Structural and functional alterations in the retrosplenial cortex following neuropathic pain.

abstract：:The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...

journal_title：Pain

authors： Wesselmann U,Lai J

更新日期：1997-12-01 00:00:00

abstract：:Adults with mood disorders frequently use prescription opioids. The factors associated with this increased use remain unclear. We used the Medical Expenditure Panel Surveys from 2005 to 2011 to measure the association of mood disorders with new opioid use and the transition to longer-term opioid use for a variety of p...

journal_title：Pain

authors： Halbert BT,Davis RB,Wee CC

更新日期：2016-11-01 00:00:00

abstract：:The responses of 144 spinothalamic tract (STT) cells were recorded in 15 anesthetized macaque monkeys (Macaca fascicularis). Three to 4 weeks prior to the acute experiment, the sciatic nerve was surgically exposed on one or both sides so that capsaicin or vehicle could be applied. Responses of STT cells recorded in 3 ...

journal_title：Pain

authors： Chung JM,Paik KS,Kim JS,Nam SC,Kim KJ,Oh UT,Hasegawa T,Chung K,Willis WD

更新日期：1993-06-01 00:00:00

abstract：:We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty and the effects of a single i.v. preoperative dose of methylprednisolone 125 mg (n=74), parecoxib 40 mg (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks and 1 year after surgery. Response rate a...

journal_title：Pain

authors： Romundstad L,Breivik H,Roald H,Skolleborg K,Romundstad PR,Stubhaug A

更新日期：2006-09-01 00:00:00

abstract：:The synaptic vesicle protein synapsin II plays an important role in the regulation of neurotransmitter release and synaptic plasticity. Here, we investigated its involvement in the synaptic transmission of nociceptive signals in the spinal cord and the development of pain hypersensitivity. We show that synapsin II is ...

journal_title：Pain

authors： Schmidtko A,Del Turco D,Coste O,Ehnert C,Niederberger E,Ruth P,Deller T,Geisslinger G,Tegeder I

更新日期：2005-05-01 00:00:00

abstract：:OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism of action, however, remains obscure. We have analysed whether treatment with onabotA is able to induce changes in interictal plasma calcitonin gene-related peptide (CGRP) concentrations, which have been shown to be increased in pat...

journal_title：Pain

authors： Cernuda-Morollón E,Ramón C,Martínez-Camblor P,Serrano-Pertierra E,Larrosa D,Pascual J

更新日期：2015-05-01 00:00:00

abstract：:The spinal gray matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply o...

journal_title：Pain

authors： Krotov V,Tokhtamysh A,Safronov BV,Belan P,Voitenko N

更新日期：2019-09-01 00:00:00

abstract：:Capsaicin-containing plant extracts have been used as topical treatments for a variety of pain syndromes for many centuries. Current products containing capsaicin in low concentrations (usually 0.025-0.075% w/w) have shown efficacy against a variety of pain conditions in clinical studies. However, in order to produce ...

journal_title：Pain

authors： Malmberg AB,Mizisin AP,Calcutt NA,von Stein T,Robbins WR,Bley KR

更新日期：2004-10-01 00:00:00

abstract：:The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura...

journal_title：Pain

authors： Juhasz G,Zsombok T,Modos EA,Olajos S,Jakab B,Nemeth J,Szolcsanyi J,Vitrai J,Bagdy G

更新日期：2003-12-01 00:00:00

abstract：:Fear-avoidance beliefs have been identified as an important psychosocial variable in patients with chronic disability doe to low back pain. The importance of fear-avoidance beliefs for individuals with acute low back pain has not been explored. Seventy-eight subjects with work-related low back pain of less than 3 week...

journal_title：Pain

authors： Fritz JM,George SZ,Delitto A

更新日期：2001-10-01 00:00:00

abstract：:Currently, opioids targeting mu-opioid receptors are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, or addiction potential. We recently developed (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a co...

