Selective regulation of 3 alpha-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: a possible mechanism to cope with peripheral nerve injury-induced chronic pain.

abstract：:A survey of the psychological characteristics of a large sample of chronic headache cases (n = 360), including classical and common migraine and tension headache sufferers, was carried out. Comparing groups defined in terms of the chronicity of their headache problems, it was found that those with a longer history of ...

journal_title：Pain

authors： Philips HC,Jahanshahi M

更新日期：1985-02-01 00:00:00

abstract：:Return of sensory nerve function in rat molars following cut or crush injury to the inferior alveolar nerve (IAN) was measured by observing the jaw opening reflex (JOR) response of the digastric muscle to electrical stimulation of individual molars or the gingiva. The IAN was injured from a lateral approach to the man...

journal_title：Pain

authors： Berger RL,Byers MR,Calkins DF

更新日期：1983-04-01 00:00:00

abstract：:OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in pat...

journal_title：Pain

authors： Cernuda-Morollón E,Ramón C,Martínez-Camblor P,Serrano-Pertierra E,Larrosa D,Pascual J

更新日期：2015-05-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) using the blood oxygen level-dependent (BOLD) contrast was used to study sensory processing in the brain of isoflurane-anesthetized mice. The use of a cryogenic surface coil in a small animal 9.4T system provided the sensitivity required for detection and quantitative analy...

journal_title：Pain

authors： Bosshard SC,Baltes C,Wyss MT,Mueggler T,Weber B,Rudin M

更新日期：2010-12-01 00:00:00

abstract：:The purpose of this study was to determine if some commonly used admission variables could predict treatment outcome on a multidisciplinary pain center. Specifically, it was designed as a prospective study of an index proposed by Maruta et al. The subjects were 104 patients. The 4 outcome measures used were staff judg...

journal_title：Pain

authors： Aronoff GM,Evans WO

更新日期：1982-09-01 00:00:00

abstract：:Recent meta-analyses have shown mindfulness-based interventions (MBIs) to be effective for chronic pain, but no pooled estimates of the effect of MBIs on acute pain are available. This meta-analysis was conducted to fill that gap. A literature search was conducted in 4 databases. Articles were eligible if they reporte...

journal_title：Pain

authors： Shires A,Sharpe L,Davies JN,Newton-John TRO

更新日期：2020-08-01 00:00:00

abstract：:Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP on...

journal_title：Pain

authors： Nicholl BI,Macfarlane GJ,Davies KA,Morriss R,Dickens C,McBeth J

更新日期：2009-01-01 00:00:00

abstract：:Patients with chronic pain in one limb, who experienced pain reduction with transcutaneous neurostimulation, were examined for sensory perception in that limb before and during electrical analgesia. Contralateral limbs and normal subjects served as controls. Sensory stimuli were quantified, a range of stimuli were pre...

journal_title：Pain

authors： Callaghan M,Sternbach RA,Nyquist JK,Timmermans G

更新日期：1978-08-01 00:00:00

abstract：:Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no m...

journal_title：Pain

authors： Ling B,Authier N,Balayssac D,Eschalier A,Coudore F

更新日期：2005-12-15 00:00:00

abstract：:The purpose of this study was to examine racial/ethnic-related differences in a four-stage model of the processing of chronic pain. The subjects were 1557 chronic pain patients (White=1084, African American=473) evaluated at a pain management clinic at a large southeastern university medical center. Using an analysis ...

journal_title：Pain

authors： Riley JL 3rd,Wade JB,Myers CD,Sheffield D,Papas RK,Price DD

更新日期：2002-12-01 00:00:00

abstract：:A variety of molecules released by inflammatory reactions in the dorsal root and dorsal root ganglion (DRG) may play important roles in the pathology of neuronal abnormalities in lumbar disc herniation. In order to elucidate the pathophysiological mechanisms of painful radiculopathy, secondary to lumbar disc herniatio...

