A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.

abstract：:This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root inj...

journal_title：Pain

authors： Mailis A,Plapler P,Ashby P,Shoichet R,Roe S

更新日期：1997-03-01 00:00:00

abstract：:Patients suffering from postherpetic neuralgia often complain about hypo- or hypersensation in the affected dermatome. The loss of thermal sensitivity has been demonstrated by quantitative sensory testing as being associated with small-fiber (Aδ- and C-fiber) deafferentation. We aimed to compare laser stimulation (rad...

journal_title：Pain

authors： Franz M,Spohn D,Ritter A,Rolke R,Miltner WHR,Weiss T

更新日期：2012-08-01 00:00:00

abstract：:The purpose of this study was to examine racial/ethnic-related differences in a four-stage model of the processing of chronic pain. The subjects were 1557 chronic pain patients (White=1084, African American=473) evaluated at a pain management clinic at a large southeastern university medical center. Using an analysis ...

journal_title：Pain

authors： Riley JL 3rd,Wade JB,Myers CD,Sheffield D,Papas RK,Price DD

更新日期：2002-12-01 00:00:00

abstract：:Endometriosis affects ∼176 million women worldwide, yet on average, women experience pain ∼10 years from symptom onset before being properly diagnosed. Standard treatments (drugs or surgery) often fail to provide long-term pain relief. Elevated levels of reactive aldehydes such as 4-hydroxynonenal (4-HNE) have been im...

journal_title：Pain

authors： McAllister SL,Sinharoy P,Vasu M,Gross ER

更新日期：2021-01-01 00:00:00

abstract：:(1) Quantitative measurements of somatosensory thresholds and skin temperature were made before (24 cases), 3-5 days after (12 cases), and 6 months after (11 cases) successful radiofrequency thermocoagulation of the proximal root and gasserian ganglion in 24 cases of idiopathic trigeminal neuralgia (TGN), 18 of whom h...

journal_title：Pain

authors： Hampf G,Bowsher D,Wells C,Miles J

更新日期：1990-03-01 00:00:00

abstract：:The results of two experiments show that ratio scales of sensory and affective verbal pain descriptors are valid, reliable and objective. In the first experiment, 16 subjects rated 15 sensory and 15 affective verbal pain descriptors by numerical magnitude estimation and by cross-modality matching to handgrip force. Ra...

journal_title：Pain

authors： Gracely RH,McGrath P,Dubner R

更新日期：1978-06-01 00:00:00

abstract：:Advances in pain measurement using ecological momentary assessments offer novel opportunities for understanding the temporal dynamics of pain. This study examined whether regime-switching models, which capture processes characterized by recurrent shifts between different states, provide clinically relevant information...

journal_title：Pain

authors： Schneider S,Junghaenel DU,Ono M,Stone AA

更新日期：2018-07-01 00:00:00

abstract：:The L5 spinal nerve ligation model of neuropathic pain in rats has been proposed as a model for sympathetically maintained pain (SMP) based on the effects of surgical or chemical sympathectomy on nerve injury induced behavior. In an attempt to confirm that the lesion produces an animal model of SMP, surgical sympathec...

journal_title：Pain

authors： Ringkamp M,Eschenfelder S,Grethel EJ,Häbler HJ,Meyer RA,Jänig W,Raja SN

更新日期：1999-02-01 00:00:00

abstract：:Cognitive strategies have received considerable interest in pain management, alongside the traditional approaches of physical intervention and behavior modification. However, the literature on these strategies is ridden with inconsistencies of terminology that present major difficulties in the conceptualization and ev...

journal_title：Pain

authors： Fernandez E

更新日期：1986-08-01 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:Central poststroke pain (CPSP) is one of the most refractory chronic pain syndromes. Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex has been demonstrated to provide moderate pain relief for CPSP. However, the mechanism underlying the pain relief remains unclear. The objective of this s...

journal_title：Pain

authors： Hosomi K,Kishima H,Oshino S,Hirata M,Tani N,Maruo T,Yorifuji S,Yoshimine T,Saitoh Y

更新日期：2013-08-01 00:00:00

abstract：:Uncoupling the protein-protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an allosteric CRMP2-derived peptide (CBD3) is antinociceptive in rodent models of inflammatory and neuropathic pain. We investigated the efficacy, duration of action, ...

journal_title：Pain

authors： Xie JY,Chew LA,Yang X,Wang Y,Qu C,Wang Y,Federici LM,Fitz SD,Ripsch MS,Due MR,Moutal A,Khanna M,White FA,Vanderah TW,Johnson PL,Porreca F,Khanna R

更新日期：2016-09-01 00:00:00

abstract：:Chronic pain often interferes with daily functioning, and may become a threat to an individual's sense of self. Despite the development of a recent theoretical account focussing upon the relationship between the presence of chronic pain and a person's self, research investigating this idea is limited. In the present s...

journal_title：Pain

authors： Van Ryckeghem DML,De Houwer J,Van Bockstaele B,Van Damme S,De Schryver M,Crombez G

更新日期：2013-12-01 00:00:00

abstract：:Pain can be endogenously modulated by heterotopic noxious conditioning stimulation (HNCS) through a mechanism which is known as diffuse noxious inhibitory control (DNIC). Since DNIC can be impaired in patients suffering from chronic pain, a comparable impaired itch inhibition may exist in patients suffering from chron...

journal_title：Pain

authors： van Laarhoven AIM,Kraaimaat FW,Wilder-Smith OH,van de Kerkhof PCM,Evers AWM

