Nociceptive processing in the human brain of infrequent task-relevant and task-irrelevant noxious stimuli. A study with event-related potentials evoked by CO2 laser radiant heat stimuli.

abstract：:Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pai...

journal_title：Pain

authors： Kim JV,Megat S,Moy JK,Asiedu MN,Mejia GL,Vagner J,Price TJ

更新日期：2016-06-01 00:00:00

abstract：:(1) Capsaicin solution was applied for 15 min around a 1 cm length of sciatic nerve in the mid upper leg of adult rats. (2) Electron microscopic examinations of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibres attributable to the capsaicin. (3) Fl...

journal_title：Pain

authors： Ainsworth A,Hall P,Wall PD,Allt G,MacKenzie ML,Gibson S,Polak JM

更新日期：1981-12-01 00:00:00

abstract：:Chronic pain patients reported pain intensity on each of 3 pain intensity scales, the visual analog, numerical and adjectival scales, and then ranked the scales in order of perceived best communication of pain intensity. All patients were able to complete an adjectival scale but 11% were unable to complete a visual an...

journal_title：Pain

authors： Kremer E,Atkinson HJ,Ignelzi RJ

更新日期：1981-04-01 00:00:00

abstract：:Coping with the demands of pain diminishes self-regulatory capacity and causes self-regulatory fatigue, which then leads to deteriorated executive task performance. It has been suggested that optimism can counteract the depletion of self-regulatory capacity. This study employed a 2 (optimism/no optimism)×2 (pain/no pa...

journal_title：Pain

authors： Boselie JJLM,Vancleef LMG,Smeets T,Peters ML

更新日期：2014-02-01 00:00:00

abstract：:Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...

journal_title：Pain

authors： Bromm B,Forth W,Richter E,Scharein E

更新日期：1992-08-01 00:00:00

abstract：:The behavioural response of infant rats to intraplantar injection of formalin consists of specific directed behaviours (limb flexion, shaking and licking the injected paw) and non-specific behaviours that are also induced by non-nociceptive stimulation (squirming, hind limb kicks and whole body jerks), with specific i...

journal_title：Pain

authors： Abbott FV,Guy ER

更新日期：1995-09-01 00:00:00

abstract：:We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...

journal_title：Pain

authors： Roca G,Aguilar JL,Gomar C,Mazo V,Costa J,Vidal F

更新日期：1996-12-01 00:00:00

abstract：:A noncontrolled, randomized, multicenter study (NCT00924664) evaluated long-term safety and effectiveness of tanezumab in patients with chronic low back pain following a randomized placebo- and active-controlled parent study that evaluated analgesic efficacy. Patients were randomized to tanezumab 10mg (n=321) or 20mg ...

journal_title：Pain

authors： Gimbel JS,Kivitz AJ,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2014-09-01 00:00:00

abstract：:Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...

journal_title：Pain

authors： Inquimbert P,Bartels K,Babaniyi OB,Barrett LB,Tegeder I,Scholz J

更新日期：2012-12-01 00:00:00

abstract：:The effects of intrathecal administration of substance P and N-methyl-D-aspartate (NMDA) were studied in the formalin test in mice. Both substances were administered 5 min before injection of formalin into the hind paw. Co-administration of substance P and NMDA intensified the response in both the 1st (0-10 min) and t...

journal_title：Pain

authors： Mjellem-Joly N,Lund A,Berge OG,Hole K

更新日期：1992-11-01 00:00:00

abstract：:This study reports a 9-18 month follow-up of a randomised controlled trial of pain management programmes for chronic, non-malignant pain. Twenty-two inpatients, 18 outpatients and 12 control subjects completed the follow-up assessments. Significant treatment effects were demonstrated by the inpatient group on pain rat...

journal_title：Pain

authors： Peters J,G Large R,Elkind G

更新日期：1992-07-01 00:00:00

abstract：:Fear-avoidance beliefs have been identified as an important psychosocial variable in patients with chronic disability doe to low back pain. The importance of fear-avoidance beliefs for individuals with acute low back pain has not been explored. Seventy-eight subjects with work-related low back pain of less than 3 week...

journal_title：Pain

authors： Fritz JM,George SZ,Delitto A

更新日期：2001-10-01 00:00:00

abstract：:In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I-III. The main limitation has been the difficulty in defining functional populations among the...

journal_title：Pain

authors： Polgár E,Sardella TCP,Tiong SYX,Locke S,Watanabe M,Todd AJ

更新日期：2013-12-01 00:00:00

abstract：:In male rats, carrageenan (CAR)-induced inflammation or exposure to a selective protein kinase C epsilon (PKC epsilon ) agonist (psi epsilon RACK) produces prolongation of the hyperalgesia induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to as hyperalgesic priming. Since many chronic...

journal_title：Pain

authors： Joseph EK,Parada CA,Levine JD

更新日期：2003-09-01 00:00:00

abstract：:Adrenal medullary transplants in the spinal subarachnoid space, by providing a continual source of opioid peptides and catecholamines, offer a potentially important adjunct in the management of chronic pain. While previous studies have shown that this approach is effective against high-intensity phasic stimuli, adrena...

journal_title：Pain

authors： Hama AT,Sagen J

更新日期：1993-02-01 00:00:00

abstract：:The Quantitative Sensory Testing (QST) protocol of the German research network on neuropathic pain (DFNS) encompassing all somatosensory modalities assesses the functioning of different nerve fibers and of central pathways. The aim of our study was: (1) to explore, whether this QST protocol is feasible for children, (...

journal_title：Pain

authors： Blankenburg M,Boekens H,Hechler T,Maier C,Krumova E,Scherens A,Magerl W,Aksu F,Zernikow B

