Endorphins in chronic pain. I. Differences in CSF endorphin levels between organic and psychogenic pain syndromes.

abstract：:There is evidence of greater opioid prescription to individuals in the United States with mental health conditions. Whether these associations generalize beyond the US prescription environment and to familial mental health and socioeconomic status (SES) has not been examined comprehensively. This study estimated assoc...

journal_title：Pain

authors： Quinn PD,Rickert ME,Franck J,Sariaslan A,Boersma K,Lichtenstein P,Larsson H,D'Onofrio BM

更新日期：2019-11-01 00:00:00

abstract：:Tactile, proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response. To study differences in the processing of different stimulus qualities, we performed a study based on functional magnetic resonance imaging. The first trigeminal branch (o...

journal_title：Pain

authors： Iannilli E,Del Gratta C,Gerber JC,Romani GL,Hummel T

更新日期：2008-10-15 00:00:00

abstract：:The local anesthetic lidocaine was injected into the dentate gyrus (DG) of alert, unrestrained rats 10 min prior to investigation within the formalin test. Regional anesthesia of the DG resulted in a reduction of pain scores when administered contralateral to the site of subcutaneous formalin injection. The analgesic ...

journal_title：Pain

authors： McKenna JE,Melzack R

更新日期：1992-04-01 00:00:00

abstract：:The nociceptive flexion reflex (NFR) has been used as a psychophysiological tool to study spinal nociceptive processes in numerous clinical and experimental studies. Despite widespread use of the NFR, few attempts have been made to empirically test and compare different scoring criteria to detect the presence/absence ...

journal_title：Pain

authors： France CR,Rhudy JL,McGlone S

更新日期：2009-09-01 00:00:00

abstract：:The habituation to sensory stimuli of different modalities is reduced in migraine patients. However, the habituation to pain has never been evaluated. Our aim was to assess the nociceptive pathway function and the habituation to experimental pain in patients with migraine. Scalp potentials were evoked by CO(2) laser s...

journal_title：Pain

authors： Valeriani M,de Tommaso M,Restuccia D,Le Pera D,Guido M,Iannetti GD,Libro G,Truini A,Di Trapani G,Puca F,Tonali P,Cruccu G

更新日期：2003-09-01 00:00:00

abstract：:Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...

journal_title：Pain

authors： Moss A,Beggs S,Vega-Avelaira D,Costigan M,Hathway GJ,Salter MW,Fitzgerald M

更新日期：2007-04-01 00:00:00

abstract：:Brief electrical pulses were applied to the pulp of individual pre-molar teeth of 14 healthy, adult volunteers via wire electrodes implanted and sealed in dentine. The sensation threshold was estimated in each individual by the Two-Alternative Forced-Choice Staircase (2AFCS) method. Seven, 5 or 4 stimulus intensities ...

journal_title：Pain

authors： Fernandes de Lima VM,Chatrian GE,Lettich E,Canfield RC,Miller CR,Soso MJ

更新日期：1982-11-01 00:00:00

abstract：:Capsaicin has been used extensively as an experimental tool and in traditional and proprietary topical medications for acute soft tissue injuries. More recently it has been prescribed for several chronic pain conditions where it is usually administered topically for periods of several weeks. Here we have studied the c...

journal_title：Pain

authors： McMahon SB,Lewin G,Bloom SR

更新日期：1991-03-01 00:00:00

abstract：:Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...

journal_title：Pain

authors： Wylde V,Lenguerrand E,Gooberman-Hill R,Beswick AD,Marques E,Noble S,Horwood J,Pyke M,Dieppe P,Blom AW

更新日期：2015-06-01 00:00:00

abstract：ABSTRACT:Efficacy of treatment is heavily dependent on experience and expectations. Moreover, humans can generalize from one experience to a perceptually similar but novel situation. We investigated whether and how this applies to pain relief, using ecologically valid tonic pain stimuli treated by surreptitiously lower...

journal_title：Pain

authors： Kampermann L,Tinnermann A,Büchel C

更新日期：2020-12-15 00:00:00

abstract：:Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood. We here detected the ROS-gen...

journal_title：Pain

authors： Kallenborn-Gerhardt W,Hohmann SW,Syhr KM,Schröder K,Sisignano M,Weigert A,Lorenz JE,Lu R,Brüne B,Brandes RP,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：:Internet-delivered interventions are emerging as a strategy to address barriers to care for individuals with chronic pain. This is the first large multicenter randomized controlled trial of Internet-delivered cognitive-behavioral therapy (CBT) for pediatric chronic pain. Participants included were 273 adolescents (205...

journal_title：Pain

authors： Palermo TM,Law EF,Fales J,Bromberg MH,Jessen-Fiddick T,Tai G

更新日期：2016-01-01 00:00:00

abstract：:Using the indirect immunofluorescence method, the distribution of cyclic GMP (cGMP) and nitric oxide synthase (NOS) was investigated in lumbar 5 dorsal root ganglia (DRGs) of untreated rats 1, 3 and 7 days following sciatic nerve section (axotomy). Untreated and axotomized (7 days) rats were also studied after perfusi...

journal_title：Pain

authors： Sten Shi TJ,Holmberg K,Xu ZD,Steinbusch H,de Vente J,Hökfelt T

更新日期：1998-12-01 00:00:00

abstract：:Fifty adult patients with chronic pain and substance dependence were admitted to an inpatient unit for treatment of addiction without primary emphasis on treatment of pain. As a group they had received considerable medical attention for their pain, but relatively little for their addictions. When compared with a group...

journal_title：Pain

authors： Finlayson RE,Maruta T,Morse RM,Swenson WM,Martin MA

更新日期：1986-08-01 00:00:00

abstract：:Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricula often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resou...

