Abstract：
:The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by subcutaneous (s.c.) injection of bee venom (BV, 0.2mg/50 microl) in rats. The effects of intraplantar injection of H-89 (a PKA inhibitor, 5-100 microg/50 microl) and chelerythrine chloride (a PKC inhibitor, 5-100 microg/50 microl) on BV-elicited persistent nociception (nociceptive flinching reflex), mechanical hyperalgesia, and inflammation were systematically investigated. Pre-treatment with H-89 dose-dependently inhibited only BV-induced mechanical hyperalgesia, but not the persistent nociception and inflammation. In contrast, pre-treatment with chelerythrine chloride dose-dependently inhibited BV-induced sustained nociception and inflammation, but not the mechanical hyperalgesia. Topical pre-treatment of the sciatic nerve with 1% capsaicin significantly blocked the inhibitory effects of the PKC inhibitor on BV-induced inflammation, but not the persistent flinching response. These results indicate that peripheral PKA and PKC involvements in BV-induced pain behaviors differ, and capsaicin-sensitive afferents appear to participate in the pro-inflammatory role of PKC in the BV pain model. Findings from the present study also suggest that targeting specific peripheral protein kinases might prove effective in the treatment of persistent pain and inflammation.
journal_name
Painjournal_title
Painauthors
Chen HS,Lei J,He X,Qu F,Wang Y,Wen WW,You HJ,Arendt-Nielsen Ldoi
10.1016/j.pain.2007.04.040subject
Has Abstractpub_date
2008-03-01 00:00:00pages
31-6issue
1-2eissn
0304-3959issn
1872-6623pii
S0304-3959(07)00245-Xjournal_volume
135pub_type
杂志文章相关文献
PAIN文献大全abstract：:Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(95)00014-J
更新日期：1995-10-01 00:00:00
abstract：:Acute zoster infection may be followed by a chronic pain syndrome, i.e., postherpetic neuralgia (PHN). Besides older age, the intensity of pain and neuronal damage within the acutely affected body region are regarded as predictors or risk factors for PHN. As an alternative approach an underlying peripheral polyneuropa...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(97)00105-X
更新日期：1997-11-01 00:00:00
abstract：:A double-blind placebo-controlled crossover trial was used to determine the effects of topical ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on the sensory disturbances in 20 patients with complex regional pain syndrome (CRPS). On two occasions separated by at least one week, sensory tests to light tou...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2009.05.017
更新日期：2009-11-01 00:00:00
abstract：:Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.08.003
更新日期：2004-11-01 00:00:00
abstract：:Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.11.012
更新日期：2007-07-01 00:00:00
abstract：:After 4 millennia of more or less documented history of cannabis use, the identification of cannabinoids, and of Δ(9)-tetrahydrocannabinol in particular, occurred only during the early 1960s, and the cloning of cannabinoid CB1 and CB2 receptors, as well as the discovery of endocannabinoids and their metabolic enzymes,...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/j.pain.2013.03.023
更新日期：2013-12-01 00:00:00
abstract：:In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.07.035
更新日期：2013-11-01 00:00:00
abstract：:Pediatric chronic pain is associated with numerous negative outcomes including increased physical disability, increased rates of depression and anxiety, and decreased quality of life (QOL). Pain catastrophizing-broadly conceptualized as including rumination, magnification, and helplessness cognitions surrounding one's...
