Abstract：
:Pain is generally considered to have a sensory and an affective component. Clinical research has suggested that morphine more potently attenuates the affective component as compared to the sensory component. Because preclinical nociception models typically focus on the sensory component of nociception, and do not assess the affective component, it is unclear whether this potency difference of morphine can also be found in preclinical models. We therefore adapted the place conditioning paradigm to investigate negative affect accompanying carrageenan-induced (0.5% intraplantar) inflammatory nociception in rats. We found that carrageenan produced clear conditioned place aversion (CPA). Morphine (0.01-10mg/kg i.p.) dose-dependently reduced carrageenan-induced CPA with a minimal effective dose (MED) of 0.03mg/kg. Since morphine has a rewarding effect by itself, morphine-induced conditioned place preference (CPP) was also investigated. Morphine induced CPP with a MED of 1mg/kg, suggesting that the rewarding effect of morphine was not responsible for reducing carrageenan-induced CPA. We also demonstrated that morphine reduced carrageenan-induced mechanical nociception as assessed in the Randall Selitto paradigm with a MED of 1mg/kg. It is concluded that the CPA model allows for an assessment of the negative affective component of carrageenan-induced nociception. Moreover, morphine was able to reduce the affective component of nociception at doses that did not affect the sensory component of nociception, and this effect was not due to its rewarding properties. The fact that this finding mirrors the clinical situation validates the use of the CPA model for assessing the affective component of nociception.
journal_name
Painjournal_title
Painauthors
van der Kam EL,De Vry J,Schiene K,Tzschentke TMdoi
10.1016/j.pain.2007.07.027subject
Has Abstractpub_date
2008-06-01 00:00:00pages
373-379issue
3eissn
0304-3959issn
1872-6623pii
00006396-200806150-00019journal_volume
136pub_type
杂志文章相关文献
PAIN文献大全abstract：:Resveratrol is a natural polyphenol that protects from cancer and cardiovascular diseases. Resveratrol is able to induce apoptotic cell death and it inhibits the cyclooxygenase (COX) cascade. We measured the antinociceptive effect of resveratrol on carrageenan-induced hyperalgesia, prostaglandin-E2 (PGE2) concentratio...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.08.010
更新日期：2008-11-30 00:00:00
abstract：:The present study examined the role of catastrophizing in predicting levels of pain and disability in a sample of individuals who had sustained soft-tissue injuries to the neck, shoulders or back following work or motor vehicle accidents. Participants were 86 (27 men, 59 women) consecutive referrals to the Atlantic Pa...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00097-9
更新日期：1998-09-01 00:00:00
abstract：:The purpose of this study was to determine if some commonly used admission variables could predict treatment outcome on a multidisciplinary pain center. Specifically, it was designed as a prospective study of an index proposed by Maruta et al. The subjects were 104 patients. The 4 outcome measures used were staff judg...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(82)90082-3
更新日期：1982-09-01 00:00:00
abstract：:A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(93)90108-2
更新日期：1993-01-01 00:00:00
abstract：:Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2005.02.006
更新日期：2005-05-01 00:00:00
abstract：:A series of 37 patients with chronic pain was investigated with regard to neurologic and psychiatric variables. Twenty of the patients were classified as having mainly organic (= somatogenic) pain syndromes while 17 patients were rather suffering from psychogenic pain syndromes. Samples of lumbar cerebrospinal fluid (...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(78)90037-4
更新日期：1978-08-01 00:00:00
abstract：:Ectopically generated and antidromically conducted nerve impulses were recorded in 5 patients with tungsten microelectrodes inserted into skin nerve fascicles. All patients had mainly positive sensory symptoms and reported paresthesiae which could be provoked by different maneuvers which suggested increased mechanosen...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90013-7
更新日期：1984-11-01 00:00:00
abstract：:The responses of 144 spinothalamic tract (STT) cells were recorded in 15 anesthetized macaque monkeys (Macaca fascicularis). Three to 4 weeks prior to the acute experiment, the sciatic nerve was surgically exposed on one or both sides so that capsaicin or vehicle could be applied. Responses of STT cells recorded in 3 ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(93)90227-G
更新日期：1993-06-01 00:00:00
abstract：:Chronic posttraumatic headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic nontraumatic headaches that manipu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001983
更新日期：2020-12-01 00:00:00
abstract：:Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001426
更新日期：2019-02-01 00:00:00
abstract：:Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium chloride transporter, KCC2, and with increases in neuronal excitability. Here, we te...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000926
更新日期：2017-07-01 00:00:00
abstract：:Previous studies have shown that the peripheral nerve regeneration process is linked to pain in several neuropathic pain models. Other studies show that sympathetic blockade may relieve pain in some pain models and clinical conditions. This study examined reduction in peripheral nerve regeneration as one possible mech...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001887
更新日期：2020-08-01 00:00:00