journal_title：Pain

authors： Obata K,Tsujino H,Yamanaka H,Yi D,Fukuoka T,Hashimoto N,Yonenobu K,Yoshikawa H,Noguchi K

更新日期：2002-09-01 00:00:00

abstract：:Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...

journal_title：Pain

authors： Liaw WJ,Stephens RL Jr,Binns BC,Chu Y,Sepkuty JP,Johns RA,Rothstein JD,Tao YX

更新日期：2005-05-01 00:00:00

abstract：:No research to date has descriptively catalogued what parents of healthy infants are naturalistically doing to manage their infant's pain over immunization appointments during the first year of life. This knowledge, in conjunction with an understanding of the relationships different parental techniques have with infan...

journal_title：Pain

authors： Lisi D,Campbell L,Pillai Riddell R,Garfield H,Greenberg S

更新日期：2013-08-01 00:00:00

abstract：:Protein kinase signal transduction pathways play critical roles in regulating nociception. Here we show that c-kit, a tyrosine kinase receptor, is expressed in lamina I and II layer of the dorsal horn. Moreover, the superficial c-kit(+) fibers originate from the dorsal root ganglion, and c-kit in lamina II inner layer...

journal_title：Pain

authors： Sun YG,Gracias NG,Drobish JK,Vasko MR,Gereau RW,Chen ZF

更新日期：2009-07-01 00:00:00

abstract：:Ectopically generated and antidromically conducted nerve impulses were recorded in 5 patients with tungsten microelectrodes inserted into skin nerve fascicles. All patients had mainly positive sensory symptoms and reported paresthesiae which could be provoked by different maneuvers which suggested increased mechanosen...

journal_title：Pain

authors： Nordin M,Nyström B,Wallin U,Hagbarth KE

更新日期：1984-11-01 00:00:00

abstract：:Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-la...

journal_title：Pain

authors： Barrière DA,Hamieh AM,Magalhães R,Traoré A,Barbier J,Bonny JM,Ardid D,Busserolles J,Mériaux S,Marchand F

更新日期：2019-10-01 00:00:00

abstract：:Intradermal injection of capsaicin induces primary hyperalgesia at the injection site and secondary hyperalgesia in the surrounding undamaged skin. The secondary hyperalgesia is thought to be due to central sensitization of the dorsal horn neurons while primary hyperalgesia is caused by sensitization of nociceptors in...

journal_title：Pain

authors： Kim HT,Park SK,Lee SE,Chung JM,Lee DH

更新日期：2001-11-01 00:00:00

abstract：:This research was designed to identify and validate facial expressions of pain occurring in a clinical chronic pain condition. Facial expressions of 28 patients with chronic temporomandibular disorder pain were videotaped during a painful clinical examination procedure and coded using an anatomically based system. Cha...

journal_title：Pain

authors： LeResche L,Dworkin SF

更新日期：1988-10-01 00:00:00

abstract：:Neuropathic pain may be effectively relieved by electric stimulation of the spinal cord (SCS). However, the underlying mechanisms for the ensuing pain relief are poorly understood. In a rat model of neuropathy displaying hypersensitivity to innocuous tactile stimuli, (allodynia), we have earlier demonstrated that SCS ...

journal_title：Pain

authors： Cui JG,O'Connor WT,Ungerstedt U,Linderoth B,Meyerson BA

更新日期：1997-10-01 00:00:00

abstract：:Bradykinin is an endogenous peptide that is thought to be a chemical mediator of the hyperalgesia following inflammation. In rat, bradykinin has been postulated to cause hyperalgesia to mechanical stimuli by releasing prostaglandin from sympathetic post-ganglionic terminals. The aim of this study was to determine whet...

journal_title：Pain

authors： Meyer RA,Davis KD,Raja SN,Campbell JN

更新日期：1992-12-01 00:00:00

abstract：ABSTRACT:Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedu...

journal_title：Pain

authors： Solcà M,Krishna V,Young N,Deogaonkar M,Herbelin B,Orepic P,Mange R,Rognini G,Serino A,Rezai A,Blanke O

