Abstract:
:In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic nerve. In order to investigate the putative involvement of the G protein-coupled metabotropic glutamate receptors (mGluRs) in the induction of this form of LTP, we applied a series of mGluR antagonists exhibiting distinct group-specific activity profiles to the spinal lumbar enlargement, prior to conditioning stimulation. The group I (mGluR1/5) and group II (mGluR2/3) mGluR antagonist (S)-alpha-methyl-4-carboxyphenylglycine or the selective mGluR1/5 antagonist (S)-4-carboxyphenylglycine consistently impaired the development of spinal LTP. However, potentiation occurred in the presence of the inactive enantiomer (R)-alpha-methyl-4-carboxyphenylglycine. LTP proved insensitive to the selective mGluR2/3 antagonists (2S)-alpha-ethylglutamic acid and LY341495, either spinally or intravenously delivered. LTP could also be induced in the presence of the selective group III (mGluR4/mGluR6-mGluR8) mGluR antagonist (RS)-alpha-methylserine-O-phosphate. However, none of the mGluR-active compounds alone noticeably altered the amplitudes of C fibre-evoked field potentials in the absence of conditioning stimulation. These findings suggest that the induction of LTP of C fibre-evoked field potentials in the spinal dorsal horn by high-frequency, high-intensity stimulation of afferent C fibres requires a group-specific mGluR recruitment, activation of mGluR1/5 but not that of mGluR4/6-8 and mGluR2/3 being a requisite step.
journal_name
Painjournal_title
Painauthors
Azkue JJ,Liu XG,Zimmermann M,Sandkühler Jdoi
10.1016/j.pain.2003.08.007keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
373-379issue
3eissn
0304-3959issn
1872-6623pii
00006396-200312000-00018journal_volume
106pub_type
杂志文章相关文献
PAIN文献大全abstract::An 82-year-old woman experienced generalized pruritus not due to skin or systemic disease. Scratching the skin with a needle induced a crisis of intense pruritus, insensitive to any drug. The pruritus had the characteristics of a central sensation. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90055-3
更新日期:1991-06-01 00:00:00
abstract::Studies in healthy human subjects and patients with irritable bowel syndrome suggest sex differences in cerebral nociceptive processing. Here we examine sex differences in functional brain activation in the rat during colorectal distention (CRD), a preclinical model of acute visceral pain. [(14)C]-iodoantipyrine was i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.025
更新日期:2009-09-01 00:00:00
abstract::Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90244-7
更新日期:1986-06-01 00:00:00
abstract::Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of a...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001322
更新日期:2018-11-01 00:00:00
abstract::This research was designed to identify and validate facial expressions of pain occurring in a clinical chronic pain condition. Facial expressions of 28 patients with chronic temporomandibular disorder pain were videotaped during a painful clinical examination procedure and coded using an anatomically based system. Cha...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90278-3
更新日期:1988-10-01 00:00:00
abstract::Reduced sensitivity to naturally occurring and laboratory pain stimuli has been observed in individuals with hypertension, high-normal blood pressure, and a family history of hypertension. The present study sought to extend these findings by examining the relationship between familial history of hypertension and pain ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2008.12.010
更新日期:2009-04-01 00:00:00
abstract::Evidence has shown that electrical stimulation at the dorsal columns attenuated the "wind-up" phenomenon in dorsal horn neurons in nerve-injured rats. This study was aimed to test the effect of spinal cord stimulation (SCS) on temporal summation (TS), the clinical correlate of the wind-up phenomenon in patients with r...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.j.pain.0000460342.69718.a2
更新日期:2015-03-01 00:00:00
abstract::G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received little research attention. We used a tag singl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.08.026
更新日期:2013-12-01 00:00:00
abstract::Test-retest reliability of a pain drawing instrument was investigated. Pain drawings of chronic pain patients (n = 51) were scored for percentage of total body surface in pain and location of pain. A test-retest reliability coefficient of r = 0.85 was calculated for a time interval that averaged 71 days. In addition, ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90202-3
更新日期:1988-04-01 00:00:00
abstract::This study evaluated the pre-emptive analgesic effect of intravenous (i.v.) ketorolac (KET) for total hip replacement (THR). Sixty patients who underwent surgery for THR under general anesthesia were randomly allocated to 3 groups. Two i.v. injections were administered: one before induction and one after surgery. The ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(94)00184-G
更新日期:1995-05-01 00:00:00
