解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:ABSTRACT:High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces spinal glial activation in a Toll-like receptor (TLR)4-dependent fashion, the aspect of sexual dimorphisms has not been thoroughly...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002033
更新日期:2021-02-01 00:00:00
abstract:ABSTRACT:The purpose of our work was to determine the role of nonopioid peptides derived from opioid prohormones in sensory hypersensitivity characteristics of neuropathic pain and to propose a pharmacological approach to restore the balance of these endogenous opioid systems. Nonopioid peptides may have a pronocicepti...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002045
更新日期:2021-02-01 00:00:00
abstract:ABSTRACT:The burden of pain in newborn infants has been investigated in numerous studies, but little is known about the appropriateness of the use of pain scales according to the specific type of pain or infant condition. This systematic review aimed to evaluate the reporting of neonatal pain scales in randomized trial...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002046
更新日期:2021-02-01 00:00:00
abstract:ABSTRACT:While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain. Improving surgical pain management is essential. We conducted a single-site, three-arm, parallel-group random...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002195
更新日期:2021-01-12 00:00:00
abstract::Endometriosis affects ∼176 million women worldwide, yet on average, women experience pain ∼10 years from symptom onset before being properly diagnosed. Standard treatments (drugs or surgery) often fail to provide long-term pain relief. Elevated levels of reactive aldehydes such as 4-hydroxynonenal (4-HNE) have been im...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001949
更新日期:2021-01-01 00:00:00
abstract::Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling pathway has been shown to regulate synaptic differentiation and transmission. Therefore, this study was to investigate the function of the Notch signaling pathway in the ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002014
更新日期:2021-01-01 00:00:00
abstract::Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no treatment). The precise cognitive-emotional factors contributing to the origins of nocebo effects are poorly understood. We aimed to test the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002017
更新日期:2021-01-01 00:00:00
abstract:ABSTRACT:Efficacy of treatment is heavily dependent on experience and expectations. Moreover, humans can generalize from one experience to a perceptually similar but novel situation. We investigated whether and how this applies to pain relief, using ecologically valid tonic pain stimuli treated by surreptitiously lower...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002166
更新日期:2020-12-15 00:00:00
abstract::Chronic posttraumatic headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic nontraumatic headaches that manipu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001983
更新日期:2020-12-01 00:00:00
abstract::Currently, opioids targeting mu-opioid receptors are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a co...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001968
更新日期:2020-12-01 00:00:00
abstract:ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002160
更新日期:2020-11-30 00:00:00
abstract::We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002144
更新日期:2020-11-11 00:00:00
abstract::Experimental data have suggested that in neuropathic pain, tricyclic antidepressants may work solely through a β2-agonist action. The aim of this study was to test if the β2-agonist terbutaline relieves painful polyneuropathy. The study was a randomized, double-blind, placebo-controlled and active-controlled, 3-way, c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002140
更新日期:2020-11-06 00:00:00
abstract::Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here, we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compared with patients without PNI, suggesting that unique mechanisms drive PNI-induced pain. We studied the impact of PNI on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001986
更新日期:2020-11-01 00:00:00
abstract::The social determinants of health (SDH) are known to differentially impact outcomes from many noncommunicable diseases; however, their potential role in low back pain (LBP) is poorly defined. This review endeavours to comprehensively inform the field of their relevance. Our research question was: "How do the broad ran...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001944
更新日期:2020-11-01 00:00:00
abstract::Hydromorphone is an alternative to morphine for intrathecal drug delivery system to treat refractory cancer pain; however, there is not enough clinical evidence to prove it. In our study, 233 patients from 12 different pain management centers across China were enrolled, 121 and 112 in the intrathecal hydromorphone (IT...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001957
更新日期:2020-11-01 00:00:00
abstract::Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002126
更新日期:2020-10-26 00:00:00
abstract::Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been u...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002103
更新日期:2020-10-02 00:00:00
abstract::We aimed to investigate whether small-fibre pathology, a common skin biopsy finding in patients with fibromyalgia, implies clinically important abnormalities of somatosensory system function and verify whether it is associated with voltage-gated sodium channel variants. In 57 consecutively enrolled patients with fibro...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001920
更新日期:2020-10-01 00:00:00
abstract::Our goal was to examine the association between mental health disorders (MHD) and subsequent risk of opioid use among commercially insured youth and adults (aged 14-64 years) with comorbid chronic noncancer pain (CNCP) conditions. We conducted a retrospective cohort study using IQVIA Health Plan Claims database from J...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001934
