Abstract:
:The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T-cell populations, very little attention has been given to the converse: how T cells may affect opioid regulation. We find here that, in addition to displaying significantly increased baseline pain sensitivity across various pain modalities, T-cell-deficient mice (CD-1 nude, Rag1 null mutant, and Cd4 null mutant) exhibit pronounced deficiencies in morphine inhibition of thermal or inflammatory pain. Nude mice are also deficient in endogenous opioid-mediated analgesia, exhibiting no stress-induced analgesia from restraint. The relevant T-cell subpopulation seems to be CD4 T cells because adoptive transfer of them but not CD8 cells into nude mice rescues both the pain and morphine analgesia phenotypes. As previously reported, we also observe a sex difference in CD-1 mice, with females requiring 2- to 3-fold more morphine than males to produce equal analgesia. Nude mice display no sex differences in morphine analgesia, and the sex difference is restored in nude mice of either sex receiving CD4 T cells from CD-1 donor male or female mice. These results suggest that CD4 T cells play an as yet unappreciated role in opioid analgesia and may be a driver of sex differences therein.
journal_name
Painjournal_title
Painauthors
Rosen SF,Ham B,Haichin M,Walters IC,Tohyama S,Sotocinal SG,Mogil JSdoi
10.1097/j.pain.0000000000001420subject
Has Abstractpub_date
2019-02-01 00:00:00pages
358-366issue
2eissn
0304-3959issn
1872-6623pii
00006396-201902000-00009journal_volume
160pub_type
杂志文章相关文献
PAIN文献大全abstract::In the present study 366 patients suffering acute or chronic musculoskeletal pain of different origin were given vibratory stimulation for the pain. Many of the patients had previously had treatments of various kinds without satisfactory relief. The effect of vibratory stimulation was assessed during and after stimula...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90808-X
更新日期:1984-09-01 00:00:00
abstract::Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception. Peripheral inflammation increases expression of BDNF preferentially in dorsal root ganglion cells that...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00264-6
更新日期:2002-11-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.025
更新日期:2010-12-01 00:00:00
abstract::An abundance of animal research suggests that fear inhibits pain whereas anxiety increases it. Human studies on this topic are more scarce, and the existing evidence seems rather inconsistent. Therefore, we aimed to investigate the divergent effects of both negative emotional states-that is, pain-related fear and anxi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.02.005
更新日期:2012-05-01 00:00:00
abstract::Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00324-x
更新日期:2003-01-01 00:00:00
abstract::Somatovisceral convergence was demonstrated in recordings from 15 of 16 spinothalamic tract cells in the lower thoracic spinal cords of anesthetized monkeys. Inputs were produced by mechanical (or sometimes electrical) stimulation of the skin over the lower trunk and by electrical stimulation of the greater splanchnic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(81)90002-6
更新日期:1981-10-01 00:00:00
abstract::The effect of different formalin concentrations on the nociceptive response in the formalin test was examined in mice. Subcutaneous formalin injection induces 2 distinct periods of high licking activity: an early phase lasting the first 5 min, and a late phase lasting 20-30 min after the injection. Formalin concentrat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91167-H
更新日期:1990-08-01 00:00:00
abstract::The present paper presents the relationship between the total body-pain (TBP) score, defined as the total number of areas shaded on a pain drawing, and the pain from one area, the Shoulder-Neck (SN), among subjects in or out of full-time gainful work respectively. Furthermore, relationships between pain-score, self-ex...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00053-6
更新日期:1999-09-01 00:00:00
abstract::Two models of the relationship between paraspinal EMG and low back pain have been proposed. Specific predictions arising from these are listed and the literature relating to them reviewed. Recent research on patterns of EMG rather than absolute levels is also discussed. It is concluded that there is no consistent evid...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(84)90093-9
更新日期:1984-10-01 00:00:00
abstract::Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001676
更新日期:2019-12-01 00:00:00
abstract::Neuroimaging studies of patients with chronic pain have shown that neurotransmitter abnormalities, including increases in glutamate and decreases in GABA, could be responsible for the cortical hyperactivity and hyperalgesia/allodynia observed in some pain conditions. These finding are particularly evident in the insul...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000615
更新日期:2016-10-01 00:00:00
abstract::The effects of vibratory stimulation on muscular pain threshold were investigated in 28 healthy subjects. Pain sensation was evaluated by the subjects' verbal reports in response to electrical stimulation of the vastus medialis muscle. Concomitant variations of blink response evoked as a component of the startle react...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90046-1
更新日期:1986-02-01 00:00:00
abstract::Patients suffering from postherpetic neuralgia often complain about hypo- or hypersensation in the affected dermatome. The loss of thermal sensitivity has been demonstrated by quantitative sensory testing as being associated with small-fiber (Aδ- and C-fiber) deafferentation. We aimed to compare laser stimulation (rad...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.04.029
更新日期:2012-08-01 00:00:00
abstract::Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.06.010
更新日期:2012-11-01 00:00:00
abstract::A preliminary report of clinical study revealed that chronic discogenic low back pain could be treated by intradiscal methylene blue (MB) injection. We investigated the effect of intradiscal MB injection for the treatment of chronic discogenic low back pain in a randomized placebo-controlled trial. We recruited 136 pa...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.01.021
更新日期:2010-04-01 00:00:00
abstract::A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence has demonstrated a correlation between the expression of some of these molecular markers and transmission of signals related to distinct ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.04.022
更新日期:2012-10-01 00:00:00
abstract::A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the pati...
