Generalization of placebo pain relief.

abstract：:Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...

journal_title：Pain

authors： North RB,Han M,Zahurak M,Kidd DH

更新日期：1994-04-01 00:00:00

abstract：:Laser evoked potentials (LEPs) are nociceptive-related brain responses to activation of cutaneous nociceptors by laser radiant heat stimuli. We previously showed that LEP amplitude during the P2 period (approximately 400 ms) was increased by rare noxious stimuli, inside and outside the focus of spatial attention. It w...

journal_title：Pain

authors： Legrain V,Bruyer R,Guérit JM,Plaghki L

更新日期：2003-06-01 00:00:00

abstract：:Children of parents with chronic pain have higher rates of pain and internalizing (eg, anxiety and depressive) symptoms than children of parents without chronic pain. Parental modeling of pain behaviour and reinforcement of child pain have been hypothesized to underlie these relationships. These mechanisms were tested...

journal_title：Pain

authors： Higgins KS,Chambers CT,Rosen NO,Sherry S,Mohammadi S,Lynch M,Campbell-Yeo M,Clark AJ

更新日期：2019-11-01 00:00:00

abstract：:Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...

journal_title：Pain

authors： Elliott K,Hynansky A,Inturrisi CE

更新日期：1994-12-01 00:00:00

abstract：:Persons with chronic musculoskeletal pain may be hypervigilant for pain-related cues which, paradoxically, may be maintaining their pain. Several randomized controlled trials have assessed whether a modified dot-probe protocol (ie, attention bias modification [ABM]) reduces chronic pain- and pain-related symptoms in p...

journal_title：Pain

authors： Carleton RN,Asmundson GJG,Korol SL,LeBouthillier DM,Hozempa K,Katz JD,Vlaeyen JWS,Crombez G

更新日期：2020-03-01 00:00:00

abstract：:Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...

journal_title：Pain

authors： Byers MR,Neuhaus SJ,Gehrig JD

更新日期：1982-07-01 00:00:00

abstract：:The influence of contextual factors on the pain evoked by a noxious stimulus is not well defined. In this study, a -20 degrees C rod was placed on one hand for 500 ms while we manipulated the evaluative context (or 'meaning') of, warning about, and visual attention to, the stimulus. For meaning, a red (hot, more tissu...

journal_title：Pain

authors： Moseley GL,Arntz A

更新日期：2007-12-15 00:00:00

abstract：:Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may highlight potential intervention strategies. This study uses a novel...

journal_title：Pain

authors： Smith D,Wilkie R,Croft P,Parmar S,McBeth J

更新日期：2018-06-01 00:00:00

abstract：:In rats anaesthetised with Saffan (Glaxovet), inhibition of the tail flick reflex evoked by electrical stimulation in the dorsal periaqueductal grey matter (PAG) was accompanied by an increase in blood pressure, tachycardia, vasodilatation in hind limb muscle, an increase in respiration, pupillodilatation and widening...

journal_title：Pain

authors： Lovick TA

更新日期：1985-03-01 00:00:00

abstract：:This study evaluated two brief (3-5 min) interventions for controlling responses to acute pain. Eighty male subjects were randomly assigned to 1 of 2 intervention groups (Positive Emotion Induction (PEI) or Brief Relaxation (BR)) or to 1 of 2 control groups (No-instruction or Social Demand). The PEI focused on re-crea...

journal_title：Pain

authors： Bruehl S,Carlson CR,McCubbin JA

更新日期：1993-07-01 00:00:00

abstract：:This study investigated the antinociceptive effect of opioids given via intraperitoneal and intrathecal routes in a diabetes-induced neuropathic pain model in rats. Streptozotocin induced diabetes in 91% of juvenile male Wistar rats at the dose of 150 mg/kg (75 mg/kg intraperitoneal on 2 successive days). When compare...

journal_title：Pain

authors： Zurek JR,Nadeson R,Goodchild CS

更新日期：2001-02-01 00:00:00

abstract：:The induction of hyperalgesia upon capsaicin administration requires activation of specific sub-classes of nociceptive afferent C-fibres providing nociceptive input to the central nervous system. It has been demonstrated in animal models that the endocannabinoid anandamide has anti-hyperalgesic properties upon capsaic...

journal_title：Pain

authors： Rukwied R,Watkinson A,McGlone F,Dvorak M

更新日期：2003-04-01 00:00:00

abstract：:Pain is generally considered to have a sensory and an affective component. Clinical research has suggested that morphine more potently attenuates the affective component as compared to the sensory component. Because preclinical nociception models typically focus on the sensory component of nociception, and do not asse...

journal_title：Pain

authors： van der Kam EL,De Vry J,Schiene K,Tzschentke TM

更新日期：2008-06-01 00:00:00

abstract：:We compared patient-controlled analgesia (PCA) and continuous infusion (CI) morphine delivery in a randomized controlled trial in adolescents during oropharyngeal mucositis pain after bone marrow transplantation. Results from 20 patients who completed 7 or more days on study (10 PCA, 10 CI) were evaluated. The group m...

journal_title：Pain

authors： Mackie AM,Coda BC,Hill HF

更新日期：1991-09-01 00:00:00

abstract：:Pain patients' retrospective reports of pain are important to physicians and other health professionals in helping to decide on future treatment plans. Unfortunately patients' memory of pain can be inaccurate and subject to overestimation. This study examined variables which influenced accuracy of remembering pain in ...

