Abstract：
:Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analysis of hemodynamic changes caused by neural activity in the mouse brain in response to electrical forepaw stimulation at different amplitudes. A gradient echo-echo planar imaging (GE-EPI) sequence was used to acquire five coronal brain slices of 0.5mm thickness. BOLD signal changes were observed in primary and secondary somatosensory cortices, the thalamus and the insular cortex, important regions involved in sensory and nociceptive processing. Activation was observed consistently bilateral despite unilateral stimulation of the forepaw. The temporal BOLD profile was segregated into two signal components with different temporal characteristics. The maximum BOLD amplitude of both signal components correlated strongly with the stimulation amplitude. Analysis of the dynamic behavior of the somatosensory 'fast' BOLD component revealed a decreasing signal decay rate constant k(off) with increasing maximum BOLD amplitude (and stimulation amplitude). This study demonstrates the feasibility of a robust BOLD fMRI protocol to study nociceptive processing in isoflurane-anesthetized mice. The reliability of the method allows for detailed analysis of the temporal BOLD profile and for investigation of somatosensory and noxious signal processing in the brain, which is attractive for characterizing genetically engineered mouse models.
journal_name
Painjournal_title
Painauthors
Bosshard SC,Baltes C,Wyss MT,Mueggler T,Weber B,Rudin Mdoi
10.1016/j.pain.2010.08.025subject
Has Abstractpub_date
2010-12-01 00:00:00pages
655-663issue
3eissn
0304-3959issn
1872-6623pii
00006396-201012000-00017journal_volume
151pub_type
杂志文章相关文献
PAIN文献大全abstract：:Morphine is widely used to treat severe pain in neonatal intensive care unit patients. Animal studies suggest adverse long-term side effects of neonatal morphine, but a follow-up study of 5-year-old children who participated in a morphine-placebo controlled trial as newborns found no such effects on the child's genera...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2012.12.006
更新日期：2013-03-01 00:00:00
abstract：:The analgesic efficacy of the novel anxiolytic buspirone in tests of acute thermal, mechanical and formalin-induced chemical-inflammatory pain were examined. Buspirone produced dose- and time-dependent analgesia in all nociceptive tests, with greatest effects against chemical and mechanical pain. Buspirone was less po...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90181-4
更新日期：1989-10-01 00:00:00
abstract：:In knee osteoarthritis (OA), pain sensitization has been linked to a more severe symptomatology, but the prognostic implications of pain sensitivity in people undergoing conservative treatment such as physiotherapy are not established. This study aimed to prospectively investigate the association between features of p...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001288
更新日期：2018-09-01 00:00:00
abstract：:Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/j.pain.2004.06.013
更新日期：2004-09-01 00:00:00
abstract：:Sensitization of purinergic P2X3 receptors (P2X3Rs) is a major mechanism contributing to injury-induced exaggerated pain responses. We showed in a previous study that cyclic adenosine monophosphate (cAMP)-dependent guanine nucleotide exchange factor 1 (Epac1) in rat sensory dorsal root ganglia (DRGs) is upregulated af...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000547
更新日期：2016-07-01 00:00:00
abstract：:Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90085-X
更新日期：1984-08-01 00:00:00
abstract：:Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.05.002
更新日期：2009-08-01 00:00:00
abstract：:We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(91)90179-2
更新日期：1991-05-01 00:00:00
abstract：:Clinicians use patients' recall of pain and disability relief as indicators of therapeutic effectiveness. Recall can change over time, however, and is influenced by factors other than true relief, including current health status. We have determined the trend in the relative contribution of current pain/disability and ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(01)00377-3
更新日期：2002-01-01 00:00:00
abstract：:Evidence of the relationship between childhood abuse and pain problems in adulthood has been based on cross-sectional studies using retrospective self-reports of childhood victimization. The objective of the current study was to determine whether childhood victimization increases risk for adult pain complaints, using ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(01)00270-6
更新日期：2001-05-01 00:00:00
abstract：:Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.01.056
更新日期：2011-06-01 00:00:00
abstract：:The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90152-2
更新日期：1992-05-01 00:00:00
abstract：:A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by 2 isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1 (NO-GC1) and 2 (NO-GC2). However, the specific functions of the 2 iso...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001440
更新日期：2019-03-01 00:00:00
abstract：:Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pa...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001758
更新日期：2020-03-01 00:00:00
abstract：:Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve inju...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.10.024
更新日期：2013-02-01 00:00:00
abstract：:A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression. Treatment was given, in randomized order, for periods of 4 weeks, separated by 1 week wash-o...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(89)90108-5
