Phantom phenomena in mastectomized patients and their relation to chronic and acute pre-mastectomy pain.

abstract：:Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP on...

journal_title：Pain

authors： Nicholl BI,Macfarlane GJ,Davies KA,Morriss R,Dickens C,McBeth J

更新日期：2009-01-01 00:00:00

abstract：:In order to clarify the mechanism of reference of pain following cordotomy (ROPC), the authors investigated ROPC in 66 patients undergoing percutaneous cervical cordotomy (PCC) and examined the features of ROPC and the correlation between the occurrence of ROPC and the pre-operative pain states, as well as the results...

journal_title：Pain

authors： Nagaro T,Amakawa K,Kimura S,Arai T

更新日期：1993-05-01 00:00:00

abstract：:The habituation to sensory stimuli of different modalities is reduced in migraine patients. However, the habituation to pain has never been evaluated. Our aim was to assess the nociceptive pathway function and the habituation to experimental pain in patients with migraine. Scalp potentials were evoked by CO(2) laser s...

journal_title：Pain

authors： Valeriani M,de Tommaso M,Restuccia D,Le Pera D,Guido M,Iannetti GD,Libro G,Truini A,Di Trapani G,Puca F,Tonali P,Cruccu G

更新日期：2003-09-01 00:00:00

abstract：:Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up ...

journal_title：Pain

authors： Stokvis A,van der Avoort DJC,van Neck JW,Hovius SER,Coert HJ

更新日期：2010-12-01 00:00:00

abstract：:The treatment of neuropathic pain remains a clinical challenge because of its unclear mechanisms and broad clinical morbidity. Matrix metalloproteinase (MMP)-9 and MMP-2 have previously been described as key components in neuropathic pain because of their facilitation of inflammatory cytokine maturation and induction ...

journal_title：Pain

authors： Li J,Xu L,Deng X,Jiang C,Pan C,Chen L,Han Y,Dai W,Hu L,Zhang G,Cheng Z,Liu W

更新日期：2016-08-01 00:00:00

abstract：:Disabling neuropathic pain (NeuP) is a common sequel of diabetic peripheral neuropathy (DPN). We aimed to characterise the sensory phenotype of patients with and without NeuP, assess screening tools for NeuP, and relate DPN severity to NeuP. The Pain in Neuropathy Study (PiNS) is an observational cross-sectional multi...

journal_title：Pain

authors： Themistocleous AC,Ramirez JD,Shillo PR,Lees JG,Selvarajah D,Orengo C,Tesfaye S,Rice ASC,Bennett DLH

更新日期：2016-05-01 00:00:00

abstract：:Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...

journal_title：Pain

authors： Gomis A,Miralles A,Schmidt RF,Belmonte C

更新日期：2007-07-01 00:00:00

abstract：:Dysfunction in the motor system is a feature of persistent whiplash associated disorders. Little is known about motor dysfunction in the early stages following injury and of its progress in those persons who recover and those who develop persistent symptoms. This study measured prospectively, motor system function (ce...

journal_title：Pain

authors： Sterling M,Jull G,Vicenzino B,Kenardy J,Darnell R

更新日期：2003-05-01 00:00:00

abstract：:Colonoscopy is an invaluable tool for the screening and diagnosis of many colonic diseases. For most colonoscopies, moderate sedation is used during the procedure. However, insufflation of the colon produces a nociceptive stimulus that is usually accompanied by facial grimacing/groaning while under sedation. The objec...

journal_title：Pain

authors： Becerra L,Aasted CM,Boas DA,George E,Yücel MA,Kussman BD,Kelsey P,Borsook D

更新日期：2016-04-01 00:00:00

abstract：:The significance of preamputation pain for the development of postamputation stump and phantom pain has been discussed over the years and is still a matter of dispute. It has been argued that preamputation pain increases the risk of phantom pain and that phantom pain is a revivification of pain experienced before the ...

journal_title：Pain

authors： Nikolajsen L,Ilkjaer S,Krøner K,Christensen JH,Jensen TS

更新日期：1997-09-01 00:00:00

abstract：:A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...

journal_title：Pain

authors： Ma C,LaMotte RH

更新日期：2005-01-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative...

journal_title：Pain

authors： Yang YR,He Y,Zhang Y,Li Y,Li Y,Han Y,Zhu H,Wang Y

更新日期：2007-01-01 00:00:00

abstract：:Physical and psychosocial disability in patients with chronic pain have been shown to be associated with patients' pain-related beliefs, tendency to catastrophize, and pain coping strategy use. However, little is known about whether beliefs, catastrophizing, and coping strategies are independently associated with pati...

journal_title：Pain

authors： Turner JA,Jensen MP,Romano JM

更新日期：2000-03-01 00:00:00

abstract：:Current knowledge on pain-related cerebral networks has relied so far on stimulus-induced brain responses, but not on the analysis of brain activity during spontaneous pain attacks. In this case report, correlation between intracerebral field potentials and online sensations during spontaneously painful epileptic seiz...

journal_title：Pain

authors： Isnard J,Magnin M,Jung J,Mauguière F,Garcia-Larrea L

更新日期：2011-04-01 00:00:00

abstract：:Fibromyalgia is a painful syndrome of non-articular origin, predominantly involving muscles, and the commonest cause of chronic widespread musculoskeletal pain. The diversity of therapeutic programs for patients with fibromyalgia reflects both the lack of a known pathophysiology for this disorder and the low efficacy ...

