听力与言语-语言病理学

行为科学

医学伦理学

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  • Sex-dependent role of microglia in disulfide high mobility group box 1 protein-mediated mechanical hypersensitivity.

    abstract:ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002033

    authors: Agalave NM,Rudjito R,Farinotti AB,Khoonsari PE,Sandor K,Nomura Y,Szabo-Pardi TA,Urbina CM,Palada V,Price TJ,Erlandsson Harris H,Burton MD,Kultima K,Svensson CI

    更新日期:2021-02-01 00:00:00

  • Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain.

    abstract:ABSTRACT:The purpose of our work was to determine the role of nonopioid peptides derived from opioid prohormones in sensory hypersensitivity characteristics of neuropathic pain and to propose a pharmacological approach to restore the balance of these endogenous opioid systems. Nonopioid peptides may have a pronocicepti...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002045

    authors: Piotrowska A,Starnowska-Sokół J,Makuch W,Mika J,Witkowska E,Tymecka D,Ignaczak A,Wilenska B,Misicka A,Przewłocka B

    更新日期:2021-02-01 00:00:00

  • The use and reporting of neonatal pain scales: a systematic review of randomized trials.

    abstract:ABSTRACT:The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized trial...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002046

    authors: Olsson E,Ahl H,Bengtsson K,Vejayaram DN,Norman E,Bruschettini M,Eriksson M

    更新日期:2021-02-01 00:00:00

  • Brief preoperative mind-body therapies for total joint arthroplasty patients: a randomized controlled trial.

    abstract:ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002195

    authors: Hanley AW,Gililland J,Erickson J,Pelt C,Peters C,Rojas J,Garland EL

    更新日期:2021-01-12 00:00:00

  • Aberrant reactive aldehyde detoxification by aldehyde dehydrogenase-2 influences endometriosis development and pain-associated behaviors.

    abstract::Endometriosis affects ∼176 million women worldwide, yet on average, women experience pain ∼10 years from symptom onset before being properly diagnosed. Standard treatments (drugs or surgery) often fail to provide long-term pain relief. Elevated levels of reactive aldehydes such as 4-hydroxynonenal (4-HNE) have been im...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001949

    authors: McAllister SL,Sinharoy P,Vasu M,Gross ER

    更新日期:2021-01-01 00:00:00

  • Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain.

    abstract::Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling pathway has been shown to regulate synaptic differentiation and transmission. Therefore, this study was to investigate the function of the Notch signaling pathway in the ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002014

    authors: Duan H,Shen F,Li L,Tu Z,Chen P,Chen P,Wang Z,Liang W,Wang Y

    更新日期:2021-01-01 00:00:00

  • An experimental investigation into the mediating role of pain-related fear in boosting nocebo hyperalgesia.

    abstract::Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no treatment). The precise cognitive-emotional factors contributing to the origins of nocebo effects are poorly understood. We aimed to test the...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002017

    authors: Thomaidou MA,Veldhuijzen DS,Meulders A,Evers AWM

    更新日期:2021-01-01 00:00:00

  • Generalization of placebo pain relief.

    abstract:ABSTRACT:Efficacy of treatment is heavily dependent on experience and expectations. Moreover, humans can generalize from one experience to a perceptually similar but novel situation. We investigated whether and how this applies to pain relief, using ecologically valid tonic pain stimuli treated by surreptitiously lower...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002166

    authors: Kampermann L,Tinnermann A,Büchel C

    更新日期:2020-12-15 00:00:00

  • Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache.

    abstract::Chronic posttraumatic headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic nontraumatic headaches that manipu...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001983

    authors: Domenichiello AF,Jensen JR,Zamora D,Horowitz M,Yuan ZX,Faurot K,Mann JD,Mannes AJ,Ramsden CE

    更新日期:2020-12-01 00:00:00

  • Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of nonevoked ongoing pain.

    abstract::Currently, opioids targeting mu-opioid receptors are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a co...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001968

    authors: Massaly N,Temp J,Machelska H,Stein C

    更新日期:2020-12-01 00:00:00

  • Enhancing analgesic spinal cord stimulation for chronic pain with personalized immersive virtual reality.

