The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation.


:Previous studies indicate that descending modulation of nociception is progressively increased following persistent inflammation. The present study was designed to further examine the role of supraspinal neurons in descending modulation following persistent inflammation. Constant levels of paw withdrawal (PW) and tail flick (TF) latencies to noxious heat stimuli were achieved in lightly anesthetized rats (pentobarbital sodium 3-10 mg/kg/h, i.v.). Electrical stimulation (ES, 0.1 ms, 100 Hz, 20-200 A) was delivered to the rostral ventromedial medulla (RVM), mainly the nucleus raphe magnus (NRM). ES produced intensity-dependent inhibition of PW and TF. Following a unilateral hindpaw inflammation produced by injection of complete Freund's adjuvant (CFA), ES-produced inhibition underwent time-dependent changes. There was an initial decrease at 3 h after inflammation and a subsequent increase after inflammation in the excitability of RVM neurons and the inhibition of nocifensive responses. These changes were most robust after stimulation of the inflamed paw although similar findings were seen on the non-inflamed paw and tail. The inflammation-induced dynamic changes in descending modulation appeared to be correlated with changes in the activation of the N-methyl--aspartate (NMDA) excitatory amino acid receptor. Microinjection of an NMDA receptor antagonist, AP5 (1 pmol), resulted in an increase in the current intensity required for inhibition of the PW and TF. The effect of AP5 was less at 3 h after inflammation and significantly greater at 11-24 h after inflammation. In a subsequent experiment, ES-produced inhibition of nocifensive responses after inflammation was examined following selective chemical lesions of the nuclei reticularis gigantocellularis (NGC). Compared to vehicle-injected animals, microinjection of a soma-selective excitotoxin, ibotenic acid, enhanced ES-produced inhibition at 3 h but not at 24 h after inflammation. We propose that these time course changes reflect dynamic alterations in concomitant descending facilitation and inhibition. At early time points, NMDA receptor and NGC activation enhance descending facilitation; as time progresses, the dose-response curve of NMDA shifts to the left and descending inhibition dominates and masks any descending facilitation.






Terayama R,Dubner R,Ren K





Has Abstract


2002-05-01 00:00:00
















  • Patient utilities in chronic musculoskeletal pain: how useful is the standard gamble method?

    abstract::The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goossens ME,Vlaeyen JW,Rutten-van Mölken MP,van der Linden SM

    更新日期:1999-03-01 00:00:00

  • The relationship of pain and depression to cognitive function in rheumatoid arthritis patients.

    abstract::The purpose of this study was to assess the hypothesis that pain and depression negatively impact the cognitive functioning of individuals with rheumatoid arthritis (RA). One hundred twenty-one community-dwelling RA patients (ages 34-84) completed a battery of cognitive tasks and multiple measures of pain and depressi...


    pub_type: 杂志文章


    authors: Brown SC,Glass JM,Park DC

    更新日期:2002-04-01 00:00:00

  • Quantification of local and referred muscle pain in humans after sequential i.m. injections of hypertonic saline.

    abstract::The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...


    pub_type: 临床试验,杂志文章


    authors: Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

    更新日期:1997-01-01 00:00:00

  • Follow-up results from a randomised controlled trial evaluating in- and outpatient pain management programmes.

    abstract::This study reports a 9-18 month follow-up of a randomised controlled trial of pain management programmes for chronic, non-malignant pain. Twenty-two inpatients, 18 outpatients and 12 control subjects completed the follow-up assessments. Significant treatment effects were demonstrated by the inpatient group on pain rat...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Peters J,G Large R,Elkind G

    更新日期:1992-07-01 00:00:00

  • Modulation of pain-induced endothelial dysfunction by hypnotisability.

    abstract::Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial d...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jambrik Z,Santarcangelo EL,Rudisch T,Varga A,Forster T,Carli G

    更新日期:2005-08-01 00:00:00

  • Unexplained peculiarities of the dorsal root ganglion.

    abstract::The cell soma of primary afferent neurons in the dorsal root ganglion (DRG) is assigned by classical neurophysiology the role of a metabolic depot, charged with supporting the peripheral sensory ending, the conducting axon, and the central synaptic terminals. However, certain peculiarities of DRG morphology and physio...


    pub_type: 杂志文章,评审


    authors: Devor M

    更新日期:1999-08-01 00:00:00

  • Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord.

    abstract::The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and the development of pain hypersensitivity. We show that synapsin II is ...


    pub_type: 杂志文章


    authors: Schmidtko A,Del Turco D,Coste O,Ehnert C,Niederberger E,Ruth P,Deller T,Geisslinger G,Tegeder I

    更新日期:2005-05-01 00:00:00

  • Personalized evaluation of self-hypnosis as a treatment of chronic pain: a repertory grid analysis.

    abstract::Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this associ...


    pub_type: 杂志文章


    authors: Large RG,James FR

    更新日期:1988-11-01 00:00:00

  • Chronic stress exacerbates neuropathic pain via the integration of stress-affect-related information with nociceptive information in the central nucleus of the amygdala.

    abstract::Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...


