Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain.

abstract：:Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (ce...

journal_title：Pain

authors： Sterling M,Jull G,Vicenzino B,Kenardy J,Darnell R

更新日期：2003-05-01 00:00:00

abstract：:Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when u...

journal_title：Pain

authors： Harden RN,Maihofner C,Abousaad E,Vatine JJ,Kirsling A,Perez RSGM,Kuroda M,Brunner F,Stanton-Hicks M,Marinus J,van Hilten JJ,Mackey S,Birklein F,Schlereth T,Mailis-Gagnon A,Graciosa J,Connoly SB,Dayanim D,Massey M,Fr

更新日期：2017-08-01 00:00:00

abstract：:Intra-articular injection of Freund's complete adjuvant (FCA) into the rat knee joint produces a swelling of the joint and long lasting hypersensitivity. In this study we have used this model and in vivo electrophysiology to investigate the time course of spinal changes underlying chronic secondary hypersensitivity, b...

journal_title：Pain

authors： Martindale JC,Wilson AW,Reeve AJ,Chessell IP,Headley PM

更新日期：2007-12-15 00:00:00

abstract：:The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...

journal_title：Pain

authors： Wilson JF,Brockopp GW,Kryst S,Steger H,Witt WO

更新日期：1992-09-01 00:00:00

abstract：:Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Intriguingly, several reports showed that capsaicin also inhibits Na+ currents but the mechanisms remain unclear. To explore this non-TRPV1 action we applied capsaicin to HEK293 cells stably expressing inactivation-deficient rat skele...

journal_title：Pain

authors： Wang SY,Mitchell J,Wang GK

更新日期：2007-01-01 00:00:00

abstract：:The effects of lateral reticular nucleus (LRN) stimulation on the responses to tooth pulp (TP) stimulation of neurons located in the trigeminal (V) sensory (39 units) and motor (33 units) nuclei were assessed in anesthetized rats. Only neurons which responded to TP stimulation with bursts of spikes that were in a cons...

journal_title：Pain

authors： Sotgiu ML,Bellinzona M

更新日期：1991-07-01 00:00:00

abstract：:Inflammatory thermal hyperalgesia is principally mediated through transient receptor potential vanilloid 1 (TRPV1) channels, as demonstrated by prior studies using models of cutaneous inflammation. Muscle pain is significantly different from cutaneous pain, and the involvement of TRPV1 in hyperalgesia induced by muscl...

journal_title：Pain

authors： Walder RY,Radhakrishnan R,Loo L,Rasmussen LA,Mohapatra DP,Wilson SP,Sluka KA

更新日期：2012-08-01 00:00:00

abstract：:Despite the presence of pathology in cancer pain, the pain experience in adult cancer patients cannot be totally explained by the extent of such pathology. Unlike chronic benign pain very little research on the role of biobehavioral factors has been conducted to help explain this paradox. The literature on the role of...

journal_title：Pain

authors： Dalton JA,Feuerstein M

更新日期：1988-05-01 00:00:00

abstract：:Nociception was studied in male mice, mostly of the C57BL/6 strain, during continuous or prolonged restriction of caloric intake (60% of ad-libitum) from midlife to senescence (up to 105 weeks). Restricted mice showed fewer licking or biting responses 20-60 min after hind paw injection of 5% formalin at 46 and 70 week...

journal_title：Pain

authors： Hargraves WA,Hentall ID

更新日期：2005-04-01 00:00:00

abstract：:Psychologic assessment and treatment of the family of the chronic pain patient has been thought to be of benefit in the outcome of pain therapy. The present study was designed to determine the presence of psychologic symptoms in the spouses of pain patients and the relationship of distress levels between the marital p...

journal_title：Pain

authors： Shanfield SB,Heiman EM,Cope N,Jones JR

更新日期：1979-12-01 00:00:00

abstract：:The human palm has a lower heat detection threshold and a higher heat pain threshold than hairy skin. Neurophysiological studies of monkeys suggest that glabrous skin has fewer low threshold heat nociceptors (AMH type 2) than hairy skin. Accordingly, we used a temperature-controlled contact heat evoked potential (CHEP...

journal_title：Pain

authors： Granovsky Y,Matre D,Sokolik A,Lorenz J,Casey KL

更新日期：2005-06-01 00:00:00

abstract：:Analgesic response, incidental pain and pain mechanism were evaluated in order to predict the chances of pain relief in advanced cancer patients. In an observation period of about 2 months, 130 patients were followed at home until death using only a pharmacological approach to control pain according to the WHO ladders...

journal_title：Pain

authors： Mercadante S,Maddaloni S,Roccella S,Salvaggio L

更新日期：1992-08-01 00:00:00

abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...

journal_title：Pain

authors： Smith SM,Amtmann D,Askew RL,Gewandter JS,Hunsinger M,Jensen MP,McDermott MP,Patel KV,Williams M,Bacci ED,Burke LB,Chambers CT,Cooper SA,Cowan P,Desjardins P,Etropolski M,Farrar JT,Gilron I,Huang IZ,Katz M,Kerns RD

更新日期：2016-05-01 00:00:00

abstract：:The present study examined the role of spinal cholinergic modulation of spinal mechanical and thermal transmission. Intrathecal administration of the cholinergic muscarinic receptor antagonists atropine or scopolamine in awake rats produced a dose-dependent decrease in the nociceptive mechanical withdrawal threshold o...

