Abstract:
:The present study examined antinociception produced by systemic administration of caffeine in the rat hot-plate (HP) and formalin tests and addressed several aspects of the mechanism of action of caffeine. Locomotor activity was monitored throughout. Caffeine produced a dose-related antinociception the HP (50-100 mg/kg) and formalin tests (12.5-75 mg/kg). When observed during the formalin test, caffeine stimulated locomotor activity between 12.5 and 50 mg/kg; this was followed by a depression in activity at 75 mg/kg. Caffeine did not produce an anti-inflammatory effect as determined by hindpaw plethysmometry, suggesting that antinociception was not secondary to an anti-inflammatory action. Peripheral co-administration of caffeine with the formalin did not produce antinociception, suggesting a predominant central rather than peripheral site of action for caffeine. Naloxone (10 mg/kg) did not reduce the antinociceptive or locomotor stimulant effects of caffeine, suggesting a lack of involvement of endogenous opioids in these actions. Phentolamine (5 mg/kg) enhanced antinociception by caffeine in both the HP and formalin tests, but inhibited locomotor stimulation. Prazosin (0.15 mg/kg) mimicked the action of phentolamine on locomotor stimulation, but idazoxan (0.5 mg/kg) mimicked the action of phentolamine on antinociception in the formalin test. These observations suggest an involvement of different alpha-adrenergic receptors in the two actions of phentolamine. Microinjection of 6-hydroxydopamine (6-OHDA) into the locus coeruleus, which depleted noradrenaline (NA) in the spinal cord and forebrain, inhibited the action of caffeine in the HP test. This was mimicked by intrathecal 6-OHDA which depleted NA in the spinal cord, but not by microinjection of 6-OHDA into the dorsal bundle which depleted NA in the forebrain. These results suggest an integral involvement of noradrenergic mechanisms in the antinociceptive action of caffeine in the HP and formalin tests and in locomotor stimulation, but the nature of this involvement differs for the 3 end points.
journal_name
Painjournal_title
Painauthors
Sawynok J,Reid AR,Doak GJdoi
10.1016/0304-3959(94)00169-Fsubject
Has Abstractpub_date
1995-05-01 00:00:00pages
203-213issue
2eissn
0304-3959issn
1872-6623pii
00006396-199505000-00006journal_volume
61pub_type
杂志文章相关文献
PAIN文献大全abstract::Phantom urinary phenomena are a relatively rare disease entity. Literature search has revealed only one case following cystectomy, seven cases following spinal cord injury and several other cases in hemodialysis patients. This report presents a case of painful phantom bladder following cystectomy for chronic kidney an...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90011-3
更新日期:1979-10-01 00:00:00
abstract::Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice: spinal mechanisms underlying nerve injury-induced allodynia are microglial dependent in male but not female mice. Whe...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001265
更新日期:2018-09-01 00:00:00
abstract::Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.10.022
更新日期:2009-01-01 00:00:00
abstract::Trigeminal neuralgia (TN) is a rare form of neuropathic facial pain characterised by severe, paroxysmal pains in the face. Little is known about the decision process in treatment of TN, and management with anti-epileptic drugs or surgical procedures carries risks of side effects, recurrence and complications. One hund...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.02.009
更新日期:2007-10-01 00:00:00
abstract::The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001723
更新日期:2020-02-01 00:00:00
abstract::Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::In the present study the question was addressed whether sensitivity to experimental pain stimuli differs between families, which are previously characterized by the degree of cold tolerance (very insensitive or very sensitive) of one family member. A total of 232 healthy medical students were screened for cold pain to...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.11.012
更新日期:2008-08-15 00:00:00
abstract::The mechanisms of chronic pain in irritable bowel syndrome (IBS) have been widely investigated but remain unclear. The present study investigated the relation between visceral hypersensitivity, cutaneous thermal sensitivity, and central pain mechanisms. Rectal sensitivity was assessed with a barostat, and forearm and ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.10.005
更新日期:2010-01-01 00:00:00
abstract::Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001676
更新日期:2019-12-01 00:00:00
abstract::No research to date has descriptively catalogued what parents of healthy infants are naturalistically doing to manage their infant's pain over immunization appointments during the first year of life. This knowledge, in conjunction with an understanding of the relationships different parental techniques have with infan...
