Abstract：
:Mechanisms of hypnotic analgesia were investigated by examining changes in the R-III, a nociceptive spinal reflex, during hypnotic reduction of pain sensation and unpleasantness. The R-III was measured in 15 healthy volunteers who gave VAS-sensory and VAS-affective ratings of an electrical stimulus during conditions of resting wakefulness, suggestions for hypnotic analgesia, and attempted suppression of the reflex during non-hypnotic conditions. The H-reflex was also measured to monitor and control for general changes in alpha-motoneuron excitability. Hypnotic sensory analgesia was related to reduction in the R-III after controlling for changes in the H-reflex (R2 = 0.51, P < 0.003), suggesting that hypnotic sensory analgesia is at least in part mediated by descending antinociceptive mechanisms that exert control at spinal levels in response to hypnotic suggestion. The relationship between hypnotic affective analgesia and reduction in R-III approached significance (R2 = 0.26; P = 0.053). Reduction in R-III was 67% as great and accounted for 51% of the variance in reduction of pain sensation. In turn, reduction in pain sensation was 75% as great and accounted for 77% of the variance in reduction of unpleasantness. The results suggest that 3 general mechanisms may be involved in hypnotic analgesia. The first, implicated by reductions in R-III, is related to spinal cord antinociceptive mechanisms. The second, implicated by reductions in pain sensation over and beyond reductions in R-III, may be related to brain mechanisms that serve to prevent awareness of pain once nociception has reached higher centers, as suggested by Hilgard.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Painjournal_title
Painauthors
Kiernan BD,Dane JR,Phillips LH,Price DDdoi
10.1016/0304-3959(94)00134-Zsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
39-47issue
1eissn
0304-3959issn
1872-6623pii
00006396-199501000-00003journal_volume
60pub_type
杂志文章相关文献
PAIN文献大全abstract：:Pain cannot be directly measured in neonates. Therefore, scores based on indirect behavioural signals such as crying, or physiological signs such as blood pressure, are used to quantify neonatal pain both in clinical practice and in clinical studies. The aim of this study was to determine which of the physiological an...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000485
更新日期：2016-08-01 00:00:00
abstract：:The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T-cell populations, very little attention has been ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001420
更新日期：2019-02-01 00:00:00
abstract：:Behavioral analgesic techniques such as distraction reduce pain in both clinical and experimental settings. Individuals differ in the magnitude of distraction-induced analgesia, and additional study is needed to identify the factors that influence the pain relieving effects of distraction. Catastrophizing, a set of ne...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2009.11.012
更新日期：2010-05-01 00:00:00
abstract：:Vascular head pain is thought to result from activation of trigeminal sensory nerve fibers innervating cranial blood vessels. Support for this hypothesis was sought by searching in the trigeminal brain-stem subnucleus caudalis (SNC) for neuronal responses evoked by electrical stimulation of the middle meningeal artery...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(86)90244-7
更新日期：1986-06-01 00:00:00
abstract：:Electron microscopy was used to study normal human extracted teeth in order to define the junctions between sensory nerve endings and other cells in external pulp and inner dentin at the crown tip. Two sets of associated cells were found: (1) Connective tissue cells. The pulpal fibroblast newtork made occasional desmo...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(82)90012-4
更新日期：1982-07-01 00:00:00
abstract：:Clinical evidence suggests that cutaneous and visceral pain differ in sensory, affective, and motivational realms, yet there has been little comparative characterization of these types of pain. This study uses psychophysical measures to compare directly visceral and cutaneous pain and sensitivity. Healthy subjects (10...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(02)00023-4
更新日期：2002-06-01 00:00:00
abstract：:Antinociceptive effects of the 2 (each 1000 mg, orally) non-steroidal anti-inflammatory drugs (NSAIDs) acetaminophen (paracetamol) and antipyrine (phenazone) were investigated with a non-inflammatory experimental pain model in 32 healthy volunteers. Phasic pain was induced by intracutaneously applied brief electrical ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0304-3959(92)90165-8
更新日期：1992-08-01 00:00:00
abstract：:We evaluated the construct validity (including responsiveness), reliability, and feasibility of the Pain Squad multidimensional smartphone-based pain assessment application (app) in children and adolescents with cancer, using 2 descriptive studies with repeated measures. Participants (8-18 years) undergoing cancer tre...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000000385
更新日期：2015-12-01 00:00:00
abstract：:Spinal synaptic plasticity is believed to drive central sensitization that underlies the persistent nature of neuropathic pain. Our recent data showed that synaptic plasticity in the dorsal horn is cell type specific: intense afferent stimulation produced long-term potentiation (LTP) in excitatory spinothalamic tract ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001014
更新日期：2017-11-01 00:00:00
abstract：:The effects of electrical and chemical stimulation of the arcuate nucleus of the hypothalamus (ARH) on the tail flick latency (TFL) and paw pressure withdrawal threshold (PWT) were investigated in the lightly pentobarbital-anesthetized and acutely prepared rat. Electrical stimulation of the ARH for 20 sec at 8 Hz prod...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(90)91114-X
更新日期：1990-04-01 00:00:00
abstract：:The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively been investigated during the past decade. The aim of the present study was to investigate the peripheral involvement of PKA and PKC in persistent nociceptive response, evoked pain behaviors, and inflammation induced by s...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.04.040
更新日期：2008-03-01 00:00:00
abstract：:The induction of hyperalgesia upon capsaicin administration requires activation of specific sub-classes of nociceptive afferent C-fibres providing nociceptive input to the central nervous system. It has been demonstrated in animal models that the endocannabinoid anandamide has anti-hyperalgesic properties upon capsaic...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(02)00401-3
更新日期：2003-04-01 00:00:00
abstract：:The presence of a trigger point is essential to the myofascial pain syndrome. This study centres on identifying clearer criteria for the presence of trigger points in the quadratus lumborum and gluteus medius muscle by investigating the occurrence and inter-rater reliability of trigger point symptoms. Using the sympto...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/0304-3959(94)90125-2
更新日期：1994-09-01 00:00:00
abstract：:The effects of high temperature (53-61 degrees C) on membrane currents (I(heat)) or depolarization (V(heat)) induced by noxious heat were studied in cultured dorsal root ganglia neurons from neonatal rats using the whole cell patch clamp technique. I(heat) or V(heat) produced by 3 s ramps of increasing temperature bet...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(01)00401-8
更新日期：2002-02-01 00:00:00
abstract：:Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this stud...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pain.0000000000000002
更新日期：2015-01-01 00:00:00
abstract：:Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(94)90185-6
更新日期：1994-07-01 00:00:00
abstract：:Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...