journal_title：Pain

authors： Zhuo M,Gebhart GF

更新日期：1991-08-01 00:00:00

abstract：:In this study, we examined the relationship between astrocyte activation in the cuneate nucleus (CN) and behavioral hypersensitivity after chronic constriction injury (CCI) of the median nerve. In addition, we also examined the effects of pre-emptive treatment with a number of drugs on astrocyte activation and hyperse...

journal_title：Pain

authors： Chen JJ,Lue JH,Lin LH,Huang CT,Chiang RP,Chen CL,Tsai YJ

更新日期：2010-01-01 00:00:00

abstract：:In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...

journal_title：Pain

authors： Brennum J,Arendt-Nielsen L,Horn A,Secher NH,Jensen TS

更新日期：1993-01-01 00:00:00

abstract：:Extracellular adenosine triphosphate (ATP), acting at P2X ionotropic receptors, is implicated in numerous sensory processes. Exogenous ATP has been shown to be algogenic in both animals and humans. Research focus has been directed towards the P2X(3) receptor, as it is preferentially expressed on nociceptive C-fibers a...

journal_title：Pain

authors： Honore P,Kage K,Mikusa J,Watt AT,Johnston JF,Wyatt JR,Faltynek CR,Jarvis MF,Lynch K

更新日期：2002-09-01 00:00:00

abstract：:Previous studies indicate that descending modulation of nociception is progressively increased following persistent inflammation. The present study was designed to further examine the role of supraspinal neurons in descending modulation following persistent inflammation. Constant levels of paw withdrawal (PW) and tail...

journal_title：Pain

authors： Terayama R,Dubner R,Ren K

更新日期：2002-05-01 00:00:00

abstract：:Multidimensional models of pain processing distinguish the sensory, motivational, and affective components of the pain experience. Efforts to understand underlying mechanisms have focused on isolating the roles of specific brain structures, including both limbic and non-limbic cortical areas, in the processing of noci...

journal_title：Pain

authors： Uhelski ML,Davis MA,Fuchs PN

更新日期：2012-04-01 00:00:00

abstract：:Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induced allodynia are microglial dependent in male but not female mice. Whe...

journal_title：Pain

authors： Mapplebeck JCS,Dalgarno R,Tu Y,Moriarty O,Beggs S,Kwok CHT,Halievski K,Assi S,Mogil JS,Trang T,Salter MW

更新日期：2018-09-01 00:00:00

abstract：:The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model. Measurement of pain intensity was made before medication and then at 30, 60, 90...

journal_title：Pain

authors： Jones SF,McQuay HJ,Moore RA,Hand CW

更新日期：1988-08-01 00:00:00

abstract：:Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define t...

journal_title：Pain

authors： Mogil JS,Wilson SG,Bon K,Lee SE,Chung K,Raber P,Pieper JO,Hain HS,Belknap JK,Hubert L,Elmer GI,Chung JM,Devor M

更新日期：1999-03-01 00:00:00

abstract：:Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from corti...

journal_title：Pain

authors： Leite-Almeida H,Cerqueira JJ,Wei H,Ribeiro-Costa N,Anjos-Martins H,Sousa N,Pertovaara A,Almeida A

更新日期：2012-11-01 00:00:00

abstract：:The spinal gray matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply o...

journal_title：Pain

authors： Krotov V,Tokhtamysh A,Safronov BV,Belan P,Voitenko N

更新日期：2019-09-01 00:00:00

abstract：:The relation between personality characteristics and the psychological functioning of headache patients has long been a topic of interest. Early investigations focused on clinical and anecdotal reports while recent research has moved toward a more objective evaluation of headache groups by using the MMPI. However, the...

journal_title：Pain

authors： Williams DE,Thompson KJ,Haber JD,Raczynski JM

更新日期：1986-02-01 00:00:00

abstract：:Posttraumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs. However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed at evaluating the efficacy and safety of loxoprofen patch (LX...

journal_title：Pain

authors： Fujiki EN,Netto NA,Kraychete DC,Daher MT,Tardini R,Nakamoto A,Lopes DG

更新日期：2019-07-01 00:00:00

abstract：:A cohort of 243 female sewing machine operators were studied by questionnaire and clinical examinations with the purpose to study the efficiency of a screening questionnaire-based method to identify prevalent and incident cases of neck-shoulder disorders. The cross-sectional correlation between self-reported neck-shou...

journal_title：Pain

authors： Kaergaard A,Andersen JH,Rasmussen K,Mikkelsen S

更新日期：2000-06-01 00:00:00

abstract：:Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...

journal_title：Pain

authors： Freidin MB,Tsepilov YA,Stanaway IB,Meng W,Hayward C,Smith BH,Khoury S,Parisien M,Bortsov A,Diatchenko L,Børte S,Winsvold BS,Brumpton BM,Zwart JA,Aulchenko YS,Suri P,Williams FMK,HUNT All-In Pain.

更新日期：2020-09-30 00:00:00

abstract：:The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 day...

journal_title：Pain

authors： Ottoson D,Ekblom A,Hansson P

更新日期：1981-02-01 00:00:00

abstract：:A young female outpatient experienced painful tonic contractions in the right triceps surae muscles as a result of a partial damage of the right peroneal nerve. Electrophysiological recordings of the soleus muscle showed a tonic EMG activity and an hyperexcitability of the monosynaptic H reflex (Hmax/Mmax ratio: 90%)....

journal_title：Pain

authors： Wilier JC

更新日期：1988-03-01 00:00:00