更新日期：1989-01-01 00:00:00
abstract：:The present study was undertaken to investigate the possible involvement of peripheral nociceptors in 3 diagnostic categories of elderly patients with chronic pain. The 3 diagnostic groups consisted of: chronic lower lumbar pain of degenerative musculoskeletal etiology (LLP), post-herpetic neuralgia (PHN) and pain of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91104-Q
更新日期：1990-04-01 00:00:00
abstract：:The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (through the ectonucleotidase activity of prostatic acid phosphatase [PAP]) and adenosine A1 receptors (A1Rs) in resin...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001246
更新日期：2018-08-01 00:00:00
abstract：:The relationship was investigated between algogenic potential of gallbladder pathology and occurrence/extent of sensory and trophic changes in the referred area. Five groups of subjects were studied, with: symptomatic gallbladder calculosis (3-20 colics); asymptomatic calculosis; symptomatic gallbladder shape abnormal...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2004.12.024
更新日期：2005-03-01 00:00:00
abstract：:Noradrenaline increases thermal hyperalgesia in skin previously sensitized by capsaicin. The aim of the present study was to determine whether a vasoconstrictor ischaemic effect of noradrenaline increases thermal hyperalgesia. Heat pain thresholds were measured in the capsaicin-treated and untreated skin on the forear...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(96)03115-6
更新日期：1996-09-01 00:00:00
abstract：:Previous research implicates an endogenous central pain inhibitory mechanism in opiate analgesia, analgesia produced by focal electrical stimulation of the brain, and acupuncture analgesia. This investigation evaluates the possibility that analgesia produced by hypnosis is also mediated by such a mechanism. Results su...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(77)90085-9
更新日期：1977-10-01 00:00:00
abstract：:Studies on the efficacy of ketamine in the treatment of chronic pain indicate that prolonged or repetitive infusions are required to ensure prolonged pain relief. Few studies address ketamine-induced toxicity. Here we present data on the occurrence of ketamine-induced liver injury during repeated administrations of S(...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2011.03.026
更新日期：2011-09-01 00:00:00
abstract：:Laser evoked potentials (LEPs) are nociceptive-related brain responses to activation of cutaneous nociceptors by laser radiant heat stimuli. We previously showed that LEP amplitude during the P2 period (approximately 400 ms) was increased by rare noxious stimuli, inside and outside the focus of spatial attention. It w...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0304-3959(02)00451-7
更新日期：2003-06-01 00:00:00
abstract：:Pro-inflammatory cytokine production after nociceptive stimuli is pivotal for hyperalgesia. As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.11.011
更新日期：2010-02-01 00:00:00
abstract：:After a pilot study had indicated that the topical application of guanethidine might be of value in the treatment of tooth dentine hypersensitivity, a double-blind study was undertaken to investigate whether guanethidine was more effective than a distilled water control in alleviating dentinal pain. In 39 adult subjec...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(93)90205-4
更新日期：1993-08-01 00:00:00
abstract：:This laboratory-based study examined lagged associations between child pain behavior and maternal responses as a function of maternal catastrophizing (CAT). Mothers completed the parent version of the Pain Catastrophizing Scale. Children participated in a validated water ingestion procedure to induce abdominal discomf...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000963
更新日期：2017-09-01 00:00:00
abstract：:It has been confirmed that the voltage-gated persistent sodium currents mediate the generation of subthreshold membrane potential oscillations (SMPOs) and contribute to shaping repetitive firing. Our previous study indicated that gabapentin (GBP) administration induced a dose-dependent inhibition of SMPO in chronicall...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.01.020
更新日期：2009-05-01 00:00:00
abstract：:Increased blood pressure and sweet taste are often associated with decreased pain sensitivity. Animal research suggests that endogenous opioids are involved in both these relationships. Fifty-eight healthy young adults (36 male, 22 female) participated in two sessions receiving a placebo tablet or 50mg of naltrexone o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.05.003
更新日期：2008-03-01 00:00:00
abstract：:There is extensive evidence that spinal excitatory amino acids (EAAs) like glutamate (Glu) and aspartate (Asp) are important in the processing of nociceptive behaviors caused by incisions. To better understand EAA-induced dorsal horn sensitization caused by surgery, we examined the time course and extent of spinal ami...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00241-5
更新日期：2002-11-01 00:00:00
abstract：:Chronic pain not only interferes with daily activities, it may also have a negative impact on the perceived integrity of one's self through self-discrepancies. Self-discrepancies are experienced distances between the actual self and self-guides that can exist from 2 perspectives (ie, own and other). Self-discrepancies...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.11.009
更新日期：2011-02-01 00:00:00
