Abstract:
:Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were injected in the volar forearm skin of 32 healthy volunteers. To investigate possible redundancies between channels, a full-factorial study design was used. Injections were performed in a prerandomized, double-blind, and balanced design. Each injection included a three-step pH protocol from pH 7.0 over pH 6.5 to pH 6.0 with a step duration of 90 seconds. Pain was reported by volunteers on a numerical scale every 10 seconds during injections. Confirming the primary hypothesis, the combination of all 3 antagonists reduced acid-induced pain at pH 6.0. Because of the full-factorial design, it could be concluded that BCTC alone, but not A-967079 or amiloride, or any combination thereof, was responsible for the observed effects, suggesting TRPV1 as primary sensor for pH 6.0-induced pain. Surprisingly, A-967079 even enhanced pain induced by pH 6.0. In cultured mouse dorsal root ganglion neurons, TPRV1 dependence of pH 6-induced calcium responses could be confirmed. Responses of hTRPV1 to acidic stimulation showed a maximum around pH6, providing an explanation for the pH-dependent inhibition by BCTC. A-967079 sensitizes pH responses is a TRPA1-responsive dorsal root ganglion neuron population, and a direct effect of A-967079 on hTRPA1 and hTRPV1 was excluded. In conclusion, inhibiting TRPV1-mediated acidosis-induced pain could be a symptomatic and potentially also a disease-modifying approach.
journal_name
Painjournal_title
Painauthors
Heber S,Ciotu CI,Hartner G,Gold-Binder M,Ninidze N,Gleiss A,Kress HG,Fischer MJMdoi
10.1097/j.pain.0000000000001848subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1532-1541issue
7eissn
0304-3959issn
1872-6623pii
00006396-202007000-00011journal_volume
161pub_type
杂志文章相关文献
PAIN文献大全abstract::Recent studies demonstrate that some brain structures activated by pain are also engaged when an individual observes someone else in pain, and that these empathy-related responses are modulated as a function of the affective link between the empath and the individual in pain. In this study we test the hypothesis that ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.07.017
更新日期:2008-05-01 00:00:00
abstract::Is a person's response to one noxious stimulus similar to his/her responses to other noxious stimuli? This long-investigated topic in pain research has provided inconclusive results. In the present study, 2 samples were studied: one using 60 healthy volunteers and the other using 29 patients with coronary artery disea...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90135-X
更新日期:1994-09-01 00:00:00
abstract::The role of 5-hydroxytryptamine (5-HT)(4), 5-HT(6), and 5-HT(7) receptors in formalin-induced secondary allodynia and hyperalgesia in rats was assessed. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term secondary mechanical allodynia and hyperalgesia. Pretreatment (-10...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.020
更新日期:2011-03-01 00:00:00
abstract::Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained im...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90218-M
更新日期:1991-12-01 00:00:00
abstract::Injection of high-dose of morphine into the spinal lumbar intrathecal (i.t.) space of rats elicits a nociceptive behavioural syndrome characterized by periodic bouts of spontaneous agitation and severe vocalization. The induced behavioural response such as vocalization and agitation was observed dose-dependently by i....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00296-3
更新日期:2003-12-01 00:00:00
abstract::Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002126
更新日期:2020-10-26 00:00:00
abstract::A secondary zone of cutaneous hyperalgesia in humans is characterized by increased pain to mechanical stimuli. In contrast, the perception of heat stimuli delivered to a secondary zone of hyperalgesia in humans often shows a paradoxical decrease in magnitude. A number of studies have shown that the responses of spinal...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(98)00079-7
更新日期:1998-08-01 00:00:00
abstract::Neuropathic pain affects millions of people worldwide, causing substantial disability and greatly impairing quality of life. Commonly used analgesics or antihyperalgesic compounds are generally characterized by limited therapeutic outcomes. Thus, there is a compelling need for novel therapeutic strategies able to prev...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.06.023
更新日期:2014-10-01 00:00:00
abstract::This study critically examines the reported exercise-induced analgesia effect in view of the potential stress-induced analgesia of pain testing itself. Two designs were used to test whether previous findings of analgesia were induced by the exercise procedures or by the stress of the pain testing procedures themselves...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90048-G
更新日期:1992-02-01 00:00:00
abstract::Neuropathic pain can be a predictor of severe emotional distress, up to full-blown depressive states. In these patients, it is important to move beyond the sole treatment of pain, to recognize depressive symptoms, and to ultimately improve the quality of life. We systematically searched for published and unpublished c...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001622
更新日期:2019-10-01 00:00:00
abstract::Skin conductance and heart rate measures obtained from subjects previous to, during, and after their performance of the cold pressor task were correlated with their responses to the McGill Pain Questionnaire administered immediately after the completion of the cold pressor task. A reliable relationship between skin co...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(82)90146-4
更新日期:1982-01-01 00:00:00
