Abstract:
:Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (cervical range of movement (ROM), joint position error (JPE) and activity of the superficial neck flexors (EMG) during a test of cranio-cervical flexion) as well as a measure of fear of re-injury (TAMPA) in 66 whiplash subjects within 1 month of injury and then 2 and 3 months post injury. Subjects were classified at 3 months post injury using scores on the neck disability index: recovered (<8), mild pain and disability (10-28) or moderate/severe pain and disability (>30). Motor system function was also measured in 20 control subjects. All whiplash groups demonstrated decreased ROM and increased EMG (compared to controls) at 1 month post injury. This deficit persisted in the group with moderate/severe symptoms but returned to within normal limits in those who had recovered or reported persistent mild pain at 3 months. Increased EMG persisted for 3 months in all whiplash groups. Only the moderate/severe group showed greater JPE, within 1 month of injury, which remained unchanged at 3 months. TAMPA scores of the moderate/severe group were higher than those of the other two groups. The differences in TAMPA did not impact on ROM, EMG or JPE. This study identifies, for the first time, deficits in the motor system, as early as 1 month post whiplash injury, that persisted not only in those reporting moderate/severe symptoms at 3 months but also in subjects who recovered and those with persistent mild symptoms.
journal_name
Painjournal_title
Painauthors
Sterling M,Jull G,Vicenzino B,Kenardy J,Darnell Rdoi
10.1016/s0304-3959(02)00420-7keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
65-73issue
1-2eissn
0304-3959issn
1872-6623pii
S0304395902004207journal_volume
103pub_type
杂志文章相关文献
PAIN文献大全abstract::An electrophysiological study was carried out in anesthetized rats to characterize the properties of single neurons in trigeminal (V) subnucleus caudalis. Each neuron was functionally classified in terms of its cutaneous mechanoreceptive field properties as low-threshold mechanoreceptive (LTM), wide dynamic range (WDR...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)90010-B
更新日期:1990-06-01 00:00:00
abstract::Movement is changed in pain, but the mechanisms remain unclear. Key questions are unresolved such as whether activation can be inhomogeneously distributed within a muscle in a manner that is specific to the location of noxious input. This study addressed this question using high-density electromyography (EMG) to study...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001317
更新日期:2018-11-01 00:00:00
abstract::Two cases of reflex sympathetic dystrophy in the upper extremity of patients with traumatic cervical spinal cord injuries are reported. Both patients had very incomplete lesions with early neurological recovery, suggesting an underlying central cord syndrome. Although reflex sympathetic dystrophy is often seen followi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90046-0
更新日期:1984-04-01 00:00:00
abstract::In male rats, carrageenan (CAR)-induced inflammation or exposure to a selective protein kinase C epsilon (PKC epsilon ) agonist (psi epsilon RACK) produces prolongation of the hyperalgesia induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to as hyperalgesic priming. Since many chronic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00175-1
更新日期:2003-09-01 00:00:00
abstract::Recent research has focused on identification of clinically meaningful subgroupings within the chronic pain population in contrast to prior emphasis on the homogeneity of these patients. The present study investigates site of pain as a potentially useful classification variable for identification of differences among ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90085-X
更新日期:1984-08-01 00:00:00
abstract::Past research has shown that pain catastrophizing contributes to heightened pain experience. The hypothesis advanced in this study was that individuals who score high on measures of pain catastrophizing would also perceive more intense pain in others. The study also examined the role of pain behaviour as a determinant...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.02.007
更新日期:2006-07-01 00:00:00
abstract::Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.01.011
更新日期:2009-04-01 00:00:00
abstract::Studies in healthy human subjects and patients with irritable bowel syndrome suggest sex differences in cerebral nociceptive processing. Here we examine sex differences in functional brain activation in the rat during colorectal distention (CRD), a preclinical model of acute visceral pain. [(14)C]-iodoantipyrine was i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.025
更新日期:2009-09-01 00:00:00
abstract::A growing body of literature suggests that the experience of clinical pain differs across ethnocultural groups. Additionally, some evidence indicates greater sensitivity to experimentally induced pain among African Americans; however, most studies have included only one pain modality. This study examined ethnic differ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.08.013
更新日期:2005-01-01 00:00:00
abstract::This study records the consistency of transcutaneous electrical nerve stimulation (TENS) pulse frequency and pulse pattern used by 13 chronic patients over a 1 year period. The results show that patients prefer specific pulse frequencies and pulse patterns unique to the individual and that they turn to such frequencie...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90090-K
更新日期:1991-03-01 00:00:00
