Botulinum toxin type A selectivity for certain types of pain is associated with capsaicin-sensitive neurons.

abstract：:(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...

journal_title：Pain

authors： Hampf G,Bowsher D,Wells C,Miles J

更新日期：1990-03-01 00:00:00

abstract：:Chronic low back pain (CLBP) patients with pain and symptomatology incongruent with physical pathology have been found to have a poorer outcome to medical treatment and rehabilitation, and to use health care resources excessively. To examine possible psychological and behavioral bases for this pattern, this investigat...

journal_title：Pain

authors： Reesor KA,Craig KD

更新日期：1988-01-01 00:00:00

abstract：:Alterations in sensory processing have been demonstrated in chronic low back and neck pain. However, it has not been yet systematically summarized how early these changes occur in spinal pain. This systematic review examines the available literature measuring somatosensory function in acute (<6 weeks) and subacute (6-...

journal_title：Pain

authors： Marcuzzi A,Dean CM,Wrigley PJ,Hush JM

更新日期：2015-02-01 00:00:00

abstract：:Quantitative sensory testing of heat pain sensation has become an important tool to evaluate small caliber afferent nerve function in peripheral neuropathy. In earlier studies, we found that topical application of capsaicin in humans results in the loss of epidermal nerve fibers (ENFs) with a corresponding decrease in...

journal_title：Pain

authors： Khalili N,Wendelschafer-Crabb G,Kennedy WR,Simone DA

更新日期：2001-04-01 00:00:00

abstract：:Nerve growth factor (NGF) is known to produce hyperalgesia as well as to stimulate synthesis of neuropeptides in dorsal root ganglia (DRG). In the present study, we wanted to determine the effects of local NGF administration and assess to which extent mast cell-dependent factors are mediating NGF responses. Rats recei...

journal_title：Pain

authors： Amann R,Schuligoi R,Herzeg G,Donnerer J

更新日期：1996-02-01 00:00:00

abstract：:When a peripheral nerve is severed, damaged sensory fibers emit a barrage of impulses that lasts for many seconds, or even several minutes ('injury discharge'). We have shown in rats that local anesthetic blockade of this discharge suppresses autotomy (a behavioral model of neuropathic pain). Correspondingly, mimickin...

journal_title：Pain

authors： Seltzer Z,Cohn S,Ginzburg R,Beilin B

更新日期：1991-04-01 00:00:00

abstract：:Migraine headache is one of the most common neurological disorders. The pathological conditions that directly initiate afferent pain signaling are poorly understood. In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology....

journal_title：Pain

authors： Yan J,Edelmayer RM,Wei X,De Felice M,Porreca F,Dussor G

更新日期：2011-01-01 00:00:00

abstract：:In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I-III. The main limitation has been the difficulty in defining functional populations among the...

journal_title：Pain

authors： Polgár E,Sardella TCP,Tiong SYX,Locke S,Watanabe M,Todd AJ

更新日期：2013-12-01 00:00:00

abstract：:Individual differences in interoceptive sensitivity are associated with differences in reported intensity of emotional experience, vulnerability to anxiety and mood disorder and capacity for emotional self-regulation. Enhanced sensitivity to autonomic state is often accompanied by increased autonomic reactivity. Here ...

journal_title：Pain

authors： Pollatos O,Füstös J,Critchley HD

更新日期：2012-08-01 00:00:00

abstract：:Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies revealed that NPY dose-dependently increased hotplate response latency, and to a lesser degree, thermal paw withdrawal latency (PWL); ...

journal_title：Pain

authors： Taiwo OB,Taylor BK

更新日期：2002-04-01 00:00:00

abstract：:An electrophysiological study was carried out in anesthetized rats to characterize the properties of single neurons in trigeminal (V) subnucleus caudalis. Each neuron was functionally classified in terms of its cutaneous mechanoreceptive field properties as low-threshold mechanoreceptive (LTM), wide dynamic range (WDR...

journal_title：Pain

authors： Hu JW

更新日期：1990-06-01 00:00:00

abstract：:Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may highlight potential intervention strategies. This study uses a novel...

journal_title：Pain

authors： Smith D,Wilkie R,Croft P,Parmar S,McBeth J

更新日期：2018-06-01 00:00:00

abstract：:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic...

journal_title：Pain

authors： Lang E,Hord HA,Denson D

更新日期：1996-11-01 00:00:00

abstract：:Sensitization of purinergic P2X3 receptors (P2X3Rs) is a major mechanism contributing to injury-induced exaggerated pain responses. We showed in a previous study that cyclic adenosine monophosphate (cAMP)-dependent guanine nucleotide exchange factor 1 (Epac1) in rat sensory dorsal root ganglia (DRGs) is upregulated af...

journal_title：Pain

authors： Gu Y,Li G,Chen Y,Huang LM

更新日期：2016-07-01 00:00:00

abstract：:Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...

journal_title：Pain

authors： Egan KJ,Ready LB,Nessly M,Greer BE

更新日期：1992-04-01 00:00:00

abstract：:Pain catastrophizing is associated with enhanced temporal summation of pain (TS-Pain). However, because prior studies have found that pain catastrophizing is not associated with a measure of spinal nociception (nociceptive flexion reflex [NFR] threshold), this association may not result from changes in spinal nocicept...