journal_title：Pain

authors： Quijada-Carrera J,Valenzuela-Castaño A,Povedano-Gómez J,Fernández-Rodriguez A,Hernánz-Mediano W,Gutierrez-Rubio A,de la Iglesia-Salgado JL,García-López A

更新日期：1996-05-01 00:00:00

abstract：:A number of investigators have suggested that the generic classification temporomandibular disorders (TMD) may consist of several subsets of patients. Two primary factors are to be significant in discriminating subgroups, namely, presence or absence of TM joint abnormalities and psychological characteristics such as t...

journal_title：Pain

authors： Rudy TE,Turk DC,Zaki HS,Curtin HD

更新日期：1989-03-01 00:00:00

abstract：:With increasing concerns about the potential harm of long-term opioid therapy, there is a need for the development and implementation of alternative treatment strategies for patients with chronic pain who have been using opioids for a prolonged period of time. Based on the findings from a recent qualitative investigat...

journal_title：Pain

authors： Andrews NE,Strong J,Meredith PJ,Fleming JA

更新日期：2016-02-01 00:00:00

abstract：:Fourteen patients whose post-herpetic neuralgia could not be alleviated by conventional methods were treated with cryocautery using a stick of solid carbon dioxide (dry ice) applied directly to the hyperesthetic skin areas of the cutaneous scars. Follow-up evaluation revealed that 5 of 14 subjects maintained excellent...

journal_title：Pain

authors： Suzuki H,Ogawa S,Nakagawa H,Kanayama T,Taj K,Saitoh H,Ohshima Y

更新日期：1980-12-01 00:00:00

abstract：:Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...

journal_title：Pain

authors： Chen YW,Huang KL,Liu SY,Tzeng JI,Chu KS,Lin MT,Wang JJ

更新日期：2004-11-01 00:00:00

abstract：:To characterize the contribution of interleukin-6 (IL-6) to spinal cord injury pain (SCIP), we employed a clinically relevant rat contusion model of SCIP. Using Western blots, we measured IL-6 levels in lumbar segments (L1-L5), at the lesion site (T10), and in the corresponding lumbar and thoracic dorsal root ganglia ...

journal_title：Pain

authors： Guptarak J,Wanchoo S,Durham-Lee J,Wu Y,Zivadinovic D,Paulucci-Holthauzen A,Nesic O

更新日期：2013-07-01 00:00:00

abstract：:Both mu opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists are implicated in the regulation of neuropathic pain in post-nerve injury preclinical pain models. This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on ...

journal_title：Pain

authors： Leung A,Wallace MS,Ridgeway B,Yaksh T

更新日期：2001-03-01 00:00:00

abstract：:Nerve growth factor (NGF) is known to produce hyperalgesia as well as to stimulate synthesis of neuropeptides in dorsal root ganglia (DRG). In the present study, we wanted to determine the effects of local NGF administration and assess to which extent mast cell-dependent factors are mediating NGF responses. Rats recei...

journal_title：Pain

authors： Amann R,Schuligoi R,Herzeg G,Donnerer J

更新日期：1996-02-01 00:00:00

abstract：:Neuropathic pain can be a predictor of severe emotional distress, up to full-blown depressive states. In these patients, it is important to move beyond the sole treatment of pain, to recognize depressive symptoms, and to ultimately improve the quality of life. We systematically searched for published and unpublished c...

journal_title：Pain

authors： Caruso R,Ostuzzi G,Turrini G,Ballette F,Recla E,Dall'Olio R,Croce E,Casoni B,Grassi L,Barbui C

更新日期：2019-10-01 00:00:00

abstract：:The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by s...

journal_title：Pain

authors： Chen HS,Lei J,He X,Qu F,Wang Y,Wen WW,You HJ,Arendt-Nielsen L

更新日期：2008-03-01 00:00:00

abstract：:The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE1 on the transmission of diff...

journal_title：Pain

authors： Saito Y,Kaneko M,Kirihara Y,Kosaka Y,Collins JG

更新日期：1995-12-01 00:00:00

abstract：:The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/k...

journal_title：Pain

authors： Sawynok J,Reid AR,Doak GJ

更新日期：1995-05-01 00:00:00

abstract：:Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...

journal_title：Pain

authors： Wylde V,Sayers A,Lenguerrand E,Gooberman-Hill R,Pyke M,Beswick AD,Dieppe P,Blom AW

更新日期：2015-01-01 00:00:00

abstract：:The spinal ascending pathways responsible for neuronal ventrobasal (VB) thalamic responses elicited by joint stimulation of the posterior paw were determined in arthritic rats used as a model of experimental pain. Responses of a same neurone to mechanical (movement--pressure--brushing) or thermal stimulation (50 degre...

journal_title：Pain

authors： Guilbaud G,Peschanski M,Briand A,Gautron M

更新日期：1986-09-01 00:00:00

abstract：:To inform case definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association, and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on muscu...

journal_title：Pain

authors： Sarquis LMM,Coggon D,Ntani G,Walker-Bone K,Palmer KT,Felli VE,Harari R,Barrero LH,Felknor SA,Gimeno D,Cattrell A,Vargas-Prada S,Bonzini M,Solidaki E,Merisalu E,Habib RR,Sadeghian F,Kadir MM,Warnakulasuriya SSP,Matsu

更新日期：2016-05-01 00:00:00

abstract：:Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera to...

journal_title：Pain

authors： Baseer N,Al-Baloushi AS,Watanabe M,Shehab SA,Todd AJ

更新日期：2014-11-01 00:00:00