Abstract:
:Venlafaxine hydrochloride (Effexor) is a structurally novel antidepressant that inhibits reuptake of 5-hydroxytryptamine and noradrenaline, but unlike the older antidepressants, has few side-effects. The objective of this study was to determine whether venlafaxine relieves thermal hyperalgesia in rats with neuropathic pain due to chronic constriction injury (CCI) of the sciatic nerve. Paw withdrawal latency (PWL) to heat was tested for each hind paw. A painful neuropathy was induced in 24 male Sprague-Dawley rats (Group 1) as described by Bennett and Xie. Rats randomly received either oral venlafaxine (22 mg/kg) or placebo via gavage feeding beginning the day after surgery. Postoperative PWL testing began 3 days after CCI (Time 0). A second group of 12 rats (Group 2) was used to confirm that venlafaxine reverses hyperalgesia in rats with a fully developed neuropathic lesion. These animals began to receive oral venlafaxine (22 mg/kg) starting on the third postoperative day, after the presence of thermal hyperalgesia was verified through PWL testing. Testing was continued for 5 days, during venlafaxine administration. A third group of 12 rats (Group 3) had activity measured before and after treatment with venlafaxine (22 mg/kg). Rats in the placebo group developed thermal hyperalgesia while those that received venlafaxine did not. Venlafaxine also appeared to have a mild non-specific analgesic effect that increased PWL in the sham limb. In Group 2, thermal hyperalgesia was present on day 3, but following treatment with venlafaxine, thermal hyperalgesia resolved. Activity measurements confirmed that venlafaxine was not sedating in this rat model.
journal_name
Painjournal_title
Painauthors
Lang E,Hord HA,Denson Ddoi
10.1016/S0304-3959(96)03223-Xsubject
Has Abstractpub_date
1996-11-01 00:00:00pages
151-155issue
1eissn
0304-3959issn
1872-6623pii
00006396-199611000-00019journal_volume
68pub_type
杂志文章相关文献
PAIN文献大全abstract::When faced with the problem of pain one can attempt a solution aimed at relief (assimilation) or a solution aimed at acceptance (accommodation). Using this dual process model of adaptation to pain, this study compares acute and chronic pain patients on their approach to problem solving. Three hundred and sixty-four pa...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.10.020
更新日期:2008-07-31 00:00:00
abstract::Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00077-0
更新日期:2003-08-01 00:00:00
abstract::Migraine headache is one of the most common neurological disorders. The pathological conditions that directly initiate afferent pain signaling are poorly understood. In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology....
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.09.036
更新日期:2011-01-01 00:00:00
abstract::We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. W...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(00)00474-7
更新日期:2001-05-01 00:00:00
abstract::Epidural and intrathecal techniques are well established techniques in cancer pain. However, several questions remain unresolved. The several problems of long-term spinal opioid treatment in advance cancer patients were reviewed. Indications for the use of spinal opioids include patients treated by systemic opioids wi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/S0304-3959(98)00118-3
更新日期:1999-01-01 00:00:00
abstract::A series of 37 patients with chronic pain was investigated with regard to neurologic and psychiatric variables. Twenty of the patients were classified as having mainly organic (= somatogenic) pain syndromes while 17 patients were rather suffering from psychogenic pain syndromes. Samples of lumbar cerebrospinal fluid (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(78)90037-4
更新日期:1978-08-01 00:00:00
abstract::After 4 millennia of more or less documented history of cannabis use, the identification of cannabinoids, and of Δ(9)-tetrahydrocannabinol in particular, occurred only during the early 1960s, and the cloning of cannabinoid CB1 and CB2 receptors, as well as the discovery of endocannabinoids and their metabolic enzymes,...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2013.03.023
更新日期:2013-12-01 00:00:00
abstract::Atypical odontalgia (AO) is an intraoral pain condition of currently unknown mechanisms. In 10 AO patients and 10 matched healthy controls, we examined the effect of intravenous infusion of an N-methyl-D-aspartate (NMDA) receptor antagonist S-ketamine and a mu-opioid agonist fentanyl on spontaneous AO pain and on an a...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.pain.2006.09.032
更新日期:2007-05-01 00:00:00
abstract::Resveratrol is a natural polyphenol that protects from cancer and cardiovascular diseases. Resveratrol is able to induce apoptotic cell death and it inhibits the cyclooxygenase (COX) cascade. We measured the antinociceptive effect of resveratrol on carrageenan-induced hyperalgesia, prostaglandin-E2 (PGE2) concentratio...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.08.010
更新日期:2008-11-30 00:00:00
abstract::Experimental muscle pain was elicited by bolus injection of 0.15 ml of 5% hypertonic saline into the human masseter muscle. The sensory experience was described using 10-cm visual analogue scales (VAS) and the McGill Pain Questionnaires (MPQ) on 10 subjects. Effects of pain on deliberately unilateral mastication were ...
journal_title:Pain
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3959(95)00133-6
更新日期:1996-02-01 00:00:00
abstract::In a rat model of artificial ureteral calculosis, the aim of the study was to characterize the behavioural manifestations of direct visceral pain and to evaluate the relationship between number, duration and complexity of the visceral episodes and the extent of referred lumbar muscular hyperalgesia. As evidenced by no...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(94)00208-V
更新日期:1995-06-01 00:00:00
abstract::Musculoskeletal trauma and pain can sensitize central pain mechanisms, but whether these normalize on recovery is unknown. This study compared the extent of pain referral in individuals recovered from a musculoskeletal trauma and healthy controls. Twenty pain-free participants recovered from a shoulder fracture and 20...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000001234
更新日期:2018-10-01 00:00:00
abstract::Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(83)90113-6
更新日期:1983-07-01 00:00:00
abstract::The ascending Method of Limits, used for the determination of pressure pain thresholds (PPT), is not a psychophysically robust method. The present study sought to determine if the examiner's expectancy, based on whether the measurement site was clinically 'painful' or 'non-painful', would bias the obtained PPT values....