更新日期：2020-11-30 00:00:00

abstract：:We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. W...

journal_title：Pain

authors： Fox A,Kesingland A,Gentry C,McNair K,Patel S,Urban L,James I

更新日期：2001-05-01 00:00:00

abstract：:The aim of the present study has been to assess the responsiveness of various types of chronic pain to opioids given i.v. and tested against placebo in a double-blind, randomized fashion. Pain classified as primary nociceptive was effectively alleviated (P greater than 0.001) while neuropathic deafferentation pain was...

journal_title：Pain

authors： Arnér S,Meyerson BA

更新日期：1988-04-01 00:00:00

abstract：:Chronic complications of traumatic brain injury represent one of the greatest financial burdens and sources of suffering in the society today. A substantial number of these patients suffer from posttraumatic headache (PTH), which is typically associated with tactile allodynia. Unfortunately, this phenomenon has been u...

journal_title：Pain

authors： Wattiez AS,Castonguay WC,Gaul OJ,Waite JS,Schmidt CM,Reis AS,Rea BJ,Sowers LP,Cintrón-Pérez CJ,Vázquez-Rosa E,Pieper AA,Russo AF

更新日期：2020-10-02 00:00:00

abstract：:Past research has shown that pain catastrophizing contributes to heightened pain experience. The hypothesis advanced in this study was that individuals who score high on measures of pain catastrophizing would also perceive more intense pain in others. The study also examined the role of pain behaviour as a determinant...

journal_title：Pain

authors： Sullivan MJ,Martel MO,Tripp DA,Savard A,Crombez G

更新日期：2006-07-01 00:00:00

abstract：:Neuropathic pain can be a predictor of severe emotional distress, up to full-blown depressive states. In these patients, it is important to move beyond the sole treatment of pain, to recognize depressive symptoms, and to ultimately improve the quality of life. We systematically searched for published and unpublished c...

journal_title：Pain

authors： Caruso R,Ostuzzi G,Turrini G,Ballette F,Recla E,Dall'Olio R,Croce E,Casoni B,Grassi L,Barbui C

更新日期：2019-10-01 00:00:00

abstract：:Aiming at developing a new, noninvasive approach to spinal cord neuromodulation, we evaluated whether transcutaneous direct current (DC) stimulation induces long-lasting changes in the central pain pathways in human beings. A double-blind crossover design was used to investigate the effects of anodal direct current (2...

journal_title：Pain

authors： Cogiamanian F,Vergari M,Schiaffi E,Marceglia S,Ardolino G,Barbieri S,Priori A

更新日期：2011-02-01 00:00:00

abstract：:Current treatments for post-injury movement-evoked pain are inadequate. Non-opioids may complement opioids, which preferentially reduce spontaneous pain, but most have incomplete efficacy as single agents. This trial evaluates efficacy of a gabapentin-rofecoxib combination following hysterectomy. In addition to IV-PCA...

journal_title：Pain

authors： Gilron I,Orr E,Tu D,O'Neill JP,Zamora JE,Bell AC

更新日期：2005-01-01 00:00:00

abstract：:To inform case definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association, and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on muscu...

journal_title：Pain

authors： Sarquis LMM,Coggon D,Ntani G,Walker-Bone K,Palmer KT,Felli VE,Harari R,Barrero LH,Felknor SA,Gimeno D,Cattrell A,Vargas-Prada S,Bonzini M,Solidaki E,Merisalu E,Habib RR,Sadeghian F,Kadir MM,Warnakulasuriya SSP,Matsu

更新日期：2016-05-01 00:00:00

abstract：:The analgesic effect of systemic ibuprofen was investigated with two human experimental pain models: (i) static mechanical stimulation of the inter digital web between the 2nd and 3rd finger and (ii) primary and secondary hyperalgesia induced by a 7-min burn injury on the calf. In each double-blind, randomized, two-wa...

journal_title：Pain

authors： Petersen KL,Brennum J,Dahl JB

更新日期：1997-04-01 00:00:00