertebral pain.

    abstract::The present study is a long-term report on 69 patients undergoing unilateral percutaneous cervical cordotomy for vertebral pain due to neoplastic bone metastases. The pain was unilateral or bilateral and was characterised by a chronic and/or an incident component. Seventy-one per cent (49/69) of the patients benefitte...


    pub_type: 杂志文章


    authors: Ischia S,Luzzani A,Ischia A,Pacini L

    更新日期:1984-06-01 00:00:00

  • From the gate to the neuromatrix.

    abstract::The gate control theory's most important contribution to understanding pain was its emphasis on central neural mechanisms. The theory forced the medical and biological sciences to accept the brain as an active system that filters, selects and modulates inputs. The dorsal horns, too, were not merely passive transmissio...


    pub_type: 杂志文章,评审


    authors: Melzack R

    更新日期:1999-08-01 00:00:00

  • Nitric oxide (NO) and nociceptive processing in the spinal cord.

    abstract::There is considerable evidence to implicate N-methyl-D-aspartate (NMDA) receptor activation in the mechanisms that underly thermal hyperalgesia in the spinal cord. As many of the effects of NMDA receptor activation appear to be ultimately mediated through production of nitric oxide (NO), recent reports have begun to d...


    pub_type: 杂志文章,评审


    authors: Meller ST,Gebhart GF

    更新日期:1993-02-01 00:00:00

  • The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.

    abstract::We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. W...


    pub_type: 杂志文章


    authors: Fox A,Kesingland A,Gentry C,McNair K,Patel S,Urban L,James I

    更新日期:2001-05-01 00:00:00

  • Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study.

    abstract::Based on concepts that endogenous opioids participate in neural transmission of pain, the present study in central poststroke pain (CPSP) patients investigated changes in opioid receptor (OR) binding in neural structures centrally involved in the processing of pain. Five patients with central pain after lesions in the...


    pub_type: 杂志文章


    authors: Willoch F,Schindler F,Wester HJ,Empl M,Straube A,Schwaiger M,Conrad B,Tölle TR

    更新日期:2004-04-01 00:00:00

  • Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat.

    abstract::The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...


    pub_type: 杂志文章


    authors: Khandwala H,Hodge E,Loomis CW

    更新日期:1997-09-01 00:00:00

  • Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis.

    abstract::Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define t...


    pub_type: 杂志文章


    authors: Mogil JS,Wilson SG,Bon K,Lee SE,Chung K,Raber P,Pieper JO,Hain HS,Belknap JK,Hubert L,Elmer GI,Chung JM,Devor M

    更新日期:1999-03-01 00:00:00

  • Reduction in movement-evoked pain and fatigue during initial 30-minute TENS treatment predicts TENS responders in women with fibromyalgia.

    abstract::We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...


    pub_type: 杂志文章


    authors: Vance CG,Zimmerman MB,Dailey DL,Rakel BA,Geasland KM,Chimenti RL,Williams JM,Golchha M,Crofford LJ,Sluka KA

    更新日期:2020-11-11 00:00:00

  • Sleep pattern in an experimental model of osteoarthritis.

    abstract::Osteoarthritis (OA) is a major healthcare burden of increasing prevalence. It has been demonstrated that the relationship between pain and sleep produces changes in sleep patterns and pain perception. However, electrophysiological studies in animal models of pain are limited. The current study examined the effect of c...


    pub_type: 杂志文章


    authors: Silva A,Andersen ML,Tufik S

    更新日期:2008-12-01 00:00:00

  • Parent physical and mental health contributions to interpersonal fear avoidance processes in pediatric chronic pain.

    abstract::Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...


    pub_type: 杂志文章


    authors: Birnie KA,Heathcote LC,Bhandari RP,Feinstein A,Yoon IA,Simons LE

    更新日期:2020-06-01 00:00:00

  • Severity of chronic pain in an elderly population in Sweden--impact on costs and quality of life.

    abstract::Chronic pain is associated with large societal costs, but few studies have investigated the total costs of chronic pain with respect to elderly subjects. The elderly usually require informal care, care performed by municipalities, and care for chronic diseases, all factors that can result in extensive financial burden...


    pub_type: 杂志文章


    authors: Bernfort L,Gerdle B,Rahmqvist M,Husberg M,Levin LÅ

    更新日期:2015-03-01 00:00:00

  • Sensitization of trigeminal brainstem pathways in a model for tear deficient dry eye.

    abstract::Chronic dry eye disease (DE) is associated with an unstable tear film and symptoms of ocular discomfort. The characteristics of symptoms suggest a key role for central neural processing; however, little is known about central neuroplasticity and DE. We used a model for tear deficient DE and assessed effects on eye bli...


    pub_type: 杂志文章


    authors: Rahman M,Okamoto K,Thompson R,Katagiri A,Bereiter DA

    更新日期:2015-05-01 00:00:00

  • Cross-sex hormone administration changes pain in transsexual women and men.

    abstract::Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male t...


    pub_type: 杂志文章


    authors: Aloisi AM,Bachiocco V,Costantino A,Stefani R,Ceccarelli I,Bertaccini A,Meriggiola MC

    更新日期:2007-11-01 00:00:00

  • The use of topical 4% lidocaine in spheno-palatine ganglion blocks for the treatment of chronic muscle pain syndromes: a randomized, controlled trial.

    abstract::To assess the efficacy of 4% topical lidocaine in spheno-palatine blocks, a randomized controlled trial was carried out on patients with chronic muscle pain syndromes. Sixty-one patients (42 with fibromyalgia (FM) and 19 with myofascial pain syndrome (MPS)) completed the trial. Outcome measures included pain intensity...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scudds RA,Janzen V,Delaney G,Heck C,McCain GA,Russell AL,Teasell RW,Varkey G,Woodbury GM

    更新日期:1995-07-01 00:00:00