journal_title：Pain
pub_type： 杂志文章,meta分析,评审
doi：10.1097/j.pain.0000000000001342
更新日期：2018-12-01 00:00:00
abstract：ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000002195
更新日期：2021-01-12 00:00:00
abstract：:Mindfulness-based stress reduction (MBSR) is a structured 8-week group program teaching mindfulness meditation and mindful yoga exercises. MBSR aims to help participants develop nonjudgmental awareness of moment-to-moment experience. Fibromyalgia is a clinical syndrome with chronic pain, fatigue, and insomnia as major...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2010.10.043
更新日期：2011-02-01 00:00:00
abstract：:Migraine encompasses a broader spectrum of sensory symptoms than just headache. These "other" symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinal...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1097/j.pain.0000000000001531
更新日期：2019-07-01 00:00:00
abstract：:Locus of control (LOC) beliefs, long thought important in adjustment to persistent pain, were studied among 160 subjects (67 males and 93 females) referred to a comprehensive pain rehabilitation program. The subscale structure of the Multidimensional Health Locus of Control (MHLC) was factorially replicated in our sam...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91141-5
更新日期：1990-09-01 00:00:00
abstract：:We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(91)90109-B
更新日期：1991-09-01 00:00:00
abstract：:This paper presents the results of a detailed study of the pain epidemiology and health related quality of life (HRQL) in 150 chronic non-malignant pain patients consecutively referred to a Danish multidisciplinary pain center. Mean pain severity was 71.6 (SD = 18.5) on the VAS scale. Forty-two percent reported poor q...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(97)00126-7
更新日期：1997-12-01 00:00:00
abstract：:The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T-cell populations, very little attention has been ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001420
更新日期：2019-02-01 00:00:00
abstract：:Existing estimates of sociodemographic disparities in chronic pain in the United States are based on cross-sectional data, often treat pain as a binary construct, and rarely test for nonresponse or other types of bias. This study uses 7 biennial waves of national data from the Health and Retirement Study (1998-2010; n...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000762
更新日期：2017-02-01 00:00:00
abstract：:Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(92)90165-8
更新日期：1992-08-01 00:00:00
abstract：:In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/0304-3959(92)90241-3
更新日期：1992-06-01 00:00:00
abstract：:Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.08.019
更新日期：2005-11-01 00:00:00
abstract：:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(96)03223-X
更新日期：1996-11-01 00:00:00
abstract：:When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90166-U
更新日期：1991-04-01 00:00:00
abstract：:The present study examined the role of spinal cholinergic modulation of spinal mechanical and thermal transmission. Intrathecal administration of the cholinergic muscarinic receptor antagonists atropine or scopolamine in awake rats produced a dose-dependent decrease in the nociceptive mechanical withdrawal threshold o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90078-C
更新日期：1991-08-01 00:00:00
abstract：:We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1097/j.pain.0000000000001609
更新日期：2019-08-01 00:00:00
abstract：:Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000827
更新日期：2017-04-01 00:00:00
abstract：:Lamina I of the spinal cord plays a key role in sensory transmission between afferent activity and the CNS. Studies have shown lamina I neurones to have distinct response properties compared to deep dorsal horn neurones, but little is known regarding excitatory amino acid mechanisms in their responses. Spinal electrop...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2003.12.004
更新日期：2004-03-01 00:00:00
abstract：:Recently, Bennett and Xie reported that when the sciatic nerve of the rat is ligated loosely, the rat develops a pain syndrome with many features similar to those observed in neuropathic pain states in man. Anatomical and physiological studies to date indicate that the major pathology is a loss of large diameter myeli...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90229-Q
更新日期：1991-12-01 00:00:00
abstract：:In the present study the question was addressed whether sensitivity to experimental pain stimuli differs between families, which are previously characterized by the degree of cold tolerance (very insensitive or very sensitive) of one family member. A total of 232 healthy medical students were screened for cold pain to...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.11.012
更新日期：2008-08-15 00:00:00
abstract：:Patients with chronic low back pain (LBP) frequently demonstrate high scores for fear-avoidance beliefs and distress. We need better knowledge about fear-avoidance beliefs and distress in early stages of LBP. The objectives of this study were to compare the level of fear-avoidance beliefs and distress in patients with...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.09.020
更新日期：2004-12-01 00:00:00
abstract：:Chronic severe cervico-facial pain syndrome associated with a whiplash-type injury was successfully treated with epidural spinal cord stimulation. The patient had been in pain for 9 years, responding temporarily only to stellate ganglion blocks. The patient has now been painless for 18 months. We have been unable to f...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(98)00218-8
更新日期：1999-03-01 00:00:00
abstract：:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000567
更新日期：2016-08-01 00:00:00