abstract：:Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (ce...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(02)00420-7
更新日期：2003-05-01 00:00:00
abstract：:Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.01.056
更新日期：2011-06-01 00:00:00
abstract：:A survey of the psychological characteristics of a large sample of chronic headache cases (n = 360), including classical and common migraine and tension headache sufferers, was carried out. Comparing groups defined in terms of the chronicity of their headache problems, it was found that those with a longer history of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(85)90286-6
更新日期：1985-02-01 00:00:00
abstract：:Expectations modulate the subjective experience of pain by increasing sensitivity to nociceptive inputs, an effect mediated by brain regions such as the insula. However, it is still unknown whether the neural structures underlying pain expectancy hold sensory-specific information or, alternatively, code for modality-i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001237
更新日期：2018-08-01 00:00:00
abstract：:Abnormal endogenous pain modulation was suggested as a potential mechanism for chronic pain, ie, increased pain facilitation and/or impaired pain inhibition underlying symptoms manifestation. Endogenous pain modulation function can be tested using psychophysical methods such as temporal summation of pain (TSP) and con...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1097/j.pain.0000000000001263
更新日期：2018-08-01 00:00:00
abstract：:On a no treatment trial, a group of 24 oriental subjects rated cold pressor pain as significantly more painful and distressing than did a group of 24 occidental subjects. For half of the Orientals and half of the Occidentals, a second trial was conducted after acupuncture analgesia had been induced. The remaining 12 O...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(77)90086-0
更新日期：1977-10-01 00:00:00
abstract：:Numerous behavioral pain measures have been validated for young children, but none is appropriate to assess pain in emergency departments (EDs), where caregivers need a simple, easily completed scale. Our objective was to elaborate and validate a tool, relevant in any painful situation, with agitation or prostration, ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.02.024
更新日期：2012-08-01 00:00:00
abstract：:Several studies have implicated a potential role for histamine H(3) receptors in pain processing, although the data are somewhat conflicting. In the present study we investigated the effects of the novel potent and highly selective H(3) receptor antagonists GSK189254 (6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.11.006
更新日期：2008-08-15 00:00:00
abstract：:Topically applied norepinephrine, dopamine, serotonin, GABA and glycine, and systemically administered clonidine, L-DOPA (plus carbidopa) and 5-hydroxytryptophan completely suppressed the cutaneous hyper-irritability produced in the trigeminal sensory distribution by picrotoxin overlying the caudal medulla. Cholinergi...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(81)90136-6
更新日期：1981-08-01 00:00:00
abstract：:Rats and humans manifest elevated response thresholds to aversive stimuli during gestation and parturition. This pregnancy-associated antinociception is mediated, in part, by a spinal cord dynorphin/kappa antinociceptive system. Simulating the maternal pregnancy blood concentration profile (in non-pregnant animals) of...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(95)00092-5
更新日期：1996-01-01 00:00:00
abstract：:Cannabinoids are emerging as potential options for neuropathic pain treatment. This study evaluated an oral cannabinoid, nabilone, in the treatment of refractory human diabetic peripheral neuropathic pain (DPN). We performed a single-center, randomized, double-blind, placebo-controlled, flexible-dose study with an enr...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.2012.06.024
更新日期：2012-10-01 00:00:00
abstract：:microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.11.010
更新日期：2013-03-01 00:00:00
abstract：:Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies invest...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1097/j.pain.0000000000000304
更新日期：2015-11-01 00:00:00
abstract：:The results of a considerable number of recent prospective studies have demonstrated that greater acute pain severity in herpes zoster patients is associated with a significantly greater risk of developing postherpetic neuralgia (PHN). Only a few studies have examined the relationships between acute pain severity and ...
journal_title：Pain
pub_type： 杂志文章,meta分析
doi：10.1016/S0304-3959(01)00347-5
更新日期：2001-10-01 00:00:00
abstract：:Locus of control (LOC) beliefs, long thought important in adjustment to persistent pain, were studied among 160 subjects (67 males and 93 females) referred to a comprehensive pain rehabilitation program. The subscale structure of the Multidimensional Health Locus of Control (MHLC) was factorially replicated in our sam...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91141-5
更新日期：1990-09-01 00:00:00
abstract：:Microvascular decompression (MVD) of cranial nerves has become an established treatment for trigeminal and (vago)glossopharyngeal neuralgia and for hemifacial spasm. The authors present the case of a 64-year-old man who had a 3.5-year history of severe, drug-resistant hemibody pain with sensory and autonomic disturban...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2014.04.023
更新日期：2014-08-01 00:00:00
abstract：:In recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.01.029
更新日期：2006-05-01 00:00:00
abstract：:Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(03)00077-0
更新日期：2003-08-01 00:00:00
