Abstract:
:Ten patients who suffered from severe cancer-related pain participated in a randomised, double-blind and cross-over study to compare the effectiveness and acceptability of epidural and subcutaneous administration of morphine. The patients titrated themselves pain-free in 48 h using a patient controlled analgesia system. The median daily doses calculated from the consumption of the last 4-h study period were 372 mg for subcutaneous and 106 mg for epidural administration. The two modes of morphine administration turned out to be comparable in terms of both effectiveness and acceptability. Both treatments provided better pain relief with less adverse effects compared with the prestudy oral morphine treatment.
journal_name
Painjournal_title
Painauthors
Kalso E,Heiskanen T,Rantio M,Rosenberg PH,Vainio Adoi
10.1016/0304-3959(96)03161-2subject
Has Abstractpub_date
1996-10-01 00:00:00pages
443-9issue
2-3eissn
0304-3959issn
1872-6623journal_volume
67pub_type
临床试验,杂志文章,随机对照试验相关文献
PAIN文献大全abstract::This study reports a 9-18 month follow-up of a randomised controlled trial of pain management programmes for chronic, non-malignant pain. Twenty-two inpatients, 18 outpatients and 12 control subjects completed the follow-up assessments. Significant treatment effects were demonstrated by the inpatient group on pain rat...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0304-3959(92)90110-W
更新日期:1992-07-01 00:00:00
abstract::Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000827
更新日期:2017-04-01 00:00:00
abstract::We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...
journal_title:Pain
pub_type: 杂志文章,meta分析
doi:10.1097/j.pain.0000000000001609
更新日期:2019-08-01 00:00:00
abstract::This article reports on a study that examines the influence of task-related factors on nurses' pain assessments and decision regarding interventions. In an experimental design pediatric nurses (n = 202), were exposed to different cases, each case being a combination of a vignette and a videotape. For every case subjec...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/0304-3959(95)00147-6
更新日期:1996-04-01 00:00:00
abstract::The role of 5-hydroxytryptamine (5-HT)(4), 5-HT(6), and 5-HT(7) receptors in formalin-induced secondary allodynia and hyperalgesia in rats was assessed. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-term secondary mechanical allodynia and hyperalgesia. Pretreatment (-10...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.12.020
更新日期:2011-03-01 00:00:00
abstract::Distinct developmental trajectories for neck disability and posttraumatic stress disorder (PTSD) symptoms after whiplash injury have recently been identified. This study aimed to identify baseline predictors of membership to these trajectories and to explore their dual development. In a prospective study, 155 individu...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.01.056
更新日期:2011-06-01 00:00:00
abstract::The Quantitative Sensory Testing (QST) protocol of the German research network on neuropathic pain (DFNS) encompassing all somatosensory modalities assesses the functioning of different nerve fibers and of central pathways. The aim of our study was: (1) to explore, whether this QST protocol is feasible for children, (...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2010.01.011
更新日期:2010-04-01 00:00:00
abstract::Chronic neuropathic pain is associated with long-term changes at multiple levels of the neuroaxis, including in the brain, where electrical stimulation has been used to manage severe pain conditions. However, the clinical outcome of deep brain stimulation is often mixed, and the mechanisms are poorly understood. By me...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2011.07.011
更新日期:2011-11-01 00:00:00
abstract::Manipulative therapy is frequently used in the management of musculoskeletal pain. A frequently reported clinical feature of this treatment is the immediacy with which it appears to initiate improvement in pain and function. A randomised, double blind, placebo controlled, repeated measures design was employed to study...