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(97)00174-7
更新日期:1998-02-01 00:00:00
abstract::The ability to sense and respond to thermal stimuli at varied environmental temperatures is essential for survival in seasonal areas. In this study, we show that mice respond similarly to ramping changes in temperature from a wide range of baseline temperatures. Further investigation suggests that this ability to adap...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.001
更新日期:2014-10-01 00:00:00
abstract::We evaluated the construct validity (including responsiveness), reliability, and feasibility of the Pain Squad multidimensional smartphone-based pain assessment application (app) in children and adolescents with cancer, using 2 descriptive studies with repeated measures. Participants (8-18 years) undergoing cancer tre...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000385
更新日期:2015-12-01 00:00:00
abstract::This research was designed to identify and validate facial expressions of pain occurring in a clinical chronic pain condition. Facial expressions of 28 patients with chronic temporomandibular disorder pain were videotaped during a painful clinical examination procedure and coded using an anatomically based system. Cha...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(88)90278-3
更新日期:1988-10-01 00:00:00
abstract::Spinal long-term potentiation (LTP) elicited by noxious stimulation enhances the responsiveness of dorsal horn nociceptive neurons to their normal input, and may represent a key mechanism of central sensitization by which acute pain could turn into a chronic pain state. This study investigated the electrophysiological...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.05.002
更新日期:2009-08-01 00:00:00
abstract::Phantom urinary phenomena are a relatively rare disease entity. Literature search has revealed only one case following cystectomy, seven cases following spinal cord injury and several other cases in hemodialysis patients. This report presents a case of painful phantom bladder following cystectomy for chronic kidney an...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(79)90011-3
更新日期:1979-10-01 00:00:00
abstract::The main goal of current pain management approaches is to increase the patients' quality of life by improving pain coping skills and by reducing the levels of disability in daily life, often despite persistent pain. Direct measurement of quality of life is of crucial importance in economic evaluation research, in whic...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3959(98)00232-2
更新日期:1999-03-01 00:00:00
abstract::Pro-inflammatory cytokine production after nociceptive stimuli is pivotal for hyperalgesia. As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced i...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.11.011
更新日期:2010-02-01 00:00:00
abstract::Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pai...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000513
更新日期:2016-06-01 00:00:00
abstract::This preliminary study examined the self-efficacy of family caregivers with regard to helping cancer patients manage pain at end of life. A sample of 63 family caregivers of hospice-eligible cancer patients with pain provided ratings of their self-efficacy in assisting the patient in pain management and rated their ow...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(02)00448-7
更新日期:2003-05-01 00:00:00
abstract::Ten patients who suffered from severe cancer-related pain participated in a randomised, double-blind and cross-over study to compare the effectiveness and acceptability of epidural and subcutaneous administration of morphine. The patients titrated themselves pain-free in 48 h using a patient controlled analgesia syste...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(96)03161-2
更新日期:1996-10-01 00:00:00
abstract::The N-methyl-D-aspartic acid (NMDA) receptor antagonist D, L-2-amino-5-phosphonopentanoic acid (AP5) caused a stronger inhibition of wind-up in single wide dynamic range (WDR) neurons after carrageenan inflammation compared with control neurons without inflammation in the receptive field. This indicates that even a sh...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00155-4
更新日期:1999-12-01 00:00:00
abstract::Formalin injection into the hindpaw of rats produces many neurons with c-fos protein-like immunoreactivity (fos-neurons) in the medial 3/4 of the ipsilateral dorsal horn laminae I and II at the junction of 4th and 5th lumbar segments (the sciatic territory). The tibial nerve transection 2 or 3 days earlier resulted in...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00014-J
更新日期:1995-10-01 00:00:00
abstract::Tramadol hydrochloride is a synthetic mu-opioid agonist with additional monoaminergic activity. Tramadol's analgesic effect has been equated with that of pethidine, with a more favourable side-effect profile. Tramadol has been the most-selling prescription analgesic in Germany for several years, and it is now availabl...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(95)00056-X
更新日期:1995-07-01 00:00:00
abstract::Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without neurological abnormalities and without clinically objectifiable cause. Similarities to neuropathic pain conditions have ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002126
更新日期:2020-10-26 00:00:00
abstract::We studied whether striatal alpha(2)-adrenoceptors or N-methyl-d-aspartate (NMDA) receptors influence descending regulation of neuropathic hypersensitivity in the rat by microinjecting an alpha(2)-adrenoceptor agonist or NMDA-receptor antagonist into the dorsal striatum in animals with a spinal nerve ligation-induced ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.08.009
更新日期:2008-07-01 00:00:00
abstract::Since a number of patients with Parkinson's Disease (PD) complain of painful sensations, we studied whether the central processing of nociceptive inputs is abnormal in PD. To test this hypothesis, we recorded scalp CO(2) laser evoked potentials (LEPs) to hand skin stimulation in 18 pain-free PD patients with unilatera...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.06.022
更新日期:2008-05-01 00:00:00