Abstract：
:Nociception was studied in male mice, mostly of the C57BL/6 strain, during continuous or prolonged restriction of caloric intake (60% of ad-libitum) from midlife to senescence (up to 105 weeks). Restricted mice showed fewer licking or biting responses 20-60 min after hind paw injection of 5% formalin at 46 and 70 weeks, but not at 93 weeks. Also, they showed longer response latencies around 46 weeks of age in the 52 degrees C hot-plate test, which partial tail amputation failed to affect, although it did produce at least 2 weeks of chronic neuropathic hypersensitivity in ad libitum controls. Injection of collagen subcutaneously at 36-42 weeks led to chronic hyperalgesia in the DBA/1 but not the C57BL/6 strain, measured weekly by the barely nociceptive 50 degrees C hot-plate test to minimize damage. This collagen-induced arthritic hyperalgesia was then gradually and reversibly blocked during 9-15 weeks of caloric restriction starting at 53-58 weeks. In longitudinal trials on normal mice, performed every 2-4 weeks between 42 and 105 weeks with the 50 degrees C hot-plate, caloric restriction led to altered latencies (higher relative to controls) only in the last 10-20 weeks, perhaps because it delayed the onset of age-related peripheral neuropathies. In conclusion, long-term caloric restriction leads to significant hypoalgesia in pre-senescent mice subjected to above-threshold pain of widely different durations, the effect disappearing at later ages unless spontaneous neuropathies become influential. A reduction in cumulative food intake thus appears to generate antinociceptive signals in adult male mice, perhaps serving specifically to promote riskier behavior during prolonged food shortages.
journal_name
Painjournal_title
Painauthors
Hargraves WA,Hentall IDdoi
10.1016/j.pain.2005.01.010keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
455-461issue
3eissn
0304-3959issn
1872-6623pii
00006396-200504000-00017journal_volume
114pub_type
杂志文章相关文献
PAIN文献大全abstract：:Current treatments for post-injury movement-evoked pain are inadequate. Non-opioids may complement opioids, which preferentially reduce spontaneous pain, but most have incomplete efficacy as single agents. This trial evaluates efficacy of a gabapentin-rofecoxib combination following hysterectomy. In addition to IV-PCA...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2004.10.008
更新日期：2005-01-01 00:00:00
abstract：:Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Nonhistaminergic itch pathways are suggested to dominate in AD itch, contributing to an "itch-scratch-itch cycle" that prolongs and worsens itch, pain, and skin lesions. We hypothesized that nonhistaminergic neuronal sensitization contributes to i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000980
更新日期：2017-09-01 00:00:00
abstract：:Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2012.06.010
更新日期：2012-11-01 00:00:00
abstract：:Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when u...
journal_title：Pain
pub_type： 杂志文章,多中心研究
doi：10.1097/j.pain.0000000000000927
更新日期：2017-08-01 00:00:00
abstract：:Nonopioid agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are the most commonly used class of analgesics. Increasing evidence suggests that cyclooxygenase (COX) inhibition at both peripheral and central sites can contribute to the antihyperalgesic effects of NSAIDs, with the predominant clinical effect ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1097/j.pain.0000000000000176
更新日期：2015-07-01 00:00:00
abstract：:Loss of high-voltage-activated (HVA) calcium current (ICa) and gain of low-voltage-activated (LVA) ICa after painful peripheral nerve injury cause elevated excitability in sensory neurons. Nerve injury is also accompanied by increased expression of the extracellular matrix glycoprotein thrombospondin-4 (TSP4), and int...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000612
更新日期：2016-09-01 00:00:00
abstract：:In a study to determine how children describe the experience of pain, we queried a convenience sample of 100 children in hospitals and 114 children in church and private schools who were between 9 and 12 years old. The questions were designed to seek correlations by age among boys and girls, and between hospitalized a...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(82)90091-4
更新日期：1982-10-01 00:00:00
abstract：:Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001848
更新日期：2020-07-01 00:00:00
abstract：:Tanezumab is a humanized monoclonal antinerve growth factor antibody in development for treatment of chronic pain. In a phase III, placebo- and active-controlled study, we investigated the efficacy and safety of tanezumab for osteoarthritis (OA) hip or knee pain. Patients (N=610) received up to 2 doses of intravenous ...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2013.04.035
更新日期：2013-09-01 00:00:00
abstract：:This report describes a placebo-controlled study of transcutaneous electrical nerve stimulation (TENS) applied to the contralateral lower leg and outer ears of an amputee with non-painful phantom sensations. The subject received TENS or placebo stimulation on separate sessions in which baseline periods of no stimulati...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(89)90098-5
更新日期：1989-03-01 00:00:00
abstract：:OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in pat...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000119
更新日期：2015-05-01 00:00:00
abstract：:Current opinion concerning the pathophysiology of tension-type headache (TTH) and its related pericranial muscle tenderness proposes a primary role of central sensitization at the level of dorsalhorn/trigeminal nucleus as well as the supraspinal level. Investigation of these phenomena can be conducted using laser-evok...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00485-2
更新日期：2003-07-01 00:00:00