journal_title:Pain
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.pain.2012.03.003
更新日期:2012-06-01 00:00:00
abstract::Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Di...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001413
更新日期:2019-01-01 00:00:00
abstract::Nitric oxide (NO), synthesised by different isoforms of nitric oxide synthase (NOS), has been linked with the development and maintenance of nociception. We studied the role of the inducible isoform, iNOS, in two different rat pain models with an inflammatory component. iNOS was immunohistochemically detected locally ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.10.028
更新日期:2006-01-01 00:00:00
abstract::Pain and thermal sensitivity thresholds in healthy volunteers were examined for diurnal variations. The subjects were 11 men aged between 22 and 27 years (means = 23.5, S.D. = 1.5). Data were collected for 2 days, with 7 measurements per day. To ensure the pain specificity of the results the subliminal modality, i.e.,...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90120-6
更新日期:1989-01-01 00:00:00
abstract::Patients with sensory disturbances of painful and non-painful character show distinct changes in touch and/or pain sensitivity. The patterns of sensory changes were compared to those of human surrogate models of neuropathic pain to assess the underlying mechanisms. We investigated 30 consecutive in-patients with dysae...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00438-9
更新日期:2002-03-01 00:00:00
abstract::The pathophysiology of burning mouth syndrome (BMS) is largely unknown. Thus, the aim was to study oral mucosal blood flow in BMS-patients using laser Doppler flowmetry (LDF). Thirteen BMS patients (11 female, two male; mean age+/-SD 64.3+/-7.9 years, mean disease duration 18.9+/-6.2 months) and 13 healthy non-smoking...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00410-3
更新日期:2001-02-15 00:00:00
abstract::The results of a considerable number of recent prospective studies have demonstrated that greater acute pain severity in herpes zoster patients is associated with a significantly greater risk of developing postherpetic neuralgia (PHN). Only a few studies have examined the relationships between acute pain severity and ...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/S0304-3959(01)00347-5
更新日期:2001-10-01 00:00:00
abstract::Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00093-6
更新日期:1997-11-01 00:00:00
abstract::Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90022-1
更新日期:1994-12-01 00:00:00
abstract::The objective of this study was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. Data were from a prospective cohort study of 1545 community-dwelling Mexican Americans aged ≥67 years from the Hispanic Established Populations for the Epide...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001711
更新日期:2020-01-01 00:00:00
abstract::This study aimed to characterize the prevalence of various pain qualities in older adults with chronic nonmalignant pain and determine the association of pain quality to other pain characteristics namely: severity, interference, distribution, and pain-associated conditions. In the population-based MOBILIZE Boston Stud...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000719
更新日期:2016-12-01 00:00:00
abstract::Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90110-4
更新日期:1994-04-01 00:00:00
abstract::In children, many psychometric properties of the visual analogue scale (VAS) are known, including the minimum clinically significant difference (10mm on a 100-mm VAS). However, its imprecision or reliability is not well known. Thus, in order to determine the reliability of this scale, a prospective cohort study was pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.01.006
更新日期:2012-04-01 00:00:00
abstract::Electrophysiological evidence has been obtained suggesting the presence of reciprocal excitation between descending pathways from the nucleus raphe magnus (NRM) and adjacent reticular formation (Ret.F) and spinal cord neurones projecting to these brain stem areas. In decerebrate and decerebellate cats, 40 spinal cord ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90094-0
更新日期:1984-10-01 00:00:00