Effects of capsaicin applied locally to adult peripheral nerve. II. Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cord.

abstract：:Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...

journal_title：Pain

authors： Beasley M,Freidin MB,Basu N,Williams FMK,Macfarlane GJ

更新日期：2019-02-01 00:00:00

abstract：:Dysmenorrhea is the most prevalent gynecological disorder in women of child-bearing age. Dysmenorrhea is associated with central sensitization and functional and structural changes in the brain. Our recent brain morphometry study disclosed that dysmenorrhea is associated with trait-related abnormal gray matter (GM) ch...

journal_title：Pain

authors： Tu CH,Niddam DM,Yeh TC,Lirng JF,Cheng CM,Chou CC,Chao HT,Hsieh JC

更新日期：2013-09-01 00:00:00

abstract：:Gait abnormalities have been suggested to provide an objective measure for joint pain in animal models. Here, we aimed to assess whether parameters of gait analysis correlate with measures of pain-related behavior in experimental monoarthritis. For this purpose, antigen-induced arthritis was induced in the left knee j...

journal_title：Pain

authors： Boettger MK,Weber K,Schmidt M,Gajda M,Bräuer R,Schaible HG

更新日期：2009-09-01 00:00:00

abstract：:Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation). In the present study, we determined whether desipra...

journal_title：Pain

authors： Sawynok J,Esser MJ,Reid AR

更新日期：1999-08-01 00:00:00

abstract：:Serotonin is critically involved in neuropathic pain. However, its role is far from being understood owing to the number of cellular targets and receptor subtypes involved. In a rat model of neuropathic pain evoked by chronic constriction injury (CCI) of the sciatic nerve, we studied the role of 5-HT(2B) receptor in d...

journal_title：Pain

authors： Urtikova N,Berson N,Van Steenwinckel J,Doly S,Truchetto J,Maroteaux L,Pohl M,Conrath M

更新日期：2012-06-01 00:00:00

abstract：:Hindlimb pain models developed in rats have been transposed to mice, but assumed sciatic nerve neuroanatomic similarities have not been examined. We compared sciatic nerve structural organization in mouse strains (C57BL/6J, DBA/2J, and B6129PF2/J) and rat strains (Wistar, Brown Norway, and Sprague-Dawley). Dissection ...

journal_title：Pain

authors： Rigaud M,Gemes G,Barabas ME,Chernoff DI,Abram SE,Stucky CL,Hogan QH

更新日期：2008-05-01 00:00:00

abstract：:A large sample of staff physicians and residents (n = 193) responded to a questionnaire in which they were asked to rate 10 pain descriptors for level of applicability to 4 common acute and chronic pain syndromes. The purpose of the study was to examine the extent to which physicians would agree on the ratings, and wh...

journal_title：Pain

authors： Tearnan BH,Dar R

更新日期：1986-07-01 00:00:00

abstract：:Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...

journal_title：Pain

authors： Lee MJ,Park BY,Cho S,Park H,Kim ST,Chung CS

更新日期：2019-12-01 00:00:00

abstract：:We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...

journal_title：Pain

authors： Mackie AM,Coda BC,Hill HF

更新日期：1991-09-01 00:00:00

abstract：:Treatment of neuropathic pain is a major clinical challenge that has been met with minimal success. After peripheral nerve injury, a decrease in the expression of the K-Cl cotransporter KCC2, a major neuronal Cl(-) extruder, leads to pathologic alterations in GABA(A) and glycine receptor function in the spinal cord. T...

journal_title：Pain

authors： Asiedu M,Ossipov MH,Kaila K,Price TJ

更新日期：2010-02-01 00:00:00

abstract：:In recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources...

journal_title：Pain

authors： Miranda-Cardenas Y,Rojas-Piloni G,Martínez-Lorenzana G,Rodríguez-Jiménez J,López-Hidalgo M,Freund-Mercier MJ,Condés-Lara M

更新日期：2006-05-01 00:00:00

abstract：:The present paper presents the relationship between the total body-pain (TBP) score, defined as the total number of areas shaded on a pain drawing, and the pain from one area, the Shoulder-Neck (SN), among subjects in or out of full-time gainful work respectively. Furthermore, relationships between pain-score, self-ex...

journal_title：Pain

authors： Ektor-Andersen J,Isacsson SO,Lindgren A,Ørbæk P,Malmö Shoulder-Neck Study group.

更新日期：1999-09-01 00:00:00

abstract：:Despite decades of research, hundreds of studies, and a number of recent reviews, the effects of aging on the experience of pain remain poorly understood. Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elder...

journal_title：Pain

authors： Edwards RR,Fillingim RB,Ness TJ

更新日期：2003-01-01 00:00:00

abstract：:Chronic pain after laparoscopic cholecystectomy is related to postoperative pain during the first postoperative week, but it is unknown which components of the early pain response is important. In this prospective study, 100 consecutive patients were examined preoperatively, 1 week postoperatively, and 3, 6, and 12 mo...

journal_title：Pain

authors： Blichfeldt-Eckhardt MR,Ording H,Andersen C,Licht PB,Toft P

更新日期：2014-11-01 00:00:00

abstract：:Posttraumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs. However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed at evaluating the efficacy and safety of loxoprofen patch (LX...