abstract：:To quantify performance differences between patients with low-back pain (LBP) and a control group during their performance of a repetitive isodynamic lifting task. Case-control study was done. LBP patients were recruited and tested at an outpatient ambulatory chronic pain rehabilitation program before treatment was be...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(03)00247-1
更新日期：2003-09-01 00:00:00
abstract：:Effects of electrical stimulation of the cervical vagus nerve were determined in cervical or lumbar spinal neurons in 27 rats anesthetized with pentobarbital. Ipsilateral cervical vagus stimulation (ICVS) increased activity of 44 neurons in the C1 segment. At the same stimulation parameters, contralateral cervical vag...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90013-2
更新日期：1992-10-01 00:00:00
abstract：:Forty patients with chronic pain below the waist level not amenable to conventional medical and/or surgical treatment were randomly assigned to one or two different methods of acupuncture, after studying the underlying pain mechanisms using a Multidisciplinary Pain Clinic approach and the differential spinal block (DS...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(76)90006-3
更新日期：1976-09-01 00:00:00
abstract：:Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain leve...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(92)90054-F
更新日期：1992-02-01 00:00:00
abstract：:Is a person's response to one noxious stimulus similar to his/her responses to other noxious stimuli? This long-investigated topic in pain research has provided inconclusive results. In the present study, 2 samples were studied: one using 60 healthy volunteers and the other using 29 patients with coronary artery disea...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)90135-X
更新日期：1994-09-01 00:00:00
abstract：:Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.04.022
更新日期：2006-11-01 00:00:00
abstract：:A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(89)90023-7
更新日期：1989-02-01 00:00:00
abstract：:After 4 millennia of more or less documented history of cannabis use, the identification of cannabinoids, and of Δ(9)-tetrahydrocannabinol in particular, occurred only during the early 1960s, and the cloning of cannabinoid CB1 and CB2 receptors, as well as the discovery of endocannabinoids and their metabolic enzymes,...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/j.pain.2013.03.023
更新日期：2013-12-01 00:00:00
abstract：:Intradental nerve activity (INA) induced by cold stimulation of human teeth is regularly accompanied by pain perception. In this study a mathematical model was developed in order to quantify the relationship between INA and pain. In 5 patients (45 experiments) INA was recorded using electrodes implanted in lower incis...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90052-6
更新日期：1984-04-01 00:00:00
abstract：:We describe qualitative and quantitative development and preliminary validation of the Patient Assessment for Low Back Pain-Impacts (PAL-I), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Concept elicitation and cognitive interviews (qualitative methods) were used to identi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001309
更新日期：2018-10-01 00:00:00
abstract：:The assessment and development of pain in children is reviewed in the first part of a two-part series. Assessment of pain in children has relied on self-report measures that have included visual analogue procedures using concrete stimuli for ratings. Behavioral assessment procedures are more sophisticated, but researc...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/0304-3959(86)90206-X
更新日期：1986-11-01 00:00:00
abstract：:The processes of individual adaptation to chronic pain are complex and occur across multiple domains. We examined the social, cognitive, and affective context of daily pain adaptation in individuals with fibromyalgia and osteoarthritis. By using a sample of 260 women with fibromyalgia or osteoarthritis, we examined th...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2013.10.007
更新日期：2014-02-01 00:00:00
abstract：:Cultures differ as to typical linguistic reports and classifications of pain. In some languages upwards of a dozen specific pain terms are in common use, each indicating a particular pain experience. In other languages a single inclusive term is the norm, perhaps with optional qualifiers added to make desired distinct...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(80)90025-1
更新日期：1980-08-01 00:00:00
abstract：:On a no treatment trial, a group of 24 oriental subjects rated cold pressor pain as significantly more painful and distressing than did a group of 24 occidental subjects. For half of the Orientals and half of the Occidentals, a second trial was conducted after acupuncture analgesia had been induced. The remaining 12 O...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(77)90086-0
更新日期：1977-10-01 00:00:00
abstract：:The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90152-2
更新日期：1992-05-01 00:00:00
abstract：:Age and sex differences were investigated in children's self-report of venipuncture pain. Equal numbers of boys and girls aged 3-15 years (n = 110) made separate ratings of the intensity and unpleasantness of their needle pain, using a paired Visual Analogue Scale (VAS) technique. The parents of these children used th...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(98)00201-2
更新日期：1999-03-01 00:00:00
abstract：:Chronic pain is currently considered a public health problem with high costs to the individual and society. To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain. The aims of this study were to estimate the prevalence of chronic pain in the adult Danish pop...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.07.023
更新日期：2012-12-01 00:00:00
abstract：:Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001676
更新日期：2019-12-01 00:00:00