journal_title：Pain

authors： Massaly N,Temp J,Machelska H,Stein C

更新日期：2020-12-01 00:00:00

abstract：:In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...

journal_title：Pain

authors： Dolique T,Favereaux A,Roca-Lapirot O,Roques V,Léger C,Landry M,Nagy F

更新日期：2013-11-01 00:00:00

abstract：:Cross-sectional research in clinical samples, as well as experimental studies in healthy adults, suggests that the experiences of pain and sleep are bi-directionally connected. However, whether sleep and pain experiences are prospectively linked to one another on a day-to-day basis in the general population has not pr...

journal_title：Pain

authors： Edwards RR,Almeida DM,Klick B,Haythornthwaite JA,Smith MT

更新日期：2008-07-01 00:00:00

abstract：:Genetic influence on the sensory, motor and histopathological outcome of transient spinal cord ischemia was studied in Sprague-Dawley (SD), spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Ischemia caused minor motor deficits and no identifiable morphological damage in the spinal cord of the majority of SD...

journal_title：Pain

authors： Wiesenfeld-Hallin Z,Hao JX,Xu XJ,Aldskogius H,Seiger Å

更新日期：1993-11-01 00:00:00

abstract：:The tricyclic antidepressant drugs (TCAs) are commonly used in the treatment of chronic, especially neuropathic, pain. We evaluated their possible effect on a new model of neuropathic pain-related behaviour induced by ligatures tied loosely around the common sciatic nerve. The effects of 3 TCAs with different monoamin...

journal_title：Pain

authors： Ardid D,Guilbaud G

更新日期：1992-05-01 00:00:00

abstract：:The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within...

journal_title：Pain

authors： Rolke R,Baron R,Maier C,Tölle TR,Treede -DR,Beyer A,Binder A,Birbaumer N,Birklein F,Bötefür IC,Braune S,Flor H,Huge V,Klug R,Landwehrmeyer GB,Magerl W,Maihöfner C,Rolko C,Schaub C,Scherens A,Sprenger T,Valet M,

更新日期：2006-08-01 00:00:00

abstract：:Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...

journal_title：Pain

authors： Wylde V,Sayers A,Lenguerrand E,Gooberman-Hill R,Pyke M,Beswick AD,Dieppe P,Blom AW

更新日期：2015-01-01 00:00:00

abstract：:The experiments determined the ventilatory effects of epidurally injected morphine and sufentanil in rats in the absence and in the presence of chlordiazepoxide, a drug that may alleviate the effects of stress. Soon after administration of morphine as well as of sufentanil, ventilation was more profoundly depressed wh...

journal_title：Pain

authors： Van den Hoogen RHWM,Bervoets KJW,Colpaert FC

更新日期：1989-04-01 00:00:00

abstract：:Our objectives were to determine whether procedural pain and glucose exposure are associated with altered structural and functional brain development differently in preterm males and females, and neurodevelopment at 18-month corrected age. Fifty-one very preterm neonates (22 males; median [interquartile range] gestati...

journal_title：Pain

authors： Schneider J,Duerden EG,Guo T,Ng K,Hagmann P,Bickle Graz M,Grunau RE,Chakravarty MM,Hüppi PS,Truttmann AC,Miller SP

更新日期：2018-03-01 00:00:00

abstract：:Both physicians and nurses are responsible for adequate pain management. The aim of this study was to assess pain management behavior of physicians and nurses, and to evaluate the effects of a Pain Monitoring Program for nurses on the extent to which nurses administer analgesics. The Pain Monitoring Program consisted ...

journal_title：Pain

authors： de Rond MEJ,de Wit R,van Dam FSAM,Muller MJ

更新日期：2000-12-15 00:00:00

abstract：:The effects of nitrous oxide (N2O) are thought to be mediated by several pharmacological pathways at different levels of the central nervous system. Here, we focus on excitatory glutamatergic transmission in the superficial dorsal horn of the spinal cord with respect to its importance for the nociceptive processing. T...

