Abstract:
:Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to environmental stress. This suggests that there are different 'types' of pain. We exploited genetic differences among inbred strains of mice in an attempt to define these primary 'types'; that is, to identify the fundamental parameters of pain processing. Eleven randomly-chosen inbred mouse strains were tested for their basal sensitivity on 12 common measures of nociception. These measures provided for a range of different nociceptive dimensions including noxious stimulus modality, location, duration and etiology, among others. Since individual members of inbred strains are identical at all genetic loci, the observation of correlated strain means in any given pair of nociceptive assays is an index of genetic correlation between these assays, and hence an indication of common physiological mediation. Obtained correlation matrices were subjected to multivariate analyses to identify constellations of nociceptive assays with common genetic mediation. This analysis revealed three major clusters of nociception: (1) baseline thermal nociception, (2) spontaneously-emitted responses to chemical stimuli, and (3) baseline mechanical sensitivity and cutaneous hypersensitivity. Many other nociceptive parameters that might a priori have been considered closely related proved to be genetically divergent.
journal_name
Painjournal_title
Painauthors
Mogil JS,Wilson SG,Bon K,Lee SE,Chung K,Raber P,Pieper JO,Hain HS,Belknap JK,Hubert L,Elmer GI,Chung JM,Devor Mdoi
10.1016/s0304-3959(98)00196-1keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
83-93issue
1-2eissn
0304-3959issn
1872-6623journal_volume
80pub_type
杂志文章相关文献
PAIN文献大全abstract::Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(99)00259-6
更新日期:2000-03-01 00:00:00
abstract::An evaluation of the analgesic, mood and side effects of the combination of intramuscular morphine and oral cocaine was conducted in 17 patients with postoperative pain and 19 others with chronic malignant pain for the purpose of assessing the therapeutic merits of so-called 'euphoriant' elixirs in the management of p...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(87)90004-2
更新日期:1987-10-01 00:00:00
abstract::The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...
journal_title:Pain
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2005.07.002
更新日期:2005-10-01 00:00:00
abstract::We report a case control study comparing patients attending a pain clinic whose symptoms were not considered medically explained (cases) with those whose symptoms were considered medically explained (controls). Principal comparisons were psychiatric morbidity, medication use, and iatrogenic factors assessed by intervi...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(98)00074-8
更新日期:1998-06-01 00:00:00
abstract::The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000401
更新日期:2016-02-01 00:00:00
abstract::Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation). In the present study, we determined whether desipra...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00043-3
更新日期:1999-08-01 00:00:00
abstract:ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002195
更新日期:2021-01-12 00:00:00
abstract::Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patien...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(95)00160-3
更新日期:1996-03-01 00:00:00
abstract::Many studies of pain and nociception use short-lasting acute stimuli which may have limited relevance to prolonged or chronic pain states. Using extracellular single-unit recording in the dorsal horn of the rat lumbar spinal cord the present study examines the response of neurones to a long-lasting nociceptive stimulu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90023-6
更新日期:1987-09-01 00:00:00
abstract::The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00334-7
更新日期:2001-09-01 00:00:00
abstract::Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00113-4
更新日期:1998-10-01 00:00:00
abstract::Chronic posttraumatic headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic nontraumatic headaches that manipu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001983
更新日期:2020-12-01 00:00:00
abstract::A descriptive, longitudinal design was used to examine changes in current, worst, and least pain intensity during hospitalization for a vaso-occlusive episode in children with sickle cell disease. Other dimensions of the pain experience including location and quality were also evaluated. Children reported severe pain ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00374-3
更新日期:2003-03-01 00:00:00
abstract::Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when u...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1097/j.pain.0000000000000927
更新日期:2017-08-01 00:00:00
abstract::We investigated the role of endogenous opioid systems in the analgesic effects induced by repetitive transcranial magnetic stimulation (rTMS). We compared the analgesic effects of motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) stimulation before and after naloxone or placebo treatment, in a randomized, do...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.10.032