    abstract:ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002160

    authors: Solcà M,Krishna V,Young N,Deogaonkar M,Herbelin B,Orepic P,Mange R,Rognini G,Serino A,Rezai A,Blanke O

    更新日期:2020-11-30 00:00:00

  • Reduction in movement-evoked pain and fatigue during initial 30-minute TENS treatment predicts TENS responders in women with fibromyalgia.

    abstract::We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002144

    authors: Vance CG,Zimmerman MB,Dailey DL,Rakel BA,Geasland KM,Chimenti RL,Williams JM,Golchha M,Crofford LJ,Sluka KA

    更新日期:2020-11-11 00:00:00

  • A randomized, controlled trial of a β2-agonist in painful polyneuropathy.

    abstract::Experimental data have suggested that in neuropathic pain, tricyclic antidepressants may work solely through a β2-agonist action. The aim of this study was to test if the β2-agonist terbutaline relieves painful polyneuropathy. The study was a randomized, double-blind, placebo-controlled and active-controlled, 3-way, c...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002140

    authors: Gillving M,Demant D,Holbech JV,Gylfadottir SS,Bach FW,Jensen TS,Finnerup NB,Sindrup SH

    更新日期:2020-11-06 00:00:00

  • Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion.

    abstract::Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001986

    authors: Salvo E,Campana WM,Scheff NN,Nguyen TH,Jeong SH,Wall I,Wu AK,Zhang S,Kim H,Bhattacharya A,Janal MN,Liu C,Albertson DG,Schmidt BL,Dolan JC,Schmidt RE,Boada MD,Ye Y

    更新日期:2020-11-01 00:00:00

  • Low back pain and the social determinants of health: a systematic review and narrative synthesis.

    abstract::The social determinants of health (SDH) are known to differentially impact outcomes from many noncommunicable diseases; however, their potential role in low back pain (LBP) is poorly defined. This review endeavours to comprehensively inform the field of their relevance. Our research question was: "How do the broad ran...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001944

    authors: Karran EL,Grant AR,Moseley GL

    更新日期:2020-11-01 00:00:00

  • Intrathecal delivery of hydromorphone vs morphine for refractory cancer pain: a multicenter, randomized, single-blind, controlled noninferiority trial.

    abstract::Hydromorphone is an alternative to morphine for intrathecal drug delivery system to treat refractory cancer pain; however, there is not enough clinical evidence to prove it. In our study, 233 patients from 12 different pain management centers across China were enrolled, 121 and 112 in the intrathecal hydromorphone (IT...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001957

    authors: Ma K,Jin Y,Wang L,Feng ZY,Song T,Yang XQ,Chen FQ,Duan BL,Huang YQ,Xie GL,Bao HG,Wang K,Xu JT,Lu Y,Liu YQ

    更新日期:2020-11-01 00:00:00

  • Altered trigeminal pain processing on brainstem level in persistent idiopathic facial pain.

    abstract::Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002126

    authors: Ziegeler C,Schulte LH,May A

    更新日期:2020-10-26 00:00:00

  • Different forms of traumatic brain injuries cause different tactile hypersensitivity profiles.

    abstract::Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been u...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002103

    authors: Wattiez AS,Castonguay WC,Gaul OJ,Waite JS,Schmidt CM,Reis AS,Rea BJ,Sowers LP,Cintrón-Pérez CJ,Vázquez-Rosa E,Pieper AA,Russo AF

    更新日期:2020-10-02 00:00:00

  • Small-fibre pathology has no impact on somatosensory system function in patients with fibromyalgia.

    abstract::We aimed to investigate whether small-fibre pathology, a common skin biopsy finding in patients with fibromyalgia, implies clinically important abnormalities of somatosensory system function and verify whether it is associated with voltage-gated sodium channel variants. In 57 consecutively enrolled patients with fibro...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001920

    authors: Fasolino A,Di Stefano G,Leone C,Galosi E,Gioia C,Lucchino B,Terracciano A,Di Franco M,Cruccu G,Truini A

    更新日期:2020-10-01 00:00:00

  • Patterns of prescription opioid utilization among adolescents and adults with comorbid chronic pain and mental health diagnosis.

