Serotonin-containing neurons: their possible role in pain and analgesia.

abstract：:Pain has the capacity to interfere with daily tasks. Although task interference by pain is largely unintentional, it can be controlled to a certain extent. Such top-down control over pain has been believed to be reduced in patients with fibromyalgia (FM). In this study, we investigated task interference and distractio...

journal_title：Pain

authors： Van Ryckeghem DML,Rost S,Kissi A,Vögele C,Crombez G

更新日期：2018-06-01 00:00:00

abstract：:The objective of this study was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. Data were from a prospective cohort study of 1545 community-dwelling Mexican Americans aged ≥67 years from the Hispanic Established Populations for the Epide...

journal_title：Pain

authors： Sodhi JK,Karmarkar A,Raji M,Markides KS,Ottenbacher KJ,Al Snih S

更新日期：2020-01-01 00:00:00

abstract：:The M-current has been proposed as a potential target for analgesia under neuropathic pain conditions. M-currents and/or their molecular correlates, KCNQ proteins, have been demonstrated in key elements of the nociceptive system including spinal and dorsal root ganglion neurons. Here we demonstrate that retigabine, a ...

journal_title：Pain

authors： Roza C,Lopez-Garcia JA

更新日期：2008-09-15 00:00:00

abstract：:A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different ar...

journal_title：Pain

authors： Laitinen LV,Eriksson TA

更新日期：1985-06-01 00:00:00

abstract：:A cohort of 243 female sewing machine operators were studied by questionnaire and clinical examinations with the purpose to study the efficiency of a screening questionnaire-based method to identify prevalent and incident cases of neck-shoulder disorders. The cross-sectional correlation between self-reported neck-shou...

journal_title：Pain

authors： Kaergaard A,Andersen JH,Rasmussen K,Mikkelsen S

更新日期：2000-06-01 00:00:00

abstract：:The objective of the study was to examine the 1-year cumulative incidence of episodic neck pain and to explore its associations with individual risk factors, including a history of previous neck injury. A baseline cross-sectional survey of an adult general population sample made up of all 7669 adults aged 18-75 years,...

journal_title：Pain

authors： Croft PR,Lewis M,Papageorgiou AC,Thomas E,Jayson MIV,Macfarlane GJ,Silman AJ

更新日期：2001-09-01 00:00:00

abstract：:Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spina...

journal_title：Pain

authors： Sagen J,Winker MA,Proudfit HK

更新日期：1983-07-01 00:00:00

abstract：:Theoretical models and evidence increasingly identify chronic pain as a family issue. To date, much of this work has focused on risk conferred by parental chronic pain status despite evidence suggesting parent mental illness and non-pain-related chronic illness may also contribute to poorer chronic pain outcomes in ch...

journal_title：Pain

authors： Birnie KA,Heathcote LC,Bhandari RP,Feinstein A,Yoon IA,Simons LE

更新日期：2020-06-01 00:00:00

abstract：:The present study evaluated the efficacy of a clinician-guided Internet-delivered cognitive behaviour therapy (iCBT) program, the Pain Course, to reduce disability, anxiety, and depression associated with chronic pain. Sixty-three adults with chronic pain were randomised to either a Treatment Group or waitlist Control...

journal_title：Pain

authors： Dear BF,Titov N,Perry KN,Johnston L,Wootton BM,Terides MD,Rapee RM,Hudson JL

更新日期：2013-06-01 00:00:00

abstract：:Although the administration of opioids is the most effective treatment for pain, their efficacy is limited by the development of tolerance. The midbrain periaqueductal gray matter (PAG) participates in opioid analgesia and tolerance. Microinjection of morphine into PAG produces antinociception, probably through neuron...

journal_title：Pain

authors： Tortorici V,Morgan MM,Vanegas H

更新日期：2001-01-01 00:00:00

abstract：:An indentical questionnaire are administered separately to 100 chronic pain patients and a close family member of each. The majority of patients and relatives agreed on the answers to these questions about the pain problem. Highest congruency between patient and relative was associated with cases in which there were m...