journal_title：Pain

authors： Rhudy JL,Martin SL,Terry EL,France CR,Bartley EJ,DelVentura JL,Kerr KL

更新日期：2011-04-01 00:00:00

abstract：:Atypical odontalgia (AO) is an intraoral pain condition of currently unknown mechanisms. In 10 AO patients and 10 matched healthy controls, we examined the effect of intravenous infusion of an N-methyl-D-aspartate (NMDA) receptor antagonist S-ketamine and a mu-opioid agonist fentanyl on spontaneous AO pain and on an a...

journal_title：Pain

authors： Baad-Hansen L,Juhl GI,Jensen TS,Brandsborg B,Svensson P

更新日期：2007-05-01 00:00:00

abstract：:Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...

journal_title：Pain

authors： Eliav E,Teich S,Nitzan D,El Raziq DA,Nahlieli O,Tal M,Gracely RH,Benoliel R

更新日期：2003-08-01 00:00:00

abstract：:The social determinants of health (SDH) are known to differentially impact outcomes from many noncommunicable diseases; however, their potential role in low back pain (LBP) is poorly defined. This review endeavours to comprehensively inform the field of their relevance. Our research question was: "How do the broad ran...

journal_title：Pain

authors： Karran EL,Grant AR,Moseley GL

更新日期：2020-11-01 00:00:00

abstract：:We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...

journal_title：Pain

authors： Vance CG,Zimmerman MB,Dailey DL,Rakel BA,Geasland KM,Chimenti RL,Williams JM,Golchha M,Crofford LJ,Sluka KA

更新日期：2020-11-11 00:00:00

abstract：:Pain patients' retrospective reports of pain are important to physicians and other health professionals in helping to decide on future treatment plans. Unfortunately patients' memory of pain can be inaccurate and subject to overestimation. This study examined variables which influenced accuracy of remembering pain in ...

journal_title：Pain

authors： Jamison RN,Sbrocco T,Parris WCV

更新日期：1989-06-01 00:00:00

abstract：:Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means. We have now investigated if ERK is activated in the spinal cord after a spinal nerve ligation (SNL) and if thi...

journal_title：Pain

authors： Zhuang ZY,Gerner P,Woolf CJ,Ji RR

更新日期：2005-03-01 00:00:00

abstract：:Pain is a biologically relevant signal and response to bodily threat, associated with the urge to restore the integrity of the body. Immediate protective responses include increased arousal, selective attention, escape, and facial expressions, followed by recuperative avoidance and safety-seeking behaviors. To facilit...

journal_title：Pain

authors： Vlaeyen JWS

更新日期：2015-04-01 00:00:00

abstract：:(1) Capsaicin solution was applied for 15 min around a 1 cm length of sciatic nerve in the mid upper leg of adult rats. (2) Electron microscopic examinations of the nerve in the treated region after 14 days shows no signs of degeneration of either myelinated or unmyelinated fibres attributable to the capsaicin. (3) Fl...

journal_title：Pain

authors： Ainsworth A,Hall P,Wall PD,Allt G,MacKenzie ML,Gibson S,Polak JM

更新日期：1981-12-01 00:00:00

abstract：:Intrathecal administration of serotonin type 2 (5-HT(2)) receptor agonists, alpha-methyl-5-hydroxytryptamine maleate (alpha-m-5-HT) or (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI), produces antiallodynic effects in a rat model of neuropathic pain. In the present study, we examined the antial...

journal_title：Pain

authors： Obata H,Saito S,Sakurazawa S,Sasaki M,Usui T,Goto F

更新日期：2004-03-01 00:00:00

abstract：:Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...

journal_title：Pain

authors： Edwards RR,Almeida DM,Klick B,Haythornthwaite JA,Smith MT

更新日期：2008-07-01 00:00:00

abstract：:Intraperitoneal administration of the serotonin 5-HT1A agonist, buspirone (1-5 mg/kg), produced dose- and time-related core hypothermia that was coincident with analgesia against a thermally noxious stimulus. Surface body temperature was not altered by buspirone. The 5-HT1A antagonist, NAN-190 (2 mg/kg, s.c.), blocked...

journal_title：Pain

authors： Giordano J,Rogers L

更新日期：1992-09-01 00:00:00

abstract：:In previous studies, pain behaviors produced in the spinal nerve ligation rat model of neuropathic pain were partly reduced by surgical lumbar sympathectomy. However, systemic injection of phentolamine, an alpha-adrenoceptor blocker, was not effective in reducing pain behaviors, at least in the Sprague-Dawley strain o...

journal_title：Pain

authors： Park SK,Chung K,Chung JM

更新日期：2000-08-01 00:00:00

abstract：:Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Di...

journal_title：Pain

authors： Schug SA,Lavand'homme P,Barke A,Korwisi B,Rief W,Treede RD,IASP Taskforce for the Classification of Chronic Pain.

更新日期：2019-01-01 00:00:00

abstract：:Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involved in central sensitization, the present study examines the levels of activated N-methyl-d-aspartate (NMDA) receptors in the dorsal h...

journal_title：Pain

authors： Gao X,Kim HK,Mo Chung J,Chung K

更新日期：2007-10-01 00:00:00