    pub_type: 杂志文章


    authors: Li MJ,Liu LY,Chen L,Cai J,Wan Y,Xing GG

    更新日期:2017-04-01 00:00:00

  • Pain referral and regional deep tissue hyperalgesia in experimental human hip pain models.

    abstract::Hip disorder patients typically present with extensive pain referral and hyperalgesia. To better understand underlying mechanisms, an experimental hip pain model was established in which pain referrals and hyperalgesia could be studied under standardized conditions. In 16 healthy subjects, pain was induced by hyperton...


    pub_type: 杂志文章,随机对照试验


    authors: Izumi M,Petersen KK,Arendt-Nielsen L,Graven-Nielsen T

    更新日期:2014-04-01 00:00:00

  • Antinociceptive effect of Brazilian armed spider venom toxin Tx3-3 in animal models of neuropathic pain.

    abstract::Venoms peptides have produced exceptional sources for drug development to treat pain. In this study we examined the antinociceptive and side effects of Tx3-3, a peptide toxin isolated from Phoneutria nigriventer venom, which inhibits high-voltage-dependent calcium channels (VDCC), preferentially P/Q and R-type VDCC. W...


    pub_type: 杂志文章


    authors: Dalmolin GD,Silva CR,Rigo FK,Gomes GM,do Nascimento Cordeiro M,Richardson M,Silva MAR,Prado MAM,Gomez MV,Ferreira J

    更新日期:2011-10-01 00:00:00

  • Selective regulation of 3 alpha-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: a possible mechanism to cope with peripheral nerve injury-induced chronic pain.

    abstract::The enzyme 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR) catalyzes the synthesis and bioavailability of 3alpha,5alpha-neurosteroids as allopregnanolone (3alpha,5alpha-THP) which activates GABA(A) receptors and blocks T-type calcium channels involved in pain mechanisms. Here, we used a multidisciplinary approach ...


    pub_type: 杂志文章


    authors: Patte-Mensah C,Meyer L,Schaeffer V,Mensah-Nyagan AG

    更新日期:2010-09-01 00:00:00

  • Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice.

    abstract::microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...


    pub_type: 杂志文章


    authors: Kynast KL,Russe OQ,Möser CV,Geisslinger G,Niederberger E

    更新日期:2013-03-01 00:00:00

  • Emotional modulation of muscle pain is associated with polymorphisms in the serotonin transporter gene.

    abstract::The perception of pain is determined by a combination of genetic, neurobiological, cultural, and emotional factors. Recent studies have demonstrated an association between specific genotypes and pain perception. Particular focus has been given to the triallelic polymorphism in the promoter region of the serotonin tran...


    pub_type: 杂志文章


    authors: Horjales-Araujo E,Demontis D,Lund EK,Vase L,Finnerup NB,Børglum AD,Jensen TS,Svensson P

    更新日期:2013-08-01 00:00:00

  • Complex sociodemographic inequalities in consultations for low back pain: lessons from multilevel intersectional analysis.

    abstract:ABSTRACT:Sociodemographic inequalities in the occurrence of low back pain (LBP) are well-studied. This study aimed to examine complex sociodemographic inequalities in the risk of LBP consultation in the population from a socioeconomical intersectional perspective. Using register data, we identified 458,852 individuals ...


    pub_type: 杂志文章


    authors: Kiadaliri A,Merlo J,Englund M

    更新日期:2020-09-16 00:00:00

  • Evaluation of the fear-avoidance model with health care workers experiencing acute/subacute pain.

    abstract::Studies in the literature do not show clear evidence supporting the relationship between pain and depressive symptoms in individuals experiencing acute/subacute pain compared to those experiencing chronic pain. However, more information is needed about which variables act as mediators in the pain-depression relationsh...


    pub_type: 临床试验,杂志文章


    authors: Corbière M,Zaniboni S,Coutu MF,Franche RL,Guzman J,Dawson K,Yassi A

    更新日期:2011-11-01 00:00:00

  • Epidural administration of opiates by a new device.

    abstract::Epidural administration of opiates as a long-term treatment of cancer pain, even for out-patients, is now well established. Most reports describe intermittent injections given several times a day, which may have technical and personal disadvantages. Continuous epidural infusion may be preferable. This report describes...


    pub_type: 杂志文章


    authors: Ingemar F,Ahlgren H,Ahlgren MBE

    更新日期:1987-12-01 00:00:00

  • The relation between pain beliefs, negative thoughts, and psychosocial functioning in chronic pain patients.

    abstract::Cognitions and beliefs appear important in predicting adjustment to chronic pain. The current study examines how cognitions and beliefs are related to psychosocial functioning. One hundred and sixty-three chronic pain out-patients were assessed. Regression analyses were performed using scores on the Pain Beliefs and P...


    pub_type: 杂志文章


    authors: Stroud MW,Thorn BE,Jensen MP,Boothby JL

    更新日期:2000-02-01 00:00:00

  • Quantitative sensory examination during epidural anaesthesia and analgesia in man: effects of morphine.

    abstract::In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Brennum J,Arendt-Nielsen L,Horn A,Secher NH,Jensen TS