journal_title：Pain
pub_type： 杂志文章
doi：10.1097/j.pain.0000000000001676
更新日期：2019-12-01 00:00:00
abstract：:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2012.03.026
更新日期：2012-09-01 00:00:00
abstract：:A visual analog scale (VAS) method of assessing headache pain was compared with a standard categorical four-grade scale (4GS) in a randomized, placebo-controlled, double-blind, clinical trial involving 792 treated migraine outpatients who received oral rizatriptan 5 mg, sumatriptan 50 mg, or placebo for a moderate or ...
journal_title：Pain
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0304-3959(01)00315-3
更新日期：2001-08-01 00:00:00
abstract：:Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/S0304-3959(98)00120-1
更新日期：1998-11-01 00:00:00
abstract：:Recent studies demonstrate that some brain structures activated by pain are also engaged when an individual observes someone else in pain, and that these empathy-related responses are modulated as a function of the affective link between the empath and the individual in pain. In this study we test the hypothesis that ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.07.017
更新日期：2008-05-01 00:00:00
abstract：:In the present study the question was addressed whether sensitivity to experimental pain stimuli differs between families, which are previously characterized by the degree of cold tolerance (very insensitive or very sensitive) of one family member. A total of 232 healthy medical students were screened for cold pain to...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.11.012
更新日期：2008-08-15 00:00:00
abstract：:Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at ...
journal_title：Pain
pub_type： 临床试验,杂志文章
doi：10.1016/s0304-3959(97)03362-9
更新日期：1997-06-01 00:00:00
abstract：:Non-invasive, movement-based models were used to investigate muscle pain. In rats, the masseter muscle was rapidly stretched or electrically stimulated during forced lengthening to produce eccentric muscle contractions (EC). Both EC and stretching disrupted scattered myofibers and produced intramuscular plasma extrava...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2010.02.022
更新日期：2010-05-01 00:00:00
abstract：:Pain is generally considered to have a sensory and an affective component. Clinical research has suggested that morphine more potently attenuates the affective component as compared to the sensory component. Because preclinical nociception models typically focus on the sensory component of nociception, and do not asse...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.07.027
更新日期：2008-06-01 00:00:00
abstract：:The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any p...
journal_title：Pain
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pain.2012.08.003
更新日期：2012-12-01 00:00:00
abstract：:A short form of the McGill Pain Questionnaire (SF-MPQ) has been developed. The main component of the SF-MPQ consists of 15 descriptors (11 sensory; 4 affective) which are rated on an intensity scale as 0 = none, 1 = mild, 2 = moderate or 3 = severe. Three pain scores are derived from the sum of the intensity rank valu...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(87)91074-8
更新日期：1987-08-01 00:00:00
abstract：:In a consecutive series of 227 psychiatric hospital admissions, data were recorded in respect of the complaint of pain. Eighty-six (38%) had pain. Fourty-four (19%) mentioned it spontaneously and 49 (22%) had no relevant physical cause. Women were affected more often than men (P less than 0.01) and tended to complain ...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/0304-3959(77)90146-4
更新日期：1978-04-01 00:00:00
abstract：:Since a number of patients with Parkinson's Disease (PD) complain of painful sensations, we studied whether the central processing of nociceptive inputs is abnormal in PD. To test this hypothesis, we recorded scalp CO(2) laser evoked potentials (LEPs) to hand skin stimulation in 18 pain-free PD patients with unilatera...
journal_title：Pain
pub_type： 杂志文章
doi：10.1016/j.pain.2007.06.022
更新日期：2008-05-01 00:00:00
abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...
journal_title：Pain
pub_type： 杂志文章,随机对照试验
doi：10.1097/j.pain.0000000000000502
更新日期：2016-05-01 00:00:00
