Abstract:
:Previous studies have shown that the peripheral nerve regeneration process is linked to pain in several neuropathic pain models. Other studies show that sympathetic blockade may relieve pain in some pain models and clinical conditions. This study examined reduction in peripheral nerve regeneration as one possible mechanism for relief of neuropathic pain by sympathetic blockade. A "microsympathectomy," consisting of cutting the gray rami containing sympathetic postganglionic axons where they enter the L4 and L5 spinal nerves, reduced mechanical hypersensitivity in 2 different rat neuropathic pain models. In the spinal nerve ligation model, in which some functional regeneration and reinnervation of the ligated spinal nerve can be observed, microsympathectomy reduced functional and anatomical measures of regeneration as well as expression of growth-associated protein 43 (GAP43), a regeneration-related protein. In the spared nerve injury model, in which functional reinnervation is not possible and the futile regeneration process results in formation of a neuroma, microsympathectomy reduced neuroma formation and GAP43 expression. In both models, microsympathectomy reduced macrophage density in the sensory ganglia and peripheral nerve. This corroborates previous work showing that sympathetic nerves may locally affect immune function. The results further highlight the challenge of improving pain in neuropathic conditions without inhibiting peripheral nerve regeneration that might otherwise be possible and desired.
journal_name
Painjournal_title
Painauthors
Xie W,Strong JA,Zhang JMdoi
10.1097/j.pain.0000000000001887subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1925-1936issue
8eissn
0304-3959issn
1872-6623pii
00006396-202008000-00024journal_volume
161pub_type
杂志文章相关文献
PAIN文献大全abstract::Although classical trigeminal neuralgia (CTN) is frequently caused by neurovascular contact (NVC) at the trigeminal root entry zone (REZ), both anatomical and MRI studies have shown that NVC of the trigeminal nerve frequently occurs in individuals without CTN. To assess the accuracy of MRI in distinguishing symptomati...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1016/j.pain.2014.04.020
更新日期:2014-08-01 00:00:00
abstract::These experiments quantitatively analyzed effects of electrical midbrain stimulation on a nociceptive hind limb flexion reflex in rats anesthetized with sodium pentobarbital. We recorded the force of isometric hind limb flexion withdrawal, and related flexor electromyographic (EMG) activity, elicited by noxious heat (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90092-9
更新日期:1988-05-01 00:00:00
abstract::The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(99)00233-x
更新日期:2000-03-01 00:00:00
abstract::Current opinion concerning the pathophysiology of tension-type headache (TTH) and its related pericranial muscle tenderness proposes a primary role of central sensitization at the level of dorsalhorn/trigeminal nucleus as well as the supraspinal level. Investigation of these phenomena can be conducted using laser-evok...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00485-2
更新日期:2003-07-01 00:00:00
abstract::Internet-based educational and therapeutic programs (e-health applications) are becoming increasingly popular for a variety of psychological and physical disorders. We tested the efficacy of an online Chronic Pain Management Program, a comprehensive, fully self-directed and self-paced system that integrates social net...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.10.025
更新日期:2012-02-01 00:00:00
abstract::Clinicians use patients' recall of pain and disability relief as indicators of therapeutic effectiveness. Recall can change over time, however, and is influenced by factors other than true relief, including current health status. We have determined the trend in the relative contribution of current pain/disability and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(01)00377-3
更新日期:2002-01-01 00:00:00
abstract::Animal studies have suggested that the cerebellum, in addition to its motor functions, also has a role in pain processing and modulation, possibly because of its extensive connections with the prefrontal cortex and with brainstem regions involved in descending pain control. Consistently, human imaging studies have sho...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.04.006
更新日期:2014-07-01 00:00:00
abstract::Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002126
更新日期:2020-10-26 00:00:00
abstract::Training in relaxation is a prominent component in multi-disciplinary approaches to the management of chronic pain, although its specific potency in modulating pain has not yet been established. Using a within-session design, the specific effects of relaxation induction were evaluated in a group of benign chronic pain...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90065-6
更新日期:1988-02-01 00:00:00
abstract::Potential applications of attention bias modification (ABM) for acute and chronic pain patients are investigated. In study 1, 54 acute back pain patients (46 of whom completed the study) were recruited at their initial physiotherapy session and randomised to receive 1 session of ABM or placebo. Patients were followed ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2011.12.014
更新日期:2012-03-01 00:00:00
abstract::Clinical observations and recent studies suggest that arthritis patients vary considerably in their involvement in self-management efforts. In the literature on health promotion, there is growing recognition that patients may be at different stages of change with respect to the adoption of self-management strategies. ...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(00)00294-3
