Abstract：
:Poor women and women of color are disproportionately affected by HIV and this is particularly evident in sub-Saharan Africa. Even with increased access to antiretroviral therapy that makes HIV/AIDS a chronic manageable condition, little progress has been made to address the issues of pain caused by HIV disease in women. Women experience pain differently from men due to biological, psychological, and social factors. Despite a high prevalence of pain associated with HIV disease, pain is usually under-diagnosed and poorly treated. HIV-related pain is usually divided into two categories: nociceptive or neuropathic. Lack of knowledge of health care providers and reluctance to prescribe potent medication or antidepressants concomitantly to relieve pain contribute to the inadequate management of pain. In poor settings, the weak public health infrastructure with its limited human resources and inadequate drug supplies make high-quality palliative and end-of-life care virtually impossible. As the existing hospital infrastructure is unable to manage the large number of AIDS-related deaths, community-based palliative and end-of-life care models are urgently required. Health care providers in the developing world require training on basic pharmacology and effective analgesic care. An improved ability to assess pain and a greater understanding of HIV-specific pain syndromes and their mechanisms will enable health care providers to better alleviate pain in women. Unless the conditions under which women live are addressed, and attempts made to empower them in their daily lives, their limited ability to access treatment, care and pain relief will continue to be unacceptable.
journal_name
Painjournal_title
Painauthors
Gray G,Berger Pdoi
10.1016/j.pain.2007.10.009subject
Has Abstractpub_date
2007-11-01 00:00:00pages
S13-S21eissn
0304-3959issn
1872-6623pii
00006396-200711001-00003journal_volume
132 Suppl 1pub_type
杂志文章,评审相关文献
PAIN文献大全abstract：:Data on comparative safety of opioid analgesics are limited, but some reports suggest disproportionate mortality risk associated with methadone. Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain. This is a retrospective observational cohort d...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.03.023
更新日期：2011-08-01 00:00:00
abstract：:The GABA(B) receptor-mediated presynaptic inhibition of glycinergic transmission was studied from young rat substantia gelatinosa (SG) neurons using a conventional whole-cell patch clamp technique. Action potential-dependent glycinergic inhibitory postsynaptic currents (IPSCs) were recorded from SG neurons in the pres...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.01.005
更新日期：2008-08-31 00:00:00
abstract：:The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T-cell populations, very little attention has been ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001420
更新日期：2019-02-01 00:00:00
abstract：:Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)90110-4
更新日期：1994-04-01 00:00:00
abstract：:The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within...
journal_title：Pain
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pain.2006.01.041
更新日期：2006-08-01 00:00:00
abstract：:This report describes a placebo-controlled study of transcutaneous electrical nerve stimulation (TENS) applied to the contralateral lower leg and outer ears of an amputee with non-painful phantom sensations. The subject received TENS or placebo stimulation on separate sessions in which baseline periods of no stimulati...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(89)90098-5
更新日期：1989-03-01 00:00:00
abstract：:The effects of high temperature (53-61 degrees C) on membrane currents (I(heat)) or depolarization (V(heat)) induced by noxious heat were studied in cultured dorsal root ganglia neurons from neonatal rats using the whole cell patch clamp technique. I(heat) or V(heat) produced by 3 s ramps of increasing temperature bet...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00401-8
更新日期：2002-02-01 00:00:00
abstract：:Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.10.025
更新日期：2013-02-01 00:00:00
abstract：:Substance P like immunoreactivity (SPLI) and total protein (TP) concentrations in plasma and saliva were measured in 80 healthy female patients divided into the following four groups: women in group 1 were not pregnant and they were awaiting tubal ligation; women in group 2 were not pregnant but they experienced acute...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/S0304-3959(96)03258-7
更新日期：1997-02-01 00:00:00
abstract：:This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90082-M
更新日期：1992-03-01 00:00:00
abstract：:Changes in perception of pure thermal stimuli delivered to the hand at threshold intensity were observed during ischemic nerve block in 27 healthy subjects in order to study the significance of unmyelinated cutaneous cold receptors for thermal sensibility. Paresthesias and an increasing feeling of numbness were follow...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90112-X
更新日期：1984-12-01 00:00:00
abstract：:Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the manageme...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pain.2010.08.040
更新日期：2011-04-01 00:00:00
abstract：:Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2011.01.056
更新日期：2011-06-01 00:00:00
abstract：:To clarify the relationships between physical, and psychosocial components of chronic pain, a path analytic model was tested conceptualizing self efficacy as a mediator of disability. In turn, disability was hypothesized to mediate depression. This model could help explain the circumstances under which disability deve...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00220-6