journal_title:Pain
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pain.2013.03.036
更新日期:2013-08-01 00:00:00
abstract::Questions concerning stump, phantom and other pain problems as well as demographic data were mailed to 5000 Americans whose amputations were connected with military service. Fifty-five percent responded and of these, 78% reported phantom pain. No predisposing factors, other than presence of stump pain, correlated with...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90128-3
更新日期:1984-01-01 00:00:00
abstract::Primary afferent sensory neurons are incredibly long cells, often traversing distances of over 1 m in humans. Cutaneous sensory stimuli are transduced in the periphery by specialised end organs or free nerve endings, which code the stimulus into electrical action potentials that propagate towards the central nervous s...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001145
更新日期:2018-07-01 00:00:00
abstract::Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain leve...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90054-F
更新日期:1992-02-01 00:00:00
abstract::The literature on cognitive and cognitive-behavioral methods for pain control is selectively reviewed, with particular focus on controlled studies. Such methods include the provision of preparatory information, cognitive coping skills or strategies, the provision of preparatory information plus some form of coping ski...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(82)90154-3
更新日期:1982-03-01 00:00:00
abstract::The relation between personality characteristics and the psychological functioning of headache patients has long been a topic of interest. Early investigations focused on clinical and anecdotal reports while recent research has moved toward a more objective evaluation of headache groups by using the MMPI. However, the...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(86)90037-0
更新日期:1986-02-01 00:00:00
abstract::Fifty-seven patients (74%) who had completed a multidisciplinary pain program returned mailed questionnaires assessing both outcome and compliance measures. Significant treatment gains were observed at follow-up. Compliance with prescribed therapeutic regimens was low, averaging around 42% for individual regimens. Com...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90102-1
更新日期:1983-11-01 00:00:00
abstract::In a rat model of artificial ureteral calculosis, the aim of the study was to characterize the behavioural manifestations of direct visceral pain and to evaluate the relationship between number, duration and complexity of the visceral episodes and the extent of referred lumbar muscular hyperalgesia. As evidenced by no...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00208-V
更新日期:1995-06-01 00:00:00
abstract::The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001298
更新日期:2018-10-01 00:00:00
abstract::In response to an earlier published paper by Fordyce, some assumptions underlying the behavior management paradigm of chronic pain are critically discussed. While operant treatment has proved successful, the conclusion that operant factors play an important role in the development and maintenance of chronic benign pai...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/0304-3959(87)90016-9
更新日期:1987-09-01 00:00:00
abstract::The enzyme 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR) catalyzes the synthesis and bioavailability of 3alpha,5alpha-neurosteroids as allopregnanolone (3alpha,5alpha-THP) which activates GABA(A) receptors and blocks T-type calcium channels involved in pain mechanisms. Here, we used a multidisciplinary approach ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::The information from nociceptors is processed in the dorsal horn of the spinal cord by complex circuits involving excitatory and inhibitory interneurons. It is well documented that GluN2B and ERK1/2 phosphorylation contributes to central sensitization. Striatal-enriched protein tyrosine phosphatase (STEP) dephosphoryl...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000329
更新日期:2016-02-01 00:00:00
abstract::The aim of the present study was to determine if acupuncture stimulation inhibits sympathetic nerve activity in humans. Multiunit efferent postganglionic sympathetic activity was recorded with a tungsten microelectrode inserted in a muscle fascicle of the peroneal nerve. Mean arterial pressure, heart rate and skin blo...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/S0304-3959(97)00197-8
更新日期:1998-03-01 00:00:00
abstract::Many treatments used for women with vulvodynia are based solely upon expert opinion. This randomized trial aimed to test the relative efficacy of cognitive-behavioral therapy (CBT) and supportive psychotherapy (SPT) in women with vulvodynia. Of the 50 participants, 42 (84%) completed 10-week treatments and 47 (94%) co...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2008.09.031
更新日期:2009-01-01 00:00:00
abstract::Chronic pain due to surgery, radiotherapy, or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic nonmalignant pain, primarily with nonpharmacological strategies. Based on complete national data from the Cancer Registry of Norway and the...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001459
更新日期:2019-04-01 00:00:00
abstract::Nociceptive long-term potentiation, a use dependent increase in synaptic efficacy in the dorsal horn of the spinal cord is thought to contribute to the development of persistent pain states. So far, no study has analyzed the effects of high-frequency stimulation (HFS) of afferents from deep tissues (muscle and fascia)...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000649
更新日期:2016-10-01 00:00:00
abstract::Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies invest...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000000304
更新日期:2015-11-01 00:00:00
abstract::The effects of cognitive and competing sensory processing tasks on pain perception and as a function of time are only partially understood. To study these effects, we compared the simultaneous effects of noxious heat stimulation (HS), auditory stimulation (AS) (sinusoidally modulated speech-like signal, SMSLS), and a ...
journal_title:Pain
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.pain.2005.10.029
更新日期:2006-01-01 00:00:00
abstract::Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pai...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000513
更新日期:2016-06-01 00:00:00
abstract::Currently, opioids targeting mu-opioid receptors are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a co...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001968
更新日期:2020-12-01 00:00:00
abstract::The spinal ascending pathways responsible for neuronal ventrobasal (VB) thalamic responses elicited by joint stimulation of the posterior paw were determined in arthritic rats used as a model of experimental pain. Responses of a same neurone to mechanical (movement--pressure--brushing) or thermal stimulation (50 degre...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(86)90059-X
更新日期:1986-09-01 00:00:00