abstract::Pain has the capacity to interfere with daily tasks. Although task interference by pain is largely unintentional, it can be controlled to a certain extent. Such top-down control over pain has been believed to be reduced in patients with fibromyalgia (FM). In this study, we investigated task interference and distractio...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001196
更新日期:2018-06-01 00:00:00
abstract::Twenty patients with chronic low back pain received 12 lumbar sympathetic injections, in a series of 6 with bupivacaine and a series of 6 with saline. Changes in subjective pain intensity, EMG from paravertebral muscles, joint ranges of mobility, and daily activity levels were measured at multiple intervals throughout...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(80)90085-8
更新日期:1980-02-01 00:00:00
abstract::Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1097/j.pain.0000000000000657
更新日期:2016-10-01 00:00:00
abstract::The ability of a painful stimulus to suppress pain in another, remote area (DNIC) has been intensely studied. However, the effect of the distance between the two painful stimuli and the attentional factors during the measurement of pain perception received minimal treatment. We evaluated the effect of these factors on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.009
更新日期:2010-11-01 00:00:00
abstract::Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation). In the present study, we determined whether desipra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00043-3
更新日期:1999-08-01 00:00:00
abstract::Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.0000000000000002
更新日期:2015-01-01 00:00:00
abstract:ABSTRACT:Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance. The...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001888
更新日期:2020-09-01 00:00:00
abstract::Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00481-X
更新日期:2002-04-01 00:00:00
abstract::Ninety-two knees in 46 patients were evaluated with regard to pain: in 51 of these knees, implantation of a hinged endoprosthesis had been performed. The reliability and validity of 2 pain evaluation methods were assessed: the knee-pain questionnaire method (standard version including 10 questions and modified version...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90069-9
更新日期:1989-07-01 00:00:00
abstract::Accurate pain assessment is the foundation for effective pain management in children. At present, there is no clear consensus regarding the age at which young children are able to appropriately use self-report scales for pain. This study examined young children's ability to use the Faces Pain Scale-Revised; (FPS-R; [H...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2005.10.004
更新日期:2006-01-01 00:00:00
abstract::Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000587
更新日期:2016-08-01 00:00:00
abstract::VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly incr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.03.012
更新日期:2014-07-01 00:00:00
abstract::There is considerable evidence to implicate N-methyl-D-aspartate (NMDA) receptor activation in the mechanisms that underly thermal hyperalgesia in the spinal cord. As many of the effects of NMDA receptor activation appear to be ultimately mediated through production of nitric oxide (NO), recent reports have begun to d...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(93)90124-8
更新日期:1993-02-01 00:00:00
abstract::In this study, construct validity of 2 pain behaviour observation measurement instruments for young children aged 1 to 56 months (mean age was 20 months) with burns is assessed by using Rasch analysis. The Rasch model, wherein data should meet the model expectations, assumes that an instrument measures one unidimensio...
journal_title:Pain
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.pain.2012.07.021
更新日期:2012-11-01 00:00:00
abstract::This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00448-7
更新日期:2003-05-01 00:00:00
abstract::Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.09.018
更新日期:2007-04-01 00:00:00
abstract::The present study describes a new test of tonic pain to be used as an animal model of persistent pain. First, pain responses and edema produced by subcutaneous injection of increasing doses of honey bee venom into the hind paw of the rat were quantified. Second, the effect of morphine and aspirin on the pain responses...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(96)03075-8
更新日期:1996-08-01 00:00:00
abstract::The purpose of this study was to develop and validate a measure of patient satisfaction for patients receiving treatment for either acute or chronic pain: the Pain Treatment Satisfaction Scale (PTSS). Development of the initial questionnaire included a comprehensive literature review and interviews with patients, phys...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.09.005
更新日期:2004-12-01 00:00:00
abstract::Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.10.025
更新日期:2013-02-01 00:00:00
abstract::A mounting body of literature recommends that treatment for fibromyalgia (FM) encompass medications, exercise and improvement of coping skills. However, there is a significant gap in determining an effective counterpart to pharmacotherapy that incorporates both exercise and coping. The aim of this randomized controlle...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.08.020
更新日期:2010-11-01 00:00:00