abstract::Mindfulness-based stress reduction (MBSR) is a structured 8-week group program teaching mindfulness meditation and mindful yoga exercises. MBSR aims to help participants develop nonjudgmental awareness of moment-to-moment experience. Fibromyalgia is a clinical syndrome with chronic pain, fatigue, and insomnia as major...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.10.043
更新日期:2011-02-01 00:00:00
abstract::Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001746
更新日期:2020-03-01 00:00:00
abstract::Ten patients with organic nerve injury causing chronic neuropathic pain were tested for the effects of intravenous lidocaine versus saline upon psychophysical somatosensory variables. The variables assessed were the subjective magnitude of pain, area of mechanical hyperalgesia and presence and magnitude of thermal hea...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(92)90087-R
更新日期:1992-03-01 00:00:00
abstract::A series of 37 patients with chronic pain was investigated with regard to neurologic and psychiatric variables. Twenty of the patients were classified as having mainly organic (= somatogenic) pain syndromes while 17 patients were rather suffering from psychogenic pain syndromes. Samples of lumbar cerebrospinal fluid (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(78)90037-4
更新日期:1978-08-01 00:00:00
abstract::When faced with the problem of pain one can attempt a solution aimed at relief (assimilation) or a solution aimed at acceptance (accommodation). Using this dual process model of adaptation to pain, this study compares acute and chronic pain patients on their approach to problem solving. Three hundred and sixty-four pa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.10.020
更新日期:2008-07-31 00:00:00
abstract::Central poststroke pain (CPSP) is one of the most refractory chronic pain syndromes. Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex has been demonstrated to provide moderate pain relief for CPSP. However, the mechanism underlying the pain relief remains unclear. The objective of this s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.04.017
更新日期:2013-08-01 00:00:00
abstract::Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00481-X
更新日期:2002-04-01 00:00:00
abstract::The opiate antagonist naloxone has been reported to cause pain relief. Therefore, the effect was determined of naloxone, injected intravenously, on the activity in single neurones of the dorsomedial part of the ventral nucleus (VDM) in the thalamus of rats under urethane anaesthesia elicited by electrical stimulation ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90144-3
更新日期:1988-12-01 00:00:00
abstract:UNLABELLED:The German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) comprised 424 outpatients with chronic shoulder pain (CSP) > or =6 weeks and an average pain score of VAS > or =50 mm, who were randomly assigned to receive Chinese acupuncture (verum), sham acupuncture (sham) or conventional conservat...
journal_title:Pain
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.pain.2010.06.036
更新日期:2010-10-01 00:00:00
abstract::microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.11.010
更新日期:2013-03-01 00:00:00
abstract::As part of a comprehensive study of the natural history of herpes zoster (HZ), 57 of 94 subjects in a cohort at elevated risk for post-herpetic neuralgia (PHN) consented to collection of 3-mm skin punch biopsies from affected, mirror-image, and distant control skin at baseline and followup visits. As cutaneous innerva...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.04.002
更新日期:2010-07-01 00:00:00
abstract::Opioid use for chronic pain is limited by severe central adverse effects. We examined whether activating mu-opioid receptors (MORs) in the peripheral nervous system attenuates spinal cord injury (SCI) pain-like behavior in mice. We produced a contusive SCI at the T10 vertebral level and examined motor and sensory dysf...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001671
更新日期:2019-12-01 00:00:00
abstract::The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2006.01.041
更新日期:2006-08-01 00:00:00
abstract::(1) Capsaicin solution was applied for 15 min around a 1 cm length of sciatic nerve in the mid upper leg of adult rats. (2) Electron microscopic examinations of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibres attributable to the capsaicin. (3) Fl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(81)90637-0
更新日期:1981-12-01 00:00:00
abstract::Forty patients with cancer pain receiving intermittent narcotics were admitted to a prospective study designed to assess the cognitive effects of narcotics. Twenty patients had undergone no change in narcotic dose or type greater than or equal to 7 days (stable dose, SD, group), and 20 patients had undergone an increa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(89)90169-3
更新日期:1989-10-01 00:00:00
abstract::Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood. We here detected the ROS-gen...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.013
更新日期:2014-10-01 00:00:00
abstract::The role of proinflammatory cytokines in neuropathic and inflammatory pain is well established. Recent studies suggest that cytokines such as tumor necrosis factor-alpha (TNF) may also be involved in the development of muscle pain. To investigate the pathophysiology of intramuscular TNF, exogenous TNF (0.1-10 microg),...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00115-5
更新日期:2003-08-01 00:00:00
abstract::Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. The aims of this study were to investigate the infl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001400
更新日期:2019-01-01 00:00:00
abstract::Low Back Pain Rating scale is an index scale which includes measurements of pain intensity, disability, and physical impairment. The scale was designed to monitor the outcome of clinical trials of low back pain treatment. It has been validated in 58 patients following first-time discectomy. The scale rating can be rap...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(94)90007-8
更新日期:1994-06-01 00:00:00