Abstract：
:Blockade of the noradrenergic input to the nucleus raphe magnus (NRM) by the injection of alpha-adrenergic antagonists produces hypoalgesia. Previous studies show that this hypoalgesia is blocked by the intrathecal injection of either phentolamine or methysergide. The present study demonstrates that depletion of spinal cord serotonin, norepinephrine, or both also blocks this hypoalgesia. Together these studies suggest that the hypoalgesia produced by microinjection of noradrenergic antagonists in the NRM is mediated by the activation of both raphe-spinal serotonergic neurons and bulbospinal noradrenergic neurons.
journal_name
Painjournal_title
Painauthors
Sagen J,Winker MA,Proudfit HKdoi
10.1016/0304-3959(83)90113-6subject
Has Abstractpub_date
1983-07-01 00:00:00pages
253-263issue
3eissn
0304-3959issn
1872-6623pii
00006396-198307000-00003journal_volume
16pub_type
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