更新日期：1999-04-01 00:00:00
abstract：:Pain has the capacity to interfere with daily tasks. Although task interference by pain is largely unintentional, it can be controlled to a certain extent. Such top-down control over pain has been believed to be reduced in patients with fibromyalgia (FM). In this study, we investigated task interference and distractio...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001196
更新日期：2018-06-01 00:00:00
abstract：:The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001298
更新日期：2018-10-01 00:00:00
abstract：:Two different modes of cutaneous sensory reinnervation are thought to be engaged following nerve injury: regenerative growth of the injured nerve and 'collateral sprouting' of neighboring intact nerves. Although both processes are well known from experimental preparations, there is little unequivocal documentation of ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(87)90112-6
更新日期：1987-02-01 00:00:00
abstract：:Behavioral analgesic techniques such as distraction reduce pain in both clinical and experimental settings. Individuals differ in the magnitude of distraction-induced analgesia, and additional study is needed to identify the factors that influence the pain relieving effects of distraction. Catastrophizing, a set of ne...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.11.012
更新日期：2010-05-01 00:00:00
abstract：:Below-level central neuropathic pain (CNP) affects a large proportion of spinal cord injured individuals. To better define the dynamic changes of the spinal cord neural network contributing to the development of CNP after spinal cord injury (SCI), we characterized the morphological and behavioral correlates of CNP in ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000422
更新日期：2016-03-01 00:00:00
abstract：:Previous research has demonstrated that intravenously administered cannabinoids produce potent antinociception in rodents. The present study examined the ability of 16 cannabinoid analogs to produce antinociception and hypothermia after intrathecal administration. Fifteen of the compounds tested produced significant i...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(92)90004-U
更新日期：1992-10-01 00:00:00
abstract：:Nociceptive impulse activity was recorded extracellularly from single A delta and C primary afferents of the guinea pig's medial articular nerve after induction of an experimental osteoarthritis in the knee joint by partial medial menisectomy and transection of the anterior cruciate ligament (PMM+TACL). Also, the anal...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2006.11.012
更新日期：2007-07-01 00:00:00
abstract：:Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00481-X
更新日期：2002-04-01 00:00:00
abstract：:Physicians are frequently called upon to evaluate patients with chronic pain to (1) establish the etiology, (2) determine the extent of impairment and disability, and (3) prescribe treatment. In many cases, there is little agreement as to what evaluation procedures should be used or how to weight and integrate these f...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(88)90181-9
更新日期：1988-07-01 00:00:00
abstract：:Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/s0304-3959(97)03376-9
更新日期：1997-07-01 00:00:00
abstract：:Lamina I of the spinal cord plays a key role in sensory transmission between afferent activity and the CNS. Studies have shown lamina I neurones to have distinct response properties compared to deep dorsal horn neurones, but little is known regarding excitatory amino acid mechanisms in their responses. Spinal electrop...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2003.12.004
更新日期：2004-03-01 00:00:00
abstract：:Tactile, proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response. To study differences in the processing of different stimulus qualities, we performed a study based on functional magnetic resonance imaging. The first trigeminal branch (o...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.05.007
更新日期：2008-10-15 00:00:00
abstract：:A study was undertaken to investigate if the concepts pain, ache and hurt differ from each other in intensity and quality and to identify discriminating semantic correlates for each of these concepts. Forty-one nurses with different backgrounds in nursing and 12 patients with chronic pain syndrome were included in the...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(84)90812-1
更新日期：1984-09-01 00:00:00
abstract：:Currently, opioids targeting mu-opioid receptors are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a co...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001968
更新日期：2020-12-01 00:00:00
abstract：:Two models of the relationship between paraspinal EMG and low back pain have been proposed. Specific predictions arising from these are listed and the literature relating to them reviewed. Recent research on patterns of EMG rather than absolute levels is also discussed. It is concluded that there is no consistent evid...
journal_title：Pain
pub_type： 杂志文章,评审
doi：10.1016/0304-3959(84)90093-9
更新日期：1984-10-01 00:00:00
abstract：:Though it is clear that genomic variability plays an integral role in accounting for pain sensitivity, controversy exists over which genes are involved. While recent data suggest a "protective" (i.e., less pain) haplotype in the GTP cyclohydrolase (GCH1) gene, other research has failed to confirm this association. Pos...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2008.10.023
更新日期：2009-01-01 00:00:00