journal_title：Pain

authors： Liossi C,Failo A,Schoth DE,Williams G,Howard RF

更新日期：2018-04-01 00:00:00

abstract：:To assess the efficacy of 4% topical lidocaine in spheno-palatine blocks, a randomized controlled trial was carried out on patients with chronic muscle pain syndromes. Sixty-one patients (42 with fibromyalgia (FM) and 19 with myofascial pain syndrome (MPS)) completed the trial. Outcome measures included pain intensity...

journal_title：Pain

authors： Scudds RA,Janzen V,Delaney G,Heck C,McCain GA,Russell AL,Teasell RW,Varkey G,Woodbury GM

更新日期：1995-07-01 00:00:00

abstract：:Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...

journal_title：Pain

authors： Clark AJ,Menendez G,AlQatari M,Patel N,Arstad E,Schiavo G,Koltzenburg M

更新日期：2018-07-01 00:00:00

abstract：:Snakebites are a relevant public health problem in Central and South America. Snake bite envenomations cause intense pain, not relieved by anti-venom. The fangs of many species are short, causing subcutaneous injection. Fangs of larger species inflict subcutaneous or intramuscular envenomation. To understand pain indu...

journal_title：Pain

authors： Chacur M,Gutiérrez JM,Milligan ED,Wieseler-Frank J,Britto LR,Maier SF,Watkins LR,Cury Y

更新日期：2004-09-01 00:00:00

abstract：:A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence has demonstrated a correlation between the expression of some of these molecular markers and transmission of signals related to distinct ...

journal_title：Pain

authors： Shields SD,Ahn HS,Yang Y,Han C,Seal RP,Wood JN,Waxman SG,Dib-Hajj SD

更新日期：2012-10-01 00:00:00

abstract：:Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of m...

journal_title：Pain

authors： Staud R,Cannon RC,Mauderli AP,Robinson ME,Price DD,Vierck CJ Jr

更新日期：2003-03-01 00:00:00

abstract：:The inability of opioids to control pain over time may be influenced by different factors such as drug tolerance, hyperalgesia due to repeated morphine administration or progression of the original disease. In addition, chronic pain may alter morphine tolerance development. This study examined whether chronic morphine...

journal_title：Pain

authors： Christensen D,Kayser V

更新日期：2000-12-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) activity in the spinal cord plays a key role in sensitization to sensory stimuli during acute inflammation. In contrast, intrathecal administration of COX-2 specific inhibitors has minimal analgesic effects in an incisional model of postoperative pain. We investigated the role of COX isoforms ...

journal_title：Pain

authors： Zhu X,Conklin D,Eisenach JC

更新日期：2003-07-01 00:00:00

abstract：:The redefinition of neuropathic pain as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system," which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast...

journal_title：Pain

authors： Finnerup NB,Haroutounian S,Kamerman P,Baron R,Bennett DLH,Bouhassira D,Cruccu G,Freeman R,Hansson P,Nurmikko T,Raja SN,Rice ASC,Serra J,Smith BH,Treede RD,Jensen TS

更新日期：2016-08-01 00:00:00

abstract：:The initial stages in the development of an Arabic pain inventory are described. 279 Kuwaiti adults were asked to nominate as many words as they could think of to describe pain. A dictionary translation of the McGill Pain Questionnaire (MPQ) was prepared, and subjects judged which of these represent acceptable pain de...

journal_title：Pain

authors： Harrison A

更新日期：1988-02-01 00:00:00

abstract：:Ten patients with organic nerve injury causing chronic neuropathic pain were tested for the effects of intravenous lidocaine versus saline upon psychophysical somatosensory variables. The variables assessed were the subjective magnitude of pain, area of mechanical hyperalgesia and presence and magnitude of thermal hea...

journal_title：Pain

authors： Marchettini P,Lacerenza M,Marangoni C,Pellegata G,Sotgiu ML,Smirne S

更新日期：1992-03-01 00:00:00

abstract：:The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...

journal_title：Pain

authors： Leinisch E,Evers S,Kaempfe N,Kraemer C,Sostak P,Jürgens T,Straube A,May A

更新日期：2005-10-01 00:00:00

abstract：:Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...

journal_title：Pain

authors： Antonini G,Di Pasquale A,Cruccu G,Truini A,Morino S,Saltelli G,Romano A,Trasimeni G,Vanacore N,Bozzao A

更新日期：2014-08-01 00:00:00

abstract：:Caffeine is frequently added to mild analgesic preparations but its effect when used alone on pain has never been studied in humans. Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of ...

journal_title：Pain

authors： Ward N,Whitney C,Avery D,Dunner D

更新日期：1991-02-01 00:00:00

abstract：:Migraine headache pathophysiology involves trigeminovascular system activation, calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive transmission. Triptans are 5-HT1B/1D/(1F) receptor agonists that prejunctionally inhibit trigeminal CGRP release, but their vasoconstrictor properties limit thei...

journal_title：Pain

authors： Labastida-Ramírez A,Rubio-Beltrán E,Haanes KA,Chan KY,Garrelds IM,Johnson KW,Danser AHJ,Villalón CM,MaassenVanDenBrink A

更新日期：2020-05-01 00:00:00

abstract：:In a double-blind, cross-over study, ibuprofen (600 mg), a peripherally-acting selective kappa-opioid receptor agonist (7.5 mg), or placebo were given orally in experiments on healthy volunteers 1 h before assessment of pain thresholds to radiant heat and of pain ratings to controlled mechanical impact stimuli. Mechan...

journal_title：Pain

authors： Bickel A,Dorfs S,Schmelz M,Forster C,Uhl W,Handwerker OH

更新日期：1998-06-01 00:00:00