journal_title：Pain

authors： Fujiki EN,Netto NA,Kraychete DC,Daher MT,Tardini R,Nakamoto A,Lopes DG

更新日期：2019-07-01 00:00:00

abstract：:The termination of an unpleasant or painful somatic condition can produce a rewarding sense of relief, even if the stimulus that causes the termination is itself unpleasant or painful under normal circumstances. We aimed to identify central neural mechanisms of pain relief from capsaicin-elicited heat-hyperalgesia by ...

journal_title：Pain

authors： Mohr C,Leyendecker S,Mangels I,Machner B,Sander T,Helmchen C

更新日期：2008-10-15 00:00:00

abstract：:Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chroni...

journal_title：Pain

authors： Gustavsson A,Bjorkman J,Ljungcrantz C,Rhodin A,Rivano-Fischer M,Sjolund FK,Mannheimer C

更新日期：2012-12-01 00:00:00

abstract：:This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...

journal_title：Pain

authors： Keefe FJ,Ahles TA,Porter LS,Sutton LM,McBride CM,Pope MS,McKinstry ET,Furstenberg CP,Dalton J,Baucom DH

更新日期：2003-05-01 00:00:00

abstract：:Pain is a frequently observed non-motor symptom of patients with Parkinson's disease. In some patients, Parkinson's-related pain responds to dopaminergic treatment. In the present study, we aimed to elucidate whether subthalamic deep brain stimulation has a similar beneficial effect on pain in Parkinson's disease, and...

journal_title：Pain

authors： Sürücü O,Baumann-Vogel H,Uhl M,Imbach LL,Baumann CR

更新日期：2013-08-01 00:00:00

abstract：:This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...

journal_title：Pain

authors： Grond S,Zech D,Lehmann KA,Radbruch L,Breitenbach H,Hertel D

更新日期：1997-01-01 00:00:00

abstract：:The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura...

journal_title：Pain

authors： Juhasz G,Zsombok T,Modos EA,Olajos S,Jakab B,Nemeth J,Szolcsanyi J,Vitrai J,Bagdy G

更新日期：2003-12-01 00:00:00

abstract：:The presence of a trigger point is essential to the myofascial pain syndrome. This study centres on identifying clearer criteria for the presence of trigger points in the quadratus lumborum and gluteus medius muscle by investigating the occurrence and inter-rater reliability of trigger point symptoms. Using the sympto...

journal_title：Pain

authors： Hua NK,Van der Does E

更新日期：1994-09-01 00:00:00

abstract：:The effects of vibratory stimulation on muscular pain threshold were investigated in 28 healthy subjects. Pain sensation was evaluated by the subjects' verbal reports in response to electrical stimulation of the vastus medialis muscle. Concomitant variations of blink response evoked as a component of the startle react...

journal_title：Pain

authors： Pantaleo T,Duranti R,Bellini F

更新日期：1986-02-01 00:00:00

abstract：:Chemical cauterization of the central cornea with silver nitrate was assessed as a superficial injury model of tissue sensitization accompanying acute inflammation. Adult male Sprague-Dawley rats were anesthetized with halothane gas, and the centers of their right corneas treated with a silver nitrate applicator stick...

journal_title：Pain

authors： Wenk NH,Honda NC

更新日期：2003-10-01 00:00:00

abstract：:With increasing concerns about the potential harm of long-term opioid therapy, there is a need for the development and implementation of alternative treatment strategies for patients with chronic pain who have been using opioids for a prolonged period of time. Based on the findings from a recent qualitative investigat...

journal_title：Pain

authors： Andrews NE,Strong J,Meredith PJ,Fleming JA

更新日期：2016-02-01 00:00:00

abstract：:The neurological basis for painful temporomandibular disorders (TMD) and the higher prevalence of TMD pain in women than men is not known. To better define the circuitry and neurochemical mechanisms in the lower brainstem associated with noxious sensory inputs from the temporomandibular joint (TMJ) region a microdialy...

journal_title：Pain

authors： Bereiter DA,Shen S,Benetti AP

更新日期：2002-07-01 00:00:00

abstract：:Biopsychosocial models of chronic pain that recognize psychological and environmental factors as important aspects of adjustment to pain have been proposed for understanding chronic pain and related suffering in persons with multiple sclerosis (MS), but such models have not been empirically tested. The objective of th...

journal_title：Pain

authors： Osborne TL,Jensen MP,Ehde DM,Hanley MA,Kraft G

更新日期：2007-01-01 00:00:00

abstract：:Supraspinal opioid analgesia is mediated in part by connections between the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Morphine analgesia elicited from the PAG is respectively decreased by selective serotonergic and opioid receptor antagonists administered into the RVM, and increased by RVM neur...

journal_title：Pain

authors： Spinella M,Cooper ML,Bodnar RJ

更新日期：1996-03-01 00:00:00

abstract：:Surgery and trauma are recognised as important causes of chronic pain, although their overall contribution has not been systematically studied. This paper reports on the contribution of surgery and trauma to chronic pain among 5130 patients attending 10 outpatient clinics located throughout North Britain. Surgery cont...

journal_title：Pain

authors： Crombie IK,Davies HT,Macrae WA

更新日期：1998-05-01 00:00:00

abstract：:An empirical determination of the nature and minimum number of dimension necessary to describe responses to the McGill Pain Questionnaire, and a comparison of groups, experiencing clinical or experimentally induced pain, on the dimensions were carried out. Eighty-five patients referred to a low back pain diagnostic cl...

journal_title：Pain

authors： Crockett DJ,Prkachin KM,Craig KD

更新日期：1977-12-01 00:00:00