journal_title：Pain

authors： Georgiev SK,Kohno T,Ikoma M,Yamakura T,Baba H

更新日期：2008-01-01 00:00:00

abstract：:Chronic low back pain (CLBP) and obesity are interrelated, but the physiological mechanisms linking the 2 conditions remain to be determined. Functional brain imaging data from CLBP patients show functional and structural alterations in areas mediating the attribution of hedonic value to food. Accordingly, we hypothes...

journal_title：Pain

authors： Geha P,deAraujo I,Green B,Small DM

更新日期：2014-04-01 00:00:00

abstract：:Twenty patients with chronic low back pain received 12 lumbar sympathetic injections, in a series of 6 with bupivacaine and a series of 6 with saline. Changes in subjective pain intensity, EMG from paravertebral muscles, joint ranges of mobility, and daily activity levels were measured at multiple intervals throughout...

journal_title：Pain

authors： Brena SF,Wolf SL,Chapman SL,Hammonds WD

更新日期：1980-02-01 00:00:00

abstract：:Test-retest reliability of a pain drawing instrument was investigated. Pain drawings of chronic pain patients (n = 51) were scored for percentage of total body surface in pain and location of pain. A test-retest reliability coefficient of r = 0.85 was calculated for a time interval that averaged 71 days. In addition, ...

journal_title：Pain

authors： Margolis RB,Chibnall JT,Tait RC

更新日期：1988-04-01 00:00:00

abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...

journal_title：Pain

authors： Smith SM,Amtmann D,Askew RL,Gewandter JS,Hunsinger M,Jensen MP,McDermott MP,Patel KV,Williams M,Bacci ED,Burke LB,Chambers CT,Cooper SA,Cowan P,Desjardins P,Etropolski M,Farrar JT,Gilron I,Huang IZ,Katz M,Kerns RD

更新日期：2016-05-01 00:00:00

abstract：:The superficial dorsal horn, which is the main target for nociceptive and pruritoceptive primary afferents, contains a high density of excitatory interneurons. Our understanding of their roles in somatosensory processing has been restricted by the difficulty of distinguishing functional populations among these cells. ...

journal_title：Pain

authors： Gutierrez-Mecinas M,Bell AM,Marin A,Taylor R,Boyle KA,Furuta T,Watanabe M,Polgár E,Todd AJ

更新日期：2017-03-01 00:00:00

abstract：:Questions concerning stump, phantom and other pain problems as well as demographic data were mailed to 5000 Americans whose amputations were connected with military service. Fifty-five percent responded and of these, 78% reported phantom pain. No predisposing factors, other than presence of stump pain, correlated with...

journal_title：Pain

authors： Sherman RA,Sherman CJ,Parker L

更新日期：1984-01-01 00:00:00

abstract：:Clinical trials on the treatment of pain syndromes have adopted Patient Global Impression of Change (PGIC) as a primary outcome. However, little is known about how change in clinical status influences these ratings. The present study examined relationships between changes in pain, depressed mood, physical functioning,...

journal_title：Pain

authors： Geisser ME,Clauw DJ,Strand V,Gendreau MR,Palmer R,Williams DA

更新日期：2010-05-01 00:00:00

abstract：:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...

journal_title：Pain

authors： Walker LS,Sherman AL,Bruehl S,Garber J,Smith CA

更新日期：2012-09-01 00:00:00

abstract：:Both mu opioid agonists and N-methyl-D-aspartate (NMDA) receptor antagonists are implicated in the regulation of neuropathic pain in post-nerve injury preclinical pain models. This study characterizes the effects of intravenously infused alfentanil (a mu-receptor agonist) and ketamine (an NMDA-receptor antagonist) on ...

journal_title：Pain

authors： Leung A,Wallace MS,Ridgeway B,Yaksh T

更新日期：2001-03-01 00:00:00