Abstract:
ABSTRACT:Efficacy of treatment is heavily dependent on experience and expectations. Moreover, humans can generalize from one experience to a perceptually similar but novel situation. We investigated whether and how this applies to pain relief, using ecologically valid tonic pain stimuli treated by surreptitiously lowering the applied temperature. Using different face cues, participants experienced better treatment from one physician than another. Participants were then tested on 6 additional face cues perceptually lying between both faces. Our data from 2 independent samples (N = 18 and N = 39) show a treatment experience effect, ie, for physically identical treatments, the initially superior physician was reported to deliver stronger pain relief. More importantly, the other faces on the perceptual continuum showed a graded effect of pain relief, indicating placebo generalization. Introducing a paradigm feasible to induce placebo pain relief, we show that the generic learning principle of generalization can explain carryover effects between learned and novel treatment situations.
journal_name
Painjournal_title
Painauthors
Kampermann L,Tinnermann A,Büchel Cdoi
10.1097/j.pain.0000000000002166subject
Has Abstractpub_date
2020-12-15 00:00:00eissn
0304-3959issn
1872-6623pii
00006396-900000000-98174pub_type
杂志文章相关文献
PAIN文献大全abstract::Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2012.08.011
更新日期:2012-12-01 00:00:00
abstract::VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly incr...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.03.012
更新日期:2014-07-01 00:00:00
abstract::There is extensive evidence that spinal excitatory amino acids (EAAs) like glutamate (Glu) and aspartate (Asp) are important in the processing of nociceptive behaviors caused by incisions. To better understand EAA-induced dorsal horn sensitization caused by surgery, we examined the time course and extent of spinal ami...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00241-5
更新日期:2002-11-01 00:00:00
abstract::Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.06.010
更新日期:2012-11-01 00:00:00
abstract::The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000778
更新日期:2017-03-01 00:00:00
abstract::Previous work in this laboratory has indicated that the transplantation of adrenal medullary tissue into the subarachnoid space of the rat spinal cord can reduce pain sensitivity to acute noxious stimuli, particularly following stimulation by nicotine. This most likely results from the stimulated release of opioid pep...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(90)91093-X
更新日期:1990-07-01 00:00:00
abstract::The analgesic effect of systemic ibuprofen was investigated with two human experimental pain models: (i) static mechanical stimulation of the inter digital web between the 2nd and 3rd finger and (ii) primary and secondary hyperalgesia induced by a 7-min burn injury on the calf. In each double-blind, randomized, two-wa...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1016/s0304-3959(96)03316-7
更新日期:1997-04-01 00:00:00
abstract::The opiate antagonist naloxone has been reported to cause pain relief. Therefore, the effect was determined of naloxone, injected intravenously, on the activity in single neurones of the dorsomedial part of the ventral nucleus (VDM) in the thalamus of rats under urethane anaesthesia elicited by electrical stimulation ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90144-3
更新日期:1988-12-01 00:00:00
abstract::Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/S0304-3959(98)00118-3
更新日期:1999-01-01 00:00:00
abstract::The present study utilized recently developed diagnostic tests that permit recognition of functional deficits in spine mobility, trunk strength, endurance, coordination, and dynamic lifting capacity. Changes in these tests were compared to changes in psychological functioning (e.g., self-report of pain) as well as to ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90007-2
更新日期:1986-04-01 00:00:00
abstract::Excessive pain during medical procedures performed in unanesthetized patients is frequently reported, but can be reduced with virtual reality (VR) distraction. Increasing the person's illusion of going into the virtual world may increase how effectively VR distracts pain. Healthy volunteers aged 18-20 years participat...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/j.pain.2004.06.013
更新日期:2004-09-01 00:00:00
abstract::The spinal gray matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001586
更新日期:2019-09-01 00:00:00
abstract::Fifty adult patients with chronic pain and substance dependence were admitted to an inpatient unit for treatment of addiction without primary emphasis on treatment of pain. As a group they had received considerable medical attention for their pain, but relatively little for their addictions. When compared with a group...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90072-2
更新日期:1986-08-01 00:00:00
abstract::In primary care and physical therapy settings, we evaluated an intervention for chronic back pain patients which incorporated fear reducing and activating techniques. Primary care patients seen for back pain in primary care were screened to identify persons with significant activity limitations 8-10 weeks after their ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2004.11.007