更新日期:2011-02-01 00:00:00
abstract::Shoulder pain is common in primary care and has an unfavourable outcome in many patients. Information about predictors of outcome is scarce and inconsistent. The objective of this study was to develop clinical prediction rules for calculating the absolute risk of persistent shoulder symptoms for individual patients, 6...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2005.11.004
更新日期:2006-02-01 00:00:00
abstract::This study investigated the effects of a single administration of 6-(4-methoxyphenyl)-5-methyl-3-pyridinyl-4-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), a negative allosteric modulator (NAM) of metabotropic glutamate receptor 7 (mGluR7), on pain and on affective and cognitive behavior in neuropathic mice. The activity ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000150
更新日期:2015-06-01 00:00:00
abstract::Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood. We here detected the ROS-gen...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.013
更新日期:2014-10-01 00:00:00
abstract::G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received little research attention. We used a tag singl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.08.026
更新日期:2013-12-01 00:00:00
abstract::The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to study spinal nociceptive processes in numerous clinical and experimental studies. Despite widespread use of the NFR, few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.06.022
更新日期:2009-09-01 00:00:00
abstract::Our goal was to examine the association between mental health disorders (MHD) and subsequent risk of opioid use among commercially insured youth and adults (aged 14-64 years) with comorbid chronic noncancer pain (CNCP) conditions. We conducted a retrospective cohort study using IQVIA Health Plan Claims database from J...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001934
更新日期:2020-10-01 00:00:00
abstract::Numerous animal studies suggest that acute and chronic exposure to opioids can be associated with the development of hyperalgesia, i.e. an increased sensitivity to noxious stimuli. Hyperalgesia has been documented during withdrawal and on occasion while animals were still exposed to opioids. A pivotal role in the gene...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(03)00276-8
更新日期:2003-11-01 00:00:00
abstract::Cultures differ as to typical linguistic reports and classifications of pain. In some languages upwards of a dozen specific pain terms are in common use, each indicating a particular pain experience. In other languages a single inclusive term is the norm, perhaps with optional qualifiers added to make desired distinct...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(80)90025-1
更新日期:1980-08-01 00:00:00
abstract::Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)03376-9
更新日期:1997-07-01 00:00:00
abstract::Investigating dose-dependent effects of placebo analgesia (PA) in laboratory subjects undergoing pain testing, we evaluated 2 hypotheses: (1) greater expectancy for relief produces greater PA, and (2) cued expectancy for relief triggered by a predictive cue leads to more enhanced analgesia than does passive expectancy...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.10.024
更新日期:2012-01-01 00:00:00
abstract::For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met wi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000335
更新日期:2015-11-01 00:00:00
abstract::A number of pharmacologic treatments examined in recent randomized clinical trials (RCTs) have failed to show statistically significant superiority to placebo in conditions in which their efficacy had previously been demonstrated. Assuming the validity of previous evidence of efficacy and the comparability of the pati...
journal_title:Pain
pub_type: 共识发展会议,杂志文章
doi:10.1016/j.pain.2012.03.003
更新日期:2012-06-01 00:00:00
abstract::The present study is a long-term report on 69 patients undergoing unilateral percutaneous cervical cordotomy for vertebral pain due to neoplastic bone metastases. The pain was unilateral or bilateral and was characterised by a chronic and/or an incident component. Seventy-one per cent (49/69) of the patients benefitte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90832-7
更新日期:1984-06-01 00:00:00
abstract::Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(97)00093-6
更新日期:1997-11-01 00:00:00
abstract::Interactions between the input from cutaneous and nociceptive muscle afferents in polysynaptic reflex pathways were investigated in man. Interaction was tested by evoking reflexes before, during, and after a period of muscle pain induced by intramuscular injection of hypertonic saline. Muscle pain was induced either i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00174-8
更新日期:2000-01-01 00:00:00