更新日期：2010-04-01 00:00:00

abstract：:Medical case management has improved in the past few decades, changing the dynamic interaction between depression and prevalent medical diseases. It is relevant to describe the comorbidity between depression and medical diseases to further improve the effectiveness of case management. We analyzed the data of adults ag...

journal_title：Pain

authors： Johnson K,Politis MD,Hansen AR,McKenzie LE,Duncan DT,Zhang J

更新日期：2017-04-01 00:00:00

abstract：:Data on comparative safety of opioid analgesics are limited, but some reports suggest disproportionate mortality risk associated with methadone. Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain. This is a retrospective observational cohort d...

journal_title：Pain

authors： Krebs EE,Becker WC,Zerzan J,Bair MJ,McCoy K,Hui S

更新日期：2011-08-01 00:00:00

abstract：:The failure to translate research evidence into day-to-day clinical practices is identified as a significant reason for suboptimal quality care across the health system, including procedural pain management in children. Clinical practice guidelines (CPGs) have been developed to assist in this process by synthesizing a...

journal_title：Pain

authors： Taddio A,Rogers JM

更新日期：2015-04-01 00:00:00

abstract：:Children of parents with chronic pain have higher rates of pain and internalizing (eg, anxiety and depressive) symptoms than children of parents without chronic pain. Parental modeling of pain behaviour and reinforcement of child pain have been hypothesized to underlie these relationships. These mechanisms were tested...

journal_title：Pain

authors： Higgins KS,Chambers CT,Rosen NO,Sherry S,Mohammadi S,Lynch M,Campbell-Yeo M,Clark AJ

更新日期：2019-11-01 00:00:00

abstract：:Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...

journal_title：Pain

authors： Freidin MB,Tsepilov YA,Stanaway IB,Meng W,Hayward C,Smith BH,Khoury S,Parisien M,Bortsov A,Diatchenko L,Børte S,Winsvold BS,Brumpton BM,Zwart JA,Aulchenko YS,Suri P,Williams FMK,HUNT All-In Pain.

更新日期：2020-09-30 00:00:00

abstract：:Extracellular adenosine triphosphate (ATP), acting at P2X ionotropic receptors, is implicated in numerous sensory processes. Exogenous ATP has been shown to be algogenic in both animals and humans. Research focus has been directed towards the P2X(3) receptor, as it is preferentially expressed on nociceptive C-fibers a...

journal_title：Pain

authors： Honore P,Kage K,Mikusa J,Watt AT,Johnston JF,Wyatt JR,Faltynek CR,Jarvis MF,Lynch K

更新日期：2002-09-01 00:00:00

abstract：:A 78-year-old male patient had chronic, unrelieved abdominal pain due to mesenteric ischaemia. Unsuccessful pharmacological approaches included oral morphine plus coadjuvants as well as a sympathetic celiac plexus block which gave pain relief that lasted for 72 h. In order to obtain long-lasting relief, a trial epidur...

journal_title：Pain

authors： Ceballos A,Cabezudo L,Bovaira M,Fenollosa P,Moro B

更新日期：2000-07-01 00:00:00

abstract：:Nonopioid agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are the most commonly used class of analgesics. Increasing evidence suggests that cyclooxygenase (COX) inhibition at both peripheral and central sites can contribute to the antihyperalgesic effects of NSAIDs, with the predominant clinical effect ...

journal_title：Pain

authors： Hodkinson DJ,Khawaja N,O'Daly O,Thacker MA,Zelaya FO,Wooldridge CL,Renton TF,Williams SCR,Howard MA

更新日期：2015-07-01 00:00:00

abstract：:Postmastectomy pain (PMP), a distinctive postsurgical neuropathic pain syndrome, has been thought to be consequence of 4-6% of surgical procedures for cancer of the breast, but remains understudied and poorly documented. In this cross-sectional descriptive study, a convenience sample of 95 women who had undergone brea...

journal_title：Pain

authors： Stevens PE,Dibble SL,Miaskowski C

更新日期：1995-04-01 00:00:00

abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...

journal_title：Pain

authors： Smith SM,Amtmann D,Askew RL,Gewandter JS,Hunsinger M,Jensen MP,McDermott MP,Patel KV,Williams M,Bacci ED,Burke LB,Chambers CT,Cooper SA,Cowan P,Desjardins P,Etropolski M,Farrar JT,Gilron I,Huang IZ,Katz M,Kerns RD

更新日期：2016-05-01 00:00:00

abstract：:Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly...

journal_title：Pain

authors： Zhang H,Lund DM,Ciccone HA,Staatz WD,Ibrahim MM,Largent-Milnes TM,Seltzman HH,Spigelman I,Vanderah TW

更新日期：2018-09-01 00:00:00

abstract：:Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumo...

journal_title：Pain

authors： Forte BL,Slosky LM,Zhang H,Arnold MR,Staatz WD,Hay M,Largent-Milnes TM,Vanderah TW

更新日期：2016-12-01 00:00:00

abstract：:The effects of vibratory stimulation on muscular pain threshold were investigated in 28 healthy subjects. Pain sensation was evaluated by the subjects' verbal reports in response to electrical stimulation of the vastus medialis muscle. Concomitant variations of blink response evoked as a component of the startle react...

journal_title：Pain

authors： Pantaleo T,Duranti R,Bellini F

更新日期：1986-02-01 00:00:00

abstract：:In a consecutive series of 227 psychiatric hospital admissions, data were recorded in respect of the complaint of pain. Eighty-six (38%) had pain. Fourty-four (19%) mentioned it spontaneously and 49 (22%) had no relevant physical cause. Women were affected more often than men (P less than 0.01) and tended to complain ...

journal_title：Pain

authors： Delaplaine R,Ifabumuyi OI,Merskey H,Zarfas J

更新日期：1978-04-01 00:00:00