Abstract:
:The present study describes a new test of tonic pain to be used as an animal model of persistent pain. First, pain responses and edema produced by subcutaneous injection of increasing doses of honey bee venom into the hind paw of the rat were quantified. Second, the effect of morphine and aspirin on the pain responses was investigated. Finally, the response to concurrent injections of bee venom and formalin was examined. Subcutaneous injection of bee venom produced local inflammation, tonic-pain responses lasting from 10 min to more than 1 h, and marked edema lasting from 3 h to more than 48 h. Increasing doses of bee venom produced higher mean pain scores and increased durations of responding. The time course of the edema did not follow the time course of the pain responses. Analgesia was produced by morphine and aspirin, indicating that the bee venom test can be used to test analgesic drugs. Concurrent administration of bee venom and formalin produced pain responses similar to formalin alone, with a less profound interphase depression and a longer duration. The data suggest that the bee venom test is a valid animal model of experimental tonic pain.
journal_name
Painjournal_title
Painauthors
Lariviere WR,Melzack Rdoi
10.1016/0304-3959(96)03075-8subject
Has Abstractpub_date
1996-08-01 00:00:00pages
271-7issue
2-3eissn
0304-3959issn
1872-6623pii
0304-3959(96)03075-8journal_volume
66pub_type
杂志文章相关文献
PAIN文献大全abstract::Chronic compression of rat dorsal root ganglion (CCD) produced tactile allodynia accompanied with hyperexcitability of the myelinated Aβ dorsal root ganglion (DRG) neurons. The Aβ DRG neuron hyperexcitability exhibits as bursting discharges in response to peripherally evoked action potentials (evoked bursting [EB]). T...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.11.030
更新日期:2012-03-01 00:00:00
abstract::Although cognitive-behavioral therapies (CBT) have been demonstrated to be effective for a variety of chronic pain problems, patients vary in their response and little is known about patient characteristics that predict or moderate treatment effects. Furthermore, although cognitive-behavioral theory posits that change...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2006.09.005
更新日期:2007-02-01 00:00:00
abstract::Reflex sympathetic dystrophy (RSD) is a pain syndrome that is characterised by autonomic, motor and sensory disturbances. The syndrome has often been associated with sympathetic dysfunction. Therefore, we investigated whether there are disturbances in the sympathetic function of skin microcirculation in the various cl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00133-y
更新日期:1995-03-01 00:00:00
abstract::Recently, Bennett and Xie reported that when the sciatic nerve of the rat is ligated loosely, the rat develops a pain syndrome with many features similar to those observed in neuropathic pain states in man. Anatomical and physiological studies to date indicate that the major pathology is a loss of large diameter myeli...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90229-Q
更新日期:1991-12-01 00:00:00
abstract::We investigated the effects of acute and of chronic morphine treatment on T-lymphocyte function and natural killer (NK) cell activity in rats receiving chronic constriction injury (CCI) of the sciatic nerve. T-Lymphocyte function was evaluated based on concanavalin-A (ConA)- and phytohemagglutinin (PHA)-induced spleno...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00323-7
更新日期:2000-11-01 00:00:00
abstract::Osteoarthritis (OA) is a major healthcare burden of increasing prevalence. It has been demonstrated that the relationship between pain and sleep produces changes in sleep patterns and pain perception. However, electrophysiological studies in animal models of pain are limited. The current study examined the effect of c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.09.025
更新日期:2008-12-01 00:00:00
abstract::Neuropathic pain (NP) in cancer patients lacks standards for diagnosis. This study is aimed at reaching consensus on the application of the International Association for the Study of Pain (IASP) special interest group for neuropathic pain (NeuPSIG) criteria to the diagnosis of NP in cancer patients and on the relevanc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.09.038
更新日期:2014-12-01 00:00:00
abstract::Current knowledge on pain-related cerebral networks has relied so far on stimulus-induced brain responses, but not on the analysis of brain activity during spontaneous pain attacks. In this case report, correlation between intracerebral field potentials and online sensations during spontaneously painful epileptic seiz...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.025
更新日期:2011-04-01 00:00:00
abstract::Aerobic exercise has been shown to activate endogenous opioid and adrenergic systems and attenuate experimental pain in normal control subjects (NC). In contrast, fibromyalgia (FM) subjects' experimental pain ratings increase after aerobic exercise, suggestive of abnormal pain modulation. In order to determine whether...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.08.007