journal_title:Pain
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0304-3959(96)03221-6
更新日期:1996-11-01 00:00:00
abstract::Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced, rather than dimin...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2007.06.026
更新日期:2007-11-01 00:00:00
abstract::The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC can reduce chronic and experimental pain. However, whether left DLPFC rTMS can influence t...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001350
更新日期:2018-12-01 00:00:00
abstract::Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)00226-1
更新日期:1998-04-01 00:00:00
abstract::High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collection and reporting of adverse event data as presented in published cli...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1016/j.pain.2012.08.012
更新日期:2013-02-01 00:00:00
abstract::We have developed a model in which inflammation contiguous to and within a dorsal root ganglion (DRG) was generated by local application of complete Freund's adjuvant (CFA) to the L4 lumbar spinal nerve as it exits from the intervertebral foramen. The periganglionic inflammation (PGI) elicited a marked reduction in wi...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.11.013
更新日期:2009-03-01 00:00:00
abstract::There are few prospective studies assessing risk factors for onset of temporomandibular (TMD) pain disorders in any age group. The aim of this prospective cohort study was to identify risk factors for onset of clinically significant TMD pain (i.e., pain meeting research diagnostic criteria for myofascial pain and/or a...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.10.012
更新日期:2007-06-01 00:00:00
abstract::Burning mouth syndrome is a common disorder that frequently affects women in the 5th-7th decade. It is characterized by persisting painful symptoms mainly involving the anterior two-thirds of the tongue. For several years it has been attributed to psychological causes. We investigated the innervation of the epithelium...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2005.03.028
更新日期:2005-06-01 00:00:00
abstract::Osteoarthritis (OA) is a major healthcare burden of increasing prevalence. It has been demonstrated that the relationship between pain and sleep produces changes in sleep patterns and pain perception. However, electrophysiological studies in animal models of pain are limited. The current study examined the effect of c...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.09.025
更新日期:2008-12-01 00:00:00
abstract::Features of somatisation have been shown to predict the onset of widespread body pain. This study aims to determine to what extent persons with orofacial pain syndromes share these features and to what extent they are uniquely related to oral mechanical factors. We have conducted a population-based cross-sectional sur...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00181-1
更新日期:2002-10-01 00:00:00
abstract::Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera to...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2014.08.023
更新日期:2014-11-01 00:00:00
abstract::Neuropathic pain behaviour is not observed in neonatal rats and tactile allodynia does not develop in the spared nerve injury (SNI) model until rats are 4 weeks of age at the time of surgery. Since activated spinal microglia are known to play a key role in neuropathic pain, we have investigated whether the microglial ...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2006.09.018
更新日期:2007-04-01 00:00:00
abstract::For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met wi...
journal_title:Pain
pub_type: 杂志文章,评审
doi:10.1097/j.pain.0000000000000335
更新日期:2015-11-01 00:00:00
abstract::Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-la...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000001610
更新日期:2019-10-01 00:00:00
abstract::Systemic opioid dosing until adequate analgesia in neuropathic pain may involve intolerable and untreatable side effects. Peripheral opioid receptor mechanisms may participate in the antinociceptive effect of systemic morphine. We evaluated the effect of peripherally injected morphine alone, and the ability of the fun...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(02)00270-1
更新日期:2002-10-01 00:00:00
abstract::Heat and electrical detection thresholds were assessed in 72 patients suffering from painful temporomandibular disorder. Employing widely accepted criteria, 44 patients were classified as suffering from temporomandibular joint (TMJ) arthralgia (i.e. pain originating from the TMJ) and 28 from myalgia (i.e. pain origina...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(03)00077-0
更新日期:2003-08-01 00:00:00
abstract::Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/s0304-3959(97)03376-9
更新日期:1997-07-01 00:00:00
abstract::We previously showed 1-month of Transcutaneous Electrical Nerve Stimulation (TENS) reduces movement-evoked pain and fatigue in women with fibromyalgia (FM). Using data from this study (Fibromyalgia Activity Study with TENS, FAST), we performed a responder analysis to identify predictors of clinical improvement in pain...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000002144
更新日期:2020-11-11 00:00:00
abstract::This work aimed to evaluate the potential role of the 5-HT(7) receptor in nociception secondary to a sensitizing stimulus in mice. For this purpose, the effects of relevant ligands (5-HT(7) receptor agonists: AS-19, MSD-5a, E-55888; 5-HT(7) receptor antagonists: SB-258719, SB-269970; 5-HT(1A) receptor agonist: F-13640...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2008.11.009
更新日期:2009-02-01 00:00:00
abstract::The present paper presents the relationship between the total body-pain (TBP) score, defined as the total number of areas shaded on a pain drawing, and the pain from one area, the Shoulder-Neck (SN), among subjects in or out of full-time gainful work respectively. Furthermore, relationships between pain-score, self-ex...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/S0304-3959(99)00053-6
更新日期:1999-09-01 00:00:00
abstract::It has been confirmed that the voltage-gated persistent sodium currents mediate the generation of subthreshold membrane potential oscillations (SMPOs) and contribute to shaping repetitive firing. Our previous study indicated that gabapentin (GBP) administration induced a dose-dependent inhibition of SMPO in chronicall...
journal_title:Pain
pub_type: 杂志文章
doi:10.1016/j.pain.2009.01.020
更新日期:2009-05-01 00:00:00
abstract::This laboratory-based study examined lagged associations between child pain behavior and maternal responses as a function of maternal catastrophizing (CAT). Mothers completed the parent version of the Pain Catastrophizing Scale. Children participated in a validated water ingestion procedure to induce abdominal discomf...
journal_title:Pain
pub_type: 杂志文章
doi:10.1097/j.pain.0000000000000963
更新日期:2017-09-01 00:00:00