Abstract:
:A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different areas of the body varied between 1.0 and 2.0 mA (S.D. +/- 0.2-0.6 mA) and those of the threshold for pain between 2.5 and 4.3 mA (S.D. +/- 0.5-1.7 mA). There was no difference between the left and the right side. The interindividual range of the perception threshold varied from 0.4 to 3.0 mA and that of the pain threshold from 1.2 to 6.0 mA. Within a limited area of the body the reproducibility of the measurements was high both for the thresholds for perception and for pain. Anterolateral cordotomy caused a marked rise in the threshold for pain in the analgesic area of the body, whereas the threshold for perception did not change. It is hypothesized that the threshold for perception reflects an activation of A beta fibers and the threshold for pain an activation of A delta fibers. The new method is considered to be valuable in clinical neurology and neurosurgery.
journal_name
Painjournal_title
Painauthors
Laitinen LV,Eriksson TAdoi
10.1016/0304-3959(85)90174-5subject
Has Abstractpub_date
1985-06-01 00:00:00pages
139-150issue
2eissn
0304-3959issn
1872-6623pii
00006396-198506000-00003journal_volume
22pub_type
杂志文章相关文献
PAIN文献大全abstract::Lamina I of the spinal cord plays a key role in sensory transmission between afferent activity and the CNS. Studies have shown lamina I neurones to have distinct response properties compared to deep dorsal horn neurones, but little is known regarding excitatory amino acid mechanisms in their responses. Spinal electrop...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.12.004
更新日期:2004-03-01 00:00:00
abstract::Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been u...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002103
更新日期:2020-10-02 00:00:00
abstract::Two hundred and sixty-three ambulatory patients older than 21 years of age who were attending clinics at an oncology hospital in San Juan, Puerto Rico, were studied. They completed a questionnaire (BQ-PR) that measures 8 concerns about reporting pain and using analgesics, such as fears of addiction and tolerance and t...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(94)90203-8
更新日期:1994-08-01 00:00:00
abstract::This study aimed to investigate the efficacy of an attention training technique (ATT) on pain ratings, threshold and tolerance during the cold pressor task. One hundred and three undergraduate students were randomly assigned to receive either threat-alleviating or threat-inducing information about the task. Participan...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2010.05.027
更新日期:2010-09-01 00:00:00
abstract::Chronic low back pain (CLBP) and obesity are interrelated, but the physiological mechanisms linking the 2 conditions remain to be determined. Functional brain imaging data from CLBP patients show functional and structural alterations in areas mediating the attribution of hedonic value to food. Accordingly, we hypothes...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2013.12.027
更新日期:2014-04-01 00:00:00
abstract::The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(01)00334-7
更新日期:2001-09-01 00:00:00
abstract::Little is known about patients prescribed high doses of opioids to treat chronic non-cancer pain, though these patients may be at higher risk for medication-related complications. We describe the prevalence of high-dose opioid use and associated demographic and clinical characteristics among veterans treated in a VA r...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.08.002
更新日期:2010-12-01 00:00:00
abstract::Accurate pain assessment is the foundation for effective pain management in children. At present, there is no clear consensus regarding the age at which young children are able to appropriately use self-report scales for pain. This study examined young children's ability to use the Faces Pain Scale-Revised; (FPS-R; [H...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2005.10.004
更新日期:2006-01-01 00:00:00
abstract::Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.05.018
更新日期:2014-08-01 00:00:00
abstract::Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Intriguingly, several reports showed that capsaicin also inhibits Na+ currents but the mechanisms remain unclear. To explore this non-TRPV1 action we applied capsaicin to HEK293 cells stably expressing inactivation-deficient rat skele...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.08.002
更新日期:2007-01-01 00:00:00
abstract::The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)90164-3
更新日期:1994-03-01 00:00:00
abstract::Cognitive factors are thought to play an important mediational role between pain and consequent levels of suffering, yet there has been little investigation of these issues in older chronic pain patients. The present study sought to examine the reliability and validity of the Pain Locus of Control (PLOC) scale when us...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(99)00284-5
更新日期:2000-04-01 00:00:00
abstract::Effects of electrical stimulation of the cervical vagus nerve were determined in cervical or lumbar spinal neurons in 27 rats anesthetized with pentobarbital. Ipsilateral cervical vagus stimulation (ICVS) increased activity of 44 neurons in the C1 segment. At the same stimulation parameters, contralateral cervical vag...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90013-2
更新日期:1992-10-01 00:00:00
abstract::Chronic and acute pre-mastectomy pain as well as prevalence and characteristics of phantom phenomena following mastectomy were investigated by interview in a sample of 39 women who had undergone unilateral breast amputation. Twenty of 39 participants reported phantom sensations in the breast. Nine of the participants ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2003.10.007