    更新日期:1993-01-01 00:00:00

  • Autonomic indices and reactive pain reports on the McGill Pain Questionnaire.

    abstract::Skin conductance and heart rate measures obtained from subjects previous to, during, and after their performance of the cold pressor task were correlated with their responses to the McGill Pain Questionnaire administered immediately after the completion of the cold pressor task. A reliable relationship between skin co...


    pub_type: 杂志文章


    authors: Dowling J

    更新日期:1982-01-01 00:00:00

  • Secondary hyperalgesia and perceptual wind-up following intradermal injection of capsaicin in humans.

    abstract::Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...


    pub_type: 杂志文章


    authors: Magerl W,Wilk SH,Treede RD

    更新日期:1998-02-01 00:00:00

  • Chronic effects of topical application of capsaicin to the sciatic nerve on responses of primate spinothalamic neurons.

    abstract::The responses of 144 spinothalamic tract (STT) cells were recorded in 15 anesthetized macaque monkeys (Macaca fascicularis). Three to 4 weeks prior to the acute experiment, the sciatic nerve was surgically exposed on one or both sides so that capsaicin or vehicle could be applied. Responses of STT cells recorded in 3 ...


    pub_type: 杂志文章


    authors: Chung JM,Paik KS,Kim JS,Nam SC,Kim KJ,Oh UT,Hasegawa T,Chung K,Willis WD

    更新日期:1993-06-01 00:00:00

  • Sodium urate arthritis: effects on the sensory properties of articular afferents in the chicken.

    abstract::The physiological properties of joint capsule mechanoreceptors in the ankle joint of the chicken were studied in the 3-h period immediately after intra-articular injection of microcrystal sodium urate. The electrical activity was recorded from single C- and A-delta sensory fibres dissected from the parafibular nerve. ...


    pub_type: 杂志文章


    authors: Gentle MJ

    更新日期:1997-04-01 00:00:00

  • The consequences of long-term topical capsaicin application in the rat.

    abstract::Capsaicin has been used extensively as an experimental tool and in traditional and proprietary topical medications for acute soft tissue injuries. More recently it has been prescribed for several chronic pain conditions where it is usually administered topically for periods of several weeks. Here we have studied the c...


    pub_type: 杂志文章


    authors: McMahon SB,Lewin G,Bloom SR

    更新日期:1991-03-01 00:00:00

  • The effect of 300 mW, 830 nm laser on chronic neck pain: a double-blind, randomized, placebo-controlled study.

    abstract::A randomized, double-blind, placebo-controlled study of low-level laser therapy (LLLT) in 90 subjects with chronic neck pain was conducted with the aim of determining the efficacy of 300 mW, 830 nm laser in the management of chronic neck pain. Subjects were randomized to receive a course of 14 treatments over 7 weeks ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chow RT,Heller GZ,Barnsley L

    更新日期:2006-09-01 00:00:00

  • Exercise-induced analgesia: fact or artifact?

    abstract::This study critically examines the reported exercise-induced analgesia effect in view of the potential stress-induced analgesia of pain testing itself. Two designs were used to test whether previous findings of analgesia were induced by the exercise procedures or by the stress of the pain testing procedures themselves...


    pub_type: 杂志文章


    authors: Padawer WJ,Levine FM

    更新日期:1992-02-01 00:00:00

  • Significance of pain in psychiatric hospital patients.

    abstract::In a consecutive series of 227 psychiatric hospital admissions, data were recorded in respect of the complaint of pain. Eighty-six (38%) had pain. Fourty-four (19%) mentioned it spontaneously and 49 (22%) had no relevant physical cause. Women were affected more often than men (P less than 0.01) and tended to complain ...


    pub_type: 杂志文章


    authors: Delaplaine R,Ifabumuyi OI,Merskey H,Zarfas J

    更新日期:1978-04-01 00:00:00

  • Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations.

    abstract::A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the pati...


    pub_type: 共识发展会议,杂志文章


    authors: Dworkin RH,Turk DC,Peirce-Sandner S,Burke LB,Farrar JT,Gilron I,Jensen MP,Katz NP,Raja SN,Rappaport BA,Rowbotham MC,Backonja MM,Baron R,Bellamy N,Bhagwagar Z,Costello A,Cowan P,Fang WC,Hertz S,Jay GW,Junor R,Ker

    更新日期:2012-06-01 00:00:00

  • Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache.

    abstract::Chronic posttraumatic headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic nontraumatic headaches that manipu...


    pub_type: 杂志文章


    authors: Domenichiello AF,Jensen JR,Zamora D,Horowitz M,Yuan ZX,Faurot K,Mann JD,Mannes AJ,Ramsden CE

    更新日期:2020-12-01 00:00:00

  • Differences between functional versus organic low back pain patients.

    abstract::There are contradictory findings about whether there are differences in personality and/or amount of emotional disturbance between patients with functional versus organic low back pain. The MMPI scores of 42 back pain patients diagnosed as "organic" were compared with the scores of 37 patients classified as "functiona...


    pub_type: 杂志文章


    authors: McCreary C,Turner J,Dawson E

    更新日期:1977-10-01 00:00:00