journal_title：Pain

authors： Jamison RN,Sbrocco T,Parris WCV

更新日期：1989-06-01 00:00:00

abstract：:Eight patients with established lower limb postamputation stump pain were given lumbar intrathecal fentanyl 25 micrograms and lidocaine 70 mg 2 weeks apart in an attempt to better understand the role of peripheral and central mechanisms in this condition. Baseline pain was recorded and then analgetic and side effects ...

journal_title：Pain

authors： Jacobson L,Chabal C,Brody MC,Mariano AJ,Chaney EF

更新日期：1990-02-01 00:00:00

abstract：:The present report describes a nation-wide survey on the incidence, the indications and the efficacy of spinal cord stimulation (SCS), as assessed by the Belgian health authorities. The direct motive for this survey was the rapidly growing expenditures resulting from the increasing use of SCS. Between 1983 and 1992, n...

journal_title：Pain

authors： Kupers RC,Van den Oever R,Van Houdenhove B,Vanmechelcn W,Hepp B,Nuttin B,Gybels JM

更新日期：1994-02-01 00:00:00

abstract：:The purpose of this study was to describe and quantify changes in the movement and EMG patterns caused by tonic noxious pressure on the periosteum of the zygoma during electrically induced rhythmic jaw movements in the decerebrate rabbit. Eight New Zealand rabbits were anesthetized with urethane. EMG electrodes were p...

journal_title：Pain

authors： Schwartz G,Lund JP

更新日期：1995-11-01 00:00:00

abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...

journal_title：Pain

authors： Lawlor P,Turner K,Hanson J,Bruera E

更新日期：1997-08-01 00:00:00

abstract：:Transcutaneous electrical nerve stimulation (TNS) was used on 20 patients with severe wrist pain due to rheumatoid arthritis. Three different stimulation frequencies were used: high 70 Hz stimulation (70 TNS), low frequency 3 Hz stimulation (3 TNS) and brief trains of stimuli with an internal frequency of 70 Hz and wi...

journal_title：Pain

authors： Mannheimer C,Carlsson CA

更新日期：1979-06-01 00:00:00

abstract：:Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues. Although there is limited evidence that aquaporins are expressed in the nervous system, AQP4 is expressed in glia and AQP9 is present on some neuronal and glial mit...

journal_title：Pain

authors： Shields SD,Mazario J,Skinner K,Basbaum AI

更新日期：2007-09-01 00:00:00

abstract：:Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Pos...

journal_title：Pain

authors： Campbell CM,Edwards RR,Carmona C,Uhart M,Wand G,Carteret A,Kim YK,Frost J,Campbell JN

更新日期：2009-01-01 00:00:00

abstract：:In this study, construct validity of 2 pain behaviour observation measurement instruments for young children aged 1 to 56 months (mean age was 20 months) with burns is assessed by using Rasch analysis. The Rasch model, wherein data should meet the model expectations, assumes that an instrument measures one unidimensio...

journal_title：Pain

authors： de Jong AEE,Tuinebreijer WE,Bremer M,van Komen R,Middelkoop E,van Loey N

更新日期：2012-11-01 00:00:00

abstract：:Nerve growth factor (NGF) is known to produce hyperalgesia as well as to stimulate synthesis of neuropeptides in dorsal root ganglia (DRG). In the present study, we wanted to determine the effects of local NGF administration and assess to which extent mast cell-dependent factors are mediating NGF responses. Rats recei...

journal_title：Pain

authors： Amann R,Schuligoi R,Herzeg G,Donnerer J

更新日期：1996-02-01 00:00:00

abstract：:A cohort of 243 female sewing machine operators were studied by questionnaire and clinical examinations with the purpose to study the efficiency of a screening questionnaire-based method to identify prevalent and incident cases of neck-shoulder disorders. The cross-sectional correlation between self-reported neck-shou...

journal_title：Pain

authors： Kaergaard A,Andersen JH,Rasmussen K,Mikkelsen S

更新日期：2000-06-01 00:00:00

abstract：:The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...

journal_title：Pain

authors： Khandwala H,Hodge E,Loomis CW

更新日期：1997-09-01 00:00:00

abstract：:The behavioral response to acute tissue injury is usually characterized by different phases, but the brain mechanisms underlying changes in pain-related behavior over time are still poorly understood. We aimed to analyze time-dependent changes in metabolic activity levels of 49 forebrain structures in the formalin pai...

journal_title：Pain

authors： Porro CA,Cavazzuti M,Lui F,Giuliani D,Pellegrini M,Baraldi P

更新日期：2003-07-01 00:00:00

abstract：:We have previously reported a novel method for producing chronic nociceptive behavior in rats following compression of the trigeminal ganglion. In the present study, we have further studied the role of demyelination in the development of prolonged nociceptive behavior in the trigeminal territory. For this purpose, lys...

journal_title：Pain

authors： Ahn DK,Lee SY,Han SR,Ju JS,Yang GY,Lee MK,Youn DH,Bae YC

更新日期：2009-11-01 00:00:00

abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

journal_title：Pain

authors： Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

更新日期：1980-12-01 00:00:00

abstract：:Patients with sensory disturbances of painful and non-painful character show distinct changes in touch and/or pain sensitivity. The patterns of sensory changes were compared to those of human surrogate models of neuropathic pain to assess the underlying mechanisms. We investigated 30 consecutive in-patients with dysae...

journal_title：Pain

authors： Baumgärtner U,Magerl W,Klein T,Hopf HC,Treede RD

更新日期：2002-03-01 00:00:00