journal_title：Pain

authors： Swanson DW,Maruta T

更新日期：1980-04-01 00:00:00

abstract：:The L5 spinal nerve ligation model of neuropathic pain in rats has been proposed as a model for sympathetically maintained pain (SMP) based on the effects of surgical or chemical sympathectomy on nerve injury induced behavior. In an attempt to confirm that the lesion produces an animal model of SMP, surgical sympathec...

journal_title：Pain

authors： Ringkamp M,Eschenfelder S,Grethel EJ,Häbler HJ,Meyer RA,Jänig W,Raja SN

更新日期：1999-02-01 00:00:00

abstract：:Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysi...

journal_title：Pain

authors： Andreou AP,Holland PR,Lasalandra MP,Goadsby PJ

更新日期：2015-03-01 00:00:00

abstract：:A young female outpatient experienced painful tonic contractions in the right triceps surae muscles as a result of a partial damage of the right peroneal nerve. Electrophysiological recordings of the soleus muscle showed a tonic EMG activity and an hyperexcitability of the monosynaptic H reflex (Hmax/Mmax ratio: 90%)....

journal_title：Pain

authors： Wilier JC

更新日期：1988-03-01 00:00:00

abstract：:This study was designed to investigate the relative efficacy of cognitive-behavioral group treatment, including relaxation training, in comparison with a control condition in a sample of 20 outpatients with chronic low back pain. Subjects in both conditions also received the same physiotherapy back-education and exerc...

journal_title：Pain

authors： Nicholas MK,Wilson PH,Goyen J

更新日期：1992-03-01 00:00:00

abstract：:The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Al...

journal_title：Pain

authors： Tiemann L,May ES,Postorino M,Schulz E,Nickel MM,Bingel U,Ploner M

更新日期：2015-02-01 00:00:00

abstract：:Although calcitonin gene-related peptide (CGRP) has been shown to be elevated in jugular venous blood of adult migraineurs during acute migraine attacks, it remains unknown whether CGRP is increased outside of attacks in jugular or cubital venous blood. The aim of the present study was to compare interictal plasma lev...

journal_title：Pain

authors： Ashina M,Bendtsen L,Jensen R,Schifter S,Olesen J

更新日期：2000-05-01 00:00:00

abstract：:Pain is a frequently observed non-motor symptom of patients with Parkinson's disease. In some patients, Parkinson's-related pain responds to dopaminergic treatment. In the present study, we aimed to elucidate whether subthalamic deep brain stimulation has a similar beneficial effect on pain in Parkinson's disease, and...

journal_title：Pain

authors： Sürücü O,Baumann-Vogel H,Uhl M,Imbach LL,Baumann CR

更新日期：2013-08-01 00:00:00

abstract：:Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model...

journal_title：Pain

authors： Wodarski R,Delaney A,Ultenius C,Morland R,Andrews N,Baastrup C,Bryden LA,Caspani O,Christoph T,Gardiner NJ,Huang W,Kennedy JD,Koyama S,Li D,Ligocki M,Lindsten A,Machin I,Pekcec A,Robens A,Rotariu SM,VoB S,Segerd

更新日期：2016-10-01 00:00:00

abstract：:Ten patients with myofascial trigger point pain were entered into a double-blind cross-over study of the reversibility of myofascial trigger point injection (TPI) effects with naloxone versus placebo in order to test the hypothesis that the benefits of TPI are mediated, at least in part, through activation of an endog...

journal_title：Pain

authors： Fine PG,Milano R,Hare BD

更新日期：1988-01-01 00:00:00

abstract：:Based on concepts that endogenous opioids participate in neural transmission of pain, the present study in central poststroke pain (CPSP) patients investigated changes in opioid receptor (OR) binding in neural structures centrally involved in the processing of pain. Five patients with central pain after lesions in the...