更新日期:2005-02-01 00:00:00
abstract::Although EMLA is known to be an effective topical anesthetic, its rate of success is unknown. Indeed, researchers have suggested that EMLA may fail with young and apprehensive children. Therefore, the objectives of this study were to assess EMLA's rate of success as well as factors which predict success. A double-blin...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(95)00100-X
更新日期:1996-01-01 00:00:00
abstract::This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl.) injection of CFA induced a long lasting (28 days) hyperalgesia for both mechanical and thermal (cold)...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.12.002
更新日期:2010-03-01 00:00:00
abstract::Experimental C-fiber pain caused by radiant heat was applied to the skin area supplied by the left sural nerve of 20 subjects. Percutaneous electrical stimulation (PNS) was performed on the left sural nerve, the left superficial peroneal nerve and the right superficial radial nerve. Stimulation frequencies were: 3, 50...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90004-6
更新日期:1979-10-01 00:00:00
abstract::Pro-inflammatory cytokine production after nociceptive stimuli is pivotal for hyperalgesia. As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.11.011
更新日期:2010-02-01 00:00:00
abstract::Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.11.011
更新日期:2007-07-01 00:00:00
abstract::A short form of the McGill Pain Questionnaire (SF-MPQ) has been developed. The main component of the SF-MPQ consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate or 3 = severe. Three pain scores are derived from the sum of the intensity rank valu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)91074-8
更新日期:1987-08-01 00:00:00
abstract::Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain. ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(99)00195-5
更新日期:2000-02-01 00:00:00
abstract::Many studies of pain and nociception use short-lasting acute stimuli which may have limited relevance to prolonged or chronic pain states. Using extracellular single-unit recording in the dorsal horn of the rat lumbar spinal cord the present study examines the response of neurones to a long-lasting nociceptive stimulu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90023-6
更新日期:1987-09-01 00:00:00
abstract::Recent studies demonstrate that some brain structures activated by pain are also engaged when an individual observes someone else in pain, and that these empathy-related responses are modulated as a function of the affective link between the empath and the individual in pain. In this study we test the hypothesis that ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.07.017
更新日期:2008-05-01 00:00:00
abstract::A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(93)90108-2
更新日期:1993-01-01 00:00:00
abstract::Transcutaneous electrical nerve stimulation (TNS) was used on 20 patients with severe wrist pain due to rheumatoid arthritis. Three different stimulation frequencies were used: high 70 Hz stimulation (70 TNS), low frequency 3 Hz stimulation (3 TNS) and brief trains of stimuli with an internal frequency of 70 Hz and wi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90051-4
更新日期:1979-06-01 00:00:00
abstract::Neuropathic pain may be effectively relieved by electric stimulation of the spinal cord (SCS). However, the underlying mechanisms for the ensuing pain relief are poorly understood. In a rat model of neuropathy displaying hypersensitivity to innocuous tactile stimuli, (allodynia), we have earlier demonstrated that SCS ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00077-8
更新日期:1997-10-01 00:00:00
abstract::In superficial layers of the lumbar spinal dorsal horn, N-methyl-D-aspartate-dependent long-term potentiation (LTP) of C fibre-evoked field potentials, a synaptic model of central sensitisation and hyperalgesia, ensues the application of electrical high-frequency, high-intensity conditioning stimulation to the sciatic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.08.007
更新日期:2003-12-01 00:00:00
abstract::Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.041
更新日期:2011-04-01 00:00:00
abstract::Supraspinal opioid analgesia is mediated in part by connections between the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Morphine analgesia elicited from the PAG is respectively decreased by selective serotonergic and opioid receptor antagonists administered into the RVM, and increased by RVM neur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00192-1
更新日期:1996-03-01 00:00:00
abstract::Pain that interferes with daily life appears to be strongly age-related in cross-sectional studies, although the nature of this relationship over time has not been established. We have investigated the onset and persistence of pain and pain interference over a 3-year period to determine their association with age in o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.09.027
更新日期:2007-05-01 00:00:00