更新日期:2005-11-01 00:00:00
abstract::It has been suggested that a number of peptides may be involved in the transmission of pain. In order to evaluate the possible role of peptides in the development of headache, we have, in the present study, examined the presence of nerve fibres containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), subs...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90162-4
更新日期:1986-12-01 00:00:00
abstract::Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001986
更新日期:2020-11-01 00:00:00
abstract::Chronic pain often interferes with daily functioning, and may become a threat to an individual's sense of self. Despite the development of a recent theoretical account focussing upon the relationship between the presence of chronic pain and a person's self, research investigating this idea is limited. In the present s...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.07.055
更新日期:2013-12-01 00:00:00
abstract::Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.01.056
更新日期:2011-06-01 00:00:00
abstract::In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(92)90241-3
更新日期:1992-06-01 00:00:00
abstract::Both mu opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists are implicated in the regulation of neuropathic pain in post-nerve injury preclinical pain models. This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(00)00433-4
更新日期:2001-03-01 00:00:00
abstract::Mechanisms of hypnotic analgesia were investigated by examining changes in the R-III, a nociceptive spinal reflex, during hypnotic reduction of pain sensation and unpleasantness. The R-III was measured in 15 healthy volunteers who gave VAS-sensory and VAS-affective ratings of an electrical stimulus during conditions o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00134-Z
更新日期:1995-01-01 00:00:00
abstract::Procedural pain is associated with poorer neurodevelopment in infants born very preterm (≤ 32 weeks gestational age), however, the etiology is unclear. Animal studies have demonstrated that early environmental stress leads to slower postnatal growth; however, it is unknown whether neonatal pain-related stress affects ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.02.007
更新日期:2012-07-01 00:00:00
abstract::Many studies of pain and nociception use short-lasting acute stimuli which may have limited relevance to prolonged or chronic pain states. Using extracellular single-unit recording in the dorsal horn of the rat lumbar spinal cord the present study examines the response of neurones to a long-lasting nociceptive stimulu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90023-6
更新日期:1987-09-01 00:00:00
abstract::Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.11.009
更新日期:2011-02-01 00:00:00
abstract::The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001817
更新日期:2020-06-01 00:00:00
abstract::Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1097/j.pain.0000000000000502
更新日期:2016-05-01 00:00:00
abstract::Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(99)00259-6
更新日期:2000-03-01 00:00:00
abstract::Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(96)03223-X
更新日期:1996-11-01 00:00:00
abstract::Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in dietary n-3 and n-6 fatty acids for treatment of c...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2013.07.028
更新日期:2013-11-01 00:00:00
abstract::The proinflammatory cytokines tumor necrosis factor (TNF) α and interleukin (IL) 1β have been strongly implicated in the pathogenesis of neuropathic pain, but the intracellular signaling of these cytokines in glial cells is not fully understood. TNF receptor-associated factor 6 (TRAF6) plays a key role in signal trans...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.09.027
更新日期:2014-12-01 00:00:00
abstract::To estimate the prevalence of orofacial pain (OFP) by specific diagnostic subgroups in the general population. Cross-sectional population study. General medical practice in South East Cheshire, UK. Participants of baseline investigation who completed the full postal questionnaire (1510, adjusted study participation ra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.07.002
更新日期:2004-10-01 00:00:00
abstract::Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00351-7
更新日期:2001-11-01 00:00:00
abstract::To date, patients with bony metastases were only a small fraction of the samples studied, or they were entirely excluded. Patients with metastatic cancers, such as bone metastases, are more likely to report pain, compared to patients without metastatic cancer (50-74% and 15%, respectively). Their cancer pain results i...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.06.021
更新日期:2011-10-01 00:00:00
abstract::For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met wi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000335
更新日期:2015-11-01 00:00:00
abstract::Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90112-6
更新日期:1987-02-01 00:00:00