Abstract:
:Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain level when administered with intravenous placebo. When administered with pentazocine, clonidine caused a statistically significant increase in pentazocine analgesia. Comparison is made to other opiate-adrenergic interactions and possible mechanisms are discussed.
journal_name
Painjournal_title
Painauthors
Gordon NC,Heller PH,Levine JDdoi
10.1016/0304-3959(92)90054-Fkeywords:
subject
Has Abstractpub_date
1992-02-01 00:00:00pages
167-169issue
2eissn
0304-3959issn
1872-6623pii
00006396-199202000-00010journal_volume
48pub_type
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