Abstract:
:The experiments determined the ventilatory effects of epidurally injected morphine and sufentanil in rats in the absence and in the presence of chlordiazepoxide, a drug that may alleviate the effects of stress. Soon after administration of morphine as well as of sufentanil, ventilation was more profoundly depressed when rats had been pretreated with chlordiazepoxide. With chlordiazepoxide, respiratory depression after epidural injection of the longer acting and poorly lipid-soluble morphine could still be observed when analgesic activity had disappeared. The data are explained most parsimoniously by assuming that stress counteracts the respiratory effects of epidural opiates, and that late respiratory depression can occur in as much as the opiate continues to act at points of time when the effects of stress have disappeared.
journal_name
Painjournal_title
Painauthors
Van den Hoogen RHWM,Bervoets KJW,Colpaert FCdoi
10.1016/0304-3959(89)90159-0subject
Has Abstractpub_date
1989-04-01 00:00:00pages
103-110issue
1eissn
0304-3959issn
1872-6623pii
00006396-198904000-00014journal_volume
37pub_type
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