更新日期：2010-05-01 00:00:00

abstract：:Preclinical assessment of pain has increasingly explored operant methods that may allow behavioral assessment of ongoing pain. In animals with incisional injury, peripheral nerve block produces conditioned place preference (CPP) and activates the mesolimbic dopaminergic reward pathway. We hypothesized that activation ...

journal_title：Pain

authors： Xie JY,Qu C,Patwardhan A,Ossipov MH,Navratilova E,Becerra L,Borsook D,Porreca F

更新日期：2014-08-01 00:00:00

abstract：:We report the case of bilateral hand swelling following acupuncture therapy for chronic low back pain. Despite thorough history, examination and laboratory testing no systemic cause for the swelling could be elicited. This case highlights the incomplete knowledge of acupuncture mechanisms and that limited acupuncture ...

journal_title：Pain

authors： McCartney CJ,Herriot R,Chambers WA

更新日期：2000-02-01 00:00:00

abstract：:Nitric oxide (NO), synthesised by different isoforms of nitric oxide synthase (NOS), has been linked with the development and maintenance of nociception. We studied the role of the inducible isoform, iNOS, in two different rat pain models with an inflammatory component. iNOS was immunohistochemically detected locally ...

journal_title：Pain

authors： De Alba J,Clayton NM,Collins SD,Colthup P,Chessell I,Knowles RG

更新日期：2006-01-01 00:00:00

abstract：:Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...

journal_title：Pain

authors： Goettl VM,Larson DL,Portoghese PS,Larson AA

更新日期：1997-07-01 00:00:00

abstract：:A portable constant current electrical stimulator with bipolar felt disk electrodes was developed for quantitative assessment of cutaneous sensibility. The new method was used in the measurement of thresholds for perception and pain in healthy volunteers. The mean values of the threshold for perception in different ar...

journal_title：Pain

authors： Laitinen LV,Eriksson TA

更新日期：1985-06-01 00:00:00

abstract：:For many individuals undergoing routine surgical procedures, their satisfaction with the operation may depend upon their postoperative experience. We used the McGill Pain Questionnaire and the McGill Nausea Questionnaire to study the intensity of 5 common postoperative problems--sore throat, muscle pain, headache, bac...

journal_title：Pain

authors： Cohen MM,Tate RB

更新日期：1989-12-01 00:00:00

abstract：:Training in relaxation is a prominent component in multi-disciplinary approaches to the management of chronic pain, although its specific potency in modulating pain has not yet been established. Using a within-session design, the specific effects of relaxation induction were evaluated in a group of benign chronic pain...

journal_title：Pain

authors： Philips HC

更新日期：1988-02-01 00:00:00

abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...

journal_title：Pain

authors： Lawlor P,Turner K,Hanson J,Bruera E

更新日期：1997-08-01 00:00:00

abstract：:This study characterized the pain reported in a selected group of obstetrical patients in labor and compared the pain experienced at 2 stages of dilation, dilation of 2-5 cm and of 6-10 cm. Pain was defined as the perception of an unpleasant sensory and emotional experience with multidimensional factors that evoke beh...

journal_title：Pain

authors： Brown ST,Campbell D,Kurtz A

更新日期：1989-09-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together w...

journal_title：Pain

authors： Bannister K,Patel R,Goncalves L,Townson L,Dickenson AH

更新日期：2015-09-01 00:00:00

abstract：:Chronic widespread pain (CWP) is associated with poor health-related quality of life (HRQoL). It is unclear whether pain itself is the cause of poor HRQoL or other factors play a role. We hypothesised that new onset of CWP was associated with poor physical and mental HRQoL but that psychosocial risk markers for CWP on...

journal_title：Pain

authors： Nicholl BI,Macfarlane GJ,Davies KA,Morriss R,Dickens C,McBeth J

更新日期：2009-01-01 00:00:00

abstract：:The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (through the ectonucleotidase activity of prostatic acid phosphatase [PAP]) and adenosine A1 receptors (A1Rs) in resin...

journal_title：Pain

authors： Kan HW,Chang CH,Lin CL,Lee YC,Hsieh ST,Hsieh YL

更新日期：2018-08-01 00:00:00

abstract：:Constipation is the most common adverse event (AE) of opioid therapy. This multicenter, phase 2 study evaluated the efficacy and safety of linaclotide in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain syndromes (NCT02270983). Adults with OIC (<3 spontaneous bowel movements [SBMs]/we...

journal_title：Pain

authors： Brenner DM,Argoff CE,Fox SM,Bochenek W,D'Astoli P,Blakesley RE,Reasner DS,O'Dea CR,Cash BD

更新日期：2020-05-01 00:00:00

abstract：:Pain patients' retrospective reports of pain are important to physicians and other health professionals in helping to decide on future treatment plans. Unfortunately patients' memory of pain can be inaccurate and subject to overestimation. This study examined variables which influenced accuracy of remembering pain in ...

journal_title：Pain

authors： Jamison RN,Sbrocco T,Parris WCV

更新日期：1989-06-01 00:00:00

abstract：:Shoulder pain is common in primary care and has an unfavourable outcome in many patients. Information about predictors of outcome is scarce and inconsistent. The objective of this study was to develop clinical prediction rules for calculating the absolute risk of persistent shoulder symptoms for individual patients, 6...

journal_title：Pain

authors： Kuijpers T,van der Windt DAWM,Boeke JPA,Twisk JWR,Vergouwe Y,Bouter LM,van der Heijden GJMG

更新日期：2006-02-01 00:00:00

abstract：:Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important ad...

journal_title：Pain

authors： Melchior M,Juif PE,Gazzo G,Petit-Demoulière N,Chavant V,Lacaud A,Goumon Y,Charlet A,Lelièvre V,Poisbeau P

更新日期：2018-12-01 00:00:00