更新日期:2000-09-01 00:00:00
abstract::Tolerance to morphine-induced analgesia is an intractable phenomenon, often hindering its prolonged applications in the clinics. The enhanced pronociceptive actions of spinal pain-related molecules such as calcitonin gene-related peptide (CGRP) may underlie this phenomenon and could be a promising target for intervent...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.07.006
更新日期:2010-10-01 00:00:00
abstract::Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/S0304-3959(98)00118-3
更新日期:1999-01-01 00:00:00
abstract::The purpose of this study is to analyze cancer breakthrough pain (BP) characteristics and how BP responds to conventional cancer pain management. Seventy-four cancer pain patients with worst pain severity >or=4 out of 10 completed the Brief Pain Inventory (BPI), Memorial Symptom Assessment Scale-Short Form, Functional...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(02)00293-2
更新日期:2003-01-01 00:00:00
abstract::Opioid use for chronic pain is limited by severe central adverse effects. We examined whether activating mu-opioid receptors (MORs) in the peripheral nervous system attenuates spinal cord injury (SCI) pain-like behavior in mice. We produced a contusive SCI at the T10 vertebral level and examined motor and sensory dysf...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001671
更新日期:2019-12-01 00:00:00
abstract::Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90244-7
更新日期:1986-06-01 00:00:00
abstract::Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained im...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(91)90218-M
更新日期:1991-12-01 00:00:00
abstract::We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(96)03186-7
更新日期:1996-12-01 00:00:00
abstract::Nociception was studied in male mice, mostly of the C57BL/6 strain, during continuous or prolonged restriction of caloric intake (60% of ad-libitum) from midlife to senescence (up to 105 weeks). Restricted mice showed fewer licking or biting responses 20-60 min after hind paw injection of 5% formalin at 46 and 70 week...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.01.010
更新日期:2005-04-01 00:00:00
abstract::The characteristics and impact of pain were evaluated in a prospective cross-sectional survey of 438 ambulatory AIDS patients recruited from health care facilities in New York City. More than 60% of the patients reported 'frequent or persistent pain' during the 2 wks preceding the study. Patients with pain reported an...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(96)03215-0
更新日期:1996-12-01 00:00:00
abstract::Effects of electrical stimulation of the cervical vagus nerve were determined in cervical or lumbar spinal neurons in 27 rats anesthetized with pentobarbital. Ipsilateral cervical vagus stimulation (ICVS) increased activity of 44 neurons in the C1 segment. At the same stimulation parameters, contralateral cervical vag...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90013-2
更新日期:1992-10-01 00:00:00
abstract::Electronic diary assessment methods offer the potential to accurately characterize pain and other daily experiences. However, the frequent assessment of experiences over time often results in missing data. It is important to identify systematic reasons for missing data because such a pattern may bias study results and...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2004.02.014
更新日期:2004-06-01 00:00:00
abstract::Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced, rather than dimin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.06.026
更新日期:2007-11-01 00:00:00
abstract::This study aimed to investigate the efficacy of an attention training technique (ATT) on pain ratings, threshold and tolerance during the cold pressor task. One hundred and three undergraduate students were randomly assigned to receive either threat-alleviating or threat-inducing information about the task. Participan...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.05.027
更新日期:2010-09-01 00:00:00
abstract::Currently, opioids targeting mu-opioid receptors are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a co...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001968
更新日期:2020-12-01 00:00:00
abstract::Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions. However, subcortical nuclei, including the periaqueductal gray and the rostroventral medulla, also show selective activation when subjects expect pain relief. These brainste...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.11.011
更新日期:2007-07-01 00:00:00
abstract::This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root inj...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03301-5
更新日期:1997-03-01 00:00:00
abstract::The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001298
更新日期:2018-10-01 00:00:00
abstract::A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different ar...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(85)90174-5
更新日期:1985-06-01 00:00:00
abstract::Mounting evidence suggests that the spinal dorsal horn (SDH) contains multiple subpopulations of inhibitory interneurons that play distinct roles in somatosensory processing, as exemplified by the importance of spinal dynorphin-expressing neurons for the suppression of mechanical pain and chemical itch. Although it is...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001636
更新日期:2019-10-01 00:00:00