journal_title：Pain

authors： Willoch F,Schindler F,Wester HJ,Empl M,Straube A,Schwaiger M,Conrad B,Tölle TR

更新日期：2004-04-01 00:00:00

abstract：:Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP on...

journal_title：Pain

authors： Nicholl BI,Macfarlane GJ,Davies KA,Morriss R,Dickens C,McBeth J

更新日期：2009-01-01 00:00:00

abstract：:Many aspects of bilateral presentation or recurrence of reflex sympathetic dystrophy (RSD) are unknown. For this reason 1183 consecutive patients with RSD were analyzed. In 10 patients RSD started in symmetrical limbs. In 34 patients RSD recurred in the same limb after a period of no or few complaints and in 76 patien...

journal_title：Pain

authors： Veldman PHJM,Goris JAR

更新日期：1996-03-01 00:00:00

abstract：:In rats anesthetized with sodium pentobarbital, we quantitatively analyzed descending modulation from the midbrain of a nociceptive flexion withdrawal reflex and responses of associated spinal neurons. We monitored the isometric force of hind limb withdrawal elicited by noxious heat stimuli (42-54 degrees C, 10 sec) o...

journal_title：Pain

authors： Carstens E,Campell IG

更新日期：1992-02-01 00:00:00

abstract：:A descriptive, longitudinal design was used to examine changes in current, worst, and least pain intensity during hospitalization for a vaso-occlusive episode in children with sickle cell disease. Other dimensions of the pain experience including location and quality were also evaluated. Children reported severe pain ...

journal_title：Pain

authors： Jacob E,Miaskowski C,Savedra M,Beyer JE,Treadwell M,Styles L

更新日期：2003-03-01 00:00:00

abstract：:Using a number of complementary anatomical and molecular techniques, we studied the effects of chronic constriction injury (CCI), a model of partial nerve injury that elicits behavioral hyperalgesia, on primary sensory neurons in the rat. Dorsal root ganglia taken from animals with CCI were analyzed for alterations in...

journal_title：Pain

authors： Nahin RL,Ren K,De León M,Ruda M

更新日期：1994-07-01 00:00:00

abstract：:Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important ad...

journal_title：Pain

authors： Melchior M,Juif PE,Gazzo G,Petit-Demoulière N,Chavant V,Lacaud A,Goumon Y,Charlet A,Lelièvre V,Poisbeau P

更新日期：2018-12-01 00:00:00

abstract：:This double-blind, within-subjects experiment examined the effects of ingesting two doses of caffeine on perceptions of leg muscle pain and blood pressure during moderate intensity cycling exercise. Low caffeine consuming college-aged males (N=12) ingested one of two doses of caffeine (5 or 10 mg.kg(-1) body weight) o...

journal_title：Pain

authors： O'Connor PJ,Motl RW,Broglio SP,Ely MR

更新日期：2004-06-01 00:00:00

abstract：:We investigated the efficacy of local intraplantar (i.pl.) injection of peptide and non-peptide mu-, delta- and kappa-opioid receptor agonists in rat models of inflammatory and neuropathic pain. Locally applied agonists dose-dependently reduced formalin-induced flinching of the inflamed paw and induced antiallodynic a...

journal_title：Pain

authors： Obara I,Parkitna JR,Korostynski M,Makuch W,Kaminska D,Przewlocka B,Przewlocki R

更新日期：2009-02-01 00:00:00

abstract：:Ziconotide is a nonopioid intrathecal analgesic drug used to manage moderate to severe chronic pain. The aim of this work is to assess the safety and efficacy of intrathecal (IT) combination of ziconotide and morphine in malignant pain refractory to high doses of oral opioids. Patients with malignant pain refractory t...

journal_title：Pain

authors： Alicino I,Giglio M,Manca F,Bruno F,Puntillo F

更新日期：2012-01-01 00:00:00