Peptide-containing nerve fibres in human extracranial tissue: a morphological basis for neuropeptide involvement in extracranial pain?

abstract：:Neuropathic pain can be a predictor of severe emotional distress, up to full-blown depressive states. In these patients, it is important to move beyond the sole treatment of pain, to recognize depressive symptoms, and to ultimately improve the quality of life. We systematically searched for published and unpublished c...

journal_title：Pain

authors： Caruso R,Ostuzzi G,Turrini G,Ballette F,Recla E,Dall'Olio R,Croce E,Casoni B,Grassi L,Barbui C

更新日期：2019-10-01 00:00:00

abstract：:The present study observed the expression of the 5-hydroxytryptamine (5-HT) (1A) receptor mRNA in the lumbar spinal dorsal horn neurons following carrageenan inflammation using in situ hybridization (ISH). We also studied the co-localization of 5-HT(1A) receptor mRNA and gamma-amino butyric acid (GABA) or enkephalin (...

journal_title：Pain

authors： Zhang YQ,Gao X,Ji GC,Huang YL,Wu GC,Zhao ZQ

更新日期：2002-08-01 00:00:00

abstract：:We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions a...

journal_title：Pain

authors： Bruera E,Fainsinger R,Moore M,Thibault R,Spoldi E,Ventafridda V

更新日期：1991-05-01 00:00:00

abstract：:The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura...

journal_title：Pain

authors： Juhasz G,Zsombok T,Modos EA,Olajos S,Jakab B,Nemeth J,Szolcsanyi J,Vitrai J,Bagdy G

更新日期：2003-12-01 00:00:00

abstract：:Pain scales using faces are commonly used tools for assessing pain in children capable of communicating. However, some children require other types of pain scales because they have difficulties in understanding faces pain scales. The goal of this study was to develop and validate the "Pain Block" concrete ordinal scal...

journal_title：Pain

authors： Jung JH,Lee JH,Kim DK,Jung JY,Chang I,Kwon H,Shin J,Paek SH,Oh S,Kwak YH

更新日期：2018-04-01 00:00:00

abstract：:We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...

journal_title：Pain

authors： Vance CG,Zimmerman MB,Dailey DL,Rakel BA,Geasland KM,Chimenti RL,Williams JM,Golchha M,Crofford LJ,Sluka KA

更新日期：2020-11-11 00:00:00

abstract：:A comprehensive treatment program for chronic disability related to back disease has been presented. This program has used not only more traditional methods of medical care for the structural disabilities of chronic mechanical back disorders, but has used principles of active patient participation in the improvement p...

journal_title：Pain

authors： Cairns D,Thomas L,Mooney V,Pace BJ

更新日期：1976-09-01 00:00:00

abstract：:In knee osteoarthritis (OA), pain sensitization has been linked to a more severe symptomatology, but the prognostic implications of pain sensitivity in people undergoing conservative treatment such as physiotherapy are not established. This study aimed to prospectively investigate the association between features of p...

journal_title：Pain

authors： OʼLeary H,Smart KM,Moloney NA,Blake C,Doody CM

更新日期：2018-09-01 00:00:00

abstract：:Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...

journal_title：Pain

authors： Goettl VM,Larson DL,Portoghese PS,Larson AA

更新日期：1997-07-01 00:00:00

abstract：:Internet-delivered interventions are emerging as a strategy to address barriers to care for individuals with chronic pain. This is the first large multicenter randomized controlled trial of Internet-delivered cognitive-behavioral therapy (CBT) for pediatric chronic pain. Participants included were 273 adolescents (205...

journal_title：Pain

authors： Palermo TM,Law EF,Fales J,Bromberg MH,Jessen-Fiddick T,Tai G

更新日期：2016-01-01 00:00:00

abstract：:Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involved in central sensitization, the present study examines the levels of activated N-methyl-d-aspartate (NMDA) receptors in the dorsal h...

journal_title：Pain

authors： Gao X,Kim HK,Mo Chung J,Chung K

更新日期：2007-10-01 00:00:00

abstract：:The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by s...

journal_title：Pain

authors： Chen HS,Lei J,He X,Qu F,Wang Y,Wen WW,You HJ,Arendt-Nielsen L

更新日期：2008-03-01 00:00:00

abstract：:The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patients with the NaV1.7/I848T...

journal_title：Pain

authors： Meents JE,Bressan E,Sontag S,Foerster A,Hautvast P,Rösseler C,Hampl M,Schüler H,Goetzke R,Le TKC,Kleggetveit IP,Le Cann K,Kerth C,Rush AM,Rogers M,Kohl Z,Schmelz M,Wagner W,Jørum E,Namer B,Winner B,Zenke M,Lam

更新日期：2019-06-01 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:The present study aimed to investigate if (1) subcutaneous injection of glutamate induces pain, sensitization and vasomotor responses in humans and (2) if sex differences exist in these responses. Thirty healthy volunteers (men-15 and women-15) were included. Each subject received four subcutaneous injections (0.1ml; ...

journal_title：Pain

authors： Gazerani P,Wang K,Cairns BE,Svensson P,Arendt-Nielsen L

更新日期：2006-10-01 00:00:00

abstract：:Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...

journal_title：Pain

authors： Sagen J,Winker MA,Proudfit HK

更新日期：1983-07-01 00:00:00

abstract：:Phantom urinary phenomena are a relatively rare disease entity. Literature search has revealed only one case following cystectomy, seven cases following spinal cord injury and several other cases in hemodialysis patients. This report presents a case of painful phantom bladder following cystectomy for chronic kidney an...