更新日期:2020-10-01 00:00:00
abstract::Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002100
更新日期:2020-09-30 00:00:00
abstract:ABSTRACT:Mobile health (mHealth) apps have the potential to enhance pain management through the use of daily diaries, medication and appointment reminders, education, and facilitating communication between patients and providers. Although many pain management apps exist, the extent to which these apps use evidence-base...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002090
更新日期:2020-09-22 00:00:00
abstract:ABSTRACT:Sociodemographic inequalities in the occurrence of low back pain (LBP) are well-studied. This study aimed to examine complex sociodemographic inequalities in the risk of LBP consultation in the population from a socioeconomical intersectional perspective. Using register data, we identified 458,852 individuals ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002081
更新日期:2020-09-16 00:00:00
abstract:ABSTRACT:Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance. The...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001888
更新日期:2020-09-01 00:00:00
abstract::Recent meta-analyses have shown mindfulness-based interventions (MBIs) to be effective for chronic pain, but no pooled estimates of the effect of MBIs on acute pain are available. This meta-analysis was conducted to fill that gap. A literature search was conducted in 4 databases. Articles were eligible if they reporte...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001877
更新日期:2020-08-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) is a ubiquitous signal transduction regulator, and Hsp90 inhibitors are in clinical development as cancer therapeutics. However, there have been very few studies on the impact of Hsp90 inhibitors on pain or analgesia, a serious concern for cancer patients. We previously found that Hsp90 i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001886
更新日期:2020-08-01 00:00:00
abstract::Previous studies have shown that the peripheral nerve regeneration process is linked to pain in several neuropathic pain models. Other studies show that sympathetic blockade may relieve pain in some pain models and clinical conditions. This study examined reduction in peripheral nerve regeneration as one possible mech...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001887
更新日期:2020-08-01 00:00:00
abstract::Limited information on the prevalence and risk factors for chronic pain is available for developing countries. Therefore, we investigated the prevalence of chronic pain and the association between this pain and various personal and sociodemographic factors by including questions in the South Africa Demographic and Hou...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001844
更新日期:2020-07-01 00:00:00
abstract::Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001848
更新日期:2020-07-01 00:00:00
abstract::Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses 4 G-protein-coupled receptors (GPCRs) for adenosine, 8 GPCRs activated by nucleotides, 7 adenosine 5'-triphosphate-gated P2X ion channels, as well as the associated enzymes and transpor...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001857
更新日期:2020-07-01 00:00:00
abstract::Endogenous pain inhibition is less efficient in chronic pain patients. Diffuse noxious inhibitory control (DNIC), a form of endogenous pain inhibition, is compromised in women and older people, making them more vulnerable to chronic pain. However, the underlying mechanisms remain unclear. Here, we used a capsaicin-ind...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001810
更新日期:2020-06-01 00:00:00
abstract::Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001820
更新日期:2020-06-01 00:00:00
abstract::The use of long-term opioid therapy for chronic pain remains common, yet data on long-term outcomes, especially after dose escalation, are sparse. This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001817
更新日期:2020-06-01 00:00:00
abstract::Migraine headache pathophysiology involves trigeminovascular system activation, calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive transmission. Triptans are 5-HT1B/1D/(1F) receptor agonists that prejunctionally inhibit trigeminal CGRP release, but their vasoconstrictor properties limit thei...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001801
更新日期:2020-05-01 00:00:00
abstract::Constipation is the most common adverse event (AE) of opioid therapy. This multicenter, phase 2 study evaluated the efficacy and safety of linaclotide in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain syndromes (NCT02270983). Adults with OIC (<3 spontaneous bowel movements [SBMs]/we...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001754
更新日期:2020-05-01 00:00:00
abstract::The ability to sense visceral pain during appendicitis is diminished with age leading to delay in seeking health care and poorer clinical outcomes. To understand the mechanistic basis of this phenomenon, we examined visceral nociception in aged mouse and human tissue. Inflamed and noninflamed appendixes were collected...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001764
更新日期:2020-04-01 00:00:00
abstract::Drawing on advances in chronic pain metrics, a simplified Graded Chronic Pain Scale-Revised was developed to differentiate mild, bothersome, and high-impact chronic pain. Graded Chronic Pain Scale-Revised was validated among adult enrollees of 2 health plans (N = 2021). In this population, the prevalence of chronic pa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001758
更新日期:2020-03-01 00:00:00
abstract::Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001746
更新日期:2020-03-01 00:00:00
abstract::Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits ne...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001738
更新日期:2020-03-01 00:00:00
abstract::The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001723
更新日期:2020-02-01 00:00:00