abstract::Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00351-7
更新日期:2001-11-01 00:00:00
abstract::Compared with other European countries, French laws and restrictions concerning the use of opioids are of medium severity only. Still, together with Germany, Belgium and Spain, France belongs to the group of countries with a low national consumption of morphine, calculated by the International Narcotics Control Board ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(94)00264-F
更新日期:1995-08-01 00:00:00
abstract::Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90110-4
更新日期:1994-04-01 00:00:00
abstract::Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(96)03223-X
更新日期:1996-11-01 00:00:00
abstract::Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90165-8
更新日期:1992-08-01 00:00:00
abstract::The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 day...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(81)90043-9
更新日期:1981-02-01 00:00:00
abstract::Humans require the ability to discriminate intensities of noxious stimuli to avoid future harm. This discrimination process seems to be biased by an individual's attention to pain and involves modulation of the relative intensity differences between stimuli (ie, Weber fraction). Here, we ask whether attention networks...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001086
更新日期:2018-02-01 00:00:00
abstract::In this review, the effectiveness of behavioral and pharmacological treatments for pediatric migraine was quantitatively summarized following the meta-analytic approach outlined by Hedges and Olkin (1985). A first meta-analysis based on treatment outcome within treatment conditions revealed that thermal biofeedback an...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/0304-3959(94)00210-6
更新日期:1995-03-01 00:00:00
abstract::High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collection and reporting of adverse event data as presented in published cli...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2012.08.012
更新日期:2013-02-01 00:00:00
abstract::Twenty-six patients with severe pain associated with cancer were entered into a study where they were required to take morphine mixture for 7 days. Prior to this, their morphine dose had been optimised to provide the most favourable balance between pain relief and side effects. After 6 days of taking their optimised m...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(94)00204-R
更新日期:1995-06-01 00:00:00
abstract::Little is known about patients prescribed high doses of opioids to treat chronic non-cancer pain, though these patients may be at higher risk for medication-related complications. We describe the prevalence of high-dose opioid use and associated demographic and clinical characteristics among veterans treated in a VA r...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.002
更新日期:2010-12-01 00:00:00
abstract::Chronic pain due to surgery, radiotherapy, or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic nonmalignant pain, primarily with nonpharmacological strategies. Based on complete national data from the Cancer Registry of Norway and the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001459
更新日期:2019-04-01 00:00:00
abstract::Pain modulation by placebo mechanisms is one of the most robust and best-studied phenomena, yet almost all research investigating the mechanisms and implications of the placebo analgesia are based on adult research. After highlighting crucial aspects that need to be considered in studying pain modulation in children, ...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2014.08.036
更新日期:2014-11-01 00:00:00
abstract::A comparison between 102 depressed and 101 non-depressed pain patients, identified with the use of DSM-III criteria, showed that depressed patients were more often elderly and employed as compared to non-depressed patients who were significantly more often found to be younger (P less than 0.001) and were students (P l...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90050-9
更新日期:1987-06-01 00:00:00
abstract::Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.06.010
更新日期:2012-11-01 00:00:00
abstract::A visual analog scale (VAS) method of assessing headache pain was compared with a standard categorical four-grade scale (4GS) in a randomized, placebo-controlled, double-blind, clinical trial involving 792 treated migraine outpatients who received oral rizatriptan 5 mg, sumatriptan 50 mg, or placebo for a moderate or ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(01)00315-3
更新日期:2001-08-01 00:00:00
abstract::Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1097/j.pain.0000000000000657
更新日期:2016-10-01 00:00:00
abstract::Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/j.pain.2014.04.020
更新日期:2014-08-01 00:00:00
abstract::Several studies have implicated a potential role for histamine H(3) receptors in pain processing, although the data are somewhat conflicting. In the present study we investigated the effects of the novel potent and highly selective H(3) receptor antagonists GSK189254 (6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.11.006
更新日期:2008-08-15 00:00:00
abstract::Chronic pain is more common in the elderly and impairs functioning and quality of life. Though obesity, defined by body mass index (BMI), has been associated with pain prevalence among older adults, the mechanism of this association remains unclear. We examined components of the metabolic syndrome, insulin resistance,...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.043
更新日期:2011-01-01 00:00:00