journal_title：Pain

authors： Brena SF,Sammons EE

更新日期：1979-10-01 00:00:00

abstract：:Epidural administration of opiates as a long-term treatment of cancer pain, even for out-patients, is now well established. Most reports describe intermittent injections given several times a day, which may have technical and personal disadvantages. Continuous epidural infusion may be preferable. This report describes...

journal_title：Pain

authors： Ingemar F,Ahlgren H,Ahlgren MBE

更新日期：1987-12-01 00:00:00

abstract：:Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Intriguingly, several reports showed that capsaicin also inhibits Na+ currents but the mechanisms remain unclear. To explore this non-TRPV1 action we applied capsaicin to HEK293 cells stably expressing inactivation-deficient rat skele...

journal_title：Pain

authors： Wang SY,Mitchell J,Wang GK

更新日期：2007-01-01 00:00:00

abstract：:Brief electrical pulses were applied to the pulp of individual pre-molar teeth of 14 healthy, adult volunteers via wire electrodes implanted and sealed in dentine. The sensation threshold was estimated in each individual by the Two-Alternative Forced-Choice Staircase (2AFCS) method. Seven, 5 or 4 stimulus intensities ...

journal_title：Pain

authors： Fernandes de Lima VM,Chatrian GE,Lettich E,Canfield RC,Miller CR,Soso MJ

更新日期：1982-11-01 00:00:00

abstract：:A psychophysical investigation was carried out to examine whether heat hyperalgesia exists within the secondary mechanical hyperalgesia zone surrounding a capsaicin injection site on hairy skin. A non-contact laser stimulator was used to deliver temperature controlled stimuli to sites within and outside the zone of me...

journal_title：Pain

authors： Ali Z,Meyer RA,Campbell JN

更新日期：1996-12-01 00:00:00

abstract：:We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...

journal_title：Pain

authors： Roca G,Aguilar JL,Gomar C,Mazo V,Costa J,Vidal F

更新日期：1996-12-01 00:00:00

abstract：:Skin conductance and heart rate measures obtained from subjects previous to, during, and after their performance of the cold pressor task were correlated with their responses to the McGill Pain Questionnaire administered immediately after the completion of the cold pressor task. A reliable relationship between skin co...

journal_title：Pain

authors： Dowling J

更新日期：1982-01-01 00:00:00

abstract：:The purpose of this study was to determine if some commonly used admission variables could predict treatment outcome on a multidisciplinary pain center. Specifically, it was designed as a prospective study of an index proposed by Maruta et al. The subjects were 104 patients. The 4 outcome measures used were staff judg...

journal_title：Pain

authors： Aronoff GM,Evans WO

更新日期：1982-09-01 00:00:00

abstract：:The purpose of this study is to analyze cancer breakthrough pain (BP) characteristics and how BP responds to conventional cancer pain management. Seventy-four cancer pain patients with worst pain severity >or=4 out of 10 completed the Brief Pain Inventory (BPI), Memorial Symptom Assessment Scale-Short Form, Functional...

journal_title：Pain

authors： Hwang SS,Chang VT,Kasimis B

更新日期：2003-01-01 00:00:00

abstract：:Reports of pain during mammography show that there is great variability in both the incidence of reported pain (0.2-62%) and the intensity of that pain. Much of that variability may be due to the measures used to rate mammography pain. This is the first study that has examined the incidence, quality and intensity of m...

journal_title：Pain

authors： Kornguth PJ,Keefe FJ,Conaway MR

更新日期：1996-08-01 00:00:00

abstract：:Growing evidence suggests that leukocyte extravasation is initiated by the interaction of selectins with their ligands; as well as an essential role for P-selectin in the initial recruitment of inflammatory cells to sites of inflammation. In this study, P-selectin-deficient (P-sel-/-) mice were used to test the hypoth...

journal_title：Pain

authors： Liou JT,Lee CM,Lin YC,Chen CY,Liao CC,Lee HC,Day YJ

更新日期：2013-10-01 00:00:00

abstract：:Although systemic lidocaine has been shown to suppress postoperative pain in a clinical setting, the mechanisms of action of lidocaine have not been elucidated. The present study was therefore designed to determine the relative contribution of central and peripheral sites to the action of lidocaine on incision-induced...

journal_title：Pain

authors： Kawamata M,Sugino S,Narimatsu E,Yamauchi M,Kiya T,Furuse S,Namiki A

更新日期：2006-05-01 00:00:00

abstract：:The treatment of neuropathic pain remains a clinical challenge because of its unclear mechanisms and broad clinical morbidity. Matrix metalloproteinase (MMP)-9 and MMP-2 have previously been described as key components in neuropathic pain because of their facilitation of inflammatory cytokine maturation and induction ...

journal_title：Pain

authors： Li J,Xu L,Deng X,Jiang C,Pan C,Chen L,Han Y,Dai W,Hu L,Zhang G,Cheng Z,Liu W

更新日期：2016-08-01 00:00:00

abstract：:Neuropathic pain (NP) in cancer patients lacks standards for diagnosis. This study is aimed at reaching consensus on the application of the International Association for the Study of Pain (IASP) special interest group for neuropathic pain (NeuPSIG) criteria to the diagnosis of NP in cancer patients and on the relevanc...

journal_title：Pain

authors： Brunelli C,Bennett MI,Kaasa S,Fainsinger R,Sjgren P,Mercadante S,Lhre ET,Caraceni A,European Association for Palliative Care (EAPC) Research Network and International Association for the Study of Pain (IASP) Cancer Pain Special Interest

更新日期：2014-12-01 00:00:00