    abstract::Our goal was to examine the association between mental health disorders (MHD) and subsequent risk of opioid use among commercially insured youth and adults (aged 14-64 years) with comorbid chronic noncancer pain (CNCP) conditions. We conducted a retrospective cohort study using IQVIA Health Plan Claims database from J...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001934

    authors: Olopoenia A,Onukwugha E,Simoni-Wastila L,Camelo-Castillo W,Villalonga-Olives E,Gandhi AB,Slejko J

    更新日期:2020-10-01 00:00:00

  • Sex- and age-specific genetic analysis of chronic back pain.

    abstract::Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002100

    authors: Freidin MB,Tsepilov YA,Stanaway IB,Meng W,Hayward C,Smith BH,Khoury S,Parisien M,Bortsov A,Diatchenko L,Børte S,Winsvold BS,Brumpton BM,Zwart JA,Aulchenko YS,Suri P,Williams FMK,HUNT All-In Pain.

    更新日期:2020-09-30 00:00:00

  • Systematic evaluation of commercially available pain management apps examining behavior change techniques.

    abstract:ABSTRACT:Mobile health (mHealth) apps have the potential to enhance pain management through the use of daily diaries, medication and appointment reminders, education, and facilitating communication between patients and providers. Although many pain management apps exist, the extent to which these apps use evidence-base...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002090

    authors: Gamwell KL,Kollin SR,Gibler RC,Bedree H,Bieniak KH,Jagpal A,Tran ST,Hommel KA,Ramsey RR

    更新日期:2020-09-22 00:00:00

  • Complex sociodemographic inequalities in consultations for low back pain: lessons from multilevel intersectional analysis.

    abstract:ABSTRACT:Sociodemographic inequalities in the occurrence of low back pain (LBP) are well-studied. This study aimed to examine complex sociodemographic inequalities in the risk of LBP consultation in the population from a socioeconomical intersectional perspective. Using register data, we identified 458,852 individuals ...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000002081

    authors: Kiadaliri A,Merlo J,Englund M

    更新日期:2020-09-16 00:00:00

  • Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.

    abstract:ABSTRACT:Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance. The...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001888

    authors: Doyle TM,Janes K,Chen Z,Grace PM,Esposito E,Cuzzocrea S,Largent-Milnes TM,Neumann WL,Watkins LR,Spiegel S,Vanderah TW,Salvemini D

    更新日期:2020-09-01 00:00:00

  • The efficacy of mindfulness-based interventions in acute pain: a systematic review and meta-analysis.

    abstract::Recent meta-analyses have shown mindfulness-based interventions (MBIs) to be effective for chronic pain, but no pooled estimates of the effect of MBIs on acute pain are available. This meta-analysis was conducted to fill that gap. A literature search was conducted in 4 databases. Articles were eligible if they reporte...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001877

    authors: Shires A,Sharpe L,Davies JN,Newton-John TRO

    更新日期:2020-08-01 00:00:00

  • Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models.

    abstract::Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 i...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001886

    authors: Stine C,Coleman DL,Flohrschutz AT,Thompson AL,Mishra S,Blagg BS,Largent-Milnes TM,Lei W,Streicher JM

    更新日期:2020-08-01 00:00:00

  • Localized sympathectomy reduces peripheral nerve regeneration and pain behaviors in 2 rat neuropathic pain models.

    abstract::Previous studies have shown that the peripheral nerve regeneration process is linked to pain in several neuropathic pain models. Other studies show that sympathetic blockade may relieve pain in some pain models and clinical conditions. This study examined reduction in peripheral nerve regeneration as one possible mech...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001887

    authors: Xie W,Strong JA,Zhang JM

    更新日期:2020-08-01 00:00:00

  • Almost 1 in 5 South African adults have chronic pain: a prevalence study conducted in a large nationally representative sample.

    abstract::Limited information on the prevalence and risk factors for chronic pain is available for developing countries. Therefore, we investigated the prevalence of chronic pain and the association between this pain and various personal and sociodemographic factors by including questions in the South Africa Demographic and Hou...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001844

    authors: Kamerman PR,Bradshaw D,Laubscher R,Pillay-van Wyk V,Gray GE,Mitchell D,Chetty S

    更新日期:2020-07-01 00:00:00

  • TRPV1 antagonist BCTC inhibits pH 6.0-induced pain in human skin.

    abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001848

    authors: Heber S,Ciotu CI,Hartner G,Gold-Binder M,Ninidze N,Gleiss A,Kress HG,Fischer MJM

    更新日期:2020-07-01 00:00:00

  • Treatment of chronic neuropathic pain: purine receptor modulation.

    abstract::Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001857

    authors: Jacobson KA,Giancotti LA,Lauro F,Mufti F,Salvemini D

    更新日期:2020-07-01 00:00:00

  • Brain networks and endogenous pain inhibition are modulated by age and sex in healthy rats.

    abstract::Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women and older people, making them more vulnerable to chronic pain. However, the underlying mechanisms remain unclear. Here, we used a capsaicin-ind...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001810

    authors: Da Silva JT,Tricou C,Zhang Y,Seminowicz DA,Ro JY

    更新日期:2020-06-01 00:00:00

  • Parent physical and mental health contributions to interpersonal fear avoidance processes in pediatric chronic pain.

    abstract::Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001820

    authors: Birnie KA,Heathcote LC,Bhandari RP,Feinstein A,Yoon IA,Simons LE

    更新日期:2020-06-01 00:00:00

  • Outcomes of prescription opioid dose escalation for chronic pain: results from a prospective cohort study.

    abstract::The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001817

    authors: Morasco BJ,Smith N,Dobscha SK,Deyo RA,Hyde S,Yarborough BJH

    更新日期:2020-06-01 00:00:00

  • Lasmiditan inhibits calcitonin gene-related peptide release in the rodent trigeminovascular system.

    abstract::Migraine headache pathophysiology involves trigeminovascular system activation, calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive transmission. Triptans are 5-HT1B/1D/(1F) receptor agonists that prejunctionally inhibit trigeminal CGRP release, but their vasoconstrictor properties limit thei...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001801

    authors: Labastida-Ramírez A,Rubio-Beltrán E,Haanes KA,Chan KY,Garrelds IM,Johnson KW,Danser AHJ,Villalón CM,MaassenVanDenBrink A

    更新日期:2020-05-01 00:00:00

  • Efficacy and safety of linaclotide for opioid-induced constipation in patients with chronic noncancer pain syndromes from a phase 2 randomized study.

    abstract::Constipation is the most common adverse event (AE) of opioid therapy. This multicenter, phase 2 study evaluated the efficacy and safety of linaclotide in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain syndromes (NCT02270983). Adults with OIC (<3 spontaneous bowel movements [SBMs]/we...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001754

    authors: Brenner DM,Argoff CE,Fox SM,Bochenek W,D'Astoli P,Blakesley RE,Reasner DS,O'Dea CR,Cash BD

    更新日期:2020-05-01 00:00:00

  • Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?

    abstract::The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001764

    authors: Cibert-Goton V,Kung VWS,McGuire C,Hockley JRF,Tranter MM,Dogra H,Belai A,Blackshaw LA,Sanger GJ,Knowles CH,Araujo EJA,Winchester WJ,Bulmer DC

    更新日期:2020-04-01 00:00:00

  • Graded chronic pain scale revised: mild, bothersome, and high-impact chronic pain.

    abstract::Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pa...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001758

    authors: Von Korff M,DeBar LL,Krebs EE,Kerns RD,Deyo RA,Keefe FJ

    更新日期:2020-03-01 00:00:00

  • Evaluating the efficacy of an attention modification program for patients with fibromyalgia: a randomized controlled trial.

    abstract::Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001746

    authors: Carleton RN,Asmundson GJG,Korol SL,LeBouthillier DM,Hozempa K,Katz JD,Vlaeyen JWS,Crombez G

    更新日期:2020-03-01 00:00:00

  • Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.

    abstract::Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits ne...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001738

    authors: Wu M,Li Z,Liang L,Ma P,Cui D,Chen P,Wu G,Song XJ

    更新日期:2020-03-01 00:00:00

  • Assessing the content specificity of interpretation biases in community adolescents with persistent and interfering pain.

    abstract::The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is c...

    journal_title:Pain

    pub_type: 杂志文章

    doi:10.1097/j.pain.0000000000001723

    authors: Lau JYF,Badaoui M,Meehan AJ,Heathcote LC,Barker ED,Rimes KA

    更新日期:2020-02-01 00:00:00

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