更新日期:2004-01-01 00:00:00
abstract::The effect of PF-04457845, a potent and selective fatty acid amide hydrolase-1 (FAAH1) inhibitor, on pain due to osteoarthritis of the knee was investigated in a randomised placebo and active-controlled clinical trial. The trial involved 2 periods (separated by a 2-week washout) consisting of a 1-week wash-in phase fo...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2012.04.020
更新日期:2012-09-01 00:00:00
abstract::Morphine is increasingly used in patients with chronic non-cancer pain, but a major concern associated with chronic use relates to possible cognitive side-effects. The aim of this long-term prospective study was to evaluate the cognitive impact of oral sustained release morphine in patients with non-cancer pain. A bat...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00047-2
更新日期:2003-07-01 00:00:00
abstract::This study evaluated two brief (3-5 min) interventions for controlling responses to acute pain. Eighty male subjects were randomly assigned to 1 of 2 intervention groups (Positive Emotion Induction (PEI) or Brief Relaxation (BR)) or to 1 of 2 control groups (No-instruction or Social Demand). The PEI focused on re-crea...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(93)90096-8
更新日期:1993-07-01 00:00:00
abstract::Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population. This study investigates whether the PM genotype has an impact on the response to tramadol analgesia in postoperative patients. A prospective study design was used and 300 patients recoveri...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00212-4
更新日期:2003-09-01 00:00:00
abstract::Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001820
更新日期:2020-06-01 00:00:00
abstract::In male rats, carrageenan (CAR)-induced inflammation or exposure to a selective protein kinase C epsilon (PKC epsilon ) agonist (psi epsilon RACK) produces prolongation of the hyperalgesia induced by a subsequent exposure to an inflammatory mediator, a phenomenon referred to as hyperalgesic priming. Since many chronic...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00175-1
更新日期:2003-09-01 00:00:00
abstract::Intense stress and fear have long been known to give rise to a suppression of pain termed "stress-induced analgesia", mediated by brainstem pain-modulating circuitry, including pain-inhibiting neurons of the rostral ventromedial medulla. However, stress does not invariably suppress pain, and indeed, may exacerbate it....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.01.011
更新日期:2009-04-01 00:00:00
abstract::Topically applied norepinephrine, dopamine, serotonin, GABA and glycine, and systemically administered clonidine, L-DOPA (plus carbidopa) and 5-hydroxytryptophan completely suppressed the cutaneous hyper-irritability produced in the trigeminal sensory distribution by picrotoxin overlying the caudal medulla. Cholinergi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(81)90136-6
更新日期:1981-08-01 00:00:00
abstract::Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induced allodynia are microglial dependent in male but not female mice. Whe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001265
更新日期:2018-09-01 00:00:00
abstract::The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(92)90152-2
更新日期:1992-05-01 00:00:00
abstract::In previous studies, pain behaviors produced in the spinal nerve ligation rat model of neuropathic pain were partly reduced by surgical lumbar sympathectomy. However, systemic injection of phentolamine, an alpha-adrenoceptor blocker, was not effective in reducing pain behaviors, at least in the Sprague-Dawley strain o...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(00)00277-3
更新日期:2000-08-01 00:00:00
abstract::A comparison between 102 depressed and 101 non-depressed pain patients, identified with the use of DSM-III criteria, showed that depressed patients were more often elderly and employed as compared to non-depressed patients who were significantly more often found to be younger (P less than 0.001) and were students (P l...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(87)90050-9
更新日期:1987-06-01 00:00:00
abstract::The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3959(96)03243-5
更新日期:1997-01-01 00:00:00
abstract::The present study sought to discover whether information clarifying how the analgesic/sedative drug nitrous oxide (N2O) works would result in increased analgesic responses to painful stimuli when various concentrations of N2O were administered. Subjects were provided with high and low levels of information regarding t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90080-0
更新日期:1984-08-01 00:00:00
abstract::The habituation to sensory stimuli of different modalities is reduced in migraine patients. However, the habituation to pain has never been evaluated. Our aim was to assess the nociceptive pathway function and the habituation to experimental pain in patients with migraine. Scalp potentials were evoked by CO(2) laser s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(03)00137-4
更新日期:2003-09-01 00:00:00
abstract::Psychological trauma is associated with an increased risk for chronification of nonspecific chronic back pain (nsCLBP) independent of posttraumatic stress disorder (PTSD). However, the mechanisms underlying the role of psychological trauma in nsCLBP are less clear than in PTSD. Therefore, this study considered whether...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/01.j.pain.0000460350.30707.8d
更新日期:2015-04-01 00:00:00